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Author M Casey

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Effects of non-invasive respiratory support on gas exchange and outcomes in COVID-19 outside the ICU.

Ciara Gough, Michelle Casey, Thomas A McCartan, Alessandro N Franciosi, Derek Nash, Dominic Doyle, Neil Hyland, Grace Kavanagh, Sile Toland, Caleb Powell, Rhea O'Regan, Ruán Ó Conluain, Garrett Greene, Grace Murray, Israa Fathi Hussein, Eoin Hunt, Fatma Gargoum, David Curran, Tidi Hassan, Liam Cormican, Richard W Costello, Tom McEnery,

Non-invasive respiratory support (NRS) outside of the ICU has played an important role in the management of COVID-19 pneumonia. There is little data to guide selection of NRS modality. We present outcomes of NRS outside the ICU and discuss the effects of NRS on gas exchange with implications for management. ... Read more >>

Respir Med (Respiratory medicine)
[2021, 185:106481]

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Association of High Burden of End-stage Kidney Disease With Decreased Kidney Transplant Rates With the Updated US Kidney Allocation Policy.

Derek A DuBay, Thomas Anthony Morinelli, Zemin Su, Patrick Mauldin, Erin Weeda, Michael J Casey, Prabhaker Baliga, David J Taber,

<h4>Importance</h4>The Organ Procurement and Transplantation Network (OPTN) approved changes to the US kidney allocation system in 2019. The potential effects of this policy change using transplant rates normalized to end-stage kidney disease (ESKD) incidence have not been investigated.<h4>Objective</h4>To estimate how the OPTN kidney allocation policy will affect areas of the ... Read more >>

JAMA Surg (JAMA surgery)
[2021, :]

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Giant Carotid Artery Aneurysm.

Amy M Walter, Murray M Flett, John Nagy, Stuart A Suttie, Andrew Dalton, Matthew Casey, Graeme J K Guthrie,

Carotid artery aneurysms account for 4% of peripheral aneurysms and may present as a neck mass, with hemispheric ischaemic symptoms, or with symptoms secondary to local compression. This case explores the presentation, investigations and management of a presumed mycotic common carotid artery aneurysm in a 77-year-old male, which was repaired ... Read more >>

Vasc Endovascular Surg (Vascular and endovascular surgery)
[2021, :15385744211017114]

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Seroprevalence study of SARS-CoV-2 infection in General Practice in Ireland.

Michael Edmund O'Callaghan, Elizabeth Ryan, Cathal Walsh, Peter Hayes, Monica Casey, Pat O'Dwyer, Aidan Culhane, John W Duncan, Pat Harrold, Jarlath Healy, Emmet Kerin, Eimear Kelly, Conor Hanrahan, Ger P Lane, Bernie Lynch, Paraic Meaney, Billy O'Connell, Jim Galvin, Norelee Kennedy, Paul Burke, Nuala H O'Connell, Colum P Dunne, Liam G Glynn,

<h4>Background</h4>SARS-CoV-2 antibody testing in community settings may help us better understand the immune response to this virus and therefore help guide public health efforts.<h4>Aim</h4>Conduct a seroprevalence study of IgG antibodies in Irish GP clinics.<h4>Design and setting</h4>Participants were 172 staff and 799 patients of 15 general practices in the Midwest region ... Read more >>

BJGP Open (BJGP open)
[2021, :]

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High utilisers of emergency departments: the profile and journey of patients with mental health issues.

Melissa Casey, Dinali Perera, Joanne Enticott, Hung Vo, Stana Cubra, Ashlee Gravell, Moana Waerea, George Habib,

<h4>Objective</h4>Frequent presenters to the Emergency Department (ED) are known to have complex physical, behavioural and social needs. The study aimed to analyse the system's behaviour to generate new insights into ED high utilisers with complex mental health issues.<h4>Methods</h4>A retrospective cohort study of the ED presentations of 200 high utilisers during ... Read more >>

Int J Psychiatry Clin Pract (International journal of psychiatry in clinical practice)
[2021, :1-9]

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Estimation of the serial interval and proportion of pre-symptomatic transmission events of COVID- 19 in Ireland using contact tracing data.

Conor G McAloon, Patrick Wall, John Griffin, Miriam Casey, Ann Barber, Mary Codd, Eamonn Gormley, Francis Butler, Locksley L McV Messam, Cathal Walsh, Conor Teljeur, Breda Smyth, Philip Nolan, Martin J Green, Luke O'Grady, Kieran Culhane, Claire Buckley, Ciara Carroll, Sarah Doyle, Jennifer Martin, Simon J More,

<h4>Background</h4>The serial interval is the period of time between the onset of symptoms in an infector and an infectee and is an important parameter which can impact on the estimation of the reproduction number. Whilst several parameters influencing infection transmission are expected to be consistent across populations, the serial interval ... Read more >>

BMC Public Health (BMC public health)
[2021, 21(1):805]

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Application of action research in the field of healthcare: a scoping review protocol

Mary Casey, David Coghlan, Áine Carroll, Diarmuid Stokes, Kinley Roberts, Geralyn Hynes,

Background: Traditional research approaches are increasingly challenged in healthcare contexts as they produce abstract thinking rather than practical application. In this regard, action research is a growing area of popularity and interest, essentially because of its dual focus on theory and action. However, there is a need for action researchers ... Read more >>

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Integrating hospital and community care: using a community virtual ward model to deliver combined specialist and generalist care to patients with severe chronic respiratory disease in their homes.

Breda Cushen, Aisling Madden, Deirdre Long, Yvonne Whelan, Michael Emmet O'Brien, Deirdre Carroll, Des O'Flynn, Michelle Forde, Virginia Pye, Loretto Grogan, Margaret Casey, Karolina Farrell, Richard W Costello, Clare Lewis,

<h4>Background</h4>Chronic respiratory diseases are responsible for significant patient morbidity, mortality, and healthcare use. Community virtual ward (CVW) models of care have been successfully implemented to manage patients with complex medical conditions.<h4>Aims</h4>To explore the feasibility and clinical outcomes of a CVW model of care in patients with chronic respiratory disease.<h4>Methods</h4>Patients known ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2021, :]

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40-Hz auditory stimulation for intracranial interictal activity: A pilot study.

Robert J Quon, Grace A Leslie, Edward J Camp, Stephen Meisenhelter, Sarah A Steimel, Yinchen Song, Alan B Ettinger, Krzysztof A Bujarski, Michael A Casey, Barbara C Jobst,

<h4>Objectives</h4>To study the effects of auditory stimuli on interictal epileptiform discharge (IED) rates evident with intracranial monitoring.<h4>Materials and methods</h4>Eight subjects undergoing intracranial EEG monitoring for refractory epilepsy participated in this study. Auditory stimuli consisted of a 40-Hz tone, a 440-Hz tone modulated by a 40-Hz sinusoid, Mozart's Sonata for Two ... Read more >>

Acta Neurol Scand (Acta neurologica Scandinavica)
[2021, :]

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Assessing the Impact of COVID-19 on the Clinical Trial Objective and Analysis of Oncology Clinical Trials—Application of the Estimand Framework

Evgeny Degtyarev, Kaspar Rufibach, Yue Shentu, Godwin Yung, Michelle Casey, Stefan Englert, Feng Liu, Yi Liu, Oliver Sailer, Jonathan Siegel, Steven Sun, Rui Tang, Jiangxiu Zhou, on behalf of the Industry Working Group on Estimands in Oncology,

Abstract–Coronavirus disease 2019 (COVID-19) outbreak has rapidly evolved into a global pandemic. The impact of COVID-19 on patient journeys in oncology represents a new risk to interpretation of trial results and its broad applicability for future clinical practice. We identify key intercurrent events (ICEs) that may occur due to COVID-19 ... Read more >>

Stat Biopharm Res (Statistics in biopharmaceutical research)
[0, 12(4):427-437]

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Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study.

Nicola Disma, Katalin Virag, Thomas Riva, Jost Kaufmann, Thomas Engelhardt, Walid Habre, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

<h4>Background</h4>Neonates and infants are susceptible to hypoxaemia in the perioperative period. The aim of this study was to analyse interventions related to anaesthesia tracheal intubations in this European cohort and identify their clinical consequences.<h4>Methods</h4>We performed a secondary analysis of tracheal intubations of the European multicentre observational trial (NEonate and Children ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 126(6):1173-1181]

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Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE).

Nicola Disma, Francis Veyckemans, Katalin Virag, Tom G Hansen, Karin Becke, Pierre Harlet, Laszlo Vutskits, Suellen M Walker, Jurgen C de Graaff, Marzena Zielinska, Dusica Simic, Thomas Engelhardt, Walid Habre, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

<h4>Background</h4>Neonates and infants requiring anaesthesia are at risk of physiological instability and complications, but triggers for peri-anaesthetic interventions and associations with subsequent outcome are unknown.<h4>Methods</h4>This prospective, observational study recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 126(6):1157-1172]

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Genome Reduction Is Associated with Bacterial Pathogenicity across Different Scales of Temporal and Ecological Divergence.

Gemma G R Murray, Jane Charlesworth, Eric L Miller, Michael J Casey, Catrin T Lloyd, Marcelo Gottschalk, Alexander W Dan Tucker, John J Welch, Lucy A Weinert,

Emerging bacterial pathogens threaten global health and food security, and so it is important to ask whether these transitions to pathogenicity have any common features. We present a systematic study of the claim that pathogenicity is associated with genome reduction and gene loss. We compare broad-scale patterns across all bacteria, ... Read more >>

Mol Biol Evol (Molecular biology and evolution)
[2021, 38(4):1570-1579]

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Build me up optic cup: Intrinsic and extrinsic mechanisms of vertebrate eye morphogenesis.

Macaulie A Casey, Sarah Lusk, Kristen M Kwan,

The basic structure of the eye, which is crucial for visual function, is established during the embryonic process of optic cup morphogenesis. Molecular pathways of specification and patterning are integrated with spatially distinct cell and tissue shape changes to generate the eye, with discrete domains and structural features: retina and ... Read more >>

Dev Biol (Developmental biology)
[2021, 476:128-136]

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Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74.

Rajkumar Lalji Sahani, Raquel Diana-Rivero, Sanjeev Kumar V Vernekar, Lei Wang, Haijuan Du, Huanchun Zhang, Andres Emanuelli Castaner, Mary C Casey, Karen A Kirby, Philip R Tedbury, Jiashu Xie, Stefan G Sarafianos, Zhengqiang Wang,

Small molecules targeting the PF74 binding site of the HIV-1 capsid protein (CA) confer potent and mechanistically unique antiviral activities. Structural modifications of PF74 could further the understanding of ligand binding modes, diversify ligand chemical classes, and allow identification of new variants with balanced antiviral activity and metabolic stability. In ... Read more >>

Viruses (Viruses)
[2021, 13(3):]

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GFI1 cooperates with IKAROS/IKZF1 to activate gene expression in T-cell acute lymphoblastic leukemia

Wenxiang Sun, Jingtao Guo, David McClellan, Alexandra Poeschla, Diana Bareyan, Mattie Casey, Bradley Cairns, Dean Tantin, Michael Engel,

Growth factor independence-1 (GFI1) is a transcriptional repressor and master regulator of normal and malignant hematopoiesis. Repression by GFI1 is attributable to recruitment of LSD1-containing protein complexes via its SNAG domain. However, the full complement of GFI1 partners in transcriptional control is not known. We show that in T-ALL cells, ... Read more >>

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Skin deep: Cutaneous manifestation of PIP implant rupture.

Máire-Caitlín Casey, Edward Jason Kelly,

PIP (Poly Implant Prothèse, France) implants were readily employed for breast reconstruction until withdrawn from the market in 2010. These implants have an early and increased risk of rupture compared to non-PIP implants. This report outlines a significant cutaneous manifestation of PIP-implant rupture not previously described in the literature. This ... Read more >>

JPRAS Open (JPRAS open)
[2021, 29:10-16]

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Co-Creating Descriptors and a Definition for Person-Centred Coordinated Health Care: An Action Research Study.

Amanda Phelan, Daniela Rohde, Mary Casey, Gerard Fealy, Patrick Felle, Gabrielle O'Kelly, Helen Lloyd, Aine Carroll,

The aim of this study was to co-create a definition and generic descriptors for person-centred coordinated care for Ireland generated from service users' narratives. An overarching action research approach was used to engage and empower people to tangibly impact health policy and practice. Through focus groups and a qualitative survey, ... Read more >>

Int J Integr Care (International journal of integrated care)
[2021, 21(1):11]

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The importance of nurturing trusting relationships to embed shared decision-making during pregnancy and childbirth.

Denise O'Brien, Michelle M Butler, Mary Casey,

<h4>Objective</h4>To generate greater awareness of the contextual and relational factors that influence women's capacity to participate in shared decision-making during childbirth.<h4>Methods</h4>A three-phase participatory action research approach involving in-depth interviews and co-operative inquiry meetings.<h4>Setting</h4>Dublin, Ireland in a large maternity hospital.<h4>Participants</h4>Five postnatal women who gave birth to live healthy babies, and attended ... Read more >>

Midwifery (Midwifery)
[2021, 98:102987]

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Progressive resistance training in a post-acute, older, inpatient setting: A randomised controlled feasibility study.

Sinéad A Coleman, Conal J Cunningham, Niamh Murphy, Jean Feaheny, David Robinson, Rosaleen Lannon, Kevin McCarroll, Miriam Casey, Joseph Harbison, N Frances Horgan,

<h4>Objectives</h4>Progressive resistance training can successfully target functional decline in healthy older community-dwelling adults. There are concerns about the safety and acceptance of its use in frail older populations. The aim of this study was to evaluate the feasibility of using progressive resistance training in an older, post-acute, inpatient setting.<h4>Methods</h4>A randomised ... Read more >>

J Frailty Sarcopenia Falls (Journal of frailty, sarcopenia and falls)
[2021, 6(1):14-24]

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Estimation of the serial interval of COVID-19 in Ireland using contact tracing data

Conor McAloon, Patrick Wall, John Griffin, Miriam Casey, Ann Barber, Mary Codd, Eamonn Gormley, Francis Butler, Locksley McV Messam, Cathal Walsh, Conor Teljeur, Breda Smyth, Philip Nolan, Martin Green, Luke O’Grady, Kieran Culhane, Claire Buckley, Ciara Carroll, Sarah Doyle, Jennifer Martin, Simon More,

<h4>Background: </h4> The serial interval is the period of time between the onset of symptoms in an infector and an infectee and is an important parameter which can impact on the estimation of the reproduction number. Whilst several parameters influencing infection transmission are expected to be consistent across populations, the ... Read more >>

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The preservation potential of terrestrial biogeographic patterns.

Simon A F Darroch, Danielle Fraser, Michelle M Casey,

Extinction events in the geological past are similar to the present-day biodiversity crisis in that they have a pronounced biogeography, producing dramatic changes in the spatial distributions of species. Reconstructing palaeobiogeographic patterns from fossils therefore allows us to examine the long-term processes governing the formation of regional biotas, and potentially ... Read more >>

Proc Biol Sci (Proceedings. Biological sciences)
[2021, 288(1945):20202927]

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Integrating Primary and Secondary Care to Enhance Chronic Disease Management: A Scoping Review.

Sara Murtagh, Geoff McCombe, John Broughan, Áine Carroll, Mary Casey, Áine Harrold, Thomas Dennehy, Ronan Fawsitt, Walter Cullen,

<h4>Background</h4>In Ireland, as in many healthcare systems, health policy has committed to delivering an integrated model of care to address the increasing burden of chronic disease. Integrated care is an approach to healthcare systems delivery that aims to minimise fragmentation of patient services and improve care continuity. To this end, ... Read more >>

Int J Integr Care (International journal of integrated care)
[2021, 21(1):4]

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Vitamin D and Hospital Admission in Older Adults: A Prospective Association.

Avril Beirne, Kevin McCarroll, James Bernard Walsh, Miriam Casey, Eamon Laird, Helene McNulty, Mary Ward, Leane Hoey, Anne M Molloy, Martin Healy, Catherine Hughes, Sean Strain, Conal Cunningham,

The health effects of vitamin D are well documented, with increasing evidence of its roles beyond bone. There is, however, little evidence of the effects of vitamin D on hospitalisation among older adults. This study aimed to prospectively determine the relationship of vitamin D status in older adults with hospital ... Read more >>

Nutrients (Nutrients)
[2021, 13(2):]

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An improved set of electron-THFA cross sections refined through a neural network-based analysis of swarm data.

P W Stokes, S P Foster, M J E Casey, D G Cocks, O González-Magaña, J de Urquijo, G García, M J Brunger, R D White,

We review experimental and theoretical cross sections for electron transport in α-tetrahydrofurfuryl alcohol (THFA) and, in doing so, propose a plausible complete set. To assess the accuracy and self-consistency of our proposed set, we use the pulsed-Townsend technique to measure drift velocities, longitudinal diffusion coefficients, and effective Townsend first ionization ... Read more >>

J Chem Phys (The Journal of chemical physics)
[2021, 154(8):084306]

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