Full Text Journal Articles by
Author Lynette B Fernandes

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Identifying the core concepts of pharmacology education.

Paul J White, Elizabeth A Davis, Marina Santiago, Tom Angelo, Alison Shield, Anna-Marie Babey, Barbara Kemp-Harper, Gregg Maynard, Hesham S Al-Sallami, Ian F Musgrave, Lynette B Fernandes, Suong N T Ngo, Tina Hinton,

Pharmacology education currently lacks an agreed knowledge curriculum. Evidence from physics and biology education indicates that core concepts are useful and effective structures around which such a curriculum can be designed to facilitate student learning. Building on previous work, we developed a novel, criterion-based method to identify the core concepts ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(4):e00836]

Cited: 0 times

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Embedding responsible conduct in learning and research into an Australian undergraduate curriculum.

Lynette B Fernandes,

Responsible conduct in learning and research (RCLR) was progressively introduced into the pharmacology curriculum for undergraduate science students at The University of Western Australia. In the second year of this undergraduate curriculum, a lecture introduces students to issues such as the use of animals in teaching and responsible conduct of ... Read more >>

Biochem Mol Biol Educ (Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology)
[2017, 45(1):53-59]

Cited: 2 times

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Rhinovirus exacerbates house-dust-mite induced lung disease in adult mice.

Jennifer A Phan, Anthony Kicic, Luke J Berry, Lynette B Fernandes, Graeme R Zosky, Peter D Sly, Alexander N Larcombe,

Human rhinovirus is a key viral trigger for asthma exacerbations. To date, murine studies investigating rhinovirus-induced exacerbation of allergic airways disease have employed systemic sensitisation/intranasal challenge with ovalbumin. In this study, we combined human-rhinovirus infection with a clinically relevant mouse model of aero-allergen exposure using house-dust-mite in an attempt to ... Read more >>

PLoS One (PloS one)
[2014, 9(3):e92163]

Cited: 14 times

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The mechanism of deep inspiration-induced bronchoprotection: evidence from a mouse model.

Russell S Wong, Alexander N Larcombe, Lynette B Fernandes, Graeme R Zosky, Peter B Noble,

In healthy individuals, deep inspirations (DIs) taken prior to a bronchial challenge reduce the bronchoconstrictor response, which is termed "bronchoprotection". The mechanism(s) of DI-induced bronchoprotection is unclear. The forced oscillation technique was used to assess the effect of prior DI on subsequent bronchoconstriction to methacholine (MCh) in BALB/c mice. We ... Read more >>

Eur Respir J (The European respiratory journal)
[2012, 40(4):982-989]

Cited: 9 times

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Effects of simulated tidal and deep breathing on immature airway contraction to acetylcholine and nerve stimulation.

Thomas K Ansell, Peter B Noble, Howard W Mitchell, Adrian R West, Lynette B Fernandes, Peter K McFawn,

<h4>Background and objective</h4>In adults, respiratory movements, such as tidal and deep breaths, reduce airway smooth muscle force and cause bronchodilation. Evidence suggests that these beneficial effects of oscillatory strain do not occur in children, possibly because of reduced coupling of the airways to lung tissue or maturational differences in the ... Read more >>

Respirology (Respirology (Carlton, Vic.))
[2009, 14(7):991-998]

Cited: 11 times

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Rho kinase as a therapeutic target in the treatment of asthma and chronic obstructive pulmonary disease.

Lynette B Fernandes, Peter J Henry, Roy G Goldie,

Asthma is a complex inflammatory disease of the airways involving reversible bronchoconstriction. Chronic obstructive pulmonary disease is typified by inflammation and airflow limitation that has an irreversible component. There is now substantial evidence that Rho kinase is involved in many of the pathways that contribute to the pathologies associated with ... Read more >>

Ther Adv Respir Dis (Therapeutic advances in respiratory disease)
[2007, 1(1):25-33]

Cited: 17 times

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The impact of respiratory syncytial virus infection on endothelin receptor function and release in sheep bronchial explants.

Lynette B Fernandes, Angela C D'Aprile, Glenn J Self, Gerald B Harnett, Roy G Goldie,

We investigated the impact of respiratory syncytial virus (RSV) infection, an important asthma precipitant, on endothelin receptor function and release in sheep bronchial explants. RSV infection was confirmed using polymerase chain reaction and immunohistochemistry. Since sheep airway smooth muscle contains only endothelin-A receptors, sarafotoxin (Stx) S6c did not cause airway ... Read more >>

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2004, 44 Suppl 1:S202-6]

Cited: 2 times

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The single mediator approach to asthma therapy: is it so unreasonable?

Lynette B Fernandes, Roy G Goldie,

Asthma involves a complex syndrome of respiratory pathologies that ultimately results in bronchial obstruction and reduced lung ventilatory capacity. Inflammation of the respiratory tract underlies this disease and can be linked to the production and release of multiple mediators of bronchoconstriction and airway wall restructuring and obstruction. Disease triggers vary ... Read more >>

Curr Opin Pharmacol (Current opinion in pharmacology)
[2003, 3(3):251-256]

Cited: 2 times

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Enhanced ET(A) receptor-mediated contractile function is associated with reduced ET(A) receptor density in sheep bronchial explants maintained in culture.

Roy G Goldie, Angela C D'Aprile, Richard J Betts, Lynette B Fernandes,

We are interested in developing an airway explant culture system using sheep bronchi in which to establish respiratory viral infection and from which tissue can be used for functional, biochemical and immunohistochemical studies involving the endothelins (ETs). Freshly harvested sheep bronchial airway smooth muscle contains a homogeneous population of the ... Read more >>

Clin Sci (Lond) (Clinical science (London, England : 1979))
[2002, 103 Suppl 48:349S-352S]

Cited: 0 times

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Impact of parainfluenza-3 virus infection on endothelin receptor density and function in guinea pig airways.

Angela C D'Aprile, Lynette B Fernandes, Paul J Rigby, Roy G Goldie,

We examined the impact of parainfluenza-3 (P-3) respiratory tract viral infection on the density and function of endothelin (ET) receptor subtypes (ET(A) and ET(B)) in guinea pig tracheal smooth muscle. Total specific binding of [(125)I]ET-1 and the relative proportions of ET(A) and ET(B) binding sites for this ligand were assessed ... Read more >>

Clin Sci (Lond) (Clinical science (London, England : 1979))
[2002, 103 Suppl 48:345S-348S]

Cited: 1 time

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