Full Text Journal Articles by
Author M Connellan

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The impact of frailty on mortality after heart transplantation.

Peter S Macdonald, Natasha Gorrie, Xavier Brennan, Samira R Aili, Ricardo De Silva, Sunita R Jha, Rodrigo Fritis-Lamora, Elyn Montgomery, Kay Wilhelm, Rachel Pierce, Fiona Lam, Bruno Schnegg, Christopher Hayward, Andrew Jabbour, Eugene Kotlyar, Kavitha Muthiah, Anne M Keogh, Emily Granger, Mark Connellan, Alasdair Watson, Arjun Iyer, Paul C Jansz,

<h4>Background</h4>Frailty is prevalent in the patients with advanced heart failure; however, its impact on clinical outcomes after heart transplantation (HTx) is unclear. The aim of this study was to assess the impact of pre-transplant frailty on mortality and the duration of hospitalization after HTx.<h4>Methods</h4>We retrospectively reviewed the post-transplant outcomes of ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2020, :]

Cited: 0 times

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DCD donations and outcomes of heart transplantation: the Australian experience.

Kumud Dhital, Prakash Ludhani, Sarah Scheuer, Mark Connellan, Peter Macdonald,

<h4>Purpose</h4>There is increasing clinical utilization of hearts from the donation after circulatory death (DCD) pathway with the aim of expanding the donor pool and mitigating the ever-present discrepancy between the inadequate availability of good quality donor hearts and the rising number of patients with end-stage heart failure.<h4>Methods</h4>This article reviews the ... Read more >>

Indian J Thorac Cardiovasc Surg (Indian journal of thoracic and cardiovascular surgery)
[2020, 36(Suppl 2):224-232]

Cited: 0 times

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Outcomes of Donation After Circulatory Death Heart Transplantation in Australia.

Hong Chee Chew, Arjun Iyer, Mark Connellan, Sarah Scheuer, Jeanette Villanueva, Ling Gao, Mark Hicks, Michelle Harkness, Claudio Soto, Andrew Dinale, Priya Nair, Alasdair Watson, Emily Granger, Paul Jansz, Kavitha Muthiah, Andrew Jabbour, Eugene Kotlyar, Anne Keogh, Chris Hayward, Robert Graham, Phillip Spratt, Peter Macdonald, Kumud Dhital,

BACKGROUND:Transplantation of hearts retrieved from donation after circulatory death (DCD) donors is an evolving clinical practice. OBJECTIVES:The purpose of this study is to provide an update on the authors' Australian clinical program and discuss lessons learned since performing the world's first series of distantly procured DCD heart transplants. METHODS:The authors ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2019, 73(12):1447-1459]

Cited: 6 times

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Effect of Aspirin on All-Cause Mortality in the Healthy Elderly.

John J McNeil, Mark R Nelson, Robyn L Woods, Jessica E Lockery, Rory Wolfe, Christopher M Reid, Brenda Kirpach, Raj C Shah, Diane G Ives, Elsdon Storey, Joanne Ryan, Andrew M Tonkin, Anne B Newman, Jeff D Williamson, Karen L Margolis, Michael E Ernst, Walter P Abhayaratna, Nigel Stocks, Sharyn M Fitzgerald, Suzanne G Orchard, Ruth E Trevaks, Lawrence J Beilin, Geoffrey A Donnan, Peter Gibbs, Colin I Johnston, Barbara Radziszewska, Richard Grimm, Anne M Murray, ,

<h4>Background</h4>In the primary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial, now published in the Journal, we report that the daily use of aspirin did not provide a benefit with regard to the primary end point of disability-free survival among older adults. A numerically higher rate ... Read more >>

N Engl J Med (The New England journal of medicine)
[2018, 379(16):1519-1528]

Cited: 77 times

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Effect of Aspirin on Disability-free Survival in the Healthy Elderly.

John J McNeil, Robyn L Woods, Mark R Nelson, Christopher M Reid, Brenda Kirpach, Rory Wolfe, Elsdon Storey, Raj C Shah, Jessica E Lockery, Andrew M Tonkin, Anne B Newman, Jeff D Williamson, Karen L Margolis, Michael E Ernst, Walter P Abhayaratna, Nigel Stocks, Sharyn M Fitzgerald, Suzanne G Orchard, Ruth E Trevaks, Lawrence J Beilin, Geoffrey A Donnan, Peter Gibbs, Colin I Johnston, Joanne Ryan, Barbara Radziszewska, Richard Grimm, Anne M Murray, ,

<h4>Background</h4>Information on the use of aspirin to increase healthy independent life span in older persons is limited. Whether 5 years of daily low-dose aspirin therapy would extend disability-free life in healthy seniors is unclear.<h4>Methods</h4>From 2010 through 2014, we enrolled community-dwelling persons in Australia and the United States who were 70 ... Read more >>

N Engl J Med (The New England journal of medicine)
[2018, 379(16):1499-1508]

Cited: 48 times

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Retrieval of critically ill adults using extracorporeal membrane oxygenation: the nine-year experience in New South Wales.

D E Austin, B Burns, D Lowe, B Cartwright, A Clarke, M Dennis, M D'Souza, R Nathan, P G Bannon, D Gattas, M Connellan, P Forrest,

In New South Wales, a coordinated extracorporeal membrane oxygenation (ECMO) retrieval program has been in operation since 2007. This study describes the characteristics and outcomes of patients transported by this service. We performed a retrospective observational study and included patients who were transported on ECMO to either of two adult ... Read more >>

Anaesth Intensive Care (Anaesthesia and intensive care)
[2018, 46(6):579-588]

Cited: 0 times

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Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.

John J McNeil, Rory Wolfe, Robyn L Woods, Andrew M Tonkin, Geoffrey A Donnan, Mark R Nelson, Christopher M Reid, Jessica E Lockery, Brenda Kirpach, Elsdon Storey, Raj C Shah, Jeff D Williamson, Karen L Margolis, Michael E Ernst, Walter P Abhayaratna, Nigel Stocks, Sharyn M Fitzgerald, Suzanne G Orchard, Ruth E Trevaks, Lawrence J Beilin, Colin I Johnston, Joanne Ryan, Barbara Radziszewska, Michael Jelinek, Mobin Malik, Charles B Eaton, Donna Brauer, Geoff Cloud, Erica M Wood, Suzanne E Mahady, Suzanne Satterfield, Richard Grimm, Anne M Murray, ,

<h4>Background</h4>Aspirin is a well-established therapy for the secondary prevention of cardiovascular events. However, its role in the primary prevention of cardiovascular disease is unclear, especially in older persons, who have an increased risk.<h4>Methods</h4>From 2010 through 2014, we enrolled community-dwelling men and women in Australia and the United States who were ... Read more >>

N Engl J Med (The New England journal of medicine)
[2018, 379(16):1509-1518]

Cited: 102 times

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The Role of Emotional Intelligence in Community Integration and Return to Work After Acquired Brain Injury.

Sarah E Hall, Joanne M Wrench, Madeleine Connellan, Neira Ott, Sarah J Wilson,

<h4>Objective</h4>To investigate whether emotional intelligence (EI) skills measured via the Perceiving, Understanding, and Managing Emotions branches of the Mayer-Salovey-Caruso Emotional Intelligence Test V2.0 are associated with community integration (CI) and return to work (RTW) after moderate-to-severe acquired brain injury (ABI), after accounting for other established predictors.<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>Outpatient follow-up services ... Read more >>

Arch Phys Med Rehabil (Archives of physical medicine and rehabilitation)
[2019, 100(3):464-473]

Cited: 1 time

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Nosocomial infections acquired by patients treated with extracorporeal membrane oxygenation.

Danielle E Austin, Stephen J Kerr, Suhel Al-Soufi, Mark Connellan, Phillip Spratt, Emma Goeman, Priya Nair,

BACKGROUND:Infectious complications in patients treated with extracorporeal membrane oxygenation (ECMO) are a frequent contributor to morbidity and mortality in this group. Defining the characteristics of ECMO-related infections may inform treatment decisions, including antimicrobial therapy. METHODS:A retrospective observational study in an Australian intensive care unit, including adult patients treated with ECMO ... Read more >>

Crit Care Resusc (Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine)
[2017, 19(Suppl 1):68-75]

Cited: 3 times

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Primary percutaneous coronary intervention for inferior ST-segment elevation myocardial infarction in a patient supported by the HeartWare left ventricular assist device.

Roberto Spina, Maithri Siriwardena, Nicole Bart, Mayooran Namasivayam, Mark Connellan, Paul Jansz, Philip Spratt, Christopher S Hayward, Eugene Kotlyar, Brendan Gunalingam,

A 63-year-old man with an ischaemic cardiomyopathy, supported by the HeartWare left ventricular assist device (LVAD), presented with ventricular tachycardia and inferior ST-elevation myocardial infarction (STEMI) with associated acute right ventricular (RV) dysfunction. He underwent primary percutaneous coronary intervention with balloon angioplasty and placement of three drug-eluting stents in the ... Read more >>

Intern Med J (Internal medicine journal)
[2017, 47(9):1068-1071]

Cited: 0 times

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Long distance heart transplantation: a tale of two cities.

Pankaj Jain, Roslyn A Prichard, Mark B Connellan, Kumud K Dhital, Peter S Macdonald,

In this 'paired' case report, we describe two heart transplants performed 3 days apart at our centre. Both cases involved very prolonged transportation time of the donor heart. In one case, the donor heart was transported in an ice chest, while in the other case the organ was transported using a ... Read more >>

Intern Med J (Internal medicine journal)
[2017, 47(10):1202-1205]

Cited: 2 times

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Reversibility of Frailty After Bridge-to-Transplant Ventricular Assist Device Implantation or Heart Transplantation.

Sunita R Jha, Malin K Hannu, Phillip J Newton, Kay Wilhelm, Christopher S Hayward, Andrew Jabbour, Eugene Kotlyar, Anne Keogh, Kumud Dhital, Emily Granger, Mark Connellan, Paul Jansz, Phillip M Spratt, Elyn Montgomery, Angela Smith, Michelle Harkess, Peta Tunicliff, Patricia M Davidson, Peter S Macdonald,

<h4>Background</h4>We recently reported that frailty is independently predictive of increased mortality in patients with advanced heart failure referred for heart transplantation (HTx). The aim of this study was to assess the impact of frailty on short-term outcomes after bridge-to-transplant ventricular assist device (BTT-VAD) implantation and/or HTx and to determine if ... Read more >>

Transplant Direct (Transplantation direct)
[2017, 3(7):e167]

Cited: 16 times

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The impact of a specialized inpatient and day patient group programme on clinical outcome in older adolescents and young adults with mental illness.

P McCrossan, A Ryan, M Connellan, P Power,

Introduction Effective transition from child and adolescent mental health services (CAMHS) to adult services is one of the main challenges currently facing child psychiatry today The Young Adult 1Programme (YAP) based at St. Patrick's University Hospital Dublin, is a group based day programme especially designed to meet the needs of ... Read more >>

Ir J Psychol Med (Irish journal of psychological medicine)
[2017, 34(1):39-44]

Cited: 1 time

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The relationship between cognitive and neuroimaging outcomes in children treated for acute lymphoblastic leukemia with chemotherapy only: A systematic review.

Simone Hearps, Marc Seal, Vicki Anderson, Maria McCarthy, Madeleine Connellan, Peter Downie, Cinzia De Luca,

Cognitive late-effects have been identified in patients treated with chemotherapy-only protocols for childhood acute lymphoblastic leukemia (ALL), yet the underlying neuropathology is not well understood. This review synthesized recent findings from eight articles investigating the relationship between neurocognitive and neuroimaging outcomes for patients treated for ALL with chemotherapy-only protocols. Reported ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2017, 64(2):225-233]

Cited: 9 times

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Predictors of Acute Kidney Injury in Cardiac Transplantation.

R Tjahjono, M Connellan, E Granger,

<h4>Background</h4>Acute kidney injury (AKI) is an outcome that represents a significant increase in morbidity and mortality rates; however, limited information exists about the incidence of AKI after cardiac transplantation.<h4>Methods</h4>This single-center, retrospective study from 2009 to 2014 analyzed pre-, intra-, and post-operative characteristics of 111 patients who underwent orthotopic cardiac transplantation ... Read more >>

Transplant Proc (Transplantation proceedings)
[2016, 48(1):167-172]

Cited: 7 times

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Extracorporeal heart perfusion before heart transplantation: the heart in a box.

Peter S Macdonald, Hong C Chew, Mark Connellan, Kumud Dhital,

<h4>Purpose of review</h4>Cold static storage is a time-tested and simple method of preserving hearts retrieved from optimal donors after brain death (DBD). The increasing gap between supply and demand for donor organs together with changing donor and recipient characteristics have led to renewed interest in the use of machine perfusion ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2016, 21(3):336-342]

Cited: 14 times

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Long-term biventricular HeartWare ventricular assist device support--Case series of right atrial and right ventricular implantation outcomes.

Sajad Shehab, Peter S Macdonald, Anne M Keogh, Eugene Kotlyar, Andrew Jabbour, Desiree Robson, Phillip J Newton, Sriram Rao, Louis Wang, Sabine Allida, Mark Connellan, Emily Granger, Kumud Dhital, Phillip Spratt, Paul C Jansz, Christopher S Hayward,

<h4>Background</h4>There is limited information on outcomes using the HeartWare ventricular assist device (HVAD; HeartWare, Framington, MA) as a biventricular assist device, especially with respect to site of right ventricular assist device (RVAD) implantation.<h4>Methods</h4>Outcomes in 13 patients with dilated cardiomyopathy and severe biventricular failure who underwent dual HVAD implantation as bridge ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2016, 35(4):466-473]

Cited: 19 times

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Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: a case series.

Kumud K Dhital, Arjun Iyer, Mark Connellan, Hong C Chew, Ling Gao, Aoife Doyle, Mark Hicks, Gayathri Kumarasinghe, Claude Soto, Andrew Dinale, Bruce Cartwright, Priya Nair, Emily Granger, Paul Jansz, Andrew Jabbour, Eugene Kotlyar, Anne Keogh, Christopher Hayward, Robert Graham, Phillip Spratt, Peter Macdonald,

<h4>Background</h4>Orthotopic heart transplantation is the gold-standard long-term treatment for medically refractive end-stage heart failure. However, suitable cardiac donors are scarce. Although donation after circulatory death has been used for kidney, liver, and lung transplantation, it is not used for heart transplantation. We report a case series of heart transplantations from ... Read more >>

Lancet (Lancet (London, England))
[2015, 385(9987):2585-2591]

Cited: 80 times

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Genetics of epilepsy: The testimony of twins in the molecular era.

Lata Vadlamudi, Roger L Milne, Kate Lawrence, Sarah E Heron, Jazmin Eckhaus, Deborah Keay, Mary Connellan, Yvonne Torn-Broers, R Anne Howell, John C Mulley, Ingrid E Scheffer, Leanne M Dibbens, John L Hopper, Samuel F Berkovic,

<h4>Objective</h4>Analysis of twins with epilepsy to explore the genetic architecture of specific epilepsies, to evaluate the applicability of the 2010 International League Against Epilepsy (ILAE) organization of epilepsy syndromes, and to integrate molecular genetics with phenotypic analyses.<h4>Methods</h4>A total of 558 twin pairs suspected to have epilepsy were ascertained from twin ... Read more >>

Neurology (Neurology)
[2014, 83(12):1042-1048]

Cited: 21 times

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Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial.

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Cost-effective strategies to maintain healthy active lifestyle in aging populations are required to address the global burden of age-related diseases. ASPREE will examine whether the potential primary prevention benefits of low dose aspirin outweigh the risks in older healthy individuals. Our primary hypothesis is that daily oral 100 mg enteric-coated ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2013, 36(2):555-564]

Cited: 55 times

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Obstetric events as a risk factor for febrile seizures: a community-based twin study.

Ingo Helbig, Kate M Lawrence, Mary M Connellan, Yvonne Torn-Broers, Lata Vadlamudi, Jazmin Eckhaus, Roger L Milne, John L Hopper, Samuel F Berkovic,

Adverse events during the perinatal period have traditionally been thought to contribute to the risk of febrile seizures although an association has not been found in large epidemiological studies. Disease-discordant twins provide a means to assess the role of non-shared environmental factors while matching for confounding factors and avoiding difficulties ... Read more >>

Twin Res Hum Genet (Twin research and human genetics : the official journal of the International Society for Twin Studies)
[2008, 11(6):634-640]

Cited: 1 time

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Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations.

Ingrid E Scheffer, Louise A Harkin, Bronwyn E Grinton, Leanne M Dibbens, Samantha J Turner, Marta A Zielinski, Ruwei Xu, Graeme Jackson, Judith Adams, Mary Connellan, Steven Petrou, R Mark Wellard, Regula S Briellmann, Robyn H Wallace, John C Mulley, Samuel F Berkovic,

SCN1B, the gene encoding the sodium channel beta 1 subunit, was the first gene identified for generalized epilepsy with febrile seizures plus (GEFS+). Only three families have been published with SCN1B mutations. Here, we present four new families with SCN1B mutations and characterize the associated phenotypes. Analysis of SCN1B was ... Read more >>

Brain (Brain : a journal of neurology)
[2007, 130(Pt 1):100-109]

Cited: 132 times

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Is benign rolandic epilepsy genetically determined?

Lata Vadlamudi, A Simon Harvey, Mary M Connellan, Roger L Milne, John L Hopper, Ingrid E Scheffer, Samuel F Berkovic,

Benign rolandic epilepsy (BRE) is considered to be a genetically determined idiopathic partial epilepsy. We studied twins with BRE and compared the concordance with a twin sample of idiopathic generalized epilepsy (IGE). All eight BRE pairs (six monozygous [MZ], two dizygous [DZ]) were discordant. MZ pairwise concordance was 0 (95% ... Read more >>

Ann Neurol (Annals of neurology)
[2004, 56(1):129-132]

Cited: 24 times

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Prevention of perinatal group B streptococcal disease: screening practice in public hospitals in Victoria.

M Connellan, E M Wallace,

<h4>Objectives</h4>To survey clinical protocols for prevention of early-onset group B streptococcal disease (EOGBSD) of the newborn in public maternity hospitals.<h4>Design</h4>Postal questionnaire with telephone follow-up when required.<h4>Setting</h4>All hospitals that undertook deliveries in public patients in the State of Victoria, November 1997 to January 1998.<h4>Results</h4>The survey was sent to 84 hospitals: 71 ... Read more >>

Med J Aust (The Medical journal of Australia)
[2000, 172(7):317-320]

Cited: 8 times

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Serum levels of quinine following intramuscular administration to children.

J Stace, F A Shann, S Walters, M Connellan, M Edstein,

The serum quinine level was assayed in 31 children four hours after receiving an intramuscular injection of quinine dihydrochloride; in 14 children the level was also assayed 2 hours after the injection. The quinine was quickly absorbed from muscle, with serum quinine levels being significantly higher at 2 hours than ... Read more >>

P N G Med J (Papua and New Guinea medical journal)
[1983, 26(1):21-24]

Cited: 0 times

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