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Author M Celeste Simon

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Clarifying the translational potential of B-I09.

Juan R Del Valle, Brian C Betts, Xue-Zhong Yu, Sophie Janssens, Bart N Lambrecht, M Celeste Simon, Chih-Chi Andrew Hu,

Nat Chem Biol (Nature chemical biology)
[2020, 16(11):1152]

Cited: 0 times

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The tumor microenvironment.

Nicole M Anderson, M Celeste Simon,

A tumor is not simply a group of cancer cells, but rather a heterogeneous collection of infiltrating and resident host cells, secreted factors and extracellular matrix. Tumor cells stimulate significant molecular, cellular and physical changes within their host tissues to support tumor growth and progression. An emerging tumor microenvironment is ... Read more >>

Curr. Biol. (Current biology : CB)
[2020, 30(16):R921-R925]

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Cancer Cells Don't Live Alone: Metabolic Communication within Tumor Microenvironments.

Fuming Li, M Celeste Simon,

Solid tumors reside in harsh tumor microenvironments (TMEs) together with various stromal cell types. During tumor progression and metastasis, both tumor and stromal cells undergo rapid metabolic adaptations. Tumor cells metabolically coordinate or compete with their "neighbors" to maintain biosynthetic and bioenergetic demands while escaping immunosurveillance or therapeutic interventions. Here, ... Read more >>

Dev. Cell (Developmental cell)
[2020, 54(2):183-195]

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Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis.

Peiwei Huangyang, Fuming Li, Pearl Lee, Itzhak Nissim, Aalim M Weljie, Anthony Mancuso, Bo Li, Brian Keith, Sam S Yoon, M Celeste Simon,

Cell Metab (Cell metabolism)
[2020, 31(5):1032]

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FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome.

Fuming Li, Peiwei Huangyang, Michelle Burrows, Kathy Guo, Romain Riscal, Jason Godfrey, Kyoung Eun Lee, Nan Lin, Pearl Lee, Ian A Blair, Brian Keith, Bo Li, M Celeste Simon,

The crosstalk between deregulated hepatocyte metabolism and cells within the tumour microenvironment, as well as the consequent effects on liver tumorigenesis, are not completely understood. We show here that hepatocyte-specific loss of the gluconeogenic enzyme fructose 1,6-bisphosphatase 1 (FBP1) disrupts liver metabolic homeostasis and promotes tumour progression. FBP1 is universally ... Read more >>

Nat Cell Biol (Nature cell biology)
[2020, 22(6):728-739]

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Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.

Samir Devalaraja, Tsun Ki Jerrick To, Ian W Folkert, Ramakrishnan Natesan, Md Zahidul Alam, Minghong Li, Yuma Tada, Konstantin Budagyan, Mai T Dang, Li Zhai, Graham P Lobel, Gabrielle E Ciotti, T S Karin Eisinger-Mathason, Irfan A Asangani, Kristy Weber, M Celeste Simon, Malay Haldar,

The immunosuppressive tumor microenvironment (TME) is a major barrier to immunotherapy. Within solid tumors, why monocytes preferentially differentiate into immunosuppressive tumor-associated macrophages (TAMs) rather than immunostimulatory dendritic cells (DCs) remains unclear. Using multiple murine sarcoma models, we find that the TME induces tumor cells to produce retinoic acid (RA), which ... Read more >>

Cell (Cell)
[2020, 180(6):1098-1114.e16]

Cited: 0 times

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Publisher Correction: Cellular adaptation to oxygen deficiency beyond the Nobel award.

José López-Barneo, M Celeste Simon,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):1140]

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Cellular adaptation to oxygen deficiency beyond the Nobel award.

José López-Barneo, M Celeste Simon,

Nat Commun (Nature communications)
[2020, 11(1):607]

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Targeting glutamine metabolism slows soft tissue sarcoma growth.

Pearl Lee, Dania Malik, Nicholas Perkons, Peiwei Huangyang, Sanika Khare, Seth Rhoades, Yao-Yu Gong, Michelle Burrows, Jennifer M Finan, Itzhak Nissim, Terence P F Gade, Aalim M Weljie, M Celeste Simon,

Tumour cells frequently utilize glutamine to meet bioenergetic and biosynthetic demands of rapid cell growth. However, glutamine dependence can be highly variable between in vitro and in vivo settings, based on surrounding microenvironments and complex adaptive responses to glutamine deprivation. Soft tissue sarcomas (STSs) are mesenchymal tumours where cytotoxic chemotherapy ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):498]

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Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis.

Peiwei Huangyang, Fuming Li, Pearl Lee, Itzhak Nissim, Aalim M Weljie, Anthony Mancuso, Bo Li, Brian Keith, Sam S Yoon, M Celeste Simon,

The remarkable cellular and genetic heterogeneity of soft tissue sarcomas (STSs) limits the clinical benefit of targeted therapies. Here, we show that expression of the gluconeogenic isozyme fructose-1,6-bisphosphatase 2 (FBP2) is silenced in a broad spectrum of sarcoma subtypes, revealing an apparent common metabolic feature shared by diverse STSs. Enforced ... Read more >>

Cell Metab. (Cell metabolism)
[2020, 31(1):174-188.e7]

Cited: 3 times

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BACH1 Orchestrates Lung Cancer Metastasis.

Nicole M Anderson, M Celeste Simon,

Cell (Cell)
[2019, 179(3):800]

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BACH1 Orchestrates Lung Cancer Metastasis.

Nicole M Anderson, M Celeste Simon,

Two studies in this issue position the stabilization of the transcription factor BACH1 as a critical node in the metastasis of lung cancer and propose two new therapeutic approaches for this leading cause of cancer-related deaths (Lignitto et al., 2019; Wiel et al., 2019). ... Read more >>

Cell (Cell)
[2019, 178(2):265-267]

Cited: 0 times

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Gamma-Glutamyltransferase 1 Promotes Clear Cell Renal Cell Carcinoma Initiation and Progression.

Ankita Bansal, Danielle J Sanchez, Vivek Nimgaonkar, David Sanchez, Romain Riscal, Nicolas Skuli, M Celeste Simon,

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer. While the localized form of this disease can be treated surgically, advanced and metastatic stages are resistant to chemotherapies. Although more innovative treatments, such as targeted or immune-based therapies, exist, the need for new therapeutic options ... Read more >>

Mol. Cancer Res. (Molecular cancer research : MCR)
[2019, 17(9):1881-1892]

Cited: 1 time

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Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis.

Nan Lin, Jessica E S Shay, Hong Xie, David S M Lee, Nicolas Skuli, Qiaosi Tang, Zilu Zhou, Andrew Azzam, Hu Meng, Haichao Wang, Garret A FitzGerald, M Celeste Simon,

Colonic tissues in Inflammatory Bowel Disease (IBD) patients exhibit oxygen deprivation and activation of hypoxia-inducible factor 1α and 2α (HIF-1α and HIF-2α), which mediate cellular adaptation to hypoxic stress. Notably, macrophages and neutrophils accumulate preferentially in hypoxic regions of the inflamed colon, suggesting that myeloid cell functions in colitis are ... Read more >>

Front Immunol (Frontiers in immunology)
[2018, 9:2565]

Cited: 1 time

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Perseverance when the going gets tough.

M Celeste Simon,

Nat. Cell Biol. (Nature cell biology)
[2018, 20(9):1008]

Cited: 0 times

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Hidden features: exploring the non-canonical functions of metabolic enzymes.

Peiwei Huangyang, M Celeste Simon,

The study of cellular metabolism has been rigorously revisited over the past decade, especially in the field of cancer research, revealing new insights that expand our understanding of malignancy. Among these insights is the discovery that various metabolic enzymes have surprising activities outside of their established metabolic roles, including in ... Read more >>

Dis Model Mech (Disease models & mechanisms)
[2018, 11(8):]

Cited: 3 times

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Genetic and metabolic hallmarks of clear cell renal cell carcinoma.

Danielle J Sanchez, M Celeste Simon,

Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by deregulated hypoxia-inducible factor signaling, mutation of several key chromatin modifying enzymes, and numerous alterations in cellular metabolism. Pre-clinical studies have historically been limited to cell culture models, however, the identification of critical tumor suppressors and oncogenes from large-scale patient ... Read more >>

Biochim Biophys Acta Rev Cancer (Biochimica et biophysica acta. Reviews on cancer)
[2018, 1870(1):23-31]

Cited: 13 times

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Transcriptional control of kidney cancer.

Danielle J Sanchez, M Celeste Simon,

Science (Science (New York, N.Y.))
[2018, 361(6399):226-227]

Cited: 1 time

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PPARγ is dispensable for clear cell renal cell carcinoma progression.

Danielle J Sanchez, David J Steger, Nicolas Skuli, Ankita Bansal, M Celeste Simon,

OBJECTIVE:Clear cell renal cell carcinoma (ccRCC) is a subtype of kidney cancer defined by robust lipid accumulation, which prior studies have indicated plays an important role in tumor progression. We hypothesized that the peroxisome proliferator-activated receptor gamma (PPARγ), detected in both ccRCC tumors and cell lines, promotes lipid storage in ... Read more >>

Mol Metab (Molecular metabolism)
[2018, 14:139-149]

Cited: 3 times

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Glutathione metabolism in cancer progression and treatment resistance.

Ankita Bansal, M Celeste Simon,

Glutathione (GSH) is the most abundant antioxidant found in living organisms and has multiple functions, most of which maintain cellular redox homeostasis. GSH preserves sufficient levels of cysteine and detoxifies xenobiotics while also conferring therapeutic resistance to cancer cells. However, GSH metabolism plays both beneficial and pathogenic roles in a ... Read more >>

J Cell Biol (The Journal of cell biology)
[2018, 217(7):2291-2298]

Cited: 47 times

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Platelet-derived growth factor receptor-α and -β promote cancer stem cell phenotypes in sarcomas.

Kevin K Chang, Changhwan Yoon, Brendan C Yi, William D Tap, M Celeste Simon, Sam S Yoon,

Sarcomas are malignant tumors derived from mesenchymal tissues and may harbor a subset of cells with cancer stem-like cell (CSC) properties. Platelet-derived growth factor receptors α and β (PDGFR-α/β) play an important role in the maintenance of mesenchymal stem cells. Here we examine the role of PDGFR-α/β in sarcoma CSCs. ... Read more >>

(Oncogenesis)
[2018, 7(6):47]

Cited: 4 times

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Hif1α Deletion Limits Tissue Regeneration via Aberrant B Cell Accumulation in Experimental Pancreatitis.

Kyoung Eun Lee, Michelle Spata, Richard Maduka, Robert H Vonderheide, M Celeste Simon,

Pancreatitis is an inflammatory disease of the exocrine pancreas and ranks among the most common gastrointestinal disorders. Inflamed tissues frequently experience conditions of insufficient oxygen availability, or hypoxia. Here, we demonstrate that hypoxia and consequent stabilization of the hypoxia-inducible factor 1α (HIF1α) transcription factor occur in murine and human pancreatitis. ... Read more >>

Cell Rep (Cell reports)
[2018, 23(12):3457-3464]

Cited: 1 time

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Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.

Joshua D Ochocki, Sanika Khare, Markus Hess, Daniel Ackerman, Bo Qiu, Jennie I Daisak, Andrew J Worth, Nan Lin, Pearl Lee, Hong Xie, Bo Li, Bradley Wubbenhorst, Tobi G Maguire, Katherine L Nathanson, James C Alwine, Ian A Blair, Itzhak Nissim, Brian Keith, M Celeste Simon,

Kidney cancer, one of the ten most prevalent malignancies in the world, has exhibited increased incidence over the last decade. The most common subtype is "clear cell" renal cell carcinoma (ccRCC), which features consistent metabolic abnormalities, such as highly elevated glycogen and lipid deposition. By integrating metabolomics, genomic, and transcriptomic ... Read more >>

Cell Metab (Cell metabolism)
[2018, 27(6):1263-1280.e6]

Cited: 14 times

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IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers.

Hong Xie, Chih-Hang Anthony Tang, Jun H Song, Anthony Mancuso, Juan R Del Valle, Jin Cao, Yan Xiang, Chi V Dang, Roy Lan, Danielle J Sanchez, Brian Keith, Chih-Chi Andrew Hu, M Celeste Simon,

Myc activation is a primary oncogenic event in many human cancers; however, these transcription factors are difficult to inhibit pharmacologically, suggesting that Myc-dependent downstream effectors may be more tractable therapeutic targets. Here, we show that Myc overexpression induces endoplasmic reticulum (ER) stress and engages the inositol-requiring enzyme 1α (IRE1α)/X-box binding ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2018, 128(4):1300-1316]

Cited: 7 times

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Detection of Hypoxia and HIF in Paraffin-Embedded Tumor Tissues.

Fuming Li, Kyoung Eun Lee, M Celeste Simon,

Hypoxia (insufficient O2 availability) is involved in various biological processes, such as tumorigenesis and inflammation. Hypoxia results in stabilization of hypoxia-inducible factors (HIFs) including HIF1α and HIF2α. Here we describe a protocol to detect mouse and human tissue hypoxia by using Hypoxyprobe and immunohistochemical staining for HIF1α and HIF2α. ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2018, 1742:277-282]

Cited: 2 times

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