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Author Luca Afferi

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Oncologic Surveillance for Variant Histology Bladder Cancer after Radical Cystectomy.

Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G Schultz, Chiara Lonati, Agostino Mattei, R Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat, Marco Moschini,

<h4>Purpose</h4>Presently, major guidelines do not provide specific recommendations on oncologic surveillance for patients who harbor VH BCa at radical cystectomy. We aimed to create a personalized follow-up scheme that dynamically weighs OCM versus the risk of recurrence for VH BCa, and to compare it with a similar one for pUC.<h4>Methods</h4>Within ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001886]

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Single staff cystectomy in a low-volume center: Oncological outcomes and complications.

Philipp Baumeister, Davide Galioto, Marco Moschini, Chiara Lonati, Stefania Zamboni, Luca Afferi, Patrick Stucki, Hansjörg Danuser, Dirk Lehnick, Livio Mordasini, Agostino Mattei,

<h4>Introduction</h4>Radical cystectomy (RC) with bilateral pelvic lymph node dissection (PLND) is a complex surgical procedure, associated with substantial perioperative complications. Previous studies suggested reserving it to high-volume centers in order to improve oncological and perioperative outcomes. However, only limited data exist regarding low-volume centers with highly experienced surgeons. We aimed ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, :]

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Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy.

Chiara Lonati, Philipp Baumeister, Paola Irene Ornaghi, Ettore Di Trapani, Ottavio De Cobelli, Michael Rink, Robert Jeffrey Karnes, Cédric Poyet, Giuseppe Simone, Luca Afferi, Andrea Necchi, Alberto Briganti, Francesco Montorsi, Wojciech Krajewski, Alessandro Antonelli, Maria Angela Cerruto, Stefania Zamboni, Claudio Simeone, Livio Mordasini, Agostino Mattei, Marco Moschini, ,

<h4>Background</h4>Correct identification of variant histologies (VHs) of bladder cancer (BCa) at transurethral resection of the bladder (TURB) could drive the subsequent treatment.<h4>Objective</h4>To evaluate the concordance in detecting VHs between TURB and radical cystectomy (RC) specimens in BCa patients.<h4>Design, setting, and participants</h4>We retrospectively analyzed 1881 BCa patients who underwent TURB and ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Postoperative peripheral neuropathies associated with patient positioning during robot-assisted laparoscopic radical prostatectomy (RARP): A systematic review of the literature.

Julian Cornelius, Jonas Mudlagk, Luca Afferi, Philipp Baumeister, Agostino Mattei, Marco Moschini, Christophe Iselin, Livio Mordasini,

<h4>Objective</h4>To perform a systematic review of the literature concerning postoperative peripheral neuropathies associated with patient positioning during robot-assisted laparoscopic radical prostatectomy (RARP).<h4>Patients and methods</h4>A systematic review on articles published from January 1, 1990 to March 15, 2020 was performed in accordance with the PRISMA declaration (Preferred Reporting Items for Systematic ... Read more >>

Prostate (The Prostate)
[2021, 81(7):361-367]

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A comparison of perioperative outcomes of laparoscopic versus open nephroureterectomy for upper tract urothelial carcinoma: a propensity score matching analysis.

Luca Afferi, Mohammad Abufaraj, Francesco Soria, David D'Andrea, Evanguelos Xylinas, Thomas Seisen, Morgan Roupret, Chiara Lonati, Alexandre De la Taille, Benoit Peyronnet, Ekaterina Laukhtina, Benjamin Pradere, Andrea Mari, Wojciech Krajewski, Mario Alvarez-Maestro, Eiji Kikuchi, Keisuke Shigeta, Piotr Chlosta, Francesco Montorsi, Alberto Briganti, Giuseppe Simone, Paola I Ornaghi, Maria Angela Cerruto, Alessandro Antonelli, Kazumasa Matsumoto, Pierre I Karakiewicz, Livio Mordasini, Agostino Mattei, Shahrokh F Shariat, Marco Moschini,

<h4>Background</h4>Radical nephroureterectomy (RNU) with the concomitant excision of the distal ureter and bladder cuff is the current standard of care for the treatment of muscle invasive and/or high-risk upper tract urothelial carcinoma (UTUC). In small uncontrolled studies, laparoscopic RNU has been suggested to be associated with better perioperative outcomes compared ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2021, :]

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Immediate Shockwave Lithotripsy vs Delayed Shockwave Lithotripsy After Urgent Ureteral Stenting in Patients with Ureteral or Pyeloureteral Urolithiasis: A Matched-Pair Analysis.

Julian Cornelius, Dominique Zumbühl, Luca Afferi, Livio Mordasini, Carlo Di Bona, Stefania Zamboni, Marco Moschini, Edoardo Pozzi, Andrea Salonia, Agostino Mattei, Hansjörg Danuser, Philipp Baumeister,

<b><i>Introduction:</i></b> The most common cause of acute renal colic is a ureteral obstruction caused by ureterolithiasis. Urgent intervention is often necessary due to intractable pain. Early extracorporeal shockwave lithotripsy (SWL) as an alternative treatment option to ureteral stenting becomes forgotten in times of rising ureterorenoscopy. However, definitive guidelines are lacking, ... Read more >>

J Endourol (Journal of endourology)
[2021, 35(5):721-727]

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Restaging Transurethral Resection of Bladder Tumours after BCG Immunotherapy Induction in Patients with T1 Non-Muscle-Invasive Bladder Cancer Might not Be Associated with Oncologic Benefit.

Wojciech Krajewski, Marco Moschini, Łukasz Nowak, Sławomir Poletajew, Andrzej Tukiendorf, Luca Afferi, Jeremy Teoh, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Alessandra Gozzo, Andrea Mari, Ettore Di Trapani, Kees Hendricksen, Mario Alvarez-Maestro, Andrea Rodriguez Serrano, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Guillaume Ploussard, Paweł Rajwa, Ekaterina Laukhtina, Aleksandra Zdrojowy-Wełna, Anna Kołodziej, Andrzej Paradysz, Karl Tully, Joanna Krajewska, Radosław Piszczek, Evanguelos Xylinas, Romuald Zdrojowy,

<h4>Background and purpose</h4>The European Association of Urology guidelines recommend restaging transurethral resection of bladder tumours (reTURB) 2-6 weeks after primary TURB. However, in clinical practice some patients undergo a second TURB procedure after Bacillus Calmette-Guérin immunotherapy (BCG)induction. To date, there are no studies comparing post-BCG reTURB with the classic pre-BCG ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(10):]

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Delaying BCG immunotherapy onset after transurethral resection of non-muscle-invasive bladder cancer is associated with adverse survival outcomes.

Wojciech Krajewski, Marco Moschini, Joanna Chorbińska, Łukasz Nowak, Sławomir Poletajew, Andrzej Tukiendorf, Luca Afferi, Jeremy Yuen-Chun Teoh, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Francesco Cianflone, Andrea Mari, Ettore Di Trapani, Kees Hendricksen, Mario Alvarez-Maestro, Andrea Rodríguez-Serrano, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Guillaume Ploussard, Ekaterina Laukhtina, Karl Tully, Anna Kołodziej, Joanna Krajewska, Radosław Piszczek, Evanguelos Xylinas, Romuald Zdrojowy, ,

<h4>Purpose</h4>This study was carried out to assess whether a prolonged time between primary transurethral resection of non-muscle-invasive bladder cancer (TURB) and implementation of bacillus Calmette-Guerin (BCG) immunotherapy (time to BCG; TTBCG) is associated with adverse oncological survival in patients with T1 high-grade (HG) non-muscle-invasive bladder cancer (NMIBC).<h4>Materials and methods</h4>Data on 429 ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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Precision medicine in localized bladder cancer: Personalizing therapies to improve outcomes.

Roberto Carando, Giuseppe Mario Ludovico, Michele Zazzara, Stefania Zamboni, Luca Afferi, Claudio Simeone, Wojciech Krajewski, Marco Moschini,

In the last decades, only few improvements have been made in the comprehension of bladder cancer tumor leading to few improvements in the development of new diagnostic and therapeutic approaches.However, in the last years several step forwards in the field of precision medicine have been made. In this review we ... Read more >>

Arch Esp Urol (Archivos espanoles de urologia)
[2020, 73(10):1016-1022]

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Frailty impact on postoperative complications and early mortality rates in patients undergoing radical cystectomy for bladder cancer: a systematic review.

Paola I Ornaghi, Luca Afferi, Alessandro Antonelli, Maria A Cerruto, Livio Mordasini, Agostino Mattei, Philipp Baumeister, Giancarlo Marra, Wojciech Krajewski, Andrea Mari, Francesco Soria, Benjamin Pradere, Evanguelos Xylinas, Alessandro Tafuri, Marco Moschini,

<b>Objective</b>: To assess the prevalence of frailty, a status of vulnerability to stressors leading to adverse health events, in bladder cancer patients undergoing radical cystectomy (RC), and test the impact of frailty measurements on postoperative adverse outcomes. <b>Methods</b>: A systematic review of English-language articles published up to April 2020 was ... Read more >>

Arab J Urol (Arab journal of urology)
[2020, 19(1):9-23]

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Prediction of the Need for an Extended Lymphadenectomy at the Time of Radical Cystectomy in Patients with Bladder Cancer.

Marco Moschini, Luca Afferi, Giorgio Gandaglia, David D'Andrea, Stefania Zamboni, Carlo Di Bona, Livio Mordasini, Agostino Mattei, Philipp Baumeister, Alberto Martini, Giusy Burgio, Shahrokh F Shariat, Rafael Sanchez-Salas, Xavier Cathelineau, Armando Stabile, Emanuele Zaffuto, Andrea Salonia, Renzo Colombo, Andrea Necchi, Francesco Montorsi, Alberto Briganti, Andrea Gallina,

<h4>Background</h4>A prospective randomized trial (LEA AUO AB 25/02) found no survival benefit in extended compared with limited pelvic lymph node dissection (PLND) templates in bladder cancer (BCa) patients treated with radical cystectomy (RC). However, the rate of lymph node invasion (LNI) in the standard and extended templates was lower than ... Read more >>

Eur Urol Focus (European urology focus)
[2020, :]

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Comparing oncological outcomes of laparoscopic vs open radical nephroureterectomy for the treatment of upper tract urothelial carcinoma: A propensity score-matched analysis.

Marco Moschini, Stefania Zamboni, Luca Afferi, Benjamin Pradere, Mohammad Abufaraj, Francesco Soria, David D'Andrea, Morgan Roupret, Alexandre De la Taille, Claudio Simeone, Agostino Mattei, Romain Mathieu, Karim Bensalah, Manfred Peter Wirth, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Giuseppe Simone, Michele Gallucci, Carlo Di Bona, Giancarlo Marra, Andrea Mari, Ettore Di Trapani, Mario Alvarez Maestro, Wojciech Krajewski, Shahrokh F Shariat, Evanguelos Xylinas, Philipp Baumeister,

<h4>Objectives</h4>To compare oncological outcomes of open (ORNU) and laparoscopic radical nephroureterectomy (LRNU) after controlling for preoperative patient-derived factors.<h4>Patients and methods</h4>We evaluated a multi-institutional collaborative database composed of 3984 patients diagnosed with upper tract urothelial carcinoma (UTUC) treated with RNU between 2006 and 2018. To adjust for potential selection bias, propensity ... Read more >>

Arab J Urol (Arab journal of urology)
[2020, 19(1):31-36]

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Prognostic Implications of Multiparametric Magnetic Resonance Imaging and Concomitant Systematic Biopsy in Predicting Biochemical Recurrence After Radical Prostatectomy in Prostate Cancer Patients Diagnosed with Magnetic Resonance Imaging-targeted Biopsy.

Giorgio Gandaglia, Guillaume Ploussard, Massimo Valerio, Giancarlo Marra, Marco Moschini, Alberto Martini, Mathieu Roumiguié, Nicola Fossati, Armando Stabile, Jean-Baptiste Beauval, Bernard Malavaud, Simone Scuderi, Francesco Barletta, Luca Afferi, Arnas Rakauskas, Paolo Gontero, Agostino Mattei, Francesco Montorsi, Alberto Briganti,

<h4>Background</h4>The prognostic role of multiparametric magnetic resonance imaging (mpMRI) and systematic biopsy in predicting biochemical recurrence (BCR) after radical prostatectomy (RP) in prostate cancer (PCa) patients has not been addressed yet.<h4>Objective</h4>To develop a risk tool predicting BCR after RP in patients diagnosed with magnetic resonance imaging (MRI)-targeted biopsy.<h4>Design, setting, and ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(6):739-747]

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Performance and safety of treatment options for erectile dysfunction in patients with spinal cord injury: A review of the literature.

Luca Afferi, Jürgen Pannek, Arthur Louis Burnett, Cedric Razaname, Stamatina Tzanoulinou, Wojciech Bobela, Rodrigo Araujo Fraga da Silva, Mikael Sturny, Nikos Stergiopulos, Julian Cornelius, Marco Moschini, Christophe Iselin, Andrea Salonia, Agostino Mattei, Livio Mordasini,

<h4>Background</h4>For a large proportion of patients with spinal cord injury, sexuality and reproduction are important issues. However, sparse data exist regarding available treatment options for this patient population.<h4>Objectives</h4>We sought to review performance and safety rates of all currently available treatment options for erectile dysfunction in spinal cord injury men.<h4>Materials and ... Read more >>

Andrology (Andrology)
[2020, 8(6):1660-1673]

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Adjuvant chemotherapy is ineffective in patients with bladder cancer and variant histology treated with radical cystectomy with curative intent.

Stefania Zamboni, Luca Afferi, Francesco Soria, Atiqullah Aziz, Mohammad Abufaraj, Cedric Poyet, Andrea Necchi, David D'Andrea, Giuseppe Simone, Mariaconsiglia Ferriero, Ettore Di Trapani, Claudio Simeone, Alessandro Antonelli, Andrea Gallina, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Giorgio Gandaglia, Agostino Mattei, Philipp Baumeister, Livio Mordasini, Kees Hendricksen, Charlotte S Voskuilen, Michael Rink, Shahrokh F Shariat, Evanguelous Xylinas, Marco Moschini,

<h4>Objectives</h4>Adjuvant chemotherapy (ACT) is recommended for non-organ-confined bladder cancer (BCa) after radical cystectomy (RC) and pelvic lymph node dissection (PLND), but there are sparse data regarding its specific efficacy in patients with histological variants. The aim of our study was to evaluate the role of ACT on survival outcomes in ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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The impact of preoperative nutritional status on post-surgical complication and mortality rates in patients undergoing radical cystectomy for bladder cancer: a systematic review of the literature.

Paola Irene Ornaghi, Luca Afferi, Alessandro Antonelli, Maria Angela Cerruto, Katia Odorizzi, Alessandra Gozzo, Livio Mordasini, Agostino Mattei, Philipp Baumeister, Julian Cornelius, Alessandro Tafuri, Marco Moschini,

<h4>Purpose</h4>To investigate the impact of preoperative nutritional factors [body mass index (BMI)], hypoalbuminemia (< 3.5 g/dL, sarcopenia) on complication and mortality rates after radical cystectomy (RC) for bladder cancer.<h4>Methods</h4>The PubMed database was systematically searched for studies investigating the effect of nutritional status on postoperative outcomes after RC. English-language articles published between March ... Read more >>

World J Urol (World journal of urology)
[2021, 39(4):1045-1081]

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The effectiveness of multiparametric magnetic resonance imaging in bladder cancer (Vesical Imaging-Reporting and Data System): A systematic review.

Roberto Carando, Luca Afferi, Giancarlo Marra, Wojciech Krajewski, Vincenzo Pagliarulo, Mohammad Abufaraj, Evanguelos Xylinas, Xavier Cathelineau, Rafael Sanchez-Salas, Marco Moschini,

<h4>Objective</h4>To evaluate the role of the Vesical Imaging-Reporting and Data System (VI-RADS) score in the diagnostic pathway of bladder cancer.<h4>Methods</h4>A systemic search of the contemporary literature was performed in December 2019 using the Medical Literature Analysis and Retrieval System Online (MEDLINE), the Excerpta Medica dataBASE (EMBASE), and Web of Science ... Read more >>

Arab J Urol (Arab journal of urology)
[2020, 18(2):67-71]

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The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration.

Luca Afferi, Stefania Zamboni, R Jeffrey Karnes, Florian Roghmann, Paul Sargos, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Agostino Mattei, Gerald Bastian Schulz, Kees Hendricksen, Charlotte S Voskuilen, Michael Rink, Cedric Poyet, Ottavio De Cobelli, Ettore di Trapani, Claudio Simeone, Matteo Soligo, Giuseppe Simone, Gabriele Tuderti, Mario Alvarez-Maestro, Luis Martínez-Piñeiro, Atiqullah Aziz, Shahrokh F Shariat, Mohammad Abufaraj, Evanguelos Xylinas, Marco Moschini, ,

<h4>Purpose</h4>To assess the impact of perioperative chemotherapy on survival in cN+ BCa patients and analyze it according to the pN status.<h4>Methods</h4>A retrospective analysis was conducted on 639 BCa patients with cTanyN1-3M0 BCa treated with radical cystectomy (RC) and bilateral lymph node dissection (LND) with or without perioperative chemotherapy in ten tertiary referral ... Read more >>

World J Urol (World journal of urology)
[2021, 39(2):443-451]

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Trends in risk-group distribution and Pentafecta outcomes in patients treated with nerve-sparing, robot-assisted radical prostatectomy: a 10-year low-intermediate volume single-center experience.

Luca Afferi, Marco Moschini, Philipp Baumeister, Stefania Zamboni, Julian Cornelius, Gallus Ineichen, Agostino Mattei, Livio Mordasini,

<h4>Purpose</h4>To evaluate the trends in risk-group distribution and Pentafecta outcomes in patients treated with nerve-sparing (NS), robot-assisted radical prostatectomy (RARP) in a single low-intermediate volume prostate cancer (PCa) center over a 10-year period.<h4>Materials and methods</h4>We queried a prospectively maintained database for patients who underwent NS RARP between 2009 and 2018 ... Read more >>

World J Urol (World journal of urology)
[2021, 39(2):389-397]

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Re: Adjuvant Chemotherapy in Upper Tract Urothelial Carcinoma (the POUT Trial): A Phase 3, Open-label, Randomised Controlled Trial.

Luca Afferi, Marco Moschini, Agostino Mattei, Francesco Montorsi, Alberto Briganti, Xavier Cathelineau, Rafael Sanchez-Salas,

Eur Urol (European urology)
[2020, 78(2):289-290]

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Standardized and Simplified Robot-assisted Superextended Pelvic Lymph Node Dissection for Prostate Cancer: The Monoblock Technique.

Agostino Mattei, Christoph Würnschimmel, Philipp Baumeister, Ajet Hyseni, Luca Afferi, Marco Moschini, Livio Mordasini, Pietro Grande,

<h4>Background</h4>Extended pelvic lymph node dissection (ePLND) remains the most accurate procedure for lymph node staging in intermediate- and high-risk prostate cancer (PCa) patients undergoing radical prostatectomy (RP). A superextended pelvic lymph node dissection (sePLND) can be considered in selected very-high-risk PCa patients.<h4>Objective</h4>To demonstrate a reproducible robot-assisted technique for sePLND at ... Read more >>

Eur Urol (European urology)
[2020, 78(3):424-431]

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Biomarkers predicting oncological outcomes of high-risk non-muscle-invasive bladder cancer.

Luca Afferi, Marco Moschini, Marcus G Cumberbatch, James W Catto, Roberto M Scarpa, Francesco Porpiglia, Agostino Mattei, Rafael Sanchez-Salas, Francesco Esperto, ,

INTRODUCTION:The European Organization for Research and Treatment of Cancer (EORTC) and the Spanish Urological Club for Oncological Treatment (CUETO) scoring systems show limited accuracy for the prediction of disease recurrence and progression of non-muscle-invasive bladder cancer (NMIBC). This aspect is even more relevant in the category of HR NMIBC. Biomarkers ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2020, 72(3):265-278]

Cited: 1 time

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Multiparametric magnetic resonance imaging ultrasound-guided fusion biopsy during active surveillance: A single-centre study.

Kilian Röthlin, Stefania Zamboni, Marco Moschini, Patrick Stucki, Luca Afferi, Philipp Baumeister, Agostino Mattei,

<h4>Objective</h4>To analyse the role of multiparametric magnetic resonance imaging (mpMRI) ultrasound (US)-guided fusion biopsy (FB) in patients with low-risk prostate cancer (PCa) under active surveillance (AS).<h4>Patients and methods</h4>Our retrospective study included 47 patients under AS who consecutively underwent both FB and standard biopsy (SB), from May 2015 until November 2017. ... Read more >>

Arab J Urol (Arab journal of urology)
[2020, 18(3):142-147]

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The VENUSS prognostic model to predict disease recurrence following surgery for non-metastatic papillary renal cell carcinoma: development and evaluation using the ASSURE prospective clinical trial cohort.

Tobias Klatte, Kevin M Gallagher, Luca Afferi, Alessandro Volpe, Nils Kroeger, Silvia Ribback, Alan McNeill, Antony C P Riddick, James N Armitage, Tevita F 'Aho, Tim Eisen, Kate Fife, Axel Bex, Allan J Pantuck, Grant D Stewart,

<h4>Background</h4>The current World Health Organization classification recognises 12 major subtypes of renal cell carcinoma (RCC). Although these subtypes differ on molecular and clinical levels, they are generally managed as the same disease, simply because they occur in the same organ. Specifically, there is a paucity of tools to risk-stratify patients ... Read more >>

BMC Med (BMC medicine)
[2019, 17(1):182]

Cited: 6 times

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Adjuvant chemotherapy in bladder cancer patients with histological variants: time to change the approach?

Luca Afferi, Stefania Zamboni, Philipp Baumeister, Livio Mordasini, Agostino Mattei, Marco Moschini,

Transl Androl Urol (Translational andrology and urology)
[2019, 8(Suppl 3):S280-S282]

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