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Author Lucie Vettoretti

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COVID-19 patients display distinct SARS-CoV-2 specific T-cell responses according to disease severity.

Marie Kroemer, Laurie Spehner, Lucie Vettoretti, Adeline Bouard, Guillaume Eberst, Sebastien Pili Floury, Gilles Capellier, Quentin Lepiller, Emeline Orillard, Laura Mansi, Anne-Laure Clairet, Virginie Westeel, Samuel Limat, Maxime Dubois, Léa Malinowski, Louis Bohard, Christophe Borg, Catherine Chirouze, Kevin Bouiller,

Adaptive Immune responses generated by SARS-CoV-2 virus in convalescent patients according to disease severity remain poorly characterized. To this end, we designed a prospective study (NCT04365322) that included 60 COVID-19 convalescent patients (1-month post infection) in two cohorts respectively entitled mild illness and severe pneumonia. The monitoring of peripheral immune ... Read more >>

J. Infect. (The Journal of infection)
[2020, :4816]

Cited: 0 times

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Prone Positioning for Severe Acute Respiratory Distress Syndrome in COVID-19 Patients by a Dedicated Team: A Safe and Pragmatic Reallocation of Medical and Surgical Work Force in Response to the Outbreak.

Alexandre Doussot, Floriane Ciceron, Emilie Cerutti, Lucie Salomon du Mont, Laurent Thines, Gilles Capellier, Jean-Baptiste Pretalli, Philippe Evrard, Lucie Vettoretti, Patrick Garbuio, Anne-Sophie Brunel, Sebastien Pili-Floury, Zaher Lakkis,

OBJECTIVE:The aim of this study was to define whether rapidly reallocating health care workers not experienced with PP for performing PP in ICU is feasible and safe. SUMMARY BACKGROUND DATA:In the setting of severe acute respiratory distress syndrome (ARDS), the use of prone and supine positioning procedures (PP) has been ... Read more >>

Ann. Surg. (Annals of surgery)
[2020, :]

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Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study.

Mercedes Ibarz, Ariane Boumendil, Lenneke E M Haas, Marian Irazabal, Hans Flaatten, Dylan W de Lange, Alessandro Morandi, Finn H Andersen, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agwald Öhman, Bernardo Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, Andreas Valentin, Ximena Watson, Tilemachos Zaferidis, Bertrand Guidet, Antonio Artigas, ,

BACKGROUND:The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Sepsis incidence has risen in recent years and identification of outcomes is of considerable public importance. We aimed to determine ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2020, 10(1):56]

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Liberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome.

Loic Barrot, Pierre Asfar, Frederic Mauny, Hadrien Winiszewski, Florent Montini, Julio Badie, Jean-Pierre Quenot, Sebastien Pili-Floury, Belaid Bouhemad, Guillaume Louis, Bertrand Souweine, Olivier Collange, Julien Pottecher, Bruno Levy, Marc Puyraveau, Lucie Vettoretti, Jean-Michel Constantin, Gilles Capellier, ,

BACKGROUND:In patients with acute respiratory distress syndrome (ARDS), the National Heart, Lung, and Blood Institute ARDS Clinical Trials Network recommends a target partial pressure of arterial oxygen (Pao2) between 55 and 80 mm Hg. Prospective validation of this range in patients with ARDS is lacking. We hypothesized that targeting the ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2020, 382(11):999-1008]

Cited: 9 times

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The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study.

Bertrand Guidet, Dylan W de Lange, Ariane Boumendil, Susannah Leaver, Ximena Watson, Carol Boulanger, Wojciech Szczeklik, Antonio Artigas, Alessandro Morandi, Finn Andersen, Tilemachos Zafeiridis, Christian Jung, Rui Moreno, Sten Walther, Sandra Oeyen, Joerg C Schefold, Maurizio Cecconi, Brian Marsh, Michael Joannidis, Yuriy Nalapko, Muhammed Elhadi, Jesper Fjølner, Hans Flaatten, ,

PURPOSE:Premorbid conditions affect prognosis of acutely-ill aged patients. Several lines of evidence suggest geriatric syndromes need to be assessed but little is known on their relative effect on the 30-day survival after ICU admission. The primary aim of this study was to describe the prevalence of frailty, cognition decline and ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(1):57-69]

Cited: 3 times

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Clinical effectiveness of single dose of intravenous dexamethasone on the duration of ropivacaine axillary brachial plexus block: the randomized placebo-controlled ADEXA trial.

Jean-Christophe Clement, Guillaume Besch, Marc Puyraveau, Tommy Grelet, David Ferreira, Lucie Vettoretti, Sébastien Pili-Floury, Emmanuel Samain, Francis Berthier,

BACKGROUND AND OBJECTIVES:The effect of intravenous dexamethasone on the duration of axillary plexus block performed using ropivacaine is not described. The aim of this study is to assess the effect of intravenous dexamethasone on the duration of axillary plexus block analgesia after distal upper arm surgery. METHODS:In this prospective, randomized, ... Read more >>

Reg Anesth Pain Med (Regional anesthesia and pain medicine)
[2019, 44(3):]

Cited: 2 times

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Impact of intravenous exenatide infusion for perioperative blood glucose control on myocardial ischemia-reperfusion injuries after coronary artery bypass graft surgery: sub study of the phase II/III ExSTRESS randomized trial.

Guillaume Besch, Andrea Perrotti, Lucie Salomon du Mont, Marc Puyraveau, Xavier Ben-Said, Maude Baltres, Benoit Barrucand, Guillaume Flicoteaux, Lucie Vettoretti, Emmanuel Samain, Sidney Chocron, Sebastien Pili-Floury,

BACKGROUND:The aim of the study was to investigate whether intravenous (iv) infusion of exenatide, a synthetic GLP-1 receptor agonist, could provide a protective effect against myocardial ischemia-reperfusion injury after coronary artery bypass graft (CABG) surgery. METHODS:A sub study analysis of patients > 18 years admitted for elective CABG and included in the ... Read more >>

Cardiovasc Diabetol (Cardiovascular diabetology)
[2018, 17(1):140]

Cited: 3 times

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Early post-operative cognitive dysfunction after closed-loop versus manual target controlled-infusion of propofol and remifentanil in patients undergoing elective major non-cardiac surgery: Protocol of the randomized controlled single-blind POCD-ELA trial.

Guillaume Besch, Lucie Vettoretti, Melanie Claveau, Nathalie Boichut, Nicolas Mahr, Yannis Bouhake, Ngai Liu, Thierry Chazot, Emmanuel Samain, Sebastien Pili-Floury,

INTRODUCTION:Post-operative cognitive dysfunction (POCD) is frequent in patients older than 60 years undergoing major non-cardiac surgery, and increases both morbidity and mortality. Anesthetic drugs may exert neurotoxic effects and contribute to the genesis of POCD. The hypothesis of the POCD-ELA trial was that closed-loop target-controlled infusion of propofol and remifentanil ... Read more >>

Medicine (Baltimore) (Medicine)
[2018, 97(40):e12558]

Cited: 1 time

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Time to blood culture positivity: An independent predictor of infective endocarditis and mortality in patients with Staphylococcus aureus bacteraemia.

S Siméon, V Le Moing, S Tubiana, X Duval, D Fournier, J-P Lavigne, M-L Erpelding, C-A Gustave, S Desage, C Chirouze, F Vandenesch, P Tattevin, ,

OBJECTIVES:Time to blood culture positivity (TTP), a routinely available parameter in automated blood culture systems, may be a proxy for infectious burden in patients with bloodstream infections. We aimed to study the association between TTP and infective endocarditis (IE), or death, in patients with Staphylococcus aureus bacteraemia. METHODS:VIRSTA is a ... Read more >>

Clin. Microbiol. Infect. (Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases)
[2019, 25(4):481-488]

Cited: 1 time

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Correction to: Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit.

Bertrand Guidet, Hans Flaatten, Ariane Boumendil, Alessandro Morandi, Finn H Andersen, Antonio Artigas, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agwald Öhman, Bernardo Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, Andreas Valentin, Ximena Watson, Tilemachos Zafeiridis, Dylan W De Lange, ,

In the original publication Dr Patrick Meybohm of the Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Frankfurt University Hospital, Frankfurt, Germany was inadvertently omitted from the list of investigators. ... Read more >>

Intensive Care Med (Intensive care medicine)
[2018, 44(9):1598-1601]

Cited: 0 times

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Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit.

Bertrand Guidet, Hans Flaatten, Ariane Boumendil, Alessandro Morandi, Finn H Andersen, Antonio Artigas, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agwald Öhman, Bernardo Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, Andreas Valentin, Ximena Watson, Tilemachos Zafeiridis, Dylan W De Lange, ,

PURPOSE:To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU. METHODS:This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up. RESULTS:LST limitation was identified in 1356/5021 (27.2%) ... Read more >>

Intensive Care Med (Intensive care medicine)
[2018, 44(7):1027-1038]

Cited: 7 times

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Oral Streptococcal Endocarditis, Oral Hygiene Habits, and Recent Dental Procedures: A Case-Control Study.

Xavier Duval, Sarah Millot, Catherine Chirouze, Christine Selton-Suty, Vanessa Moby, Pierre Tattevin, Christophe Strady, Edouard Euvrard, Nelly Agrinier, Daniel Thomas, Bruno Hoen, François Alla, ,

Background.:We aimed to compare oral hygiene habits, orodental status, and dental procedures in patients with infective endocarditis (IE) according to whether the IE-causing microorganism originated in the oral cavity. Methods.:We conducted an assessor-blinded case-control study in 6 French tertiary-care hospitals. Oral hygiene habits were recorded using a self-administered questionnaire. Orodental ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2017, 64(12):1678-1685]

Cited: 10 times

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Factors associated with 12 week case-fatality in Staphylococcus aureus bacteraemia: a prospective cohort study.

P Braquet, F Alla, C Cornu, F Goehringer, L Piroth, C Chirouze, M Revest, C Lechiche, X Duval, V Le Moing, ,

Staphylococcus aureus bacteraemia (SAB) is a frequent and deadly disease. Given the lack of a randomized trial, optimal first-line antibiotic treatment is still debated. Our aim was to identify prognostic factors in SAB patients and to analyse the impact of first-line antibiotics. The VIRSTA prospective cohort study was conducted in ... Read more >>

Clin. Microbiol. Infect. (Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases)
[2016, 22(11):948.e1-948.e7]

Cited: 6 times

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Staphylococcus aureus infective endocarditis versus bacteremia strains: Subtle genetic differences at stake.

Coralie Bouchiat, Karen Moreau, Sébastien Devillard, Jean-Philippe Rasigade, Amandine Mosnier, Tom Geissmann, Michèle Bes, Anne Tristan, Gérard Lina, Frédéric Laurent, Lionel Piroth, Nejla Aissa, Xavier Duval, Vincent Le Moing, François Vandenesch, ,

Infective endocarditis (IE)((1)) is a severe condition complicating 10-25% of Staphylococcus aureus bacteremia. Although host-related IE risk factors have been identified, the involvement of bacterial features in IE complication is still unclear. We characterized strictly defined IE and bacteremia isolates and searched for discriminant features. S. aureus isolates causing community-acquired, ... Read more >>

Infect. Genet. Evol. (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2015, 36:524-530]

Cited: 17 times

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Staphylococcus aureus Bloodstream Infection and Endocarditis--A Prospective Cohort Study.

Vincent Le Moing, François Alla, Thanh Doco-Lecompte, François Delahaye, Lionel Piroth, Catherine Chirouze, Pierre Tattevin, Jean-Philippe Lavigne, Marie-Line Erpelding, Bruno Hoen, François Vandenesch, Xavier Duval, ,

To update the epidemiology of S. aureus bloodstream infection (SAB) in a high-income country and its link with infective endocarditis (IE).All consecutive adult patients with incident SAB (n = 2008) were prospectively enrolled between 2009 and 2011 in 8 university hospitals in France.SAB was nosocomial in 54%, non-nosocomial healthcare related ... Read more >>

PLoS ONE (PloS one)
[2015, 10(5):e0127385]

Cited: 31 times

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Age of transfused blood in critically ill adults.

Jacques Lacroix, Paul C Hébert, Dean A Fergusson, Alan Tinmouth, Deborah J Cook, John C Marshall, Lucy Clayton, Lauralyn McIntyre, Jeannie Callum, Alexis F Turgeon, Morris A Blajchman, Timothy S Walsh, Simon J Stanworth, Helen Campbell, Gilles Capellier, Pierre Tiberghien, Laurent Bardiaux, Leo van de Watering, Nardo J van der Meer, Elham Sabri, Dong Vo, , ,

BACKGROUND: Fresh red cells may improve outcomes in critically ill patients by enhancing oxygen delivery while minimizing the risks of toxic effects from cellular changes and the accumulation of bioactive materials in blood components during prolonged storage. METHODS: In this multicenter, randomized, blinded trial, we assigned critically ill adults to ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2015, 372(15):1410-1418]

Cited: 229 times

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Evaluation of the number of opportunities for hand hygiene in hospital: a new methodological approach.

Céline Slekovec, Véronique Denizot, Lucie Vettoretti, Anne Ponchon, Frédéric Mauny, Didier Hocquet, Xavier Bertrand, Daniel Talon,

OBJECTIVE: To assess the number of alcohol-based hand rubbing (ABHR) opportunities in different wards of a university hospital. MATERIALS AND METHODS: The amount of care procedures was measured in nine wards (4 medical wards, 4 surgical wards, 1 intensive care unit) over a two-year period. We converted the number of ... Read more >>

Int J Nurs Stud (International journal of nursing studies)
[2013, 50(3):413-418]

Cited: 1 time

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Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.

Lucie Vettoretti, Patrick Plésiat, Cédric Muller, Farid El Garch, Gilles Phan, Inna Attrée, Arnaud Ducruix, Catherine Llanes,

Retrospective analysis of 189 nonredundant strains of Pseudomonas aeruginosa sequentially recovered from the sputum samples of 46 cystic fibrosis (CF) patients over a 10-year period (1998 to 2007) revealed that 53 out of 189 (28%) samples were hypersusceptible to the beta-lactam antibiotic ticarcillin (MIC < or = 4 microg/ml) (phenotype ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2009, 53(5):1987-1997]

Cited: 51 times

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The human papillomavirus type 18 E6 oncoprotein induces Vascular Endothelial Growth Factor 121 (VEGF121) transcription from the promoter through a p53-independent mechanism.

Nicolas Clere, Laurent Bermont, Sylvie Fauconnet, Isabelle Lascombe, Maëlle Saunier, Lucie Vettoretti, Marie-Laure Plissonnier, Christiane Mougin,

Altered angiogenic response is associated with high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. Vascular Endothelial Growth Factor (VEGF) is one of the most potent inducers of angiogenesis and is up-regulated in carcinoma of the cervix. Infection by high-risk human papillomavirus and persistent expression of viral oncogene ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2007, 313(15):3239-3250]

Cited: 17 times

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