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Author Luciano Azevedo

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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial.

Fernando G Zampieri, Flávia R Machado, Rodrigo S Biondi, Flávio G R Freitas, Viviane C Veiga, Rodrigo C Figueiredo, Wilson J Lovato, Cristina P Amêndola, Murillo S C Assunção, Ary Serpa-Neto, Jorge L R Paranhos, José Andrade, Michele M G Godoy, Edson Romano, Felipe Dal Pizzol, Emerson B Silva, Miqueias M L Silva, Miriam C V Machado, Luiz Marcelo S Malbouisson, Airton L O Manoel, Marlus M Thompson, Lanese M Figueiredo, Rafael M Soares, Tamiris A Miranda, Lucas M de Lima, Eliana V Santucci, Thiago D Corrêa, Luciano C P Azevedo, John A Kellum, Lucas P Damiani, Nilton B Silva, Alexandre B Cavalcanti, ,

<h4>Importance</h4>Slower intravenous fluid infusion rates could reduce the formation of tissue edema and organ dysfunction in critically ill patients; however, there are no data to support different infusion rates during fluid challenges for important outcomes such as mortality.<h4>Objective</h4>To determine the effect of a slower infusion rate vs control infusion rate ... Read more >>

JAMA (JAMA)
[2021, 326(9):830-838]

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Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial.

Fernando G Zampieri, Flávia R Machado, Rodrigo S Biondi, Flávio G R Freitas, Viviane C Veiga, Rodrigo C Figueiredo, Wilson J Lovato, Cristina P Amêndola, Ary Serpa-Neto, Jorge L R Paranhos, Marco A V Guedes, Eraldo A Lúcio, Lúcio C Oliveira-Júnior, Thiago C Lisboa, Fábio H Lacerda, Israel S Maia, Cintia M C Grion, Murillo S C Assunção, Airton L O Manoel, João M Silva-Junior, Péricles Duarte, Rafael M Soares, Tamiris A Miranda, Lucas M de Lima, Rodrigo M Gurgel, Denise M Paisani, Thiago D Corrêa, Luciano C P Azevedo, John A Kellum, Lucas P Damiani, Nilton Brandão da Silva, Alexandre B Cavalcanti, ,

<h4>Importance</h4>Intravenous fluids are used for almost all intensive care unit (ICU) patients. Clinical and laboratory studies have questioned whether specific fluid types result in improved outcomes, including mortality and acute kidney injury.<h4>Objective</h4>To determine the effect of a balanced solution vs saline solution (0.9% sodium chloride) on 90-day survival in critically ... Read more >>

JAMA (JAMA)
[2021, :]

Cited: 0 times

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Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis.

, Manu Shankar-Hari, Claire L Vale, Peter J Godolphin, David Fisher, Julian P T Higgins, Francesca Spiga, Jelena Savovic, Jayne Tierney, Gabriel Baron, Julie S Benbenishty, Lindsay R Berry, Niklas Broman, Alexandre Biasi Cavalcanti, Roos Colman, Stefanie L De Buyser, Lennie P G Derde, Pere Domingo, Sharifah Faridah Omar, Ana Fernandez-Cruz, Thijs Feuth, Felipe Garcia, Rosario Garcia-Vicuna, Isidoro Gonzalez-Alvaro, Anthony C Gordon, Richard Haynes, Olivier Hermine, Peter W Horby, Nora K Horick, Kuldeep Kumar, Bart N Lambrecht, Martin J Landray, Lorna Leal, David J Lederer, Elizabeth Lorenzi, Xavier Mariette, Nicolas Merchante, Nor Arisah Misnan, Shalini V Mohan, Michael C Nivens, Jarmo Oksi, Jose A Perez-Molina, Reuven Pizov, Raphael Porcher, Simone Postma, Reena Rajasuriar, Athimalaipet V Ramanan, Philippe Ravaud, Pankti D Reid, Abraham Rutgers, Aranzazu Sancho-Lopez, Todd B Seto, Sumathi Sivapalasingam, Arvinder Singh Soin, Natalie Staplin, John H Stone, Garth W Strohbehn, Jonas Sunden-Cullberg, Julian Torre-Cisneros, Larry W Tsai, Hubert van Hoogstraten, Tom van Meerten, Viviane Cordeiro Veiga, Peter E Westerweel, Srinivas Murthy, Janet V Diaz, John C Marshall, Jonathan A C Sterne,

<h4>Importance</h4>Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm.<h4>Objective</h4>To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes.<h4>Data sources</h4>Trials were identified through systematic searches of electronic ... Read more >>

JAMA (JAMA)
[2021, 326(6):499-518]

Cited: 11 times

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TELE-critical Care verSus usual Care On ICU PErformance (TELESCOPE): protocol for a cluster-randomised clinical trial on adult general ICUs in Brazil.

Danilo Teixeira Noritomi, Otavio T Ranzani, Leonardo Jose Rolim Ferraz, Maura C Dos Santos, Eduardo Cordioli, Renata Albaladejo, Ary Serpa Neto, Thiago D Correa, Otávio Berwanger, Lubia Caus de Morais, Guilherme Schettino, Alexandre Biasi Cavalcanti, Regis Goulart Rosa, Rodrigo Santos Biondi, Jorge If Salluh, Luciano Cesar Pontes Azevedo, Adriano Jose Pereira, ,

<h4>Introduction</h4>Daily multidisciplinary rounds (DMRs) consist of systematic patient-centred discussions aiming to establish joint therapeutic goals for the next 24 hours of intensive care unit (ICU) care. The aim of the present study protocol is to evaluate whether an intervention consisting of guided DMRs, supported by a remote specialist and audit/feedback ... Read more >>

BMJ Open (BMJ open)
[2021, 11(6):e042302]

Cited: 0 times

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HIF-1α and Hypoxia Responsive Genes are Differentially Expressed in Leukocytes From Survivors and Non-Survivors Patients During Clinical Sepsis.

Bianca Lima Ferreira, Giuseppe Gianini Figueirêdo Leite, Milena Karina Colo Brunialti, Murillo Assuncao, Luciano Cesar Pontes Azevedo, Flávio Freitas, Reinaldo Salomao,

<h4>Abstract</h4>Hypoxia inducible factor 1 alpha (HIF-1α) is linked to the metabolic and immune alterations in septic patients. Stabilization of HIF-1α by hypoxia or inflammation promotes the expression of several genes related to glycolytic metabolism, angiogenesis, coagulation, cell proliferation, and apoptosis. Here, we analyzed public available blood transcriptome datasets from septic ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 56(1):80-91]

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Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study.

Tài Pham, Antonio Pesenti, Giacomo Bellani, Gordon Rubenfeld, Eddy Fan, Guillermo Bugedo, José Angel Lorente, Antero do Vale Fernandes, Frank Van Haren, Alejandro Bruhn, Fernando Rios, Andres Esteban, Luciano Gattinoni, Anders Larsson, Daniel F McAuley, Marco Ranieri, B Taylor Thompson, Hermann Wrigge, Laurent J Brochard, John G Laffey, ,

<h4>Background</h4>Current incidence and outcome of patients with acute hypoxaemic respiratory failure requiring mechanical ventilation in the intensive care unit (ICU) are unknown, especially for patients not meeting criteria for acute respiratory distress syndrome (ARDS).<h4>Methods</h4>An international, multicentre, prospective cohort study of patients presenting with hypoxaemia early in the course of mechanical ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 57(6):]

Cited: 6 times

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Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial.

Renato D Lopes, Pedro Gabriel Melo de Barros E Silva, Remo H M Furtado, Ariane Vieira Scarlatelli Macedo, Bruna Bronhara, Lucas Petri Damiani, Lilian Mazza Barbosa, Júlia de Aveiro Morata, Eduardo Ramacciotti, Priscilla de Aquino Martins, Aryadne Lyrio de Oliveira, Vinicius Santana Nunes, Luiz Eduardo Fonteles Ritt, Ana Thereza Rocha, Lucas Tramujas, Sueli V Santos, Dario Rafael Abregu Diaz, Lorena Souza Viana, Lívia Maria Garcia Melro, Mariana Silveira de Alcântara Chaud, Estêvão Lanna Figueiredo, Fernando Carvalho Neuenschwander, Marianna Deway Andrade Dracoulakis, Rodolfo Godinho Souza Dourado Lima, Vicente Cés de Souza Dantas, Anne Cristine Silva Fernandes, Otávio Celso Eluf Gebara, Mauro Esteves Hernandes, Diego Aparecido Rios Queiroz, Viviane C Veiga, Manoel Fernandes Canesin, Leonardo Meira de Faria, Gilson Soares Feitosa-Filho, Marcelo Basso Gazzana, Idelzuíta Leandro Liporace, Aline de Oliveira Twardowsky, Lilia Nigro Maia, Flávia Ribeiro Machado, Alexandre de Matos Soeiro, Germano Emílio Conceição-Souza, Luciana Armaganijan, Patrícia O Guimarães, Regis G Rosa, Luciano C P Azevedo, John H Alexander, Alvaro Avezum, Alexandre B Cavalcanti, Otavio Berwanger, ,

<h4>Background</h4>COVID-19 is associated with a prothrombotic state leading to adverse clinical outcomes. Whether therapeutic anticoagulation improves outcomes in patients hospitalised with COVID-19 is unknown. We aimed to compare the efficacy and safety of therapeutic versus prophylactic anticoagulation in this population.<h4>Methods</h4>We did a pragmatic, open-label (with blinded adjudication), multicentre, randomised, controlled ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10291):2253-2263]

Cited: 14 times

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Randomized clinical trial to evaluate a routine full anticoagulation Strategy in Patients with Coronavirus Infection (SARS-CoV2) admitted to hospital: Rationale and design of the ACTION (AntiCoagulaTlon cOroNavirus)-Coalition IV trial.

Renato D Lopes, Pedro Gabriel Melo de Barros E Silva, Remo H M Furtado, Ariane Vieira Scarlatelli Macedo, Eduardo Ramacciotti, Lucas Petri Damini, Bruna Bronhara, Alexandre B Cavalcanti, Regis G Rosa, Luciano C P Azevedo, Viviane C Veiga, Flávia R Machado, Luiz Eduardo Ritt, Priscilla de Aquino Martins, John H Alexander, Alvaro Avezum, Otavio Berwanger, ,

<h4>Background</h4>Observational studies have suggested a higher risk of thrombotic events in patients with coronavirus disease 2019 (COVID-19). Moreover, elevated D-dimer levels have been identified as an important prognostic marker in COVID-19 directly associated with disease severity and progression. Prophylactic anticoagulation for hospitalized COVID-19 patients might not be enough to prevent ... Read more >>

Am Heart J (American heart journal)
[2021, 238:1-11]

Cited: 4 times

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Resuscitation fluid practices in Brazilian intensive care units: a secondary analysis of Fluid-TRIPS.

Flavio Geraldo Rezende de Freitas, Naomi Hammond, Yang Li, Luciano Cesar Pontes de Azevedo, Alexandre Biasi Cavalcanti, Leandro Taniguchi, André Gobatto, André Miguel Japiassú, Antonio Tonete Bafi, Bruno Franco Mazza, Danilo Teixeira Noritomi, Felipe Dal-Pizzol, Fernando Bozza, Jorge Ibrahin Figueira Salluh, Glauco Adrieno Westphal, Márcio Soares, Murillo Santucci César de Assunção, Thiago Lisboa, Suzana Margarete Ajeje Lobo, Achilles Rohlfs Barbosa, Adriana Fonseca Ventura, Ailson Faria de Souza, Alexandre Francisco Silva, Alexandre Toledo, Aline Reis, Allan Cembranel, Alvaro Rea Neto, Ana Lúcia Gut, Ana Patricia Pierre Justo, Ana Paula Santos, André Campos D de Albuquerque, André Scazufka, Antonio Babo Rodrigues, Bruno Bonaccorsi Fernandino, Bruno Goncalves Silva, Bruno Sarno Vidal, Bruno Valle Pinheiro, Bruno Vilela Costa Pinto, Carlos Augusto Ramos Feijo, Carlos de Abreu Filho, Carlos Eduardo da Costa Nunes Bosso, Carlos Eduardo Nassif Moreira, Carlos Henrique Ferreira Ramos, Carmen Tavares, Cidamaiá Arantes, Cintia Grion, Ciro Leite Mendes, Claudio Kmohan, Claudio Piras, Cristine Pilati Pileggi Castro, Cyntia Lins, Daniel Beraldo, Daniel Fontes, Daniela Boni, Débora Castiglioni, Denise de Moraes Paisani, Durval Ferreira Fonseca Pedroso, Ederson Roberto Mattos, Edgar de Brito Sobrinho, Edgar M V Troncoso, Edison Moraes Rodrigues Filho, Eduardo Enrico Ferrari Nogueira, Eduardo Leme Ferreira, Eduardo Souza Pacheco, Euzebio Jodar, Evandro L A Ferreira, Fabiana Fernandes de Araujo, Fabiana Schuelter Trevisol, Fábio Ferreira Amorim, Fabio Poianas Giannini, Fabrício Primitivo Matos Santos, Fátima Buarque, Felipe Gallego Lima, Fernando Antonio Alvares da Costa, Fernando Cesar Dos Anjos Sad, Fernando G Aranha, Fernando Ganem, Flavio Callil, Francisco Flávio Costa Filho, Frederico Toledo Campo Dall Arto, Geovani Moreno, Gilberto Friedman, Giulliana Martines Moralez, Guilherme Abdalla da Silva, Guilherme Costa, Guilherme Silva Cavalcanti, Guilherme Silva Cavalcanti, Gustavo Navarro Betônico, Gustavo Navarro Betônico, Hélder Reis, Helia Beatriz N Araujo, Helio Anjos Hortiz Júnior, Helio Penna Guimaraes, Hugo Urbano, Israel Maia, Ivan Lopes Santiago Filho, Jamil Farhat Júnior, Janu Rangel Alvarez, Joel Tavares Passos, Jorge Eduardo da Rocha Paranhos, José Aurelio Marques, José Gonçalves Moreira Filho, Jose Neto Andrade, José Onofre de C Sobrinho, Jose Terceiro de Paiva Bezerra, Juliana Apolônio Alves, Juliana Ferreira, Jussara Gomes, Karina Midori Sato, Karine Gerent, Kathia Margarida Costa Teixeira, Katia Aparecida Pessoa Conde, Laércia Ferreira Martins, Lanese Figueirêdo, Leila Rezegue, Leonardo Tcherniacovsk, Leone Oliveira Ferraz, Liane Cavalcante, Ligia Rabelo, Lilian Miilher, Lisiane Garcia, Luana Tannous, Ludhmila Abrahão Hajjar, Luís Eduardo Miranda Paciência, Luiz Monteiro da Cruz Neto, Macia Valeria Bley, Marcelo Ferreira Sousa, Marcelo Lourencini Puga, Marcelo Luz Pereira Romano, Marciano Nobrega, Marcio Arbex, Márcio Leite Rodrigues, Márcio Osório Guerreiro, Marcone Rocha, Maria Angela Pangoni Alves, Maria Angela Pangoni Alves, Maria Doroti Rosa, Mariza D'Agostino Dias, Miquéias Martins, Mirella de Oliveira, Miriane Melo Silveira Moretti, Mirna Matsui, Octavio Messender, Orlando Luís de Andrade Santarém, Patricio Júnior Henrique da Silveira, Paula Frizera Vassallo, Paulo Antoniazzi, Paulo César Gottardo, Paulo Correia, Paulo Ferreira, Paulo Torres, Pedro Gabrile M de Barros E Silva, Rafael Foernges, Rafael Gomes, Rafael Moraes, Raimundo Nonato Filho, Renato Luis Borba, Renato V Gomes, Ricardo Cordioli, Ricardo Lima, Ricardo Pérez López, Ricardo Rath de Oliveira Gargioni, Richard Rosenblat, Roberta Machado de Souza, Roberto Almeida, Roberto Camargo Narciso, Roberto Marco, Roberto Waltrick, Rodrigo Biondi, Rodrigo Figueiredo, Rodrigo Santana Dutra, Roseane Batista, Rouge Felipe, Rubens Sergio da Silva Franco, Sandra Houly, Sara Socorro Faria, Sergio Felix Pinto, Sergio Luzzi, Sergio Sant'ana, Sergio Sonego Fernandes, Sérgio Yamada, Sérgio Zajac, Sidiner Mesquita Vaz, Silvia Aparecida Bezerra Bezerra, Tatiana Bueno Tardivo Farhat, Thiago Martins Santos, Tiago Smith, Ulysses V A Silva, Valnei Bento Damasceno, Vandack Nobre, Vicente Cés de Souza Dantas, Vivian Menezes Irineu, Viviane Bogado, Wagner Nedel, Walther Campos Filho, Weidson Dantas, William Viana, Wilson de Oliveira Filho, Wilson Martins Delgadinho, Simon Finfer, Flavia Ribeiro Machado,

<h4>Objective</h4>To describe fluid resuscitation practices in Brazilian intensive care units and to compare them with those of other countries participating in the Fluid-TRIPS.<h4>Methods</h4>This was a prospective, international, cross-sectional, observational study in a convenience sample of intensive care units in 27 countries (including Brazil) using the Fluid-TRIPS database compiled in 2014. ... Read more >>

Rev Bras Ter Intensiva (Revista Brasileira de terapia intensiva)
[2021, 33(2):206-218]

Cited: 0 times

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Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery.

Allison Tong, Amanda Baumgart, Nicole Evangelidis, Andrea K Viecelli, Simon A Carter, Luciano Cesar Azevedo, Tess Cooper, Andrew Bersten, Lilia Cervantes, Derek P Chew, Sally Crowe, Ivor S Douglas, Ella Flemyng, Julian H Elliott, Elyssa Hannan, Peter Horby, Martin Howell, Angela Ju, Jaehee Lee, Eduardo Lorca, Deena Lynch, Karine E Manera, John C Marshall, Andrea Matus Gonzalez, Anne McKenzie, Sangeeta Mehta, Mervyn Mer, Andrew Conway Morris, Dale M Needham, Saad Nseir, Pedro Povoa, Mark Reid, Yasser Sakr, Ning Shen, Alan R Smyth, A John Simpson, Tom Snelling, Giovanni F M Strippoli, Armando Teixeira-Pinto, Antoni Torres, Tari Turner, Steve Webb, Paula R Williamson, Laila Woc-Colburn, Junhua Zhang, Jonathan C Craig, ,

<h4>Objectives</h4>Respiratory failure, multiple organ failure, shortness of breath, recovery, and mortality have been identified as critically important core outcomes by more than 9300 patients, health professionals, and the public from 111 countries in the global coronavirus disease 2019 core outcome set initiative. The aim of this project was to establish ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):503-516]

Cited: 5 times

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Quality of life and long-term outcomes after hospitalization for COVID-19: Protocol for a prospective cohort study (Coalition VII).

Regis Goulart Rosa, Caroline Cabral Robinson, Viviane Cordeiro Veiga, Alexandre Biasi Cavalcanti, Luciano César Pontes de Azevedo, Flávia Ribeiro Machado, Otavio Berwanger, Álvaro Avezum, Renato Delascio Lopes, Thiago Costa Lisboa, Cassiano Teixeira, Fernando Godinho Zampieri, Bruno Martins Tomazini, Letícia Kawano-Dourado, Daniel Schneider, Denise de Souza, Rosa da Rosa Minho Dos Santos, Sabrina Souza da Silva, Geraldine Trott, Bruna Dos Passos Gimenes, Ana Paula de Souza, Bruna Machado Barroso, Lauren Sezerá Costa, Liége Gregoletto Brognoli, Melissa Pezzetti Pelliccioli, Nicole Dos Santos Studier, Raíne Fogliati de Carli Schardosim, Tainá Aparecida Haubert, Victoria Emanuele Lobo Pallaoro, Debora Mariani de Oliveira, Pedro Isaacsson Velho, Gregory Saraiva Medeiros, Marcelo Basso Gazzana, Alexandre Prehn Zavascki, Paulo Márcio Pitrez, Roselaine Pinheiro de Oliveira, Carisi Anne Polanczyk, Luiz Antônio Nasi, Luciano Serpa Hammes, Maicon Falavigna,

<h4>Introduction</h4>The long-term effects caused by COVID-19 are unknown. The present study aims to assess factors associated with health-related quality of life and long-term outcomes among survivors of hospitalization for COVID-19 in Brazil.<h4>Methods</h4>This is a multicenter prospective cohort study nested in five randomized clinical trials designed to assess the effects of ... Read more >>

Rev Bras Ter Intensiva (Revista Brasileira de terapia intensiva)
[2021, 33(1):31-37]

Cited: 0 times

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Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial.

Viviane C Veiga, João A G G Prats, Danielle L C Farias, Regis G Rosa, Leticia K Dourado, Fernando G Zampieri, Flávia R Machado, Renato D Lopes, Otavio Berwanger, Luciano C P Azevedo, Álvaro Avezum, Thiago C Lisboa, Salomón S O Rojas, Juliana C Coelho, Rodrigo T Leite, Júlio C Carvalho, Luis E C Andrade, Alex F Sandes, Maria C T Pintão, Claudio G Castro, Sueli V Santos, Thiago M L de Almeida, André N Costa, Otávio C E Gebara, Flávio G Rezende de Freitas, Eduardo S Pacheco, David J B Machado, Josiane Martin, Fábio G Conceição, Suellen R R Siqueira, Lucas P Damiani, Luciana M Ishihara, Daniel Schneider, Denise de Souza, Alexandre B Cavalcanti, Phillip Scheinberg, ,

<h4>Objective</h4>To determine whether tocilizumab improves clinical outcomes for patients with severe or critical coronavirus disease 2019 (covid-19).<h4>Design</h4>Randomised, open label trial.<h4>Setting</h4>Nine hospitals in Brazil, 8 May to 17 July 2020.<h4>Participants</h4>Adults with confirmed covid-19 who were receiving supplemental oxygen or mechanical ventilation and had abnormal levels of at least two serum biomarkers ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2021, 372:n84]

Cited: 86 times

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Brazilian guidelines for the management of brain-dead potential organ donors. The task force of the Associação de Medicina Intensiva Brasileira, Associação Brasileira de Transplantes de Órgãos, Brazilian Research in Critical Care Network, and the General Coordination of the National Transplant System.

Glauco Adrieno Westphal, Caroline Cabral Robinson, Alexandre Biasi Cavalcanti, Anderson Ricardo Roman Gonçalves, Cátia Moreira Guterres, Cassiano Teixeira, Cinara Stein, Cristiano Augusto Franke, Daiana Barbosa da Silva, Daniela Ferreira Salomão Pontes, Diego Silva Leite Nunes, Edson Abdala, Felipe Dal-Pizzol, Fernando Augusto Bozza, Flávia Ribeiro Machado, Joel de Andrade, Luciane Nascimento Cruz, Luciano César Pontes Azevedo, Miriam Cristine Vahl Machado, Regis Goulart Rosa, Roberto Ceratti Manfro, Rosana Reis Nothen, Suzana Margareth Lobo, Tatiana Helena Rech, Thiago Costa Lisboa, Verônica Colpani, Maicon Falavigna,

<h4>Objective</h4>To contribute to updating the recommendations for brain-dead potential organ donor management.<h4>Methods</h4>A group of 27 experts, including intensivists, transplant coordinators, transplant surgeons, and epidemiologists, answered questions related to the following topics were divided into mechanical ventilation, hemodynamics, endocrine-metabolic management, infection, body temperature, blood transfusion, and checklists use. The outcomes considered ... Read more >>

Rev Bras Ter Intensiva (Revista Brasileira de terapia intensiva)
[2021, 33(1):1-11]

Cited: 0 times

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International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019.

Nicole Evangelidis, Allison Tong, Martin Howell, Armando Teixeira-Pinto, Julian H Elliott, Luciano Cesar Azevedo, Andrew Bersten, Lilia Cervantes, Derek P Chew, Sally Crowe, Ivor S Douglas, Ella Flemyng, Peter Horby, Jaehee Lee, Eduardo Lorca, Deena Lynch, John C Marshall, Anne McKenzie, Sangeeta Mehta, Mervyn Mer, Andrew Conway Morris, Saad Nseir, Pedro Povoa, Mark Reid, Yasser Sakr, Ning Shen, Alan R Smyth, Tom Snelling, Giovanni F M Strippoli, Antoni Torres, Tari Turner, Steve Webb, Paula R Williamson, Laila Woc-Colburn, Junhua Zhang, Amanda Baumgart, Sebastian Cabrera, Yeoungjee Cho, Tess Cooper, Chandana Guha, Emma Liu, Andrea Matus Gonzalez, Charlie McLeod, Patrizia Natale, Valeria Saglimbene, Andrea K Viecelli, Jonathan C Craig, ,

<h4>Objectives</h4>There are over 4,000 trials conducted in people with coronavirus disease 2019. However, the variability of outcomes and the omission of patient-centered outcomes may diminish the impact of these trials on decision-making. The aim of this study was to generate a consensus-based, prioritized list of outcomes for coronavirus disease 2019 ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(11):1612-1621]

Cited: 3 times

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Core Outcomes Set for Trials in People With Coronavirus Disease 2019.

Allison Tong, Julian H Elliott, Luciano Cesar Azevedo, Amanda Baumgart, Andrew Bersten, Lilia Cervantes, Derek P Chew, Yeoungjee Cho, Tess Cooper, Sally Crowe, Ivor S Douglas, Nicole Evangelidis, Ella Flemyng, Elyssa Hannan, Peter Horby, Martin Howell, Jaehee Lee, Emma Liu, Eduardo Lorca, Deena Lynch, John C Marshall, Andrea Matus Gonzalez, Anne McKenzie, Karine E Manera, Charlie McLeod, Sangeeta Mehta, Mervyn Mer, Andrew Conway Morris, Saad Nseir, Pedro Povoa, Mark Reid, Yasser Sakr, Ning Shen, Alan R Smyth, Tom Snelling, Giovanni Fm Strippoli, Armando Teixeira-Pinto, Antoni Torres, Tari Turner, Andrea K Viecelli, Steve Webb, Paula R Williamson, Laila Woc-Colburn, Junhua Zhang, Jonathan C Craig, ,

<h4>Objectives</h4>The outcomes reported in trials in coronavirus disease 2019 are extremely heterogeneous and of uncertain patient relevance, limiting their applicability for clinical decision-making. The aim of this workshop was to establish a core outcomes set for trials in people with suspected or confirmed coronavirus disease 2019.<h4>Design</h4>Four international online multistakeholder consensus ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(11):1622-1635]

Cited: 9 times

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Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial.

Bruno M Tomazini, Israel S Maia, Alexandre B Cavalcanti, Otavio Berwanger, Regis G Rosa, Viviane C Veiga, Alvaro Avezum, Renato D Lopes, Flavia R Bueno, Maria Vitoria A O Silva, Franca P Baldassare, Eduardo L V Costa, Ricardo A B Moura, Michele O Honorato, Andre N Costa, Lucas P Damiani, Thiago Lisboa, Letícia Kawano-Dourado, Fernando G Zampieri, Guilherme B Olivato, Cassia Righy, Cristina P Amendola, Roberta M L Roepke, Daniela H M Freitas, Daniel N Forte, Flávio G R Freitas, Caio C F Fernandes, Livia M G Melro, Gedealvares F S Junior, Douglas Costa Morais, Stevin Zung, Flávia R Machado, Luciano C P Azevedo, ,

<h4>Importance</h4>Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) is associated with substantial mortality and use of health care resources. Dexamethasone use might attenuate lung injury in these patients.<h4>Objective</h4>To determine whether intravenous dexamethasone increases the number of ventilator-free days among patients with COVID-19-associated ARDS.<h4>Design, setting, and participants</h4>Multicenter, randomized, ... Read more >>

JAMA (JAMA)
[2020, 324(13):1307-1316]

Cited: 246 times

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Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis.

, Jonathan A C Sterne, Srinivas Murthy, Janet V Diaz, Arthur S Slutsky, Jesús Villar, Derek C Angus, Djillali Annane, Luciano Cesar Pontes Azevedo, Otavio Berwanger, Alexandre B Cavalcanti, Pierre-Francois Dequin, Bin Du, Jonathan Emberson, David Fisher, Bruno Giraudeau, Anthony C Gordon, Anders Granholm, Cameron Green, Richard Haynes, Nicholas Heming, Julian P T Higgins, Peter Horby, Peter Jüni, Martin J Landray, Amelie Le Gouge, Marie Leclerc, Wei Shen Lim, Flávia R Machado, Colin McArthur, Ferhat Meziani, Morten Hylander Møller, Anders Perner, Marie Warrer Petersen, Jelena Savovic, Bruno Tomazini, Viviane C Veiga, Steve Webb, John C Marshall,

<h4>Importance</h4>Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory support.<h4>Objective</h4>To estimate the association between administration of corticosteroids compared with usual care or placebo and 28-day all-cause mortality.<h4>Design, setting, and ... Read more >>

JAMA (JAMA)
[2020, 324(13):1330-1341]

Cited: 468 times

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Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial.

Remo H M Furtado, Otavio Berwanger, Henrique A Fonseca, Thiago D Corrêa, Leonardo R Ferraz, Maura G Lapa, Fernando G Zampieri, Viviane C Veiga, Luciano C P Azevedo, Regis G Rosa, Renato D Lopes, Alvaro Avezum, Airton L O Manoel, Felipe M T Piza, Priscilla A Martins, Thiago C Lisboa, Adriano J Pereira, Guilherme B Olivato, Vicente C S Dantas, Eveline P Milan, Otavio C E Gebara, Roberto B Amazonas, Monalisa B Oliveira, Ronaldo V P Soares, Diogo D F Moia, Luciana P A Piano, Kleber Castilho, Roberta G R A P Momesso, Guilherme P P Schettino, Luiz Vicente Rizzo, Ary Serpa Neto, Flávia R Machado, Alexandre B Cavalcanti, ,

<h4>Background</h4>The efficacy and safety of azithromycin in the treatment of COVID-19 remain uncertain. We assessed whether adding azithromycin to standard of care, which included hydroxychloroquine, would improve clinical outcomes of patients admitted to the hospital with severe COVID-19.<h4>Methods</h4>We did an open-label, randomised clinical trial at 57 centres in Brazil. We ... Read more >>

Lancet (Lancet (London, England))
[2020, 396(10256):959-967]

Cited: 87 times

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Corticosteroid therapy for critically ill patients with COVID-19: A structured summary of a study protocol for a prospective meta-analysis of randomized trials.

Jonathan A C Sterne, Janet Diaz, Jesús Villar, Srinivas Murthy, Arthur S Slutsky, Anders Perner, Peter Jüni, Derek C Angus, Djillali Annane, Luciano Cesar Pontes Azevedo, Bin Du, Pierre-Francois Dequin, Anthony C Gordon, Cameron Green, Julian P T Higgins, Peter Horby, Martin J Landray, Giuseppe Lapadula, Amelie Le Gouge, Marie Leclerc, Jelena Savović, Bruno Tomazini, Balasubramanian Venkatesh, Steve Webb, John C Marshall, ,

<h4>Objectives</h4>Primary objective: To estimate the effect of corticosteroids compared with usual care or placebo on mortality up to 28 days after randomization. Secondary objectives: To examine whether the effect of corticosteroids compared with usual care or placebo on mortality up to 28 days after randomization varies between subgroups related to ... Read more >>

Trials (Trials)
[2020, 21(1):734]

Cited: 12 times

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Association of Sepsis Diagnosis at Daytime and on Weekdays with Compliance with the 3-Hour Sepsis Treatment Bundles. A Multicenter Cohort Study.

Otavio T Ranzani, Mariana Barbosa Monteiro, Bruno Adler Maccagnan Pinheiro Besen, Luciano Cesar Pontes Azevedo,

<b>Rationale</b>: Compliance with sepsis bundles is associated with better outcomes, but information to support structural actions that might improve compliance is scarce. Few studies have evaluated bundle compliance in different time periods, with conflicting results.<b>Objectives</b>: To evaluate the association of sepsis identification during the daytime versus during the nighttime and ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2020, 17(8):980-987]

Cited: 1 time

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Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19.

Alexandre B Cavalcanti, Fernando G Zampieri, Regis G Rosa, Luciano C P Azevedo, Viviane C Veiga, Alvaro Avezum, Lucas P Damiani, Aline Marcadenti, Letícia Kawano-Dourado, Thiago Lisboa, Debora L M Junqueira, Pedro G M de Barros E Silva, Lucas Tramujas, Erlon O Abreu-Silva, Ligia N Laranjeira, Aline T Soares, Leandro S Echenique, Adriano J Pereira, Flávio G R Freitas, Otávio C E Gebara, Vicente C S Dantas, Remo H M Furtado, Eveline P Milan, Nicole A Golin, Fábio F Cardoso, Israel S Maia, Conrado R Hoffmann Filho, Adrian P M Kormann, Roberto B Amazonas, Monalisa F Bocchi de Oliveira, Ary Serpa-Neto, Maicon Falavigna, Renato D Lopes, Flávia R Machado, Otavio Berwanger, ,

<h4>Background</h4>Hydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However, evidence on the safety and efficacy of these therapies is limited.<h4>Methods</h4>We conducted a multicenter, randomized, open-label, three-group, controlled trial involving hospitalized patients with suspected or confirmed Covid-19 who were receiving either no supplemental oxygen or ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(21):2041-2052]

Cited: 343 times

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COVID-19-associated ARDS treated with DEXamethasone (CoDEX): study design and rationale for a randomized trial.

Bruno Martins Tomazini, Israel Silva Maia, Flavia Regina Bueno, Maria Vitoria Aparecida Oliveira Silva, Franca Pellison Baldassare, Eduardo Leite Vieira Costa, Ricardo Antonio Bonifácio Moura, Michele Ouriques Honorato, André Nathan Costa, Alexandre Biasi Cavalcanti, Regis Goulart Rosa, Álvaro Avezum, Viviane Cordeiro Veiga, Renato Delascio Lopes, Lucas Petri Damiani, Flávia Ribeiro Machado, Otavio Berwanger, Luciano César Pontes de Azevedo, ,

<h4>Objective</h4>The infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads worldwide and is considered a pandemic. The most common manifestation of SARS-CoV-2 infection (coronavirus disease 2019 - COVID-19) is viral pneumonia with varying degrees of respiratory compromise and up to 40% of hospitalized patients might develop acute ... Read more >>

Rev Bras Ter Intensiva (Revista Brasileira de terapia intensiva)
[2020, 32(3):354-362]

Cited: 8 times

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