Full Text Journal Articles by
Author Louis David Lord

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A Complex Systems Perspective on Neuroimaging Studies of Behavior and Its Disorders.

Federico E Turkheimer, Fernando E Rosas, Ottavia Dipasquale, Daniel Martins, Erik D Fagerholm, Paul Expert, František Váša, Louis-David Lord, Robert Leech,

The study of complex systems deals with emergent behavior that arises as a result of nonlinear spatiotemporal interactions between a large number of components both within the system, as well as between the system and its environment. There is a strong case to be made that neural systems as well ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421994784]

Cited: 1 time

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Disrupted brain structural connectivity in Pediatric Bipolar Disorder with psychosis.

Henrique M Fernandes, Joana Cabral, Tim J van Hartevelt, Louis-David Lord, Carsten Gleesborg, Arne Møller, Gustavo Deco, Peter C Whybrow, Predrag Petrovic, Anthony C James, Morten L Kringelbach,

Bipolar disorder (BD) has been linked to disrupted structural and functional connectivity between prefrontal networks and limbic brain regions. Studies of patients with pediatric bipolar disorder (PBD) can help elucidate the developmental origins of altered structural connectivity underlying BD and provide novel insights into the aetiology of BD. Here we ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):13638]

Cited: 4 times

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Plastic Adaptation to Pathology in Psychiatry: Are Patients with Psychiatric Disorders Pathological Experts?

Ali Amad, Paul Expert, Louis-David Lord, Thomas Fovet, Pierre A Geoffroy,

Psychiatric disorders share the same pattern of longitudinal evolution and have courses that tend to be chronic and recurrent. These aspects of chronicity and longitudinal evolution are currently studied under the deficit-oriented neuroprogression framework. Interestingly, considering the plasticity of the brain, it is also necessary to emphasize the bidirectional nature ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, 26(3):208-223]

Cited: 0 times

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Editorial: Topological Neuroscience.

Paul Expert, Louis-David Lord, Morten L Kringelbach, Giovanni Petri,

Topology, in its many forms, describes relations. It has thus long been a central concept in neuroscience, capturing structural and functional aspects of the organization of the nervous system and their links to cognition. Recent advances in computational topology have extended the breadth and depth of topological descriptions. This Focus ... Read more >>

Netw Neurosci (Network neuroscience (Cambridge, Mass.))
[2019, 3(3):653-655]

Cited: 2 times

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Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin.

Louis-David Lord, Paul Expert, Selen Atasoy, Leor Roseman, Kristina Rapuano, Renaud Lambiotte, David J Nutt, Gustavo Deco, Robin L Carhart-Harris, Morten L Kringelbach, Joana Cabral,

Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns ('functional brain networks'), which potentially underlie different mental processes. The present study characterizes how the brain's dynamical exploration of resting-state networks is rapidly ... Read more >>

Neuroimage (NeuroImage)
[2019, 199:127-142]

Cited: 21 times

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The Plastic Adaptation to Pathology in Psychiatry. Are Patients with Psychiatric Disorders Pathological Experts?

Ali Amad, Paul Expert, Louis-David Lord, Thomas Fovet, Pierre Geoffroy,

Psychiatric disorders share the same pattern of longitudinal evolution and have courses that tend to be chronic and recurrent. These aspects of chronicity and longitudinal evolution of psychiatric disorders are currently studied under the neuroprogression framework. Interestingly, considering the plasticity of the brain, it is necessary to emphasize the bidirectional ... Read more >>

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Disrupted brain structural connectivity in Pediatric Bipolar Disorder with psychosis

Henrique Fernandes, Joana Cabral, Tim Van Hartevelt, Louis-David Lord, Carsten Gleesborg, Arne Moller, Gustavo Deco, Peter Whybrow, Predrag Petrovic, Anthony James, Morten Kringelbach,

Bipolar disorder (BD) has been linked to disrupted structural and functional connectivity between prefrontal networks and limbic brain regions. Studies of patients with pediatric bipolar disorder (PBD) can help elucidate the developmental origins of altered structural connectivity underlying BD and provide novel insights into the aetiology of BD. Here we ... Read more >>

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Altered trajectories in the dynamical repertoire of functional network states under psilocybin

Louis-David Lord, Paul Expert, Selen Atasoy, Leor Roseman, Kristina Rapuano, Renaud Lambiotte, David Nutt, Gustavo Deco, Robin Carhart-Harris, Morten Kringelbach, Joana Cabral,

Brain activity can be understood as the exploration of a dynamical landscape of activity configurations over both space and time. This dynamical landscape may be defined in terms of spontaneous transitions within a repertoire of discrete metastable states of functional connectivity (FC), which underlie different mental processes. However, it remains ... Read more >>

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Understanding principles of integration and segregation using whole-brain computational connectomics: implications for neuropsychiatric disorders.

Louis-David Lord, Angus B Stevner, Gustavo Deco, Morten L Kringelbach,

To survive in an ever-changing environment, the brain must seamlessly integrate a rich stream of incoming information into coherent internal representations that can then be used to efficiently plan for action. The brain must, however, balance its ability to <i>integrate</i> information from various sources with a complementary capacity to <i>segregate</i> ... Read more >>

Philos Trans A Math Phys Eng Sci (Philosophical transactions. Series A, Mathematical, physical, and engineering sciences)
[2017, 375(2096):]

Cited: 20 times

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Insights into Brain Architectures from the Homological Scaffolds of Functional Connectivity Networks.

Louis-David Lord, Paul Expert, Henrique M Fernandes, Giovanni Petri, Tim J Van Hartevelt, Francesco Vaccarino, Gustavo Deco, Federico Turkheimer, Morten L Kringelbach,

In recent years, the application of network analysis to neuroimaging data has provided useful insights about the brain's functional and structural organization in both health and disease. This has proven a significant paradigm shift from the study of individual brain regions in isolation. Graph-based models of the brain consist of ... Read more >>

Front Syst Neurosci (Frontiers in systems neuroscience)
[2016, 10:85]

Cited: 12 times

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The brain's code and its canonical computational motifs. From sensory cortex to the default mode network: A multi-scale model of brain function in health and disease.

Federico E Turkheimer, Robert Leech, Paul Expert, Louis-David Lord, Anthony C Vernon,

A variety of anatomical and physiological evidence suggests that the brain performs computations using motifs that are repeated across species, brain areas, and modalities. The computational architecture of cortex, for example, is very similar from one area to another and the types, arrangements, and connections of cortical neurons are highly ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2015, 55:211-222]

Cited: 24 times

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Understanding human original actions directed at real-world goals: the role of the lateral prefrontal cortex.

Tatiana Sitnikova, Bruce R Rosen, Louis-David Lord, W Caroline West,

Adaptive, original actions, which can succeed in multiple contextual situations, require understanding of what is relevant to a goal. Recognizing what is relevant may also help in predicting kinematics of observed, original actions. During action observation, comparisons between sensory input and expected action kinematics have been argued critical to accurate ... Read more >>

Neuroimage (NeuroImage)
[2014, 103:91-105]

Cited: 2 times

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Cerebral energy metabolism and the brain's functional network architecture: an integrative review.

Louis-David Lord, Paul Expert, Jeremy F Huckins, Federico E Turkheimer,

Recent functional magnetic resonance imaging (fMRI) studies have emphasized the contributions of synchronized activity in distributed brain networks to cognitive processes in both health and disease. The brain's 'functional connectivity' is typically estimated from correlations in the activity time series of anatomically remote areas, and postulated to reflect information flow ... Read more >>

J Cereb Blood Flow Metab (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2013, 33(9):1347-1354]

Cited: 38 times

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Functional brain networks before the onset of psychosis: A prospective fMRI study with graph theoretical analysis.

Louis-David Lord, Paul Allen, Paul Expert, Oliver Howes, Matthew Broome, Renaud Lambiotte, Paolo Fusar-Poli, Isabel Valli, Philip McGuire, Federico E Turkheimer,

Individuals with an at-risk mental state (ARMS) have a risk of developing a psychotic disorder significantly greater than the general population. However, it is not currently possible to predict which ARMS individuals will develop psychosis from clinical assessment alone. Comparison of ARMS subjects who do, and do not, develop psychosis ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2012, 1(1):91-98]

Cited: 17 times

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Characterization of the anterior cingulate's role in the at-risk mental state using graph theory.

Louis-David Lord, Paul Allen, Paul Expert, Oliver Howes, Renaud Lambiotte, Philip McGuire, Subrata K Bose, Samuel Hyde, Federico E Turkheimer,

The onset of positive symptoms in schizophrenia is often preceded by a prodromal phase characterized by neurocognitive abnormalities as well as changes in brain structure and function. Increasing efforts have been made to identify individuals at elevated risk of developing schizophrenia, as early intervention may help prevent progression towards psychosis. ... Read more >>

Neuroimage (NeuroImage)
[2011, 56(3):1531-1539]

Cited: 35 times

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Executive functions and prefrontal cortex: a matter of persistence?

Gareth Ball, Paul R Stokes, Rebecca A Rhodes, Subrata K Bose, Iead Rezek, Alle-Meije Wink, Louis-David Lord, Mitul A Mehta, Paul M Grasby, Federico E Turkheimer,

Executive function is thought to originates from the dynamics of frontal cortical networks. We examined the dynamic properties of the blood oxygen level dependent time-series measured with functional MRI (fMRI) within the prefrontal cortex (PFC) to test the hypothesis that temporally persistent neural activity underlies performance in three tasks of ... Read more >>

Front Syst Neurosci (Frontiers in systems neuroscience)
[2011, 5:3]

Cited: 16 times

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Rapid steroid influences on visually guided sexual behavior in male goldfish.

Louis-David Lord, Julia Bond, Richmond R Thompson,

The ability of steroid hormones to rapidly influence cell physiology through nongenomic mechanisms raises the possibility that these molecules may play a role in the dynamic regulation of social behavior, particularly in species in which social stimuli can rapidly influence circulating steroid levels. We therefore tested if testosterone (T), which ... Read more >>

Horm Behav (Hormones and behavior)
[2009, 56(5):519-526]

Cited: 26 times

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