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Author Luis A Kluth

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Increasing rates of NCCN high and very high-risk prostate cancer versus number of prostate biopsy cores.

Mike Wenzel, Christoph Würnschimmel, Claudia C Ruvolo, Luigi Nocera, Zhe Tian, Fred Saad, Alberto Briganti, Derya Tilki, Markus Graefen, Luis A Kluth, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>Recently, an increase in the rates of high-risk prostate cancer (PCa) was reported. We tested whether the rates of and low, intermediate, high and very high-risk PCa changed over time. We also tested whether the number of prostate biopsy cores contributed to changes rates over time.<h4>Methods</h4>Within the Surveillance, Epidemiology and ... Read more >>

Prostate (The Prostate)
[2021, 81(12):874-881]

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Contemporary Outcomes after Transurethral Procedures for Bladder Neck Contracture Following Endoscopic Treatment of Benign Prostatic Hyperplasia.

Clemens M Rosenbaum, Malte W Vetterlein, Margit Fisch, Philipp Reiss, Thomas Stefan Worst, Jennifer Kranz, Joachim Steffens, Luis A Kluth, Daniel Pfalzgraf, On Behalf Of The Trauma And Reconstructive Urology Working Party Of The European Association Of Urology Eau Young Academic Urologists Yau,

<h4>Objectives</h4>Bladder neck contracture (BNC) is a bothersome complication following endoscopic treatment for benign prostatic hyperplasia (BPH). The objective of our study was to give a more realistic insight into contemporary endoscopic BNC treatment and to evaluate and identify risk factors associated with inferior outcome.<h4>Material and methods</h4>We identified patients who underwent ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(13):]

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Overall survival and adverse events after treatment with darolutamide vs. apalutamide vs. enzalutamide for high-risk non-metastatic castration-resistant prostate cancer: a systematic review and network meta-analysis.

Mike Wenzel, Luigi Nocera, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Derya Tilki, Markus Graefen, Luis A Kluth, Alberto Briganti, Philipp Mandel, Francesco Montorsi, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>The most recent overall survival (OS) and adverse event (AE) data have not been compared for the three guideline-recommended high-risk non-metastatic castration-resistant prostate cancer (nmCRPC) treatment alternatives.<h4>Methods</h4>We performed a systematic review and network meta-analysis focusing on OS and AE according to the most recent apalutamide, enzalutamide, and darolutamide reports. We ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

Cited: 1 time

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Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy.

Mike Wenzel, Felix Preisser, Clarissa Wittler, Benedikt Hoeh, Peter J Wild, Alexandra Tschäbunin, Boris Bodelle, Christoph Würnschimmel, Derya Tilki, Markus Graefen, Andreas Becker, Pierre I Karakiewicz, Felix K H Chun, Luis A Kluth, Jens Köllermann, Philipp Mandel,

<h4>Background</h4>The impact of MRI-lesion targeted (TB) and systematic biopsy (SB) Gleason score (GS) as a predictor for final pathological GS still remains unclear.<h4>Methods</h4>All patients with TB + SB, and subsequent radical prostatectomy (RP) between 01/2014-12/2020 were analyzed. Rank correlation coefficient predicted concordance with pathological GS for patients' TB and SB ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(5):]

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Immunohistochemistry for Prostate Biopsy-Impact on Histological Prostate Cancer Diagnoses and Clinical Decision Making.

Philipp Mandel, Mike Wenzel, Benedikt Hoeh, Maria N Welte, Felix Preisser, Tahir Inam, Clarissa Wittler, Clara Humke, Jens Köllermann, Peter Wild, Christoph Würnschimmel, Derya Tilki, Markus Graefen, Luis A Kluth, Pierre I Karakiewicz, Felix K-H Chun, Andreas Becker,

<h4>Background</h4>To test the value of immunohistochemistry (IHC) staining in prostate biopsies for changes in biopsy results and its impact on treatment decision-making.<h4>Methods</h4>Between January 2017-June 2020, all patients undergoing prostate biopsies were identified and evaluated regarding additional IHC staining for diagnostic purpose. Final pathologic results after radical prostatectomy (RP) were analyzed ... Read more >>

Curr Oncol (Current oncology (Toronto, Ont.))
[2021, 28(3):2123-2133]

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Non-cancer mortality in elderly prostate cancer patients treated with combination of radical prostatectomy and external beam radiation therapy.

Mike Wenzel, Christoph Würnschimmel, Francesco Chierigo, Zhe Tian, Shahrokh F Shariat, Carlo Terrone, Fred Saad, Derya Tilki, Markus Graefen, Philipp Mandel, Luis A Kluth, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>To test for rates of other cause mortality (OCM) and cancer-specific mortality (CSM) in elderly prostate cancer (PCa) patients treated with the combination of radical prostatectomy (RP) and external beam radiation therapy (EBRT) versus RP alone, since elderly PCa patients may be over-treated.<h4>Methods</h4>Within the Surveillance, Epidemiology and End Results database ... Read more >>

Prostate (The Prostate)
[2021, 81(11):728-735]

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Impact of Time to Castration Resistance on Survival in Metastatic Hormone Sensitive Prostate Cancer Patients in the Era of Combination Therapies.

Mike Wenzel, Felix Preisser, Benedikt Hoeh, Maria Schroeder, Christoph Würnschimmel, Thomas Steuber, Hans Heinzer, Severine Banek, Marit Ahrens, Andreas Becker, Pierre I Karakiewicz, Felix K H Chun, Luis A Kluth, Philipp Mandel,

<h4>Background</h4>To evaluate the impact of time to castration resistance (TTCR) in metastatic hormone-sensitive prostate cancer (mHSPC) patients on overall survival (OS) in the era of combination therapies for mHSPC.<h4>Material and methods</h4>Of 213 mHSPC patients diagnosed between 01/2013-12/2020 who subsequently developed metastatic castration resistant prostate cancer (mCRPC), 204 eligible patients were ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:659135]

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Radical Cystectomy vs. Multimodality Treatment in T2N0M0 Bladder Cancer: A Population-based, Age-matched Analysis.

Marina Deuker, Marieke J Krimphove, L Franziska Stolzenbach, Claudia Collà Ruvolo, Luigi Nocera, Mila Mansour, Zhe Tian, Frederik C Roos, Andreas Becker, Luis A Kluth, Shahrokh F Shariat, Peter C Black, Wassim Kassouf, Derya Tilki, Fred Saad, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>Controversy still exists regarding efficacy of multimodality treatment (MMT) vs. radical cystectomy (RC) for urothelial carcinoma of the urinary bladder (UCUB).<h4>Methods</h4>Within the SEER database (2004-2016), we retrospectively identified patients with stage T2N0M0 UCUB. Competing risks regression (CRR) tested cancer-specific mortality (CSM) and adjusted for other-cause mortality after MMT vs. RC. ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Incidence rates and contemporary trends in primary urethral cancer.

Mike Wenzel, Luigi Nocera, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Derya Tilki, Philipp Mandel, Andreas Becker, Luis A Kluth, Felix K H Chun, Pierre I Karakiewicz,

<h4>Purpose</h4>We assessed contemporary incidence rates and trends of primary urethral cancer.<h4>Methods</h4>We identified urethral cancer patients within Surveillance, Epidemiology and End Results registry (SEER, 2004-2016). Age-standardized incidence rates per 1,000,000 (ASR) were calculated. Log linear regression analyses were used to compute average annual percent change (AAPC).<h4>Results</h4>From 2004 to 2016, 1907 patients ... Read more >>

Cancer Causes Control (Cancer causes & control : CCC)
[2021, 32(6):627-634]

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Penile length and circumference dimensions: A large study in young Italian men.

Marina Di Mauro, Camilla Tonioni, Andrea Cocci, Luis A Kluth, Giorgio Ivan Russo, Juan Gomez Rivas, Giovanni Cacciamani, Gianmartin Cito, Girolamo Morelli, Gaia Polloni, Fabrizio di Maida, Daniel Giunti, ,

The aim of the present study was to evaluate the size of the penis in flaccidity and in erection of Italian men. A total of 4,685 men living in Italy and who have been visited at the Italian urology operating units were involved in the study between January 2019 and ... Read more >>

Andrologia (Andrologia)
[2021, 53(6):e14053]

Cited: 1 time

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Reply by Authors.

Mike Wenzel, Luigi Nocera, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Derya Tilki, Markus Graefen, Luis A Kluth, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

J Urol (The Journal of urology)
[2021, 206(1):79]

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Overall Survival After Systemic Treatment in High-volume Versus Low-volume Metastatic Hormone-sensitive Prostate Cancer: Systematic Review and Network Meta-analysis.

Mike Wenzel, Christoph Würnschimmel, Luigi Nocera, Claudia Collà Ruvolo, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Derya Tilki, Markus Graefen, Luis A Kluth, Frederik C Roos, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Context</h4>Novel prospective randomized controlled observations addressing combination therapy in metastatic hormone-sensitive prostate cancer (mHSPC) have demonstrated promising overall survival (OS) outcomes.<h4>Objective</h4>To compare these novel findings and systematically review and address them within formal network meta-analyses (NMAs) that include observations from other prospective randomized controlled trials (RCTs).<h4>Evidence acquisition</h4>First, we focused on ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

Cited: 2 times

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Salvage Radical Prostatectomy: Baseline Prostate Cancer Characteristics and Survival Across SEER Registries.

Mike Wenzel, Christoph Würnschimmel, Luigi Nocera, Claudia Collà Ruvolo, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Markus Graefen, Andreas Becker, Luis A Kluth, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Objective</h4>To test for baseline prostate cancer characteristics and survival differences after salvage radical prostatectomy (SRP) across 18 Surveillance, Epidemiology and End Results (SEER) registries from 2004 to 2016.<h4>Methods</h4>We tabulated prostate-specific antigen (PSA), cT stage, age, and SRP rates across individual SEER registries. Kaplan-Meier and competing risks regression methodologies depicted cancer-specific ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Racial/Ethnic Disparities in Tumor Characteristics and Treatments in Favorable and Unfavorable Intermediate Risk Prostate Cancer.

Mike Wenzel, Luigi Nocera, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Derya Tilki, Markus Graefen, Luis A Kluth, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Purpose</h4>We hypothesized that differences in active treatment rates may exist according to race/ethnicity in favorable as well as unfavorable intermediate risk prostate cancer.<h4>Materials and methods</h4>We relied on the Surveillance, Epidemiology, and End Results 18 database 2010-2015. We stratified according to 3 racial/ethnic groups (White vs Black vs Hispanic) and prostate ... Read more >>

J Urol (The Journal of urology)
[2021, 206(1):69-79]

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The effect of lymph node dissection on cancer-specific survival in salvage radical prostatectomy patients.

Mike Wenzel, Christoph Würnschimmel, Luigi Nocera, Claudia Collà Ruvolo, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Markus Graefen, Luis A Kluth, Philipp Mandel, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>We hypothesized that lymph node dissection (LND) at salvage radical prostatectomy may be associated with lower cancer-specific mortality (CSM) and we tested this hypothesis.<h4>Methods</h4>We relied on surveillance, epidemiology, and end results (2004-2016) to identify all salvage radical prostatectomy patients. Categorical, as well as univariate and multivariate Cox regression models tested ... Read more >>

Prostate (The Prostate)
[2021, 81(6):339-346]

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Exploring the intersection of functional recurrence, patient-reported sexual function, and treatment satisfaction after anterior buccal mucosal graft urethroplasty.

Malte W Vetterlein, Almut Gödde, Valentin Zumstein, Philipp Gild, Phillip Marks, Armin Soave, Christian P Meyer, Silke Riechardt, Roland Dahlem, Margit Fisch, Luis A Kluth, ,

<h4>Purpose</h4>To evaluate the interplay of stricture recurrence, sexual function, and treatment satisfaction after substitution urethroplasty.<h4>Methods</h4>Observational study of men undergoing 1-stage buccal mucosal graft urethroplasty for anterior urethral stricture between 2009 and 2016. Patients were dichotomized by self-reported treatment satisfaction. Sexual function was assessed by validated and non-validated patient-reported outcome measures. ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Multiparametric MRI may Help to Identify Patients With Prostate Cancer in a Contemporary Cohort of Patients With Clinical Bladder Outlet Obstruction Scheduled for Holmium Laser Enucleation of the Prostate (HoLEP).

Mike Wenzel, Maria N Welte, Lina Grossmann, Felix Preisser, Lena H Theissen, Clara Humke, Marina Deuker, Simon Bernatz, Philipp Gild, Sascha Ahyai, Pierre I Karakiewicz, Boris Bodelle, Luis A Kluth, Felix K H Chun, Philipp Mandel, Andreas Becker,

<b>Objective:</b> To investigate the value of standard [digital rectal examination (DRE), PSA] and advanced (mpMRI, prostate biopsy) clinical evaluation for prostate cancer (PCa) detection in contemporary patients with clinical bladder outlet obstruction (BOO) scheduled for Holmium laser enucleation of the prostate (HoLEP). <b>Material and Methods:</b> We retrospectively analyzed 397 patients, ... Read more >>

Front Surg (Frontiers in surgery)
[2021, 8:633196]

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Sex- and Age-Related Differences in the Distribution of Metastases in Patients With Upper Urinary Tract Urothelial Carcinoma.

Marina Deuker, Giuseppe Rosiello, Lara Franziska Stolzenbach, Thomas Martin, Claudia Collà Ruvolo, Luigi Nocera, Zhe Tian, Frederik C Roos, Andreas Becker, Luis A Kluth, Derya Tilki, Shahrokh F Shariat, Fred Saad, Felix K H Chun, Pierre I Karakiewicz,

<h4>Background</h4>The distribution of metastatic sites in upper tract urothelial carcinoma (UTUC) is not well-known. Consequently, the effects of sex and age on the location of metastases is also unknown. This study sought to investigate age- and sex-related differences in the distribution of metastases in patients with UTUC.<h4>Materials and methods</h4>Within the ... Read more >>

J Natl Compr Canc Netw (Journal of the National Comprehensive Cancer Network : JNCCN)
[2021, 19(5):534-540]

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Inverse Stage Migration in Radical Prostatectomy-A Sustaining Phenomenon.

Benedikt Hoeh, Felix Preisser, Philipp Mandel, Mike Wenzel, Clara Humke, Maria-Noemi Welte, Matthias Müller, Jens Köllermann, Peter Wild, Luis A Kluth, Frederik C Roos, Felix K H Chun, Andreas Becker,

<b>Objective:</b> To investigate temporal trends in prostate cancer (PCa) radical prostatectomy (RP) candidates. <b>Materials and Methods:</b> Patients who underwent RP for PCa between January 2014 and December 2019 were identified form our institutional database. Trend analysis and logistic regression models assessed RP trends after stratification of PCa patients according to ... Read more >>

Front Surg (Frontiers in surgery)
[2021, 8:612813]

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Effect of prostatic apex shape (Lee types) and urethral sphincter length in preoperative MRI on very early continence rates after radical prostatectomy.

Mike Wenzel, Felix Preisser, Matthias Mueller, Lena H Theissen, Maria N Welte, Benedikt Hoeh, Clara Humke, Simon Bernatz, Boris Bodelle, Christoph Würnschimmel, Derya Tilki, Hartwig Huland, Markus Graefen, Frederik C Roos, Andreas Becker, Pierre I Karakiewicz, Felix K H Chun, Luis A Kluth, Philipp Mandel,

<h4>Purpose</h4>To test the effect of anatomic variants of the prostatic apex overlapping the membranous urethra (Lee type classification), as well as median urethral sphincter length (USL) in preoperative multiparametric magnetic resonance imaging (mpMRI) on the very early continence in open (ORP) and robotic-assisted radical prostatectomy (RARP) patients.<h4>Methods</h4>In 128 consecutive patients ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2021, 53(7):1297-1303]

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Sex-Related Differences Include Stage, Histology, and Survival in Urethral Cancer Patients.

Mike Wenzel, Luigi Nocera, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Derya Tilki, Philipp Mandel, Luis A Kluth, Felix K H Chun, Pierre I Karakiewicz,

<h4>Purpose</h4>To test the effect of sex on histologic subtype, stage at presentation, treatment, and cancer-specific mortality (CSM) in urethral cancer.<h4>Patients and methods</h4>We identified urethral cancer patients within the Surveillance, Epidemiology, and End Results (SEER) registry (2004-2016). After matching for tumor and patient characteristics, cumulative incidence plots and multivariable competing risks ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, 19(2):135-143]

Cited: 2 times

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Comparison of Complication Rates with Antibiotic Prophylaxis with Cefpodoxime Versus Fluoroquinolones After Transrectal Prostate Biopsy.

Mike Wenzel, Maria N Welte, Lena H Theissen, Clarissa Wittler, Benedikt Hoeh, Clara Humke, Felix Preisser, Christoph Würnschimmel, Derya Tilki, Markus Graefen, Frederik C Roos, Andreas Becker, Pierre I Karakiewicz, Felix K H Chun, Luis A Kluth, Philipp Mandel,

<h4>Background</h4>After recommended restriction of the use of fluoroquinolones, the optimal antibiotic prophylaxis for transrectal prostate biopsy is still under debate.<h4>Objective</h4>To test the effectiveness of cefpodoxime as oral antibiotic prophylaxis for transrectal prostate biopsies and the complication rates relative to fluoroquinolones.<h4>Design, setting, and participants</h4>Antibiotic prophylaxis for transrectal prostate biopsies at the ... Read more >>

Eur Urol Focus (European urology focus)
[2020, :]

Cited: 2 times

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The effect of race/ethnicity on histological subtype distribution, stage at presentation and cancer specific survival in urethral cancer.

Mike Wenzel, Marina Deuker, Franziska Stolzenbach, Luigi Nocera, Claudia Collà Ruvolo, Zhe Tian, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Luis A Kluth, Felix K H Chun, Pierre I Karakiewicz,

<h4>Objective</h4>To test the effect of race/ethnicity on histological subtype, stage at presentation, and cancer specific mortality (CSM) in urethral cancer patients.<h4>Material and methods</h4>Stratified analyses (Surveillance, Epidemiology and End Results [2004-2016]) tested the effect of race/ethnicity on histology and stage. Cumulative incidence-plots and multivariable competing-risks regression models (CRR), addressed CSM, after ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(6):369.e9-369.e17]

Cited: 1 time

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Upper Urinary Tract Tumors: Variant Histology Versus Urothelial Carcinoma.

Marina Deuker, L Franziska Stolzenbach, Claudia Collà Ruvolo, Luigi Nocera, Zhe Tian, Frederik C Roos, Andreas Becker, Luis A Kluth, Derya Tilki, Shahrokh F Shariat, Fred Saad, Felix K H Chun, Pierre I Karakiewicz,

<h4>Purpose</h4>To evaluate stage at presentation and cancer-specific mortality (CSM) in upper urinary tract tumors according to histologic subtype.<h4>Methods</h4>Within the Surveillance, Epidemiology, and End Results registry (SEER, 2004-2016), we identified patients with upper urinary tract tumors with pure variant histology (UTVH) and pure upper urinary tract urothelial carcinoma (UTUC). Cumulative incidence ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, 19(2):117-124]

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Is Standardization Transferable? Initial Experience of Urethral Surgery at the University Hospital Frankfurt.

Mike Wenzel, Marieke J Krimphove, Benedikt Lauer, Benedikt Hoeh, Matthias J Müller, Philipp Mandel, Andreas Becker, Malte W Vetterlein, Stefan C Mueller, Roland Dahlem, Margit Fisch, Felix K-H Chun, Luis A Kluth,

<b>Background:</b> Since January 2018 performance of urethroplasties is done on regular basis at the University Hospital Frankfurt (UKF). We aimed to implement and transfer an institutional standardized perioperative algorithm for urethral surgery (established at the University Hospital Hamburg-Eppendorf-UKE) using a validated Urethral Stricture Surgery Patient-Reported Outcome Measure (USS-PROM) in patients ... Read more >>

Front Surg (Frontiers in surgery)
[2020, 7:600090]

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