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Implantable Cardioverter Defibrillator Multisensor Monitoring during Home Confinement Caused by the COVID-19 Pandemic.

Matteo Ziacchi, Leonardo Calò, Antonio D'Onofrio, Michele Manzo, Antonio Dello Russo, Luca Santini, Giovanna Giubilato, Cosimo Carriere, Vincenzo Ezio Santobuono, Gianluca Savarese, Carmelo La Greca, Giuseppe Arena, Antonello Talarico, Ennio Pisanò, Massimo Giammaria, Antonio Pangallo, Monica Campari, Sergio Valsecchi, Igor Diemberger,

<h4>Aims</h4>The utilization of remote monitoring platforms was recommended amidst the COVID-19 pandemic. The HeartLogic index combines multiple implantable cardioverter defibrillator (ICD) sensors and has proved to be a predictor of impending heart failure (HF) decompensation. We examined how multiple ICD sensors behave in the periods of anticipated restrictions pertaining to ... Read more >>

Biology (Basel) (Biology)
[2022, 11(1):]

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Incidence and Predictors of Infections and All-Cause Death in Patients with Cardiac Implantable Electronic Devices: The Italian Nationwide RI-AIAC Registry.

Giuseppe Boriani, Marco Proietti, Matteo Bertini, Igor Diemberger, Pietro Palmisano, Stefano Baccarini, Francesco Biscione, Nicola Bottoni, Antonio Ciccaglioni, Alessandro Dal Monte, Franco Alberto Ferrari, Saverio Iacopino, Marcello Piacenti, Daniele Porcelli, Stefano Sangiorgio, Luca Santini, Michele Malagù, Giuseppe Stabile, Jacopo Francesco Imberti, Davide Caruso, Massimo Zoni-Berisso, Roberto De Ponti, Renato Pietro Ricci, On Behalf Of Ri-Aiac Registry Investigators,

<h4>Background</h4>The incidence of infections associated with cardiac implantable electronic devices (CIEDs) and patient outcomes are not fully known.<h4>Aim</h4>To provide a contemporary assessment of the risk of CIEDs infection and associated clinical outcomes.<h4>Methods</h4>In Italy, 18 centres enrolled all consecutive patients undergoing a CIED procedure and entered a 12-months follow-up. CIED infections, ... Read more >>

J Pers Med (Journal of personalized medicine)
[2022, 12(1):]

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Incidence and Predictors of Infections and All-Cause Death in Patients with Cardiac Implantable Electronic Devices: The Italian Nationwide RI-AIAC Registry

Giuseppe Boriani, Marco Proietti, Matteo Bertini, Igor Diemberger, Pietro Palmisano, Stefano Baccarini, Francesco Biscione, Nicola Bottoni, Antonio Ciccaglioni, Alessandro Dal Monte, Franco Alberto Ferrari, Saverio Iacopino, Marcello Piacenti, Daniele Porcelli, Stefano Sangiorgio, Luca Santini, Michele Malagù, Giuseppe Stabile, Jacopo Francesco Imberti, Davide Caruso, Massimo Zoni-Berisso, Roberto De Ponti, Renato Pietro Ricci, on behalf of RI-AIAC Registry Investigators,

Background: The incidence of infections associated with cardiac implantable electronic devices (CIEDs) and patient outcomes are not fully known. Aim: To provide a contemporary assessment of the risk of CIEDs infection and associated clinical outcomes. Methods: In Italy, 18 centres enrolled all consecutive patients undergoing a CIED procedure and entered ... Read more >>

J Pers Med (Journal of personalized medicine)
[2022, 12(1):]

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Implantable Cardioverter Defibrillator Multisensor Monitoring during Home Confinement Caused by the COVID-19 Pandemic

Matteo Ziacchi, Leonardo Calò, Antonio D’Onofrio, Michele Manzo, Antonio Dello Russo, Luca Santini, Giovanna Giubilato, Cosimo Carriere, Vincenzo Ezio Santobuono, Gianluca Savarese, Carmelo La Greca, Giuseppe Arena, Antonello Talarico, Ennio Pisanò, Massimo Giammaria, Antonio Pangallo, Monica Campari, Sergio Valsecchi, Igor Diemberger,

<h4>Simple Summary</h4> During the COVID-19 pandemic, utilization of remote monitoring platforms was recommended. The HeartLogic algorithm identifies patients at risk of heart failure events, combining multiple sensors available on implantable cardioverter defibrillators. This analysis examined how multiple CIED sensors behave in periods of anticipated restrictions pertaining to physical activity. We ... Read more >>

Biology (Basel) (Biology)
[2022, 11(1):]

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Patient acceptance of subcutaneous versus transvenous defibrillator systems: A multi-center experience.

Alessandro Vicentini, Giovanni Bisignani, Stefano De Vivo, Stefano Viani, Gianluca Savarese, Pietro Francia, Eduardo Celentano, Luca Checchi, Giovanni Carreras, Luca Santini, Filippo Lamberti, Luca Ottaviano, Antonio Scalone, Davide Giorgi, Mariolina Lovecchio, Sergio Valsecchi, Roberto Rordorf, ,

<h4>Background</h4>The subcutaneous implantable cardioverter-defibrillator (S-ICD) is an effective alternative to the transvenous ICD. No study has yet compared S-ICD and transvenous ICD by assessing patient acceptance as a patient-centered outcome.<h4>Objective</h4>To evaluate the patient acceptance of the S-ICD and to investigate its association with clinical and implantation variables. In patients with ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2022, 33(1):81-89]

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Correction to: Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial.

Francesco Perrone, Maria Carmela Piccirillo, Paolo Antonio Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M Marrocco-Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, Maria Lorenza Muiesan, Miriam Lichtner, Carlo Calzetti, Nicola Duccio Salerno, Luigi Atripaldi, Marco Cascella, Massimo Costantini, Giovanni Dolci, Nicola Cosimo Facciolongo, Fiorentino Fraganza, Marco Massari, Vincenzo Montesarchio, Cristina Mussini, Emanuele Alberto Negri, Gerardo Botti, Claudia Cardone, Piera Gargiulo, Adriano Gravina, Clorinda Schettino, Laura Arenare, Paolo Chiodini, Ciro Gallo, ,

J Transl Med (Journal of translational medicine)
[2021, 19(1):442]

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Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives.

Carlo Lavalle, Sara Trivigno, Giampaolo Vetta, Michele Magnocavallo, Marco Valerio Mariani, Luca Santini, Giovanni Battista Forleo, Massimo Grimaldi, Roberto Badagliacca, Luigi Lanata, Renato Pietro Ricci,

Flecainide is an IC antiarrhythmic drug (AAD) that received in 1984 Food and Drug Administration approval for the treatment of sustained ventricular tachycardia (VT) and subsequently for rhythm control of atrial fibrillation (AF). Currently, flecainide is mainly employed for sinus rhythm maintenance in AF and the treatment of idiopathic ventricular ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(16):]

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Mammal assemblage composition predicts global patterns in emerging infectious disease risk.

Yingying X G Wang, Kevin D Matson, Luca Santini, Piero Visconti, Jelle P Hilbers, Mark A J Huijbregts, Yanjie Xu, Herbert H T Prins, Toph Allen, Zheng Y X Huang, Willem F de Boer,

As a source of emerging infectious diseases, wildlife assemblages (and related spatial patterns) must be quantitatively assessed to help identify high-risk locations. Previous assessments have largely focussed on the distributions of individual species; however, transmission dynamics are expected to depend on assemblage composition. Moreover, disease-diversity relationships have mainly been studied ... Read more >>

Glob Chang Biol (Global change biology)
[2021, 27(20):4995-5007]

Cited: 1 time

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Multiparametric Implantable Cardioverter-Defibrillator Algorithm for Heart Failure Risk Stratification and Management: An Analysis in Clinical Practice.

Leonardo Calò, Valter Bianchi, Donatella Ferraioli, Luca Santini, Antonio Dello Russo, Cosimo Carriere, Vincenzo Ezio Santobuono, Chiara Andreoli, Carmelo La Greca, Giuseppe Arena, Antonello Talarico, Ennio Pisanò, Amato Santoro, Massimo Giammaria, Matteo Ziacchi, Miguel Viscusi, Ermenegildo De Ruvo, Monica Campari, Sergio Valsecchi, Antonio D'Onofrio, ,

<h4>Background</h4>The HeartLogic algorithm combines multiple implantable cardioverter-defibrillator sensors to identify patients at risk of heart failure (HF) events. We sought to evaluate the risk stratification ability of this algorithm in clinical practice. We also analyzed the alert management strategies adopted in the study group and their association with the occurrence ... Read more >>

Circ Heart Fail (Circulation. Heart failure)
[2021, 14(10):e008134]

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Long-term complications in patients implanted with subcutaneous implantable cardioverter-defibrillators: Real-world data from the extended ELISIR experience.

Alessio Gasperetti, Marco Schiavone, Matteo Ziacchi, Julia Vogler, Alexander Breitenstein, Mikael Laredo, Pietro Palmisano, Danilo Ricciardi, Gianfranco Mitacchione, Paolo Compagnucci, Antonio Bisignani, Andrea Angeletti, Michela Casella, Francesco Picarelli, Thomas Fink, Lukas Kaiser, Samer Hakmi, Leonardò Calò, Carlo Pignalberi, Luca Santini, Carlo Lavalle, Ennio Pisanò, Iacopo Olivotto, Claudio Tondo, Antonio Curnis, Antonio Dello Russo, Nicolas Badenco, Jan Steffel, Charles J Love, Roland Tilz, Giovanni Forleo, Mauro Biffi,

<h4>Background</h4>Recently, the Food and Drug Administration issued a recall for the subcutaneous implantable cardioverter-defibrillator (S-ICD) because of the possibility of lead ruptures and accelerated battery depletion.<h4>Objective</h4>The aim of this study was to evaluate device-related complications over time in a large real-world multicenter S-ICD cohort.<h4>Methods</h4>Patients implanted with an S-ICD from January ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, 18(12):2050-2058]

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Subcutaneous implantable cardioverter-defibrillator and defibrillation testing: A propensity-matched pilot study.

Giovanni B Forleo, Alessio Gasperetti, Alexander Breitenstein, Mikael Laredo, Marco Schiavone, Matteo Ziacchi, Julia Vogler, Danilo Ricciardi, Pietro Palmisano, Agostino Piro, Paolo Compagnucci, Xavier Waintraub, Gianfranco Mitacchione, Gianmarco Carrassa, Giulia Russo, Silvana De Bonis, Andrea Angeletti, Antonio Bisignani, Francesco Picarelli, Michela Casella, Edoardo Bressi, Giovanni Rovaris, Leonardo Calò, Luca Santini, Carlo Pignalberi, Carlo Lavalle, Maurizio Viecca, Ennio Pisanò, Iacopo Olivotto, Antonio Curnis, Antonio Dello Russo, Claudio Tondo, Charles J Love, Luigi Di Biase, Jan Steffel, Roland Tilz, Nicolas Badenco, Mauro Biffi,

<h4>Background</h4>To date, only a few comparisons between subcutaneous implantable cardioverter-defibrillator (S-ICD) patients undergoing and those not undergoing defibrillation testing (DT) at implantation (DT+ vs DT-) have been reported.<h4>Objective</h4>The purpose of this study was to compare long-term clinical outcomes of 2 propensity-matched cohorts of DT+ and DT- patients.<h4>Methods</h4>Among consecutive S-ICD patients ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, 18(12):2072-2079]

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Random population fluctuations bias the Living Planet Index.

Falko T Buschke, James G Hagan, Luca Santini, Bernard W T Coetzee,

The Living Planet Index (LPI) is a standardized indicator for tracking population trends through time. Due to its ability to aggregate many time series in a single metric, the LPI has been proposed as an indicator for the Convention on Biological Diversity's post-2020 Global Biodiversity Strategy. However, here we show ... Read more >>

Nat Ecol Evol (Nature ecology & evolution)
[2021, 5(8):1145-1152]

Cited: 1 time

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Conditional love? Co-occurrence patterns of drought-sensitive species in European grasslands are consistent with the stress-gradient hypothesis.

Melinda M J de Jonge, Ana Benítez-López, Stephan Hennekens, Luca Santini, Mark A J Huijbregts, Aafke M Schipper,

<h4>Aim</h4>The stress-gradient hypothesis (SGH) postulates that species interactions shift from negative to positive with increasing abiotic stress. Interactions between species are increasingly being recognized as important drivers of species distributions, but it is still unclear whether stress-induced changes in interactions affect continental-to-global scale species distributions. Here, we tested whether associations ... Read more >>

Glob Ecol Biogeogr (Global ecology and biogeography : a journal of macroecology)
[2021, 30(8):1609-1620]

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[50 years of electrophysiology and cardiac pacing].

Massimo Santini, Luca Santini, Fabrizio Ammirati,

During the last 50 years a continuous improvement was observed in the field of cardiac pacing and electrophysiology as for as both technological and clinical aspects were concerned. We moved from the first recording of the His bundle electrogram to the identification of the various mechanisms and sites of supraventricular ... Read more >>

G Ital Cardiol (Rome) (Giornale italiano di cardiologia (2006))
[2021, 22(5):341-351]

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Rapid Anthropocene realignment of allometric scaling rules.

Luca Santini, Nick J B Isaac,

The negative relationship between body size and population density in mammals is often interpreted as resulting from energetic constraints. In a global change scenario, however, this relationship might be expected to change, given the size-dependent nature of anthropogenic pressures and vulnerability to extinction. Here we test whether the size-density relationship ... Read more >>

Ecol Lett (Ecology letters)
[2021, 24(7):1318-1327]

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The island rule explains consistent patterns of body size evolution in terrestrial vertebrates.

Ana Benítez-López, Luca Santini, Juan Gallego-Zamorano, Borja Milá, Patrick Walkden, Mark A J Huijbregts, Joseph A Tobias,

Island faunas can be characterized by gigantism in small animals and dwarfism in large animals, but the extent to which this so-called 'island rule' provides a general explanation for evolutionary trajectories on islands remains contentious. Here we use a phylogenetic meta-analysis to assess patterns and drivers of body size evolution ... Read more >>

Nat Ecol Evol (Nature ecology & evolution)
[2021, 5(6):768-786]

Cited: 2 times

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Flecainide How and When: A Practical Guide in Supraventricular Arrhythmias.

Carlo Lavalle, Michele Magnocavallo, Martina Straito, Luca Santini, Giovanni Battista Forleo, Massimo Grimaldi, Roberto Badagliacca, Luigi Lanata, Renato Pietro Ricci,

Transcatheter ablation was increasingly and successfully used to treat symptomatic drug refractory patients affected by supraventricular arrhythmias. Antiarrhythmic drug treatment still plays a major role in patient management, alone or combined with non-pharmacological therapies. Flecainide is an IC antiarrhythmic drug approved in 1984 from the Food and Drug Administration for ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(7):]

Cited: 2 times

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Effective nonapical left ventricular pacing with quadripolar leads for cardiac resynchronization therapy.

Giovanni B Forleo, Marco Schiavone, Domenico Della Rocca, Francesco Solimene, Vincenzo Schillaci, Gregorio Covino, Massimo Sassara, Gianluca Savarese, Stefano Donzelli, Sandra Badolati, Carmelo Gerosa, Carlo Lavalle, Alessio Gasperetti, Gianfranco Mitacchione, Mariolina Lovecchio, Sergio Valsecchi, Luca Santini,

<h4>Background</h4>Current guidelines recommend avoiding apical left ventricular (LV) pacing for cardiac resynchronization therapy (CRT).<h4>Aims</h4>We investigated the feasibility of nonapical pacing with the current quadripolar LV lead technology.<h4>Methods</h4>We analyzed consecutive patients who received CRT with an LV quadripolar lead. The post--implantation position of each electrode of the LV lead was designated ... Read more >>

Kardiol Pol (Kardiologia polska)
[2021, 79(4):442-448]

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The role of brain size on mammalian population densities.

Manuela González-Suárez, Alejandro Gonzalez-Voyer, Achaz von Hardenberg, Luca Santini,

The local abundance or population density of different organisms often varies widely. Understanding what determines this variation is an important, but not yet fully resolved question in ecology. Differences in population density are partly driven by variation in body size and diet among organisms. Here we propose that the size ... Read more >>

J Anim Ecol (The Journal of animal ecology)
[2021, 90(3):653-661]

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Clinical impact of defibrillation testing in a real-world S-ICD population: Data from the ELISIR registry.

Danilo Ricciardi, Matteo Ziacchi, Alessio Gasperetti, Marco Schiavone, Francesco Picarelli, Igor Diemberger, Luca Bontempi, Natale Di Belardino, Giovanni Bisignani, Silvia De Bonis, Gianfranco Mitacchione, Vito Calabrese, Carlo Lavalle, Agostino Piro, Carlo Pignalberi, Luca Santini, Francesco Grigioni, Claudio Tondo, Mauro Biffi, Giovanni Battista Forleo,

<h4>Background</h4>Current guidelines recommend defibrillation testing (DT) performance in patients with a subcutaneous implantable cardioverter defibrillator (S-ICD), theoretically to reduce the amount of ineffective shocks. DT, however, has been proven unnecessary in transvenous ICD and real-world data show a growing trend in avoidance of DT after S-ICD implantation.<h4>Methods</h4>All patients undergoing S-ICD ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(2):468-476]

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Blockage of interleukin-1β with canakinumab in patients with Covid-19.

Lorenza Landi, Claudia Ravaglia, Emanuele Russo, Pierluigi Cataleta, Maurizio Fusari, Andrea Boschi, Diana Giannarelli, Francesca Facondini, Ilaria Valentini, Ilaria Panzini, Luigi Lazzari-Agli, Paolo Bassi, Elisa Marchionni, Rossella Romagnoli, Raffaella De Giovanni, Marina Assirelli, Federica Baldazzi, Fabio Pieraccini, Giovanna Rametta, Lucia Rossi, Luca Santini, Ivana Valenti, Federico Cappuzzo,

There is the urgent need to study the effects of immunomodulating agents as therapy for Covid-19. An observational, cohort, prospective study with 30 days of observation was carried out to assess clinical outcomes in 88 patients hospitalized for Covid-19 pneumonia and treated with canakinumab (300 mg sc). Median time from diagnosis of ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):21775]

Cited: 17 times

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The "Embrace Project": facilitating the health care professionals in diagnosis, clinical reasoning and virtuous co-management of chronic patients before, during and after the COVID-19 pandemic in Italy.

Francesco Barbieri, Roberto Orsenigo, Luca Santini, Michele Fedeli, Gianni Bardelli, Vincenzo Formisano, Gaia S Panina, Pasquale Frega,

Diagnosis (Berl) (Diagnosis (Berlin, Germany))
[2020, 7(4):401-403]

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Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial.

Francesco Perrone, Maria Carmela Piccirillo, Paolo Antonio Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M Marrocco-Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, Maria Lorenza Muiesan, Miriam Lichtner, Carlo Calzetti, Nicola Duccio Salerno, Luigi Atripaldi, Marco Cascella, Massimo Costantini, Giovanni Dolci, Nicola Cosimo Facciolongo, Fiorentino Fraganza, Marco Massari, Vincenzo Montesarchio, Cristina Mussini, Emanuele Alberto Negri, Gerardo Botti, Claudia Cardone, Piera Gargiulo, Adriano Gravina, Clorinda Schettino, Laura Arenare, Paolo Chiodini, Ciro Gallo, ,

<h4>Background</h4>Tocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients.<h4>Methods</h4>A multicenter, single-arm, hypothesis-driven trial was planned, according to a phase 2 design, to study the effect of tocilizumab on lethality rates at 14 and 30 days (co-primary endpoints, a priori ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):405]

Cited: 38 times

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Rapid Anthropocene realignment of allometric scaling rules

Luca Santini, Nick J.B. Isaac,

The negative relationship between body size and population density (SDR) in mammals is often interpreted as resulting from energetic constraints. In a global change scenario, however, this relationship might be expected to change, given the size-dependent nature of anthropogenic pressures and vulnerability to extinction. Here we test whether the SDR ... Read more >>

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Combined effects of land use and hunting on distributions of tropical mammals

Juan Gallego‐Zamorano, Ana Benítez‐López, Luca Santini, Jelle P Hilbers, Mark A J Huijbregts, Aafke M Schipper,

Land use and hunting are 2 major pressures on biodiversity in the tropics. Yet, their combined impacts have not been systematically quantified at a large scale. We estimated the effects of both pressures on the distributions of 1884 tropical mammal species by integrating species’ range maps, detailed land‐use maps (1992 ... Read more >>

Conserv Biol (Conservation biology : the journal of the Society for Conservation Biology)
[2020, 34(5):1271-1280]

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