Full Text Journal Articles by
Author M McDermott

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Leptomeningeal Relapse of Embryonal Rhabdomyosarcoma after 15 years.

S Chew, J P Gleeson, A McCarthy, G A Watson, R O'Dwyer, S Nicholson, M Capra, C Owens, M McDermott, P Daly, C Grant,

Aim Rhabdomyosarcoma (RMS) is the most common malignant soft tissue tumour of childhood. We present the case of a late relapse of RMS to the leptomeninges after 15 years. Methods A 20 year old male presented with a 3 week history of headaches and nausea. He previously had RMS of ... Read more >>

Ir Med J (Irish medical journal)
[2020, 112(10):1026]

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Contrast Saline Mixture DualFlow Injection Protocols for Low-Kilovolt Computed Tomography Angiography: A Systematic Phantom and Animal Study.

Daniel Overhoff, Gregor Jost, Michael McDermott, Barbara Wichtmann, Stefan O Schoenberg, Hubertus Pietsch, Ulrike Attenberger,

OBJECTIVE:The aim of this study was to evaluate a contrast media (CM)-saline mixture administration with DualFlow (DF) to adapt injection protocols to low-kilovolt (kV) computed tomography angiography (CTA). MATERIALS AND METHODS:In both a circulation phantom and animal model (5 Goettingen minipigs), 3 injection protocols were compared in dynamic thoracic CTA: ... Read more >>

Invest Radiol (Investigative radiology)
[2020, 55(12):785-791]

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Meningioma epigenetic grouping reveals biologic drivers and therapeutic vulnerabilities

Abrar Choudhury, Stephen Magill, Charlotte Eaton, Briana Prager, William Chen, Kyounghee Seo, Calixto-Hope Lucas, Javier Villanueva-Meyer, Tai-Chung Lam, Jenny Kan-Suen Pu, Lai-Fung Li, Gilberto Ka-Kit Leung, Harish Vasudevan, John Liu, Jason Chan, Zhixin Qiu, Michael Zhang, Michael Martin, Matthew Susko, Steve Braunstein, Nancy Ann Oberheim Bush, Jessica Schulte, Nicholas Butowski, Penny Sneed, Mitchel Berger, Arie Perry, Joanna Phillips, David Solomon, Joseph Costello, Michael McDermott, Jeremy Rich, David Raleigh,

SUMMARY Meningiomas arising from the meningothelial central nervous system lining are the most common primary intracranial tumors, and a significant cause of neurologic morbidity and mortality 1 . There are no effective medical therapies for meningioma patients 2,3 , and new treatments have been encumbered by limited understanding of meningioma ... Read more >>

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Clipper: p-value-free FDR control on high-throughput data from two conditions

Xinzhou Ge, Yiling Elaine Chen, Dongyuan Song, MeiLu McDermott, Kyla Woyshner, Antigoni Manousopoulou, Wei Li, Leo Wang, Jingyi Jessica Li,

Abstract High-throughput biological data analysis commonly involves the identification of “interesting” features (e.g., genes, genomic regions, and proteins), whose values differ between two conditions, from numerous features measured simultaneously. To ensure the reliability of such analysis, the most widely-used criterion is the false discovery rate (FDR), the expected proportion of ... Read more >>

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Analysis in epithelial ovarian cancer identifies KANSL1 as a biomarker and target gene for immune response and HDAC inhibition.

Marlena S Fejzo, Hsiao-Wang Chen, Lee Anderson, Martina Sj McDermott, Beth Karlan, Gottfried E Konecny, Dennis J Slamon,

OBJECTIVE:There is an immunoreactive subtype of ovarian cancer with a favorable prognosis, but the majority of ovarian cancers have limited immune reactivity. The reason for this is poorly understood. This study aimed to approach this question by identifying prognostically relevant genes whose prognostic mRNA expression levels correlated with a genomic ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, :]

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Efficacy of Visual Retraining in the Hemianopic Field After Stroke: Results of a Randomized Clinical Trial.

Matthew R Cavanaugh, Lisa M Blanchard, Michael McDermott, Byron L Lam, Madhura Tamhankar, Steven E Feldon,

OBJECTIVE:To evaluate the efficacy of motion discrimination training as a potential therapy for stroke-induced hemianopic visual field defects. DESIGN:Clinical Trial SUBJECTS: Forty-eight subjects with stroke-induced homonymous hemianopia were randomized into two training arms, an intervention and a control. Subjects were between 21-75 years of age and presented with no ocular ... Read more >>

Ophthalmology (Ophthalmology)
[2020, :]

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Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations.

Shannon M Smith, Robert H Dworkin, Dennis C Turk, Michael P McDermott, Christopher Eccleston, John T Farrar, Michael C Rowbotham, Zubin Bhagwagar, Laurie B Burke, Penney Cowan, Susan S Ellenberg, Scott R Evans, Roy L Freeman, Louis P Garrison, Smriti Iyengar, Alejandro Jadad, Mark P Jensen, Roderick Junor, Cornelia Kamp, Nathaniel P Katz, James Patrick Kesslak, Ernest A Kopecky, Dmitri Lissin, John D Markman, Philip J Mease, Alec B OʼConnor, Kushang V Patel, Srinivasa N Raja, Cristina Sampaio, David Schoenfeld, Jasvinder Singh, Ilona Steigerwald, Vibeke Strand, Leslie A Tive, Jeffrey Tobias, Ajay D Wasan, Hilary D Wilson,

Interpreting randomized clinical trials (RCTs) is crucial to making decisions regarding the use of analgesic treatments in clinical practice. In this article, we report on an Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) consensus meeting organized by the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, ... Read more >>

Pain (Pain)
[2020, 161(11):2446-2461]

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The Simpson grade: abandon the scale but preserve the message.

Theodore H Schwartz, Michael W McDermott,

The Simpson grading scale, developed in 1957 by Donald Simpson, has been considered the gold standard for defining the surgical extent of resection for WHO grade I meningiomas. Since its introduction, the scale and its modifications have generated enormous controversy. The Simpson grade is based on an intraoperative visual assessment ... Read more >>

J Neurosurg (Journal of neurosurgery)
[2020, :1-8]

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Mexiletine in myotonic dystrophy type-1: A randomized, double-blind, placebo-controlled trial.

Chad Heatwole, Elizabeth Luebbe, Spencer Rosero, Katy Eichinger, William Martens, James Hilbert, Jeanne Dekdebrun, Nuran Dilek, Christine Zizzi, Nicholas Johnson, Araya Puwanant, Rabi Tawil, Giovanni Schifitto, Christopher A Beck, J Franklin Richeson, Wojciech Zareba, Charles Thornton, Michael P McDermott, Richard Moxley,

OBJECTIVE:To assess mexiletine's long-term safety and effect on 6 minute walk distance in a well-defined cohort of myotonic dystrophy type-1 (DM1) patients. METHODS:We performed a randomized, double-blind, placebo-controlled trial of mexiletine (150 mg 3 times daily) to evaluate its efficacy and safety in a homogenous cohort of adult ambulatory DM1 ... Read more >>

Neurology (Neurology)
[2020, :]

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NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation.

Emily Stenke, Gabriella Aviello, Ashish Singh, Sean Martin, Des Winter, Brian Sweeney, Michael McDermott, Billy Bourke, Seamus Hussey, Ulla G Knaus,

Dysregulated redox signaling and oxidative injury are associated with inflammatory processes and fibrosis. H2O2 generation by NOX4 has been suggested as a key driver in the development of fibrosis and a small molecule drug is under evaluation in clinical trials for idiopathic pulmonary fibrosis and primary biliary cholangitis. Fibrosis is ... Read more >>

Redox Biol (Redox biology)
[2020, 37:101752]

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Columnar Lined Esophagus/Gastric Metaplasia Requires Careful Follow-up.

Nichola Sandys, Caitriona Loomes, Aoife Keane, Seamus Hussey, Annemarie Broderick, Michael McDermott, Maureen OʼSullivan, Billy Bourke,

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2020, 71(4):e136]

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Estimands and missing data in clinical trials of chronic pain treatments: advances in design and analysis.

Xueya Cai, Jennifer S Gewandter, Hua He, Dennis C Turk, Robert H Dworkin, Michael P McDermott,

In clinical trials of treatments for chronic pain, the percentage of participants who withdraw early can be as high as 50%. Major reasons for early withdrawal in these studies include perceived lack of efficacy and adverse events. Commonly used strategies for accommodating missing data include last observation carried forward, baseline ... Read more >>

Pain (Pain)
[2020, 161(10):2308-2320]

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Novel ocular findings and progressive intracranial calcification in a case of Revesz syndrome.

Jack McCaffrey, Kathleen Gorman, Michael McDermott, Stephen Farrell, Ghadir Kassab, Melanie Cotter,

Br J Haematol (British journal of haematology)
[2020, 191(3):317]

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Skeletal Muscle Pathology in Peripheral Artery Disease: A Brief Review.

Mary M McDermott, Luigi Ferrucci, Marta Gonzalez-Freire, Kate Kosmac, Christiaan Leeuwenburgh, Charlotte A Peterson, Sunil Saini, Robert Sufit,

This brief review summarizes current evidence regarding lower extremity peripheral artery disease (PAD) and lower extremity skeletal muscle pathology. Lower extremity ischemia is associated with reduced calf skeletal muscle area and increased calf muscle fat infiltration and fibrosis on computed tomography or magnetic resonance imaging. Even within the same individual, ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2020, 40(11):2577-2585]

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Mitochondrial DNA damage in calf skeletal muscle and walking performance in people with peripheral artery disease.

Sunil K Saini, Mary M McDermott, Anna Picca, Lingyu Li, Stephanie E Wohlgemuth, Kate Kosmac, Charlotte A Peterson, Lu Tian, Luigi Ferrucci, Jack M Guralnik, Robert L Sufit, Christiaan Leeuwenburgh,

BACKGROUND:Peripheral artery disease (PAD) is associated with mitochondrial dysfunction in calf skeletal muscle and a greater abundance of mitochondrial DNA (mtDNA) heteroplasmy. However, it is unknown whether calf skeletal muscle mtDNA of PAD participants harbors a greater abundance of mitochondrial DNA 4977-bp common deletion (mtDNA4977), strand breaks and oxidative damage ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2020, 160:680-689]

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Incremental Gains in the Battle against ALS.

Michael Benatar, Michael P McDermott,

N Engl J Med (The New England journal of medicine)
[2020, 383(10):979-980]

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Defect-Accommodating Intermediates Yield Selective Low-Temperature Synthesis of YMnO3 Polymorphs.

Paul K Todd, Allison Wustrow, Rebecca D McAuliffe, Matthew J McDermott, Gia Thinh Tran, Brennan C McBride, Ethan D Boeding, Daniel O'Nolan, Chia-Hao Liu, Shyam S Dwaraknath, Karena W Chapman, Simon J L Billinge, Kristin A Persson, Ashfia Huq, Gabriel M Veith, James R Neilson,

In the synthesis of complex oxides, solid-state metathesis provides low-temperature reactions where product selectivity can be achieved through simple changes in precursor composition. The influence of precursor structure, however, is less understood in solid-state synthesis. Here we present the ternary metathesis reaction (LiMnO2 + YOCl → YMnO3 + LiCl) to ... Read more >>

Inorg Chem (Inorganic chemistry)
[2020, 59(18):13639-13650]

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WHO Grade I Meningioma Recurrence: Identifying High Risk Patients Using Histopathological Features and the MIB-1 Index.

Alexander F Haddad, Jacob S Young, Ishan Kanungo, Sweta Sudhir, Jia-Shu Chen, David R Raleigh, Stephen T Magill, Michael W McDermott, Manish K Aghi,

Objective: In this study, we identify clinical, radiographic, and histopathologic prognosticators of overall, early, and post-median recurrence in World Health Organization (WHO) grade I meningiomas. We also determine a clinically relevant cutoff for MIB-1 to identify patients at high risk for recurrence. Method: A retrospective review of WHO grade I ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1522]

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Mechanisms underlying the generation of autonomorespiratory coupling amongst the respiratory central pattern generator, sympathetic oscillators, and cardiovagal premotoneurons.

Michael G Z Ghali, George Zaki Ghali, Adriana Lima, Michael McDermott, Emma Glover, Stefanos Voglis, Jennifer Humphrey, Marton Skog Steinberger König, Henry Brem, Per Uhlén, Robert F Spetzler, M Gazi Yasargil,

The respiratory rhythm and pattern and sympathetic and parasympathetic outflows are generated by distinct, though overlapping, propriobulbar arrays of neuronal microcircuit oscillators constituting networks utilizing mutual excitatory and inhibitory neuronal interactions, residing principally within the metencephalon and myelencephalon, and modulated by synaptic influences from the cerebrum, thalamus, hypothalamus, cerebellum, and ... Read more >>

J Integr Neurosci (Journal of integrative neuroscience)
[2020, 19(3):521-560]

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John D. Loeser Award Lecture: Size does matter, but it isn't everything: the challenge of modest treatment effects in chronic pain clinical trials.

Shannon M Smith, Maurizio Fava, Mark P Jensen, Omar B Mbowe, Michael P McDermott, Dennis C Turk, Robert H Dworkin,

Pain (Pain)
[2020, 161 Suppl 1:S3-S13]

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A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection.

William C Chen, Harish N Vasudevan, Abrar Choudhury, Melike Pekmezci, Calixto-Hope G Lucas, Joanna Phillips, Stephen T Magill, Matthew S Susko, Steve E Braunstein, Nancy Ann Oberheim Bush, Lauren Boreta, Jean L Nakamura, Javier E Villanueva-Meyer, Penny K Sneed, Arie Perry, Michael W McDermott, David A Solomon, Philip V Theodosopoulos, David R Raleigh,

BACKGROUND:Prognostic markers for meningioma are needed to risk-stratify patients and guide postoperative surveillance and adjuvant therapy. OBJECTIVE:To identify a prognostic gene signature for meningioma recurrence and mortality after resection using targeted gene-expression analysis. METHODS:Targeted gene-expression analysis was used to interrogate a discovery cohort of 96 meningiomas and an independent validation ... Read more >>

Neurosurgery (Neurosurgery)
[2020, :]

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Endovascular treatment of anterior cranial fossa dural arteriovenous fistula: a multicenter series.

Guilherme Dabus, Peter Kan, Carlos Diaz, Boris Pabon, Juan Andres-Mejia, Italo Linfante, Jonathan A Grossberg, Brian M Howard, Civan Islak, Naci Kocer, Osman Kizilkilic, Ajit S Puri, Anna L Kuhn, Viraj Moholkar, Santiago Ortega-Gutierrez, Edgar A Samaniego, Michael W McDermott,

PURPOSE:We report a multicenter experience using endovascular embolization as the first line approach for treatment of anterior cranial fossa (ACF) dural arteriovenous fistula (DAVF). METHODS:All patients with DAVFs located in the anterior cranial fossa who were treated with endovascular technique as a first line approach were included. Demographics, clinical presentation, ... Read more >>

Neuroradiology (Neuroradiology)
[2020, :]

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Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling

Uddalak Majumdar, Sathiyanarayanan Manivannan, Madhumita Basu, Yukie Ueyama, Mark Blaser, Emily Cameron, Michael McDermott, Joy Lincoln, Susan Cole, Stephen Wood, Elena Aikawa, Brenda Lilly, Vidu Garg,

Abstract Calcific aortic valve disease (CAVD) is an increasingly prevalent condition and endothelial dysfunction is implicated in its etiology. We previously identified nitric oxide (NO) as a calcification inhibitor by its activation of NOTCH1 , which is genetically linked to human CAVD. Here, we show that NO rescues calcification by ... Read more >>

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Targeting activated PI3K/mTOR signaling overcomes acquired resistance to CDK4/6-based therapies in preclinical models of hormone receptor-positive breast cancer.

Neil A O'Brien, Martina S J McDermott, Dylan Conklin, Tong Luo, Raul Ayala, Suruchi Salgar, Kevin Chau, Emmanuelle DiTomaso, Naveen Babbar, Faye Su, Alex Gaither, Sara A Hurvitz, Ronald Linnartz, Kristine Rose, Samit Hirawat, Dennis J Slamon,

BACKGROUND:Combined targeting of CDK4/6 and ER is now the standard of care for patients with advanced ER+/HER2- breast cancer. However, acquired resistance to these therapies frequently leads to disease progression. As such, it is critical to identify the mechanisms by which resistance to CDK4/6-based therapies is acquired and also identify ... Read more >>

Breast Cancer Res (Breast cancer research : BCR)
[2020, 22(1):89]

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Corrigendum to "Proliferative, reparative, and reactive benign bone lesions that may be confused diagnostically with true osseous neoplasm" Seminars in Diagnostic Pathology 31 (2014) 66-88.

Mark R Wick, Michael B McDermott, Paul E Swanson,

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2020, :]

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