Full Text Journal Articles by
Author Lorenzo Zaffiri

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Desensitization and management of allograft rejection.

Lorenzo Zaffiri,

<h4>Purpose of review</h4>Chronic lung allograft dysfunction (CLAD) limits the success of lung transplantation. Among the risk factors associated with CLAD, we recognize pretransplant circulating antibodies against the human leukocyte antigens (HLA), acute cellular rejection (ACR) and antibody-mediated rejection (AMR). This review will summarize current data surrounding management of desensitization, ACR, ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):314-320]

Cited: 0 times

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Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder.

Lorenzo Zaffiri, Courtney Frankel, Erika J Bush, Megan L Neely, Elizabeth N Pavlisko, Irina L Mokrova, Micah A Luftig, Scott M Palmer,

Epstein-Barr virus (EBV)-driven posttransplant lymphoproliferative disorder (PTLD) is a serious complication following lung transplant. The extent to which the presence of EBV in PTLD tissue is associated with survival is uncertain. Moreover, whether the heterogeneity in expression of EBV latency programs is related to the timing of PTLD onset remains ... Read more >>

J Med Virol (Journal of medical virology)
[2021, :]

Cited: 0 times

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Incidence and outcome of post-transplant lymphoproliferative disorders in lung transplant patients: Analysis of ISHLT Registry.

Lorenzo Zaffiri, Alex Long, Megan L Neely, Wida S Cherikh, Daniel C Chambers, Laurie D Snyder,

<h4>Background</h4>Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication following lung transplant. We studied incidence and risk factors for PTLD in adult lung transplant recipients (LTRs) using the International Society for Heart and Lung Transplantation Registry.<h4>Methods</h4>The International Society for Heart and Lung Transplantation Registry was used to identify adult, first-time, single ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2020, 39(10):1089-1099]

Cited: 0 times

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Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation.

Lorenzo Zaffiri, Rupal J Shah, Robert S Stearman, Katia Rothhaar, Amir M Emtiazjoo, Momoko Yoshimoto, Amanda J Fisher, Elizabeth A Mickler, Matthew D Gartenhaus, L T O G Cohort, Joshua M Diamond, Mark W Geraci, Jason D Christie, David S Wilkes,

<h4>Background</h4>Primary graft dysfunction (PGD) is the leading cause of early mortality after lung transplantation. Anti-collagen type-V (col(V)) immunity has been observed in animal models of ischemia-reperfusion injury (IRI) and in PGD. We hypothesized that collagen type-V is an innate danger signal contributing to PGD pathogenesis.<h4>Methods</h4>Anti-col(V) antibody production was detected by ... Read more >>

Transpl Immunol (Transplant immunology)
[2019, 56:101224]

Cited: 1 time

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The Effect of Paging Reminders on Fellowship Conference Attendance: A Multi-Program Randomized Crossover Study.

Joshua Smith, Lorenzo Zaffiri, Julie Clary, Tyler Davis, Gabriel T Bosslet,

<h4>Background</h4>Educational conferences have long served as a foundation of medical education. Sending reminder text pages prior to the start of conferences is a method that may be employed to enhance conference attendance.<h4>Objective</h4>The goal of our study was to determine if routine text paging before regularly scheduled conferences improves attendance among ... Read more >>

J Grad Med Educ (Journal of graduate medical education)
[2016, 8(3):372-377]

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Recovery of interleukin-17 production from interleukin-15-stimulated CD4+ mononuclear cells in HIV-1-infected patients with sustained viral suppression.

Lorenzo Zaffiri, Gabriella d'Ettorre, Giancarlo Ceccarelli, Mauro Andreotti, Sonia Marcellini, Noemi Giustini, Tommaso Ascoli-Bartoli, Claudio M Mastroianni, Stefano Vella, Vincenzo Vullo,

Interleukin-17 (IL-17) is a pro-inflammatory cytokine that is mainly produced by CD4+ T cells. The role of Th17 during the human immunodeficiency virus (HIV)-1 infection is still unclear, but HIV-1 infection can cause a preferential depletion of Th17 cells. It has been shown that IL-15 elicits IL-17 production from human ... Read more >>

J Interferon Cytokine Res (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research)
[2014, 34(1):35-40]

Cited: 2 times

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Brain abscess induced by Propionibacterium acnes in a patient with severe chronic sinusitis.

Lorenzo Zaffiri, Rasha Abdulmassih, Shafik Boyaji, Imad Bagh, Amanda R Campbell, Mark E Loehrke,

Propionibacterium acnes has long been considered a contaminant organism. However, recently the isolation of this emerging pathogen has become a more difficult clinical challenge. Infections of the central nervous system caused by P. acnes have been strongly associated with neurosurgical procedures. We describe a patient with Propionibacterium acnes cerebral abscess ... Read more >>

New Microbiol (The new microbiologica)
[2013, 36(3):325-329]

Cited: 5 times

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History of antibiotics: from fluoroquinolones to daptomycin (Part 2).

Lorenzo Zaffiri, Jared Gardner, Luis H Toledo-Pereyra,

In the Modern Era, physicians attested to the reciprocal influence among a technologically advanced society, rapid scientific progresses in medicine, and the need for new antimicrobials. The results of these changes were not only seen in the prolongation of life expectancy but also by the emergence of new pathogens. We ... Read more >>

J Invest Surg (Journal of investigative surgery : the official journal of the Academy of Surgical Research)
[2013, 26(4):167-179]

Cited: 4 times

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Immune reconstitution inflammatory syndrome involving the central nervous system in a patient with HIV infection: a case report and review of literature.

Lorenzo Zaffiri, Rajanshu Verma, Kevin Struzzieri, Joanne Monterroso, Donald H Batts, Mark E Loehrke,

IRIS is described as a paradoxical deterioration of clinical status upon initiation of combined anti-retroviral therapy (cART) in patients with HIV infection. Immune reconstitution inflammatory syndrome (CNS-IRIS) involving the central nervous system is rarely reported. We describe the case of 57-year-old man who developed a fatal case of CNS- IRIS. ... Read more >>

New Microbiol (The new microbiologica)
[2013, 36(1):89-92]

Cited: 6 times

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History of antibiotics. From salvarsan to cephalosporins.

Lorenzo Zaffiri, Jared Gardner, Luis H Toledo-Pereyra,

Infections have represented for a long time the leading cause of death in humans. During the 19th century, pneumonia, tuberculosis, diarrhea and diphtheria were considered the main causes of death in children and adults. Only in the late 19th century did it become possible to correlate the existence of microscopic ... Read more >>

J Invest Surg (Journal of investigative surgery : the official journal of the Academy of Surgical Research)
[2012, 25(2):67-77]

Cited: 33 times

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HIV persistence in the gut mucosa of HIV-infected subjects undergoing antiretroviral therapy correlates with immune activation and increased levels of LPS.

Gabriella d'Ettorre, Mirko Paiardini, Lorenzo Zaffiri, Mauro Andreotti, Giancarlo Ceccarelli, Cecilia Rizza, Marileda Indinnimeo, Stefano Vella, Claudio M Mastroianni, Guido Silvestri, Vincenzo Vullo,

We investigated the relationship between viral persistence in the gut, microbial translocation, and T cell activation during chronic HIV infection. Plasma levels of LPS, fraction of circulating CD8+CD38+ T cells, and levels of HIV-DNA in rectosigmoid biopsies and peripheral blood mononuclear cells were determined in 22 HIV-infected individuals and 10 ... Read more >>

Curr HIV Res (Current HIV research)
[2011, 9(3):148-153]

Cited: 43 times

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The role of HIV-DNA testing in clinical practice.

Gabriella d'Ettorre, Lorenzo Zaffiri, Giancarlo Ceccarelli, Claudio M Mastroianni, Vincenzo Vullo,

HIV-1 RNA levels and CD4+T lymphocyte counts are currently the standard markers used in clinical practice for the management of HIV infection. Nowadays it is also possible to monitor the evolution of HIV infection by measuring HIV-DNA. This measurement is a useful new clinical marker mainly been used to date ... Read more >>

New Microbiol (The new microbiologica)
[2010, 33(1):1-11]

Cited: 7 times

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Preexisting infection with human T-cell lymphotropic virus type 2 neither exacerbates nor attenuates simian immunodeficiency virus SIVmac251 infection in macaques.

Shari N Gordon, Anna R Weissman, Valentina Cecchinato, Claudio Fenizia, Zhong-Min Ma, Tzong-Hae Lee, Lorenzo Zaffiri, Vibeke Andresen, Robyn Washington Parks, Kathryn S Jones, Jean Michel Heraud, Maria Grazia Ferrari, Hye Kyung Chung, David Venzon, Renaud Mahieux, Edward L Murphy, Steven Jacobson, Christopher J Miller, Francis W Ruscetti, Genoveffa Franchini,

Coinfection with human T-cell lymphotropic virus type 2 (HTLV-2) and human immunodeficiency virus type 1 (HIV-1) has been reported to have either a slowed disease course or to have no effect on progression to AIDS. In this study, we generated a coinfection animal model and investigated whether HTLV-2 could persistently ... Read more >>

J Virol (Journal of virology)
[2010, 84(6):3043-3058]

Cited: 7 times

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Expression levels of TLRs involved in viral recognition in PBMCs from HIV-1-infected patients failing antiretroviral therapy.

Carolina Scagnolari, Carla Selvaggi, Luisa Chiavuzzo, Teresa Carbone, Lorenzo Zaffiri, Gabriella d'Ettorre, Enrico Girardi, Ombretta Turriziani, Vincenzo Vullo, Guido Antonelli,

<h4>Objective</h4>The aim of this study was to evaluate whether gene expression of Toll-like receptor (TLR)-3, TLR4, TLR7 and TLR9 was impaired in patients with chronic HIV-1 infection who were failing to respond to antiretroviral therapy.<h4>Methods</h4>Transcripts encoding TLRs were assayed by quantitative real time RT-PCR on peripheral blood mononuclear cells derived ... Read more >>

Intervirology (Intervirology)
[2009, 52(2):107-114]

Cited: 14 times

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Simplified maintenance therapy with abacavir/lamivudine/zidovudine plus tenofovir after sustained HIV load suppression: four years of follow-up.

Gabriella d'Ettorre, Lorenzo Zaffiri, Giancarlo Ceccarelli, Mauro Andreotti, Anna Paola Massetti, Stefano Vella, Claudio M Mastroianni, Vincenzo Vullo,

<h4>Purpose</h4>To assess the virologic and immunologic outcome of a treatment simplification strategy based on the substitution of protease inhibitor (PI)-based regimen with abacavir/lamivudine/zidovudine (ABC/3TC/ZDV, also known as trizivir or TZV) plus tenofovir (TDF) in viral-suppressed patients.<h4>Method</h4>The study population included 17 HIV-infected patients with undetectable viral loads over 12 months of ... Read more >>

HIV Clin Trials (HIV clinical trials)
[2007, 8(3):182-188]

Cited: 1 time

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Central role of interleukin-15 in human immunodeficiency virus (HIV)-infected patients with visceral leishmaniasis.

Gabriella d'Ettorre, Giancarlo Ceccarelli, Martina Carnevalini, Gabriele Forcina, Lorenzo Zaffiri, Anna P Massetti, Claudio M Mastroianni, Vincenzo Vullo,

To evaluate clinical and immunological parameters, interleukin (IL)-15 production and outcome of patients with visceral leishmaniasis (VL), including HIV positive patients, we analyzed 48 cases of VL. Clinical manifestations and response to therapy were similar in VL/HIV- and VL/HIV+ patients. However, relapses were more frequent in patients with HIV infection. ... Read more >>

Acta Trop (Acta tropica)
[2006, 99(1):83-87]

Cited: 8 times

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Interleukin-15 enhances the secretion of IFN-gamma and CC chemokines by natural killer cells from HIV viremic and aviremic patients.

Gabriella d'Ettorre, Mauro Andreotti, Martina Carnevalini, Carolina Andreoni, Lorenzo Zaffiri, Vincenzo Vullo, Stefano Vella, Claudio M Mastroianni,

Several lines of evidence documented a renewed interest in the role of natural killer (NK) cells in the innate immune control of HIV infection and disease progression. To further assess the role of NK cells as target for immunotherapy in HIV infection, we evaluated the priming effect of interleukin (IL)-15 ... Read more >>

Immunol Lett (Immunology letters)
[2006, 103(2):192-195]

Cited: 13 times

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