Full Text Journal Articles by
Author Luisa J Coronel

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aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.

Olivia Molinar-Inglis, Cierra A Birch, Dequina Nicholas, Lennis Orduña-Castillo, Metztli Cisneros-Aguirre, Anand Patwardhan, Buxin Chen, Neil J Grimsey, Luisa J Coronel, Huilan Lin, Patrick K Gomez Menzies, Mark A Lawson, Hemal H Patel, JoAnn Trejo,

Endothelial dysfunction is associated with vascular disease and results in disruption of endothelial barrier function and increased sensitivity to apoptosis. Currently, there are limited treatments for improving endothelial dysfunction. Activated protein C (aPC), a promising therapeutic, signals via protease-activated receptor-1 (PAR1) and mediates several cytoprotective responses, including endothelial barrier stabilization ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(49):e2106623118]

Cited: 0 times

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Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins.

Thomas H Smith, Luisa J Coronel, Julia G Li, Michael R Dores, Marvin T Nieman, JoAnn Trejo,

Protease-activated receptor-4 (PAR4) is a G protein-coupled receptor (GPCR) for thrombin and is proteolytically activated, similar to the prototypical PAR1. Due to the irreversible activation of PAR1, receptor trafficking is intimately linked to signal regulation. However, unlike PAR1, the mechanisms that control PAR4 trafficking are not known. Here, we sought ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2016, 291(35):18453-18464]

Cited: 10 times

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