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Author Lucy Vanes

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Neonatal white matter microstructure and emotional development during the pre-school years in children who were born very preterm.

Dana Kanel, Lucy Vanes, Diliana Pecheva, Laila Hadaya, Shona Falconer, Serena Counsell, David Edwards, Chiara Nosarti,

Children born very preterm (<33 weeks of gestation) are at a higher risk of developing socio-emotional difficulties compared to those born at term. In this longitudinal study, we tested the hypothesis that diffusion characteristics of white matter tracts implicated in socio-emotional processing assessed in the neonatal period are associated with ... Read more >>

eNeuro (eNeuro)
[2021, :]

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Preference uncertainty accounts for developmental effects on susceptibility to peer influence in adolescence.

Andrea M F Reiter, Michael Moutoussis, Lucy Vanes, Rogier Kievit, Edward T Bullmore, Ian M Goodyer, Peter Fonagy, Peter B Jones, , Raymond J Dolan,

Adolescents are prone to social influence from peers, with implications for development, both adaptive and maladaptive. Here, using a computer-based paradigm, we replicate a cross-sectional effect of more susceptibility to peer influence in a large dataset of adolescents 14 to 24 years old. Crucially, we extend this finding by adopting ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):3823]

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Associations Between Neonatal Brain Structure, the Home Environment, and Childhood Outcomes Following Very Preterm Birth.

Lucy D Vanes, Laila Hadaya, Dana Kanel, Shona Falconer, Gareth Ball, Dafnis Batalle, Serena J Counsell, A David Edwards, Chiara Nosarti,

<h4>Background</h4>Very preterm birth is associated with an increased risk of childhood psychopathology and cognitive deficits. However, the extent to which these developmental problems associated with preterm birth are amenable to environmental factors or determined by neurobiology at birth remains unclear.<h4>Methods</h4>We derived neonatal brain structural covariance networks using non-negative matrix factorization ... Read more >>

Biol Psychiatry Glob Open Sci (Biological psychiatry global open science)
[2021, 1(2):146-155]

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Harmonized Segmentation of Neonatal Brain MRI.

Irina Grigorescu, Lucy Vanes, Alena Uus, Dafnis Batalle, Lucilio Cordero-Grande, Chiara Nosarti, A David Edwards, Joseph V Hajnal, Marc Modat, Maria Deprez,

Deep learning based medical image segmentation has shown great potential in becoming a key part of the clinical analysis pipeline. However, many of these models rely on the assumption that the train and test data come from the same distribution. This means that such methods cannot guarantee high quality predictions ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2021, 15:662005]

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Transdiagnostic neuroimaging markers of psychiatric risk: A narrative review.

Lucy D Vanes, Raymond J Dolan,

Several decades of neuroimaging research in psychiatry have shed light on structural and functional neural abnormalities associated with individual psychiatric disorders. However, there is increasing evidence for substantial overlap in the patterns of neural dysfunction seen across disorders, suggesting that risk for psychiatric illness may be shared across diagnostic boundaries. ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2021, 30:102634]

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Cognitive control network connectivity differentially disrupted in treatment resistant schizophrenia.

Charlotte M Horne, Lucy D Vanes, Tess Verneuil, Elias Mouchlianitis, Timea Szentgyorgyi, Bruno Averbeck, Robert Leech, Rosalyn J Moran, Sukhwinder S Shergill,

Antipsychotic treatment resistance affects a third of people with schizophrenia and the underlying mechanism remains unclear. We used an fMRI emotion-yoked reward learning task, allied to prefrontal cortical glutamate levels, to explain the role of cognitive control in differentiating treatment-resistant from responsive patients. We investigated how reward learning is disrupted ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2021, 30:102631]

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Harmonised segmentation of neonatal brain MRI

Irina Grigorescu, Lucy Vanes, Alena Uus, Dafnis Batalle, Lucilio Cordero-Grande, Chiara Nosarti, David Edwards, Joseph Hajnal, Marc Modat, Maria Deprez,

<h4>ABSTRACT</h4> Deep learning based medical image segmentation has shown great potential in becoming a key part of the clinical analysis pipeline. However, many of these models rely on the assumption that the train and test data come from the same distribution. This means that such methods cannot guarantee high quality ... Read more >>

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Cognitive performance in early, treatment-resistant psychosis patients: Could cognitive control play a role in persistent symptoms?

Megan Thomas, Timea Szentgyorgyi, Lucy D Vanes, Elias Mouchlianitis, Erica F Barry, Krisna Patel, Katie Wong, Dan Joyce, Sukhwinder Shergill,

Approximately one third of psychosis patients fail to respond to conventional antipsychotic medication, which exerts its effect via striatal dopamine receptor antagonism. The present study aimed to investigate impaired cognitive control as a potential contributor to persistent positive symptoms in treatment resistant (TR) patients. 52 medicated First Episode Psychosis (FEP) ... Read more >>

Psychiatry Res (Psychiatry research)
[2021, 295:113607]

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Transdiagnostic neuroimaging markers of psychiatric risk: a narrative review

Lucy Vanes, Raymond Dolan,

<p>Several decades of neuroimaging research in psychiatry have shed light on structural and functional neural abnormalities associated with individual psychiatric disorders. However, there is increasing evidence for substantial overlap in the patterns of neural dysfunction seen across disorders, suggesting that risk for psychiatric illness may be shared across diagnostic boundaries. ... Read more >>

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Compulsivity is linked to reduced adolescent development of goal-directed control and frontostriatal functional connectivity.

Matilde M Vaghi, Michael Moutoussis, František Váša, Rogier A Kievit, Tobias U Hauser, Petra E Vértes, Nitzan Shahar, Rafael Romero-Garcia, Manfred G Kitzbichler, Edward T Bullmore, , Raymond J Dolan,

A characteristic of adaptive behavior is its goal-directed nature. An ability to act in a goal-directed manner is progressively refined during development, but this refinement can be impacted by the emergence of psychiatric disorders. Disorders of compulsivity have been framed computationally as a deficit in model-based control, and have been ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(41):25911-25922]

Cited: 3 times

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T164. NETWORK CONNECTIVITY SUPPORTING REWARD LEARNING DIFFERENTIALLY DISRUPTED IN TREATMENT RESISTANT SCHIZOPHRENIA

Charlotte Horne, Lucy Vanes, Timea Szentgyorgyi, Tess Verneuil, Elias Mouchlianitis, Robert Leech, Rosalyn Moran, Sukhi Shergill,

Abstract <h4>Background</h4> It is estimated that one third of patients with schizophrenia fail to adequately respond to antipsychotic medication, termed ‘treatment-resistance’. This occurs despite adequate blockade of D2 receptors in the brain. The parsimonious options are that treatment resistance could arise through a failure of cognitive control over the dopaminergic ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2020, 46(Suppl 1):S293-S294]

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White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood.

Lucy D Vanes, Michael Moutoussis, Gabriel Ziegler, Ian M Goodyer, Peter Fonagy, Peter B Jones, Edward T Bullmore, , Raymond J Dolan,

Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that continues to unfold throughout adolescence, is reported to be abnormal in several psychiatric disorders. Here, we ask whether psychiatric vulnerability is linked ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, 41(3):827-839]

Cited: 6 times

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Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia.

Lucy D Vanes, Elias Mouchlianitis, Krisna Patel, Erica Barry, Katie Wong, Megan Thomas, Timea Szentgyorgyi, Dan Joyce, Sukhwinder Shergill,

Psychotic illness is associated with cognitive control deficits and abnormal recruitment of neural circuits subserving cognitive control. It is unclear to what extent this dysfunction underlies the development and/or maintenance of positive and negative symptoms typically observed in schizophrenia. In this study we compared fMRI activation on a standard Stroop ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):14444]

Cited: 3 times

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Taste uncertainty explains developmental effects on susceptibility to peer influence in adolescence

Andrea M.F. Reiter, Michael Moutoussis, Lucy Vanes, Rogier Kievit, Edward Bullmore, Ian Goodyer, Peter Fonagy, Peter Jones, Raymond Dolan,

<p>Adolescence is a time of pronounced cognitive, neural, and social change. Adolescents are prone to social influence from peers, with implications for development, both adaptive and maladaptive. However, the underlying cognitive mechanisms of this influence, as well as their neuro-developmental correlates and real-life social consequences are poorly understood. Here, we ... Read more >>

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The neural mechanisms of social reward in early psychosis.

Anne-Kathrin J Fett, Elias Mouchlianitis, Paula M Gromann, Lucy Vanes, Sukhi S Shergill, Lydia Krabbendam,

In chronic psychosis, reduced trust is associated with a neural insensitivity to social reward and reduced theory of mind (ToM). Here we investigate whether these mechanisms could underlie emerging social impairments in early psychosis. Twenty-two participants with early psychosis and 25 controls (male, 13-19 years) participated in two interactive trust games ... Read more >>

Soc Cogn Affect Neurosci (Social cognitive and affective neuroscience)
[2019, 14(8):861-870]

Cited: 3 times

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S49. COGNITIVE CORRELATES OF ABNORMAL MYELINATION IN PSYCHOSIS

Lucy Vanes, Elias Mouchlianitis, Erica Barry, Krisna Patel, Katie Wong, Sukhi Shergill,

Abstract <h4>Background</h4> Psychotic illness has consistently been associated with deficits in cognitive function and reduced white matter integrity in the brain. However, the link between white matter disruptions and deficits in distinct cognitive domains remains poorly understood. <h4>Methods</h4> We assessed cognitive performance across a range of tasks (working memory, verbal ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2019, 45(Suppl 2):S325-S325]

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T81. DOES COGNITIVE CONTROL PERFORMANCE PREDICT TREATMENT RESPONSE IN PSYCHOSIS?

Timea Szentgyorgyi, Lucy Vanes, Elias Mouchlianitis, Krisna Patel, Katie Wong, Erica Barry, Dan Joyce, Tracy Collier, Sukhi Shergill,

Abstract <h4>Background</h4> Treatment resistant schizophrenia remains a salient issue in psychiatric practice with approximately 30% of patients not responding to conventional antipsychotic medication, which exerts its effect by targeting striatal dopaminergic neurons. This has led to the emergence of theories suggesting that mechanisms other than hyperdopaminergia could explain psychotic symptoms ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2019, 45(Suppl 2):S234-S235]

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5.1 The Neural Mechanisms of Social Reward in Early Psychosis

Anne-Kathrin Fett, Elias Mouchlianitis, Paula Gromann, Lucy Vanes, Sukhi Shergill, Lydia Krabbendam,

Abstract <h4>Background</h4> In chronic psychosis, the loss of trust towards others is associated with a neural insensitivity to social reward and reduced theory of mind (ToM). The aim of this study was to investigate whether these mechanisms are already present in early psychosis. <h4>Methods</h4> Twenty-two participants with early psychosis and ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2019, 45(Suppl 2):S93-S93]

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S74. HYPERACTIVATION OF LEFT MEDIAL FRONTAL AND CINGULATE GYRUS MEDIATES SOUND-INDUCED FLASH ILLUSION IN NON-AFFECTIVE PSYCHOSIS

Sunaina Soni, Rosalyn Moran, Lucy D Vanes, Elias Mouchlianitis, Rebekah L Wigton, Thomas P White, Ratna Sharma, Sukhi Shergill,

Abstract <h4>Background</h4> Humans are constantly confronted with streams of information from multiple sensory modalities for rapid processing in order to execute appropriate behaviours. Schizophrenia is characterized by a disintegration of common multimodal experiences and has been conceptualised as a disorder of connectivity and integration within the brain. In the current ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2019, 45(Suppl 2):S335-S335]

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Cognitive correlates of abnormal myelination in psychosis.

Lucy D Vanes, Elias Mouchlianitis, Erica Barry, Krisna Patel, Katie Wong, Sukhwinder S Shergill,

Psychotic illness has consistently been associated with deficits in cognitive function and reduced white matter integrity in the brain. However, the link between white matter disruptions and deficits in cognitive domains remains poorly understood. We assessed cognitive performance and white matter myelin water fraction (MWF) using multicomponent driven equilibrium single ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):5162]

Cited: 1 time

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O11.1. ASSOCIATION BETWEEN GLUTAMATE AND ACCELERATED BRAIN-AGEING IN TREATMENT-RESISTANT SCHIZOPHRENIA

Elias Mouchlianitis, James Cole, Lucy Vanes, Sukhi Shergill,

Abstract <h4>Background</h4> Previous studies have shown that glutamatergic dysfunction appears to be a stable neurobiological characteristic of antipsychotic treatment-resistance. At the same time, treatment-resistant patients show more pronounced neurostructural deficits when compared to treatment-responsive patients. However, this association between glutamate and neurostructural integrity has not been investigate before in patients ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2019, 45(Suppl 2):S193-S194]

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Mapping cortical surface features in treatment resistant schizophrenia with in vivo structural MRI.

Erica F Barry, Lucy D Vanes, Derek S Andrews, Krisna Patel, Charlotte M Horne, Elias Mouchlianitis, Peter J Hellyer, Sukhi S Shergill,

Decreases in cortical volume (CV), thickness (CT) and surface area (SA) have been reported in individuals with schizophrenia by in vivo MRI studies. However, there are few studies that examine these cortical measures as potential biomarkers of treatment resistance (TR) and treatment response (NTR) in schizophrenia. This study used structural ... Read more >>

Psychiatry Res (Psychiatry research)
[2019, 274:335-344]

Cited: 4 times

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S148. DIFFERENTIAL NEURAL REWARD MECHANISMS IN TREATMENT RESPONSIVE AND TREATMENT RESISTANT SCHIZOPHRENIA

Lucy Vanes, Elias Mouchlianitis, Tracy Collier, Bruno Averbeck, Sukhi Shergill,

Abstract <h4>Background</h4> The significant proportion of schizophrenia patients refractory to treatment targeting the dopamine system suggests that more than one mechanism may cause psychotic symptoms. Reinforcement learning tasks have frequently been employed in schizophrenia to assess dopaminergic functioning and reward processing, but studies have not directly compared groups of treatment-refractory ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2018, 44(Suppl 1):S383-S383]

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O6.8. GLUTAMATERGIC DYSFUCTION AND TREATMENT RESPONSE IN MINIMALLY TREATED AND CHRONIC SCHIZOPHRENIA PATIENTS

Elias Mouchlianitis, Lucy Vanes, Erica Barry, Krisna Patel, Katie Wong, Lilla Porfy, Sukhi Shergill,

Abstract <h4>Background</h4> Glutamatergic dysfunction as a result of NMDA receptor hypofunction has been implicated in antipsychotic treatment-resistant schizophrenia, however its nature in very early stages and chronic stages of the disease is still unknown. Data on glutamate and treatment response are currently limited in two separate studies, one in first-episode ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2018, 44(Suppl 1):S92-S93]

Cited: 0 times

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Differential neural reward mechanisms in treatment-responsive and treatment-resistant schizophrenia.

Lucy D Vanes, Elias Mouchlianitis, Tracy Collier, Bruno B Averbeck, Sukhi S Shergill,

<h4>Background</h4>The significant proportion of schizophrenia patients refractory to treatment, primarily directed at the dopamine system, suggests that multiple mechanisms may underlie psychotic symptoms. Reinforcement learning tasks have been employed in schizophrenia to assess dopaminergic functioning and reward processing, but these have not directly compared groups of treatment-refractory and non-refractory patients.<h4>Methods</h4>In ... Read more >>

Psychol Med (Psychological medicine)
[2018, 48(14):2418-2427]

Cited: 9 times

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