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Author Lumin Chen

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Cellulose nanofiber derived carbon aerogel with 3D multiscale pore architecture for high-performance supercapacitors.

Lumin Chen, Houyong Yu, Ziheng Li, Xiang Chen, Wenlong Zhou,

Carbon materials are highly promising electrode materials for supercapacitors, due to their hierarchical porous structure and large specific surface area. However, the limited specific capacitance and inferior rate capability significantly prevent their practical application. Herein, 3D interconnected hierarchical porous carbon aerogels (CNFAs) through engineering the pyrolysis chemistry of CNF are ... Read more >>

Nanoscale (Nanoscale)
[2021, 13(42):17837-17845]

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Flexible, anti-damage, and non-contact sensing electronic skin implanted with MWCNT to block public pathogens contact infection.

Duan-Chao Wang, Hou-Yong Yu, Lurong Jiang, Dongming Qi, Xinxing Zhang, Lumin Chen, Wentao Lv, Weiqiang Xu, Kam Chiu Tam,

If a person comes into contact with pathogens on public facilities, there is a threat of contact (skin/wound) infections. More urgently, there are also reports about COVID-19 coronavirus contact infection, which once again reminds that contact infection is a very easily overlooked disease exposure route. Herein, we propose an innovative ... Read more >>

Nano Res (Nano research)
[2021, :1-10]

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Confined Chemical Transitions for Direct Extraction of Conductive Cellulose Nanofibers with Graphitized Carbon Shell at Low Temperature and Pressure.

Duan-Chao Wang, Hou-Yong Yu, Dongming Qi, Yuhang Wu, Lumin Chen, Ziheng Li,

Cellulose is the most abundant renewable natural polymer on earth, but it does not conduct electricity, which limits its application expansion. The existing methods of making cellulose conductive are combined with another conductive material or high-temperature/high-pressure carbonization of the cellulose itself, while in the traditional method of sulfuric acid hydrolysis ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2021, 143(30):11620-11630]

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Androgen/Androgen Receptor Signaling in Ovarian Cancer: Molecular Regulation and Therapeutic Potentials.

Wei-Min Chung, Lumin Chen, Wei-Chun Chang, Sheng-Yuan Su, Yao-Ching Hung, Wen-Lung Ma,

Ovarian cancer (OVCA) arises from three cellular origins, namely surface epithelial cells, germ cells, and stromal cells. More than 85% of OVCAs are EOCs (epithelial ovarian carcinomas), which are the most lethal gynecological malignancies. Cancer stem/progenitor cells (CSPCs) are considered to be cancer promoters due to their capacity for unlimited ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(14):]

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Age-specific risk factors of severe pneumonia among pediatric patients hospitalized with community-acquired pneumonia.

Lumin Chen, Chong Miao, Yanling Chen, Xian Han, Ziying Lin, Hong Ye, Chengyi Wang, Huijie Zhang, Jingjing Li, Qiuyu Tang, Yuan Dong, Meng Bai, Yibing Zhu, Guanghua Liu,

<h4>Background</h4>Risk factors that predispose the development of severe community-acquired pneumonia (CAP) among pediatric CAP patients of different age ranges are yet to be identified.<h4>Methods</h4>We retrospectively analyzed pediatric in-patients (< 6 years old) diagnosed with CAP in our hospital. We subdivided patients into four age groups (< 6 months, 6 months-1 year, 1-2 years, and 2-6 years). Their medical ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2021, 47(1):100]

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The relationships between LncRNA NNT-AS1, CRP, PCT and their interactions and the refractory mycoplasma pneumoniae pneumonia in children.

Ping Chen, Zheng Huang, Lumin Chen, Shihao Zhuang, Hongli Lin, Jianfeng Xie, Kuicheng Zheng,

To investigate the relationships between LncRNA NNT-AS1, CRP, PCT and their interactions and the refractory mycoplasma pneumoniae pneumonia (RMPP) in children. Serum levels of LncRNA NNT-AS1 of RMPP and non-RMPP (NRMPP) patients were detected by real-time PCR, and were analyzed together with serum c-reactive protein (CRP) and procalcitonin (PCT). Correlations ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2059]

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Risk factors associated with wheezing in severe pediatric community-acquired pneumonia: a retrospective study.

Lumin Chen, Chong Miao, Yanling Chen, Xian Han, Ziying Lin, Hong Ye, Chengyi Wang, Huijie Zhang, Jingjing Li, Xi Liu, Libo Xu, Guanghua Liu,

<h4>Background</h4>Wheezing is a common clinical manifestation in children with pneumonia. However, the risk factors associated with the development of wheezing pneumonia and its clinical features are not fully characterized, especially in children with severe pneumonia.<h4>Methods</h4>We retrospectively recruited 1434 pediatric patients diagnosed with severe pneumonia between April 2012 and September 2019 ... Read more >>

Minerva Pediatr (Minerva pediatrica)
[2021, :]

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IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin.

Miao Tian, Xiumei Wang, Jihong Sun, Wenlong Lin, Lumin Chen, Shengduo Liu, Ximei Wu, Liyun Shi, Pinglong Xu, Xiujun Cai, Xiaojian Wang,

Occurrence of Colorectal cancer (CRC) is relevant with gut microbiota. However, role of IRF3, a key signaling mediator in innate immune sensing, has been barely investigated in CRC. Here, we unexpectedly found that the IRF3 deficient mice are hyper-susceptible to the development of intestinal tumor in AOM/DSS and Apc<sup>min/+</sup> models. ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):5762]

Cited: 2 times

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Olfactory ensheathing cells seeded decellularized scaffold promotes axonal regeneration in spinal cord injury rats.

Fangzheng Yu, Peifeng Li, Shenghu Du, KoonHei W Lui, Yutian Lin, Lumin Chen, Qi Ren, Jian Wang, Jin Mei, Jian Xiao, Junyi Zhu,

Spinal cord decellularized (DC) scaffolds can promote axonal regeneration and restore hindlimb motor function of spinal cord defect rats. However, scarring caused by damage to the astrocytes at the margin of injury can hinder axon regeneration. Olfactory ensheathing cells (OECs) integrate and migrate with astrocytes at the site of spinal ... Read more >>

J Biomed Mater Res A (Journal of biomedical materials research. Part A)
[2021, 109(5):779-787]

Cited: 2 times

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Novel design of Fe-Cu alloy coated cellulose nanocrystals with strong antibacterial ability and efficient Pb2+ removal

Lumin Chen, Houyong Yu, Christopher Deutschman, Ting Yang, Kam Chiu Tam,

We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals ([email protected]) via simple oxidation-reduction reaction. Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb²⁺ ... Read more >>

(Carbohydrate polymers.)
[2020, 234:Not Available]

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LDLR-mediated lipidome-transcriptome reprogramming in cisplatin insensitivity.

Wei-Chun Chang, Hsiao-Ching Wang, Wei-Chung Cheng, Juan-Cheng Yang, Wei-Min Chung, Yen-Pin Ho, Lumin Chen, Yao-Ching Hung, Wen-Lung Ma,

Platinum-based therapy remains the cornerstone for cancer therapy; however, its efficacy varies. The role of lipoprotein receptor-mediated lipid entry for cancer development has been reported. Yet, the roles and mechanism of the low-density lipoprotein receptor (LDLR) in chemo-sensitivities are unknown. In the current report, we used epithelial ovarian cancer (EOC), ... Read more >>

Endocr Relat Cancer (Endocrine-related cancer)
[2020, 27(2):81-95]

Cited: 1 time

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Graphene Oxide Carburization Enhanced Ionization Efficiency for TIMS Isotope Ratio Analysis of Uranium at Trace Level.

Ling Zhang, Penghui Xiong, Hailu Zhang, Lumin Chen, Jie Xu, Haoxi Wu, Zhen Qin,

Isotope analysis of trace uranium is important in nuclear safeguards and nuclear forensics, which requires the analytical methodologies with high sensitivity, accuracy, and precision. As one of the most powerful techniques in isotopic measurement, thermal ionization mass spectrometry (TIMS) usually suffers from its relatively low sensitivity in ultratrace measurements. To ... Read more >>

Anal Chem (Analytical chemistry)
[2019, 91(11):7215-7225]

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Low-Density Lipoprotein Receptor-Mediated Lipidome-Transcriptome Reprogramming Impulses to Cisplatin Insensitivity

Wei-Chun Chang, Hsiao-Ching Wang, Wei-Chung Cheng, Juan-Cheng Yang, Wei-Min Chung, Lumin Chen, Yen-Pin Ho, Yao-Ching Hung, Wen-Lung Ma,

Platinum-based therapy remains the cornerstone for cancer patient management; however, its efficacy varies. This study demonstrated the differential expressions of low-density lipoprotein receptor (LDLR) in subtypes of epithelial ovarian carcinoma (EOC) determines cisplatin sensitivity. It's sensitive in serous EOCs (low LDLR), where insensitive in endometrioid and clear cell EOCs (high ... Read more >>

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Increase Paclitaxel Sensitivity to Better Suppress Serous Epithelial Ovarian Cancer via Ablating Androgen Receptor/Aryl Hydrocarbon Receptor-ABCG2 Axis.

Wei-Min Chung, Yen-Ping Ho, Wei-Chun Chang, Yuan-Chang Dai, Lumin Chen, Yao-Ching Hung, Wen-Lung Ma,

<h4>Background</h4>Epithelial ovarian cancer (EOC) is one of the most lethal gynecological malignancies and presents chemoresistance after chemotherapy treatment. Androgen receptor (AR) has been known to participate in proliferation. Yet the mechanisms of the resistance of this drug and its linkage to the AR remains unclear.<h4>Methods</h4>To elucidate AR-related paclitaxel sensitivity, co-IP, ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(4):]

Cited: 6 times

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Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics.

Shuaifei Wang, Fangyuan Li, Ruirui Qiao, Xi Hu, Hongwei Liao, Lumin Chen, Jiahe Wu, Haibin Wu, Meng Zhao, Jianan Liu, Rui Chen, Xibo Ma, Dokyoon Kim, Jihong Sun, Thomas P Davis, Chunying Chen, Jie Tian, Taeghwan Hyeon, Daishun Ling,

Ferroptosis, an iron-based cell-death pathway, has recently attracted great attention owing to its effectiveness in killing cancer cells. Previous investigations focused on the development of iron-based nanomaterials to induce ferroptosis in cancer cells by the up-regulation of reactive oxygen species (ROS) generated by the well-known Fenton reaction. Herein, we report ... Read more >>

ACS Nano (ACS nano)
[2018, 12(12):12380-12392]

Cited: 23 times

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Design and Mechanical Analysis of Bionic Foldable Beetle Wings.

Caidong Wang, Chen Wang, Yu Ning, Lumin Chen, Xinjie Wang,

In order to improve the flight performance of collapsible aircrafts, a novel mechanism of bionic foldable wings of beetle is designed based on the four-plate mechanism theory. The folding and unfolding movements of the bionic foldable wings are driven by motor and torsion hinges. Based on the D-H method, a ... Read more >>

Appl Bionics Biomech (Applied bionics and biomechanics)
[2018, 2018:1308465]

Cited: 1 time

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Mitochondrial Acetyl-CoA Synthetase 3 is Biosignature of Gastric Cancer Progression.

Wei-Chun Chang, Wei-Chung Cheng, Bi-Hua Cheng, Lumin Chen, Li-Jing Ju, Yu-Jer Ou, Long-Bin Jeng, Mei-Due Yang, Yao-Ching Hung, Wen-Lung Ma,

Cholesterol affects cancer progression, and acetyl-CoA is the primary cholesterogenesis substrate. The previous work has defined cholesterol bioflux via lipoprotein/receptor route is the gastric cancer (GCa) prognosis biosignature. The prognosis importance of acetyl-CoA to cholesterogenesis (mevalonate pathway) in GCa is yet to be defined. Using Kaplan-Meier Plotter web-based gene survival ... Read more >>

Cancer Med (Cancer medicine)
[2018, 7(4):1240-1252]

Cited: 6 times

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Radiofrequency heat-enhanced direct intratumoral chemotherapy for prostate cancer.

Xia Wu, Feng Zhang, Peng Hu, Lumin Chen, Guocan Han, Weixian Bai, Jingfeng Luo, Ran Chen, Yurong Zhou, Jihong Sun, Xiaoming Yang,

A novel, minimally invasive interventional technique, radiofrequency heat (RFH), has been suggested to improve the efficacy of chemotherapy for solid organ tumors. However, the treatment for prostate cancer has not been completely characterized. The aim of the present study was to investigate the in vitro and in vivo efficiency of ... Read more >>

Oncol Lett (Oncology letters)
[2017, 14(6):7250-7256]

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Short androgen receptor poly-glutamine-promoted endometrial cancer is associated with benzo[a]pyrene-mediated aryl hydrocarbon receptor activation.

Lumin Chen, Bo-Ying Bao, Wei-Chun Chang, Jason Yen-Ping Ho, Bi-Hua Cheng, Chung-Lin Wang, Qifeng Tang, Wei-Chung Cheng, Hui-Wen Chang, Yao-Ching Hung, Wen-Lung Ma,

The androgen receptor (AR) poly-glutamine polymorphism (AR-Q) was reported to play role in endometrial cancer (EMCA) development, yet controversial. Environmental factors interact with genetic variation have been reported in EMCA. Aerosol toxins, polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP), are EMCA facilitators. This report examined the interplay between AR-Qs and BaP in ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2018, 22(1):46-56]

Cited: 1 time

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Gadolinium-Loaded Solid Lipid Nanoparticles as a Tumor-Absorbable Contrast Agent for Early Diagnosis of Colorectal Tumors Using Magnetic Resonance Colonography.

Jihong Sun, Shizheng Zhang, Shaojie Jiang, Weixian Bai, Fei Liu, Hong Yuan, Jiansong Ji, Jingfeng Luo, Guocan Han, Lumin Chen, Yin Jin, Peng Hu, Lei Yu, Xiaoming Yang,

Magnetic resonance (MR) contrast agents focusing on special functions are required to improve cancer diagnosis, particularly in the early stages. Here, we designed multifunctional solid lipid nanoparticles (SLNs) with simultaneous loading of gadolinium (Gd) diethylenetriaminepentaacetic acid (Gd-DTPA) and octadecylamine fluorescein isothiocyanate (FITC) to obtain Gd-FITC-SLNs as a tumor-absorbable nanoparticle contrast ... Read more >>

J Biomed Nanotechnol (Journal of biomedical nanotechnology)
[2016, 12(9):1709-1723]

Cited: 4 times

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Assessment of liver fibrosis using pharmacokinetic parameters of dynamic contrast-enhanced magnetic resonance imaging.

Zhiming Li, Jihong Sun, Lumin Chen, Ning Huang, Peng Hu, Xi Hu, Guocan Han, Yurong Zhou, Weixian Bai, Tianye Niu, Xiaoming Yang,

<h4>Purpose</h4>To evaluate the pharmacokinetic parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in diagnosing and staging liver fibrosis in rabbits.<h4>Materials and methods</h4>DCE-MRI with gadodiamide (Gd-DTPA-BMA) was performed on a 3.0 Tesla, 60 cm bore MR scanner for rabbits with CCl4 -induced liver fibrosis, and an untreated control group. Fibrosis was staged ... Read more >>

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2016, 44(1):98-104]

Cited: 11 times

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Explosive synchronization with asymmetric frequency distribution.

Wenchang Zhou, Lumin Chen, Hongjie Bi, Xin Hu, Zonghua Liu, Shuguang Guan,

In this work, we study the synchronization in a generalized Kuramoto model with frequency-weighted coupling. In particular, we focus on the situations in which the frequency distributions of oscillators are asymmetric. For typical unimodal frequency distributions, such as Lorentzian, Gaussian, triangle, and even special Rayleigh, we find that the synchronization ... Read more >>

Phys Rev E Stat Nonlin Soft Matter Phys (Physical review. E, Statistical, nonlinear, and soft matter physics)
[2015, 92(1):012812]

Cited: 3 times

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Assessment of liver fibrosis by variable flip angle T1 mapping at 3.0T.

Zhiming Li, Jihong Sun, Xi Hu, Ning Huang, Guocan Han, Lumin Chen, Yurong Zhou, Weixian Bai, Xiaoming Yang,

<h4>Purpose</h4>To evaluate the possibility of using a variable flip angle (VFA) T1 mapping technique to diagnose liver fibrosis.<h4>Materials and methods</h4>Liver fibrosis was induced in rabbits by repetitive administration of carbon tetrachloride (CCl4 ). T1 -weighted magnetic resonance imaging (MRI) was performed in 29 animals (liver fibrosis, n = 18; control, n = 11) using ... Read more >>

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2016, 43(3):698-703]

Cited: 18 times

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Radiofrequency heat-enhanced chemotherapy for breast cancer: towards interventional molecular image-guided chemotherapy.

Yurong Zhou, Guocan Han, Yue Wang, Xi Hu, Zhiming Li, Lumin Chen, Weixian Bai, Jingfeng Luo, Yajing Zhang, Jihong Sun, Xiaoming Yang,

Breast cancer is the most common malignancy in women worldwide. Recent developments in minimally invasive interventional radiology techniques have significantly improved breast cancer treatment. This study aimed to develop a novel technique for the local management of breast cancers using radiofrequency heat (RFH). We performed both in vitro experiments using ... Read more >>

Theranostics (Theranostics)
[2014, 4(11):1145-1152]

Cited: 12 times

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Androgen receptor increases CD133 expression and progenitor-like population that associate with cisplatin resistance in endometrial cancer cell line.

Lumin Chen, Wei-Chun Chang, Yao-Ching Hung, Ying-Yi Chang, Bo-Yin Bao, Hsin-Ching Huang, Wei-Min Chung, Chih-Rong Shyr, Wen-Lung Ma,

Endometrial cancer (EMC) is a sex steroid hormone-related female malignancy. Androgen and androgen receptor (androgen/AR) signals have been implicated in EMC progression. Cancer stem/progenitor cells (CSPCs) are suspected to link to chemoresistance in patients with EMC. In this study, we examined the androgen/AR roles in cisplatin resistance and CSPC population. ... Read more >>

Reprod Sci (Reproductive sciences (Thousand Oaks, Calif.))
[2014, 21(3):386-394]

Cited: 11 times

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