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Author M Casey

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Quality care metrics (QC-M) in nursing and midwifery care processes: a rapid realist review (RRR) protocol

Laserina O'Connor, Alice Coffey, Veronica Lambert, Mary Casey, Martin McNamara, Sean Paul Teeling, Jane O'Doherty, Marlize Barnard, Yvonne Corcoran, Carmel Davies, Owen Doody, Timothy Frawley, Denise O'Brien, Catherine Redmond, Rita Smith, Suja Somanadhan, Maria Noonan, Carmel Bradshaw, Dympna Tuohy, Anne Gallen,

<ns5:p><ns5:bold>Background: </ns5:bold>In 2018, the Office of the Nursing and Midwifery Services Director (ONMSD) completed phase one of work which culminated in the development and launch of seven research reports with defined suites of quality care process metrics (QC-Ms) and respective indicators for the practice areas – acute care, midwifery, children’s, ... Read more >>

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Rapid review of available evidence on the serial interval and generation time of COVID-19.

John Griffin, Miriam Casey, Áine Collins, Kevin Hunt, David McEvoy, Andrew Byrne, Conor McAloon, Ann Barber, Elizabeth Ann Lane, SImon More,

The serial interval is the time between symptom onsets in an infector-infectee pair. The generation time, also known as the generation interval, is the time between infection events in an infector-infectee pair. The serial interval and the generation time are key parameters for assessing the dynamics of a disease. A ... Read more >>

BMJ Open (BMJ open)
[2020, 10(11):e040263]

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Multidisciplinary-based Rehabilitation (MBR) Compared With Active Physical Interventions for Pain and Disability in Adults With Chronic Pain: A Systematic Review and Meta-analysis.

Máire-Bríd Casey, Keith M Smart, Ricardo Segurado, Catherine Doody,

OBJECTIVE:This systematic review and meta-analysis examined the effectiveness of multidisciplinary-based rehabilitation (MBR) in comparison with active physical interventions for adults with chronic pain. MATERIALS AND METHODS:The review was conducted in line with the recommendations provided in the Cochrane Handbook for Systematic Reviews and is reported in accordance with the Preferred ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2020, 36(11):874-886]

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Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project.

Mary Ward, Catherine F Hughes, J J Strain, Rosie Reilly, Conal Cunningham, Anne M Molloy, Geraldine Horigan, Miriam Casey, Kevin McCarroll, Maurice O'Kane, Michael J Gibney, Albert Flynn, Janette Walton, Breige A McNulty, Adrian McCann, Laura Kirwan, John M Scott, Helene McNulty,

BACKGROUND:Genome-wide and clinical studies have linked the 677C→T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR) with hypertension, whilst limited evidence shows that intervention with riboflavin (i.e. the MTHFR co-factor) can lower blood pressure (BP) in hypertensive patients with the variant MTHFR 677TT genotype. We investigated the impact of this ... Read more >>

BMC Med (BMC medicine)
[2020, 18(1):318]

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Improving the precision of search strategies for guideline surveillance.

Monica Casey, Michael Raynor, Catherine Jacob, Stephen Sharp, Emma McFarlane,

INTRODUCTION AND AIM:NICE guideline surveillance determines whether previously published guidelines need updating. The surveillance process must balance time constraints with methodological rigor. It includes a rapid review to identify new evidence to contradict, reinforce or clarify guideline recommendations. Despite this approach, the screening burden can still be high. Applying additional ... Read more >>

Res Synth Methods (Research synthesis methods)
[2020, 11(6):903-912]

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Estimand framework: Are we asking the right questions? A case study in the solid tumor setting.

Michelle Casey, Evgeny Degtyarev, María José Lechuga, Paola Aimone, Alain Ravaud, Robert J Motzer, Feng Liu, Viktoriya Stalbovskaya, Rui Tang, Emily Butler, Oliver Sailer, Susan Halabi, Daniel George,

The estimand framework requires a precise definition of the clinical question of interest (the estimand) as different ways of accounting for "intercurrent" events post randomization may result in different scientific questions. The initiation of subsequent therapy is common in oncology clinical trials and is considered an intercurrent event if the ... Read more >>

Pharm Stat (Pharmaceutical statistics)
[2020, :]

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Use of exhaled breath condensate (EBC) in the diagnosis of SARS-COV-2 (COVID-19).

Daniel J Ryan, Sinead Toomey, Stephen F Madden, Michelle Casey, Oscar S Breathnach, Patrick G Morris, Liam Grogan, Peter Branagan, Richard W Costello, Eoghan De Barra, Killian Hurley, Cedric Gunaratnam, Noel G McElvaney, Michael Emmet OBrien, Imran Sulaiman, Ross K Morgan, Bryan T Hennessy,

False negatives from nasopharyngeal swabs (NPS) using reverse transcriptase PCR (RT-PCR) in SARS-CoV-2 are high. Exhaled breath condensate (EBC) contains lower respiratory droplets that may improve detection. We performed EBC RT-PCR for SARS-CoV-2 genes (E, S, N, ORF1ab) on NPS-positive (n=16) and NPS-negative/clinically positive COVID-19 patients (n=15) using two commercial ... Read more >>

Thorax (Thorax)
[2020, :]

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How to improve recruitment, sustainability and scalability in physical activity programmes for adults aged 50 years and older: A qualitative study of key stakeholder perspectives.

Andrew O'Regan, Enrique García Bengoechea, Amanda M Clifford, Monica Casey, Stephen Gallagher, Liam Glynn, Ciaran Doyle, Catherine Woods,

INTRODUCTION:Physical inactivity among adults aged 50 years and over is a worldwide health concern. The objectives of the study were to investigate the perspectives of those involved with existing physical activity programmes on optimising recruitment, sustainability and scalability of physical activity programmes for adults aged 50 years and over. METHODS:The ... Read more >>

PLoS One (PloS one)
[2020, 15(10):e0240974]

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CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells.

Matthias Braun, Amelia Roman Aguilera, Ashmitha Sundarrajan, Dillon Corvino, Kimberley Stannard, Sophie Krumeich, Indrajit Das, Luize G Lima, Lizeth G Meza Guzman, Kunlun Li, Rui Li, Nazhifah Salim, Maria Villancanas Jorge, Sunyoung Ham, Gabrielle Kelly, Frank Vari, Ailin Lepletier, Ashwini Raghavendra, Sally Pearson, Jason Madore, Sebastien Jacquelin, Maike Effern, Brodie Quine, Lambros T Koufariotis, Mika Casey, Kyohei Nakamura, Eun Y Seo, Michael Hölzel, Matthias Geyer, Glen Kristiansen, Touraj Taheri, Elizabeth Ahern, Brett G M Hughes, James S Wilmott, Georgina V Long, Richard A Scolyer, Martin D Batstone, Jennifer Landsberg, Dimo Dietrich, Oltin T Pop, Lukas Flatz, William C Dougall, André Veillette, Sandra E Nicholson, Andreas Möller, Robert J Johnston, Ludovic Martinet, Mark J Smyth, Tobias Bald,

The activating receptor CD226 is expressed on lymphocytes, monocytes, and platelets and promotes anti-tumor immunity in pre-clinical models. Here, we examined the role of CD226 in the function of tumor-infiltrating lymphocytes (TILs) and resistance to immunotherapy. In murine tumors, a large proportion of CD8+ TILs had decreased surface expression of ... Read more >>

Immunity (Immunity)
[2020, 53(4):805-823.e15]

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Measuring the Information Obtained from a Single-Cell Sequencing Experiment

Michael Casey, Rubén Sánchez-García, Ben MacArthur,

ABSTRACT Single-cell sequencing (sc-Seq) experiments are producing increasingly large data sets. However, large data sets do not necessarily contain large amounts of information. Here, we introduce a formal framework for assessing the amount of information obtained from a sc-Seq experiment, which can be used throughout the sc-Seq analysis pipeline, including ... Read more >>

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Irish dairy farmers' engagement with animal health surveillance services: Factors influencing sample submission.

Lauren McFarland, Áine Macken-Walsh, Grace Claydon, Mícheál Casey, Alexander Douglass, Guy McGrath, Conor G McAloon,

A high-quality animal health surveillance service is required to inform policy and decision-making in food-animal disease control, to substantiate claims regarding national animal health status and for the early detection of exotic or emerging diseases. In Ireland, the Department of Agriculture, Food and the Marine provides partially subsidized testing of ... Read more >>

J Dairy Sci (Journal of dairy science)
[2020, 103(11):10614-10627]

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Baseline neuropsychological profiles in prion disease predict survival time

Saranya E. Sundaram, Adam M. Staffaroni, Nicole C. Walker, Kaitlin B. Casaletto, Megan Casey, Aili Golubjatnikov, Stacy Metcalf, Kelly O’Leary, Katherine Wong, Kendra Benisano, Sven Forner, Marta Gonzalez Catalan, Isabel E. Allen, Howard J. Rosen, Joel H. Kramer, Michael D. Geschwind,

Abstract Objective Few studies have captured the neuropsychological profile of sporadic Creutzfeldt–Jakob disease (sCJD) with neuropsychological testing, and little is known about cognitive predictors of survival. We characterized baseline neuropsychological performance in sCJD and investigated associations with survival. Methods sCJD participants who completed the MMSE (n = 118), 61 sCJD of whom ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, 7(9):1535-1545]

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The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.

Susanna S Ng, Fabian De Labastida Rivera, Juming Yan, Dillon Corvino, Indrajit Das, Ping Zhang, Rachel Kuns, Shashi Bhushan Chauhan, Jiajie Hou, Xian-Yang Li, Teija C M Frame, Benjamin A McEnroe, Eilish Moore, Jinrui Na, Jessica A Engel, Megan S F Soon, Bhawana Singh, Andrew J Kueh, Marco J Herold, Marcela Montes de Oca, Siddharth Sankar Singh, Patrick T Bunn, Amy Roman Aguilera, Mika Casey, Matthias Braun, Nazanin Ghazanfari, Shivangi Wani, Yulin Wang, Fiona H Amante, Chelsea L Edwards, Ashraful Haque, William C Dougall, Om Prakash Singh, Alan G Baxter, Michele W L Teng, Alex Loukas, Norelle L Daly, Nicole Cloonan, Mariapia A Degli-Esposti, Jude Uzonna, William R Heath, Tobias Bald, Siok-Keen Tey, Kyohei Nakamura, Geoffrey R Hill, Rajiv Kumar, Shyam Sundar, Mark J Smyth, Christian R Engwerda,

Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we show that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad ... Read more >>

Nat Immunol (Nature immunology)
[2020, 21(10):1205-1218]

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High Preservation Potential of Paleogeographic Range Size Distributions in Deep Time.

Simon A F Darroch, Michelle M Casey, Gwen S Antell, Amy Sweeney, Erin E Saupe,

AbstractReconstructing geographic range sizes from fossil data is a crucial tool in paleoecology, elucidating macroecological and macroevolutionary processes. Studies examining links between range size and extinction risk may also offer a predictive tool for identifying species most vulnerable in the "sixth mass extinction." However, the extent to which paleogeographic ranges ... Read more >>

Am Nat (The American naturalist)
[2020, 196(4):454-471]

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Incubation period of COVID-19: a rapid systematic review and meta-analysis of observational research.

Conor McAloon, Áine Collins, Kevin Hunt, Ann Barber, Andrew W Byrne, Francis Butler, Miriam Casey, John Griffin, Elizabeth Lane, David McEvoy, Patrick Wall, Martin Green, Luke O'Grady, Simon J More,

OBJECTIVES:The aim of this study was to conduct a rapid systematic review and meta-analysis of estimates of the incubation period of COVID-19. DESIGN:Rapid systematic review and meta-analysis of observational research. SETTING:International studies on incubation period of COVID-19. PARTICIPANTS:Searches were carried out in PubMed, Google Scholar, Embase, Cochrane Library as well ... Read more >>

BMJ Open (BMJ open)
[2020, 10(8):e039652]

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Improving Efficiency Using Electronic Medical Record Rounding Report & Sign-Out Report.

Meagan H Casey, Barbara Turner, Laura Edwards, Melinda Williams,

INTRODUCTION:Standardized rounding and sign-out reports can improve provider efficiency and satisfaction. The purpose of this quality improvement project was to evaluate implementing an electronic medical record-integrated neonatal intensive care unit-specific rounding report and sign-out report on provider efficiency and satisfaction. METHOD:A pre- and post-quality improvement project was implemented to evaluate ... Read more >>

J Pediatr Health Care (Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners)
[2020, 34(6):535-541]

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The relative infectiousness of asymptomatic SARS-CoV-2 infected persons compared with symptomatic individuals: A rapid scoping review.

David Mc Evoy, Conor McAloon, Aine Collins, Kevin Hunt, Francis Butler, Andrew Byrne, Miriam Casey, Ann Barber, John Griffin, Elizabeth Lane, Patrick Wall, Simon More,

Objectives: The aim of this study was to conduct a scoping review of estimates of the relative infectiousness of asymptomatic persons infected with SARS-CoV-2 compared with symptomatic individuals. Design: Rapid scoping review of literature available until 8th April 2020. Setting: International studies on the infectiousness of individuals infected with SARS-CoV-2 ... Read more >>

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Flock health survey of Irish Texel society breeders and larynx examination in Texel sheep.

Aideen Kennedy, Séamus Fagan, Colm Brady, John Fagan, Eamon Wall, Seamus Hoey, Emma Tobin, Mícheál Casey, Maresa Sheehan,

Background:Laryngeal chondritis is a disease of undetermined aetiology, characterised by oedema, ulceration, abscessation and necrosis of the laryngeal mucosa and cartilage. The initial aim of the study was to document flock health issues identified by Irish pedigree Texel breeders using a questionnaire survey. Additionally, given the reports of breed predisposition ... Read more >>

Ir Vet J (Irish veterinary journal)
[2020, 73:16]

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Novel HIV-1 capsid-targeting small molecules of the PF74 binding site.

Lei Wang, Mary C Casey, Sanjeev Kumar V Vernekar, Rajkumar Lalji Sahani, Jayakanth Kankanala, Karen A Kirby, Haijuan Du, Atsuko Hachiya, Huanchun Zhang, Philip R Tedbury, Jiashu Xie, Stefan G Sarafianos, Zhengqiang Wang,

The PF74 binding site in HIV-1 capsid protein (CA) is a compelling antiviral drug target. Although PF74 confers mechanistically distinct antiviral phenotypes by competing against host factors for CA binding, it suffers from prohibitively low metabolic stability. Therefore, there has been increasing interest in designing novel sub-chemotypes of PF74 with ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2020, 204:112626]

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Genome reduction is associated with bacterial pathogenicity across different scales of temporal and ecological divergence

Gemma Murray, Jane Charlesworth, Eric Miller, Michael Casey, Catrin Lloyd, Marcelo Gottschalk, (Dan) Tucker, John Welch, Lucy Weinert,

Abstract Emerging bacterial pathogens threaten global health and food security, and so it is important to ask whether these transitions to pathogenicity have any common features. We present a systematic study of the claim that pathogenicity is associated with genome reduction and gene loss. We compare broad-scale patterns across all ... Read more >>

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Pneumoconiosis ICD-CM Diagnosis Codes on Medicare Claims for Federal Black Lung Program Beneficiaries.

Laura Kurth, Megan Casey,

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2020, 17(7):904-906]

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Prospective Assessment of Systemic MicroRNAs as Markers of Response to Neoadjuvant Chemotherapy in Breast Cancer.

Andrew McGuire, Maire-Caitlin Casey, Ronan M Waldron, Helen Heneghan, Olga Kalinina, Emma Holian, Ailbhe McDermott, Aoife J Lowery, John Newell, Róisín M Dwyer, Nicola Miller, Maccon Keane, James A L Brown, Michael J Kerin,

Neoadjuvant chemotherapy (NACT) is used in locally advanced breast cancer to reduce tumour burden prior to surgical resection. However, only a subset of NACT treated patients will respond to treatment or achieve a pathologic complete response (pCR). This multicenter, prospective study (CTRIAL-IE (ICORG) 10-11 study) evaluated circulating microRNA as novel ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(7):]

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A review of the inclusion of equity stratifiers for the measurement of health inequalities within health and social care data collections in Ireland

Christopher Carroll, Katie Evans, Khalifa Elmusharaf, Patrick O'Donnell, Anne Dee, Diarmuid O'Donovan, Marie Casey,

Abstract Background Health equity differs from the concept of health inequality by taking into consideration the fairness of an inequality. Inequities may be culturally specific, based on social relations within a society. Measuring these inequities often requires grouping individuals. These groupings can be termed equity stratifiers. The most common ... Read more >>

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Comparison of Student Pharmacists' Clinical Interventions by Semester During APPE Internal Medicine and Critical Care Rotations.

Molly R Casey, Susan M Smith, Carrie L Griffiths,

BACKGROUND:Students contribute to health care through clinical interventions made during rotations. Previous studies assessed student interventions through cost savings instead of student progression throughout the year. OBJECTIVE:The purpose of this project is to assess clinical interventions made by student pharmacists completing internal medicine and critical care rotations during their Advanced ... Read more >>

J Pharm Pract (Journal of pharmacy practice)
[2020, :897190020938204]

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Comparison of the STORZ CMAC video laryngoscope to standard direct laryngoscopy in a Pierre Robin manikin. Randomised crossover trial.

Arnim Vlatten, Margaret Casey, Alexa Grudzinski, Scott Drysdale,

Eur J Anaesthesiol (European journal of anaesthesiology)
[2020, 37(6):504-506]

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