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Author M Hennessy

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Changes in the faecal bacterial microbiota during hospitalisation of horses with colic and the effect of different causes of colic.

Holly L Stewart, Dipti Pitta, Nagaraju Indugu, Bonnie Vecchiarelli, Meagan L Hennessy, Julie B Engiles, Louise L Southwood,

BACKGROUND:Previous studies have identified alterations in the faecal microbiota of horses with colic; however, further work is needed to interpret these findings. OBJECTIVES:To compare the faecal microbiota of horses presenting for colic at hospital admission, day 1 and day 3/discharge and with different colic duration and lesion locations. STUDY DESIGN:Prospective ... Read more >>

Equine Vet J (Equine veterinary journal)
[2020, :]

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Psychological Stress, Its Reduction, and Long-Term Consequences: What Studies with Laboratory Animals Might Teach Us about Life in the Dog Shelter.

Michael B Hennessy, Regina M Willen, Patricia A Schiml,

There is a long history of laboratory studies of the physiological and behavioral effects of stress, its reduction, and the later psychological and behavioral consequences of unmitigated stress responses. Many of the stressors employed in these studies approximate the experience of dogs confined in an animal shelter. We review how ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2020, 10(11):]

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Feasibility Assessment of an 8-week Attention-based Training Programme in the Management of Chronic Spontaneous Urticaria 

Katie Elizabeth Ridge, Niall Conlon, Martina Hennessy, Pádraic Dunne,

Abstract Background: Chronic spontaneous urticaria is a common disorder that is poorly understood and frequently misdiagnosed. Psychological difficulties are a significant factor in dermatological diseases and may also aggravate symptom burden. Mind-body interventions are used as a complementary approach to alleviate symptoms in chronic diseases and may represent a valuable ... Read more >>

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Bempegaldesleukin (BEMPEG; NKTR-214) efficacy as a single agent and in combination with checkpoint-inhibitor therapy in mouse models of osteosarcoma.

Marlene Hennessy, Andrew Wahba, Kumar Felix, Mariella Cabrera, Maria Gabriela Segura, Vikas Kundra, Murali K Ravoori, John Stewart, Eugenie S Kleinerman, V Behrana Jensen, Vidya Gopalakrishnan, Rhoneil Pena, Phi Quach, Grace Kim, Saul Kivimäe, Loui Madakamutil, Willem W Overwijk, Jonathan Zalevsky, Nancy Gordon,

Survival of patients with relapsed/refractory osteosarcoma has not improved in the last 30 years. Several immunotherapeutic approaches have shown benefit in murine osteosarcoma models, including the anti-programmed death-1 (anti-PD-1) and anti-cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4) immune checkpoint inhibitors. Treatment with the T-cell growth factor interleukin-2 (IL-2) has shown some clinical benefit but ... Read more >>

Int J Cancer (International journal of cancer)
[2020, :]

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A protocol for a systematic review of clinical practice guidelines for recurrent miscarriage.

Marita Hennessy, Rebecca Dennehy, Sarah Meaney, Declan Devane, Keelin O'Donoghue,

Recurrent miscarriage (RM) was recently re-defined by the European Society of Human Reproduction and Embryology (ESHRE) as the loss of two or more consecutive pregnancies. Before this, and indeed still in some countries, RM was defined as three or more consecutive pregnancy losses. While the incidence of RM depends on ... Read more >>

HRB Open Res (HRB open research)
[2020, 3:12]

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A protocol for a systematic review of clinical practice guidelines for recurrent miscarriage

Marita Hennessy, Rebecca Dennehy, Sarah Meaney, Declan Devane, Keelin O'Donoghue,

Recurrent miscarriage (RM) was recently re-defined by the European Society of Human Reproduction and Embryology (ESHRE) as the loss of two or more consecutive pregnancies. Before this, and indeed still in some countries, RM was defined as three or more consecutive pregnancy losses. While the incidence of RM depends on ... Read more >>

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1762P Delivery of systemic anti-cancer therapy during the COVID-19 pandemic

O. Fitzpatrick, R. Ní Dhonaill, A. Linehan, Z. Coyne, M. Hennessy, M. Clarke, E. McGee, F. Barrett, C. Matassa, D. O'Doherty, T. Doyle, A. Christie, B.T. Hennessy, L. Grogan, P.G. Morris, O.S. Breathnach, D. Cowzer,

Ann Oncol (Annals of oncology : official journal of the European Society for Medical Oncology)
[2020, 31(9):S1024-S1025]

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Endovascular salvage of an aortic anastomotic pseudoaneurysm following deep vein reconstruction.

Kirsten V Hamilton, Martin Hennessy, Keith K Hussey,

Aortoiliac reconstruction using autologous deep femoral vein (neoaortic iliac system bypass [NAIS]) is a therapeutic option for management of prosthetic aortic graft infection. Complications after NAIS are complex and reported management strategies few. Endovascular procedures offer a minimally invasive alternative to high-risk, complex open surgery. We report a case of ... Read more >>

J Vasc Surg Cases Innov Tech (Journal of vascular surgery cases and innovative techniques)
[2020, 6(4):637-640]

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Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids

Simone Creed, Anna Gutridge, Malaika Argade, Madeline Hennessy, Brent Friesen, Guido Pauli, Richard van Rijn, Andrew Riley,

<p>The seeds of the akuamma tree (<i>Picralima nitida</i>) have been used as a traditional treatment for pain and fever. Previous studies have attributed these effects to a series of indole alkaloids found within the seed extracts; however, these pharmacological studies were significantly limited in scope. Herein, an isolation protocol employing ... Read more >>

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Optimizing and simplifying post-traumatic amnesia testing after moderate-severe traumatic brain injury despite common confounders in routine practice.

M J Hennessy, L A G Marshman, L Delle Baite, J McLellan,

The duration of post-traumatic amnesia (PTA) following traumatic brain injury (TBI) is a key diagnostic and outcome indicator. However, concerningly, different PTA paradigms record different PTA durations: some over-estimate, others under-estimate, PTA. Thus, a compromise is implied. The potential effect of in-hospital confounders including opioids is unknown. Three clinical groups ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, 81:37-42]

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Temporal changes in the fecal bacterial community in Holstein dairy calves from birth through the transition to a solid diet.

Meagan L Hennessy, Nagaraju Indugu, Bonnie Vecchiarelli, Joseph Bender, Christa Pappalardo, Miranda Leibstein, John Toth, Ananya Katepalli, Satvik Garapati, Dipti Pitta,

The development of a robust microbiome is critical to the health of dairy calves, but relatively little is known about the progression of the microbiome through the weaning transition. In this study, fecal samples were obtained from ten female Holstein calves at 6 timepoints between 2-13 weeks of age. Calves ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0238882]

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1732P Prognostic indicators for COVID-19 related deaths in patients with cancer

A. Linehan, D. Cowzer, M. Hennessy, Z. Coyne, O. Fitzpatrick, A. Nolan, L. Judge, N. Cooley, D. O'Doherty, C. Matassa, T. Doyle, B.T. Hennessy, L. Grogan, P.G. Morris, O.S. Breathnach,

Ann Oncol (Annals of oncology : official journal of the European Society for Medical Oncology)
[2020, 31(9):S1014-S1014]

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1571P Chemotherapy in the COVID-19 era: The patient’s perception

M. Hennessy, A. Linehan, D. Cowzer, Z. Coyne, O. Fitzpatrick, R. Ní Dhonaill, B.T. Hennessy, L. Grogan, P.G. Morris, O.S. Breathnach,

Ann Oncol (Annals of oncology : official journal of the European Society for Medical Oncology)
[2020, 31(9):S957-S957]

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Glaucoma Community Care: Does Ongoing Shared Care Work?

Angelica Ly, Elizabeth Wong, Jessie Huang, Michael Yapp, Katherine Masselos, Michael Hennessy, Michael Kalloniatis, Barbara Zangerl,

Purpose:We assessed a novel, public, vertical integrated care model for glaucoma management in the community. Methods:This study was a retrospective, longitudinal study of 266 patients diagnosed or suspected of glaucoma. Patients were stratified to either ongoing ophthalmology-led (n = 81) or optometry-led shared care (n = 185). Demographics and clinical ... Read more >>

Int J Integr Care (International journal of integrated care)
[2020, 20(3):5]

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Optimal Timing of CT Scanning in the Rapid Access Lung Cancer Clinic.

M Hennessy, D Ryan, S Clarke, C Higgins, M Logan, E O’Brien, R Morgan,

Aims To investigate whether a ‘CT first’ approach to Rapid Access Lung Cancer Clinic (RALC) review could be feasible in an Irish context. Methods A retrospective review of our institution’s Lung Cancer Database was performed. All RALC first attendances from 2012-2018 were identified. Timing of CT was assessed as well ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(7):121]

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A model for classification of invasive fungal rhinosinusitis by computed tomography.

Guy Slonimsky, Johnathan D McGinn, Neerav Goyal, Henry Crist, Max Hennessy, Eric Gagnon, Einat Slonimsky,

Our purpose was to classify acute invasive fungal rhinosinusitis (AIFR) caused by Mucor versus Aspergillus species by evaluating computed tomography radiological findings. Two blinded readers retrospectively graded radiological abnormalities of the craniofacial region observed on craniofacial CT examinations obtained during initial evaluation of 38 patients with eventually pathology-proven AIFR (13:25, ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):12591]

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Patient demographics and management challenges in an Irish symptomatic breast cancer unit.

Zac L Coyne, Maeve Hennessy, Deirdre Duke, Arnold Hill, Liam Grogan, Oscar Breathnach, Bryan Hennessy, Patrick G Morris,

BACKGROUND:Breast cancer is the most common cancer in women. Beaumont Hospital is a nationally designated symptomatic breast cancer unit, independent of the national screening programme, BreastCheck. AIMS:We hypothesised that patients attending symptomatic breast cancer units differ from national registry data and aimed to characterise this in a retrospective study. METHODS:A ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2020, 189(4):1237-1241]

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"They Just Need to Come Down a Little Bit to your Level": A Qualitative Study of Parents' Views and Experiences of Early Life Interventions to Promote Healthy Growth and Associated Behaviours.

Marita Hennessy, Molly Byrne, Rachel Laws, Caroline Heary,

The first 1000 days is a critical window of opportunity to promote healthy growth and associated behaviours. Health professionals can play an important role, in part due to the large number of routine contacts they have with parents. There is an absence of research on the views of parents towards ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(10):]

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Local NO2 concentrations and asthma among over-50s in Ireland: A microdata analysis.

Philip Carthy, Aonghus Ó Domhnaill, Margaret O'Mahony, Anne Nolan, Frank Moriarty, Brian Broderick, Martina Hennessy, Aoife Donnelly, Owen Naughton, Sean Lyons,

BACKGROUND:Links between air pollution and asthma are less well established for older adults than some younger groups. Nitrogen dioxide (NO2) concentrations are widely used as an indicator of transport-related air pollution, and some literature suggests NO2 may directly affect asthma. METHODS:This study used data on 8162 adults >50 years old in ... Read more >>

Int J Epidemiol (International journal of epidemiology)
[2020, :]

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Ferumoxytol MR Angiography: A Novel Technique for Assessing Iliac Vasculature in Potential Kidney Transplant Recipients.

Sokratis Stoumpos, Pauline Hall Barrientos, Douglas H Black, Karen Stevenson, Martin Hennessy, Alex T Vesey, William Strauss, Ram Kasthuri, Aleksandra Radjenovic, David B Kingsmore, Giles Roditi, Patrick B Mark,

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2020, 13(8):1847-1848]

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Update on the psychometric properties and minimal important difference (MID) thresholds of the FACT-M questionnaire for use in treatment-naïve and previously treated patients with metastatic Merkel cell carcinoma.

Murtuza Bharmal, Sandra Nolte, Mickaël Henry-Szatkowski, Meliessa Hennessy, Michael Schlichting,

OBJECTIVES:For valid and reliable assessment of patients' Health-Related Quality of Life (HRQoL), it is crucial to use psychometrically robust instruments. In the context of rare diseases such as Merkel cell carcinoma (MCC), validated disease-specific instruments are often not available. The Functional Assessment of Cancer Therapy - Melanoma (FACT-M) was originally ... Read more >>

Health Qual Life Outcomes (Health and quality of life outcomes)
[2020, 18(1):145]

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Host-virus evolutionary dynamics with specialist and generalist infection strategies: Bifurcations, bistability, and chaos.

Anel Nurtay, Matthew G Hennessy, Lluís Alsedà, Santiago F Elena, Josep Sardanyés,

In this work, we have investigated the evolutionary dynamics of a generalist pathogen, e.g., a virus population, that evolves toward specialization in an environment with multiple host types. We have particularly explored under which conditions generalist viral strains may rise in frequency and coexist with specialist strains or even dominate ... Read more >>

Chaos (Chaos (Woodbury, N.Y.))
[2020, 30(5):053128]

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Spastic paraplegia type 7 associated with a broad clinical phenotype.

Luke Francis O'Donnell, Michael Hennessy,

Ir J Med Sci (Irish journal of medical science)
[2020, 189(4):1411]

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Phase separation in swelling and deswelling hydrogels with a free boundary.

Matthew G Hennessy, Andreas Münch, Barbara Wagner,

We present a full kinetic model of a hydrogel that undergoes phase separation during swelling and deswelling. The model accounts for the interfacial energy of coexisting phases, finite strain of the polymer network, and solvent transport across free boundaries. For the geometry of an initially dry layer bonded to a ... Read more >>

Phys Rev E (Physical review. E)
[2020, 101(3-1):032501]

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Are e-cigarette product advertisements on public transport driving public misunderstanding and potentially increased use?

S W Flint, M Hennessy,

Perspect Public Health (Perspectives in public health)
[2020, 140(2):91-92]

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