Full Text Journal Articles by
Author Lui Forni

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The Evolution of Toolkits and Bundles to Improve the Care of Sepsis Patients.

Greg S Martin, Sandra L Kane-Gill, Vinay Nadkarni, Lauren R Sorce, Lewis J Kaplan, Maurizio Cecconi, Elie Azoulay, Jean-Louis Teboul, Lui Forni, Jozef Kesecioglu,

Crit Care Med (Critical care medicine)
[2021, 49(11):1849-1850]

Cited: 0 times

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Limiting Acute Kidney Injury Progression In Sepsis: Study Protocol and Trial Simulation.

Luca Molinari, Fabienne Heskia, Sadudee Peerapornratana, Claudio Ronco, Louis Guzzi, Seth Toback, Robert Birch, Hadi Beyhaghi, Thomas Kwan, J Patrick Kampf, Donald M Yealy, John A Kellum, ,

<h4>Objectives</h4>To describe study design considerations and to simulate a trial of biomarker-guided sepsis management aimed to reduce acute kidney injury (acute kidney injury). Tissue inhibitor of metalloproteinases-2 and insulin-like growth factor-binding protein 7, urinary biomarkers of cell-cycle arrest, and indicators of kidney stress can detect acute kidney injury before clinical ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(10):1706-1716]

Cited: 0 times

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Management of acute kidney injury associated with Covid-19: what have we learned?

Daniel Cottam, Mitra K Nadim, Lui G Forni,

<h4>Purpose of review</h4>Although initially kidney involvement in COVID-19 infection was felt to occur relatively infrequently, this has proved not to be the case. In critically ill patients with COVID-19, multiorgan failure including acute kidney injury (AKI) is common and is associated with an increased risk of mortality and morbidity. This ... Read more >>

Curr Opin Nephrol Hypertens (Current opinion in nephrology and hypertension)
[2021, 30(6):563-570]

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Nutrients and micronutrients at risk during renal replacement therapy: a scoping review.

Mette M Berger, Marcus Broman, Lui Forni, Marlies Ostermann, Elisabeth De Waele, Paul E Wischmeyer,

<h4>Purpose of review</h4>Malnutrition is frequent in patients with acute kidney injury. Nutrient clearance during renal replacement therapy (RRT) potentially contributes to this complication. Although losses of amino acid, trace elements and vitamins have been described, there is no clear guidance regarding the role of micronutrient supplementation.<h4>Recent findings</h4>A scoping review was ... Read more >>

Curr Opin Crit Care (Current opinion in critical care)
[2021, 27(4):367-377]

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Prevention of Cardiac Surgery-Associated Acute Kidney Injury by Implementing the KDIGO Guidelines in High-Risk Patients Identified by Biomarkers: The PrevAKI-Multicenter Randomized Controlled Trial.

Alexander Zarbock, Mira Küllmar, Marlies Ostermann, Gianluca Lucchese, Kamran Baig, Armando Cennamo, Ronak Rajani, Stuart McCorkell, Christian Arndt, Hinnerk Wulf, Marc Irqsusi, Fabrizio Monaco, Ambra Licia Di Prima, Mercedes García Alvarez, Stefano Italiano, Jordi Miralles Bagan, Gudrun Kunst, Shrijit Nair, Camilla L'Acqua, Eric Hoste, Wim Vandenberghe, Patrick M Honore, John A Kellum, Lui G Forni, Philippe Grieshaber, Christina Massoth, Raphael Weiss, Joachim Gerss, Carola Wempe, Melanie Meersch,

<h4>Background</h4>Prospective, single-center trials have shown that the implementation of the Kidney Disease: Improving Global Outcomes (KDIGO) recommendations in high-risk patients significantly reduced the development of acute kidney injury (AKI) after surgery. We sought to evaluate the feasibility of implementing a bundle of supportive measures based on the KDIGO guideline in ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 133(2):292-302]

Cited: 2 times

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RAND appropriateness panel to determine the applicability of UK guidelines on the management of acute respiratory distress syndrome (ARDS) and other strategies in the context of the COVID-19 pandemic.

Mark Griffiths, Susanna Meade, Charlotte Summers, Daniel Francis McAuley, Alastair Proudfoot, Marta Montero Baladia, Paul M Dark, Kate Diomede, Simon J Finney, Lui G Forni, Chris Meadows, Ian A Naldrett, Brijesh Patel, Gavin D Perkins, Mark A Samaan, Laurence Sharifi, Ganesh Suntharalingam, Nicholas T Tarmey, Harriet F Young, Matt P Wise, Peter M Irving,

<h4>Background</h4>COVID-19 has become the most common cause of acute respiratory distress syndrome (ARDS) worldwide. Features of the pathophysiology and clinical presentation partially distinguish it from 'classical' ARDS. A Research and Development (RAND) analysis gauged the opinion of an expert panel about the management of ARDS with and without COVID-19 as ... Read more >>

Thorax (Thorax)
[2021, :]

Cited: 0 times

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Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative.

John R Prowle, Lui G Forni, Max Bell, Michelle S Chew, Mark Edwards, Morgan E Grams, Michael P W Grocott, Kathleen D Liu, David McIlroy, Patrick T Murray, Marlies Ostermann, Alexander Zarbock, Sean M Bagshaw, Raquel Bartz, Samira Bell, Azra Bihorac, Tong J Gan, Charles E Hobson, Michael Joannidis, Jay L Koyner, Denny Z H Levett, Ravindra L Mehta, Timothy E Miller, Michael G Mythen, Mitra K Nadim, Rupert M Pearse, Thomas Rimmele, Claudio Ronco, Andrew D Shaw, John A Kellum,

Postoperative acute kidney injury (PO-AKI) is a common complication of major surgery that is strongly associated with short-term surgical complications and long-term adverse outcomes, including increased risk of chronic kidney disease, cardiovascular events and death. Risk factors for PO-AKI include older age and comorbid diseases such as chronic kidney disease ... Read more >>

Nat Rev Nephrol (Nature reviews. Nephrology)
[2021, 17(9):605-618]

Cited: 0 times

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Comparison of C-C motif chemokine ligand 14 with other biomarkers for adverse kidney events after cardiac surgery.

Christina Massoth, Mira Küllmar, Dominic Enders, John A Kellum, Lui G Forni, Melanie Meersch, Alexander Zarbock, ,

<h4>Objective</h4>Outcomes after acute kidney injury are affected by both the severity and the duration of the insult. Patients with persistent acute kidney injury have higher major adverse kidney events, including 90-day mortality, renal replacement therapy, and persistent kidney dysfunction. Methods to identify these patients are urgently needed to improve outcomes. ... Read more >>

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2021, :]

Cited: 1 time

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Perioperative acute kidney injury following major abdominal surgery.

Ashley Tomlinson, Laetitia Bullman, Rishabh Singh, Lui G Forni,

Major abdominal surgery is associated with significant morbidity, not least the development of acute kidney injury. As a common perioperative complication, acute kidney injury is associated with increased length of stay, increased risk of perioperative infection and the potential development of chronic kidney disease. Moreover, the development of acute kidney ... Read more >>

Br J Hosp Med (Lond) (British journal of hospital medicine (London, England : 2005))
[2021, 82(3):1-9]

Cited: 0 times

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Clinical decision-making in older adults following emergency admission to hospital. Derivation and validation of a risk stratification score: OPERA.

Khushal Arjan, Lui G Forni, Richard M Venn, David Hunt, Luke Eliot Hodgson,

<h4>Objectives of the study</h4>Demographic changes alongside medical advances have resulted in older adults accounting for an increasing proportion of emergency hospital admissions. Current measures of illness severity, limited to physiological parameters, have shortcomings in this cohort, partly due to patient complexity. This study aimed to derive and validate a risk ... Read more >>

PLoS One (PloS one)
[2021, 16(3):e0248477]

Cited: 0 times

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Renin and Survival in Patients Given Angiotensin II for Catecholamine-Resistant Vasodilatory Shock. A Clinical Trial.

Rinaldo Bellomo, Lui G Forni, Laurence W Busse, Michael T McCurdy, Kealy R Ham, David W Boldt, Johanna Hästbacka, Ashish K Khanna, Timothy E Albertson, James Tumlin, Kristine Storey, Damian Handisides, George F Tidmarsh, Lakhmir S Chawla, Marlies Ostermann,

<b>Rationale:</b> Exogenous angiotensin II increases mean arterial pressure in patients with catecholamine-resistant vasodilatory shock (CRVS). We hypothesized that renin concentrations may identify patients most likely to benefit from such therapy.<b>Objectives:</b> To test the kinetic changes in renin concentrations and their prognostic value in patients with CRVS.<b>Methods:</b> We analyzed serum samples ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(9):1253-1261]

Cited: 13 times

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Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup.

Mitra K Nadim, Lui G Forni, Ravindra L Mehta, Michael J Connor, Kathleen D Liu, Marlies Ostermann, Thomas Rimmelé, Alexander Zarbock, Samira Bell, Azra Bihorac, Vincenzo Cantaluppi, Eric Hoste, Faeq Husain-Syed, Michael J Germain, Stuart L Goldstein, Shruti Gupta, Michael Joannidis, Kianoush Kashani, Jay L Koyner, Matthieu Legrand, Nuttha Lumlertgul, Sumit Mohan, Neesh Pannu, Zhiyong Peng, Xose L Perez-Fernandez, Peter Pickkers, John Prowle, Thiago Reis, Nattachai Srisawat, Ashita Tolwani, Anitha Vijayan, Gianluca Villa, Li Yang, Claudio Ronco, John A Kellum,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Rev Nephrol (Nature reviews. Nephrology)
[2020, 16(12):765]

Cited: 5 times

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COVID-19 infection and the kidney.

Lucas Alvarez-Belon, Alexander Sarnowski, Lui G Forni,

Despite initial reports, renal involvement, including acute kidney injury, has emerged as a serious complication of COVID-19 disease, particularly in critically ill patients. The reported prevalence varies considerably, which may reflect reporting practices, although differences in pre-existing comorbidities and socioeconomic factors, and differences between ethnic groups, almost certainly contribute. Renal ... Read more >>

Br J Hosp Med (Lond) (British journal of hospital medicine (London, England : 2005))
[2020, 81(10):1-8]

Cited: 0 times

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COVID-19 recognition and digital risk stratification.

Luke E Hodgson, Todd Leckie, Alexander Hunter, Nicolaas Prinsloo, Richard Venn, Lui Forni,

In the acute hospital setting the COVID-19 pandemic presents some unique challenges to acute patient care. These include accurate recognition of cases, confirmation of both testing requests and results, establishing patient acuity and alerting to deterioration. We report our experience introducing a digital COVID-19 assessment tool with an associated live ... Read more >>

Future Healthc J (Future healthcare journal)
[2020, 7(3):e47-e49]

Cited: 0 times

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Quality of Care for Acute Kidney Disease: Current Knowledge Gaps and Future Directions.

Kathleen D Liu, Lui G Forni, Michael Heung, Vin-Cent Wu, John A Kellum, Ravindra L Mehta, Claudio Ronco, Kianoush Kashani, Mitchell H Rosner, Michael Haase, Jay L Koyner, ,

Acute kidney injury (AKI) and acute kidney disease (AKD) are common complications in hospitalized patients and are associated with adverse outcomes. Although consensus guidelines have improved the care of patients with AKI and AKD, guidance regarding quality metrics in the care of patients after an episode of AKI or AKD ... Read more >>

Kidney Int Rep (Kidney international reports)
[2020, 5(10):1634-1642]

Cited: 2 times

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Sepsis-associated acute kidney injury: is COVID-19 different?

John A Kellum, Mitra K Nadim, Lui G Forni,

Kidney Int (Kidney international)
[2020, 98(6):1370-1372]

Cited: 6 times

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Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference: A Consensus Statement.

Marlies Ostermann, Alexander Zarbock, Stuart Goldstein, Kianoush Kashani, Etienne Macedo, Raghavan Murugan, Max Bell, Lui Forni, Louis Guzzi, Michael Joannidis, Sandra L Kane-Gill, Mathieu Legrand, Ravindra Mehta, Patrick T Murray, Peter Pickkers, Mario Plebani, John Prowle, Zaccaria Ricci, Thomas Rimmelé, Mitchell Rosner, Andrew D Shaw, John A Kellum, Claudio Ronco,

<h4>Importance</h4>In the last decade, new biomarkers for acute kidney injury (AKI) have been identified and studied in clinical trials. Guidance is needed regarding how best to incorporate them into clinical practice.<h4>Objective</h4>To develop recommendations on AKI biomarkers based on existing data and expert consensus for practicing clinicians and researchers.<h4>Evidence review</h4>At the ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(10):e2019209]

Cited: 15 times

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What every Intensivist should know about COVID-19 associated acute kidney injury.

Marlies Ostermann, Nuttha Lumlertgul, Lui G Forni, Eric Hoste,

Acute kidney injury (AKI) is a serious complication in critically ill patients with COVID-19 with a reported incidence ranging from <5% to >25%. Proposed aetiologies include hypovolemia, hemodynamic disturbance and inflammation but also specific factors like direct viral invasion, microvascular thrombosis, and altered regulation of the renin-angiotensin-aldosterone system. To date, ... Read more >>

J Crit Care (Journal of critical care)
[2020, 60:91-95]

Cited: 6 times

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Health-related quality of life in survivors of septic shock: 6-month follow-up from the ADRENAL trial.

Naomi E Hammond, Simon R Finfer, Qiang Li, Colman Taylor, Jeremy Cohen, Yaseen Arabi, Rinaldo Bellomo, Laurent Billot, Meg Harward, Christopher Joyce, Colin McArthur, John Myburgh, Anders Perner, Dorrilyn Rajbhandari, Andrew Rhodes, Kelly Thompson, Steve Webb, Balasubramanian Venkatesh, ,

<h4>Purpose</h4>To investigate the impact of hydrocortisone treatment and illness severity on health-related quality of life (HRQoL) at 6 months in septic shock survivors from the ADRENAL trial.<h4>Methods</h4>Using the EuroQol questionnaire (EQ-5D-5L) at 6 months after randomization we assessed HRQoL in patient subgroups defined by hydrocortisone or placebo treatment, gender, illness severity (APACHE II < or ≥ 25), ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(9):1696-1706]

Cited: 2 times

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Recommendations for core critical care ultrasound competencies as a part of specialist training in multidisciplinary intensive care: a framework proposed by the European Society of Intensive Care Medicine (ESICM).

Adrian Wong, Laura Galarza, Lui Forni, Daniel De Backer, Michael Slama, Bernard Cholley, Paul Mayo, Anthony McLean, Antoine Vieillard-Baron, Daniel Lichtenstein, Giovanni Volpicelli, Robert Arntfield, Ignacio Martin-Loeches, Gizella Melania Istrate, František Duška, ,

Critical care ultrasound (CCUS) is an essential component of intensive care practice. Although existing international guidelines have focused on training principles and determining competency in CCUS, few countries have managed to operationalize this guidance into an accessible, well-structured programme for clinicians training in multidisciplinary intensive care. We seek to update ... Read more >>

Crit Care (Critical care (London, England))
[2020, 24(1):393]

Cited: 0 times

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Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury.

, , , , , , Sean M Bagshaw, Ron Wald, Neill K J Adhikari, Rinaldo Bellomo, Bruno R da Costa, Didier Dreyfuss, Bin Du, Martin P Gallagher, Stéphane Gaudry, Eric A Hoste, François Lamontagne, Michael Joannidis, Giovanni Landoni, Kathleen D Liu, Daniel F McAuley, Shay P McGuinness, Javier A Neyra, Alistair D Nichol, Marlies Ostermann, Paul M Palevsky, Ville Pettilä, Jean-Pierre Quenot, Haibo Qiu, Bram Rochwerg, Antoine G Schneider, Orla M Smith, Fernando Thomé, Kevin E Thorpe, Suvi Vaara, Matthew Weir, Amanda Y Wang, Paul Young, Alexander Zarbock,

<h4>Background</h4>Acute kidney injury is common in critically ill patients, many of whom receive renal-replacement therapy. However, the most effective timing for the initiation of such therapy remains uncertain.<h4>Methods</h4>We conducted a multinational, randomized, controlled trial involving critically ill patients with severe acute kidney injury. Patients were randomly assigned to receive an ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(3):240-251]

Cited: 40 times

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Covid-19 and acute kidney injury in hospital: summary of NICE guidelines.

Nicholas M Selby, Lui G Forni, Christopher M Laing, Kerry L Horne, Rhys Dr Evans, Bethany J Lucas, Richard J Fluck,

BMJ (BMJ (Clinical research ed.))
[2020, 369:m1963]

Cited: 15 times

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Fluid Response Evaluation in Sepsis Hypotension and Shock: A Randomized Clinical Trial.

Ivor S Douglas, Philip M Alapat, Keith A Corl, Matthew C Exline, Lui G Forni, Andre L Holder, David A Kaufman, Akram Khan, Mitchell M Levy, Gregory S Martin, Jennifer A Sahatjian, Eric Seeley, Wesley H Self, Jeremy A Weingarten, Mark Williams, Douglas M Hansell,

<h4>Background</h4>Fluid and vasopressor management in septic shock remains controversial. In this randomized controlled trial, we evaluated the efficacy of dynamic measures (stroke volume change during passive leg raise) to guide resuscitation and improve patient outcome.<h4>Research question</h4>Will resuscitation that is guided by dynamic assessments of fluid responsiveness in patients with septic ... Read more >>

Chest (Chest)
[2020, 158(4):1431-1445]

Cited: 12 times

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A Multinational Observational Study Exploring Adherence With the Kidney Disease: Improving Global Outcomes Recommendations for Prevention of Acute Kidney Injury After Cardiac Surgery.

Mira Küllmar, Raphael Weiß, Marlies Ostermann, Sara Campos, Neus Grau Novellas, Gary Thomson, Michael Haffner, Christian Arndt, Hinnerk Wulf, Marc Irqsusi, Fabrizio Monaco, Ambra Licia Di Prima, Mercedes García-Alvarez, Stefano Italiano, Mar Felipe Correoso, Gudrun Kunst, Shrijit Nair, Camilla L'Acqua, Eric Hoste, Wim Vandenberghe, Patrick M Honore, John A Kellum, Lui Forni, Philippe Grieshaber, Carola Wempe, Melanie Meersch, Alexander Zarbock,

BACKGROUND:The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend a bundle of different measures for patients at increased risk of acute kidney injury (AKI). Prospective, single-center, randomized controlled trials (RCTs) have shown that management in accordance with the KDIGO recommendations was associated with a significant reduction in the incidence of ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, 130(4):910-916]

Cited: 1 time

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Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.

Marlies Ostermann, Rinaldo Bellomo, Emmanuel A Burdmann, Kent Doi, Zoltan H Endre, Stuart L Goldstein, Sandra L Kane-Gill, Kathleen D Liu, John R Prowle, Andrew D Shaw, Nattachai Srisawat, Michael Cheung, Michel Jadoul, Wolfgang C Winkelmayer, John A Kellum, ,

In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the classification and management of acute kidney injury (AKI). The guideline was derived from evidence available through February 2011. Since then, new evidence has emerged that has important implications for clinical practice in diagnosing and managing AKI. In ... Read more >>

Kidney Int (Kidney international)
[2020, 98(2):294-309]

Cited: 21 times

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