Full Text Journal Articles by
Author Lynn M Alaeddine

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Metformin: A Growing Journey from Glycemic Control to the Treatment of Alzheimer's Disease and Depression.

Mohamed El Massry, Lynn M Alaeddine, Leen Ali, Celine Saad, Assaad A Eid,

Metabolic stress, transduced as an altered cellular redox and energy status, presents as the main culprit in many diseases, including diabetes. However, its role in the pathology of neurological disorders is still not fully elucidated. Metformin, a biguanide compound, is an FDA approved antidiabetic drug generally used for the treatment ... Read more >>

Curr Med Chem (Current medicinal chemistry)
[2021, 28(12):2328-2345]

Cited: 1 time

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Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats.

Lynn M Alaeddine, Frederic Harb, Maysaa Hamza, Batoul Dia, Nahed Mogharbil, Nadim S Azar, Mohamed H Noureldein, Mirella El Khoury, Ramzi Sabra, Assaad A Eid,

Diabetic cardiomyopathy (DCM) is a well-established complication of type 1 and type 2 diabetes associated with a high rate of morbidity and mortality. DCM is diagnosed at advanced and irreversible stages. Therefore, it is of utmost need to identify novel mechanistic pathways involved at early stages to prevent or reverse ... Read more >>

Transl Res (Translational research : the journal of laboratory and clinical medicine)
[2021, 235:85-101]

Cited: 1 time

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Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study.

Ghandoura Moussa, Rana Alaaeddine, Lynn M Alaeddine, Rasha Nassra, Ahmed S F Belal, Azza Ismail, Ahmed F El-Yazbi, Yasser S Abdel-Ghany, Aly Hazzaa,

Click chemistry was used to synthesize a new series of thioquinazolinone molecules equipped with propargyl moiety,1,2,3-triazolyl and isoxazolyl rings. Our design was based on merging pharmacophores previously reported to exhibit COX-2 inhibitory activities to a thioquinazolinone-privileged scaffold. The synthesized compounds were subjected to in vitro cyclooxygenase COX-1/COX-2 and 15-LOX inhibition assays. ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2018, 144:635-650]

Cited: 6 times

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