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Author Lorena Cuenca Bermejo

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A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity.

Lorena Cuenca-Bermejo, Elisa Pizzichini, Valeria C Gonçalves, María Guillén-Díaz, Elena Aguilar-Moñino, Consuelo Sánchez-Rodrigo, Ana-María González-Cuello, Emiliano Fernández-Villalba, María Trinidad Herrero,

The diurnal rodent <i>Octodon degus</i> (<i>O. degus</i>) is considered an attractive natural model for Alzheimer's disease and other human age-related features. However, it has not been explored so far if the <i>O. degus</i> could be used as a model to study Parkinson's disease. To test this idea, 10 adult male ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(9):]

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Cardiac Tyrosine Hydroxylase Activation and Mb-Comt in Dyskinetic Monkeys

Lorena Cuenca-Bermejo, Pilar Almela, Pablo Gallo-Soljancic, José Yuste, Vicente de Pablos, Victor Bautista-Hernández, Emiliano Fernández-Villalba, María-Luisa Laorden, María-Trinidad Herrero,

The impact of age-associated disorders is increasing as the life expectancy of the population increments. Cardiovascular diseases and neurodegenerative disorders, such as Parkinson’s disease, have the highest social and economic burden and increasing evidence show interrelations between them. Particularly, dysfunction of the cardiovascular nervous system is part of the dysautonomic ... Read more >>

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Could Small Heat Shock Protein HSP27 Be a First-Line Target for Preventing Protein Aggregation in Parkinson's Disease?

Javier Navarro-Zaragoza, Lorena Cuenca-Bermejo, Pilar Almela, María-Luisa Laorden, María-Trinidad Herrero,

Small heat shock proteins (HSPs), such as HSP27, are ubiquitously expressed molecular chaperones and are essential for cellular homeostasis. The major functions of HSP27 include chaperoning misfolded or unfolded polypeptides and protecting cells from toxic stress. Dysregulation of stress proteins is associated with many human diseases including neurodegenerative diseases, such ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(6):]

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Role of Microgliosis and NLRP3 Inflammasome in Parkinson's Disease Pathogenesis and Therapy.

Fillipe M de Araújo, Lorena Cuenca-Bermejo, Emiliano Fernández-Villalba, Silvia L Costa, Victor Diogenes A Silva, Maria Trinidad Herrero,

Parkinson's disease (PD) is a neurodegenerative disorder marked primarily by motor symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated with dopaminergic neuronal loss in the Substantia Nigra pars compacta (SNpc) and deficit of dopamine in the basal ganglia. These motor symptoms can be preceded by pre-motor symptoms ... Read more >>

Cell Mol Neurobiol (Cellular and molecular neurobiology)
[2021, :]

Cited: 6 times

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Could Small Heat Shock Protein HSP27 Be a First-Line Target for Preventing Protein Aggregation in Parkinson’s Disease?

Javier Navarro-Zaragoza, Lorena Cuenca-Bermejo, Pilar Almela, María-Luisa Laorden, María-Trinidad Herrero,

Small heat shock proteins (HSPs), such as HSP27, are ubiquitously expressed molecular chaperones and are essential for cellular homeostasis. The major functions of HSP27 include chaperoning misfolded or unfolded polypeptides and protecting cells from toxic stress. Dysregulation of stress proteins is associated with many human diseases including neurodegenerative diseases, such ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(6):]

Cited: 0 times

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Heart Matters: Cardiac Dysfunction and Other Autonomic Changes in Parkinson's Disease.

Valeria C Gonçalves, Lorena Cuenca-Bermejo, Emiliano Fernandez-Villalba, Sebastian Martin-Balbuena, Maria Jose da Silva Fernandes, Carla A Scorza, Maria-Trinidad Herrero,

It has been more than 200 years since James Parkinson made the first descriptions of the disease that bears his name. Since then, knowledge about Parkinson's disease has been improved, and its pathophysiology, diagnosis, and treatments are well described in the scientific and medical literature. However, there is no way ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421990000]

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Octodon degus: a natural model of multimorbidity for ageing research.

Lorena Cuenca-Bermejo, Elisa Pizzichini, Ana Maria Gonzalez-Cuello, Maria Egle De Stefano, Emiliano Fernandez-Villalba, María-Trinidad Herrero,

Integrating the multifactorial processes co-occurring in both physiological and pathological human conditions still remains one of the main challenges in translational investigation. Moreover, the impact of age-associated disorders has increased, which underlines the urgent need to find a feasible model that could help in the development of successful therapies. In ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2020, 64:101204]

Cited: 1 time

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Study of the Link Between Neuronal Death, Glial Response, and MAPK Pathway in Old Parkinsonian Mice.

Ana Luisa Gil-Martinez, Lorena Cuenca-Bermejo, Pablo Gallo-Soljancic, Consuelo Sanchez-Rodrigo, Virginia Izura, Harry W M Steinbusch, Emiliano Fernandez-Villalba, Maria Trinidad Herrero,

<b>Background</b>: Parkinson's disease (PD) is described as an age-related neurodegenerative disorder. However, the vast majority of research is carried out using experimental models of young animals lacking the implications of the decline processes associated with aging. It has been suggested that several molecular pathways are involved in the perpetuation of ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:214]

Cited: 1 time

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Cardiac Tyrosine Hydroxylase Activation and MB-COMT in Dyskinetic Monkeys 

Lorena Cuenca-Bermejo, Pilar Almela, Pablo Gallo-Soljancic, Jose Yuste, Vicente de Pablos, Víctor Bautista-Hernández, Emiliano Fernández-Villalba, María-Luisa Laorden, María-Trinidad Herrero,

<h4>Background: </h4> The impact of age-associated disorders is increasing as the life expectancy of the population increments. Cardiovascular diseases and neurodegenerative disorders, such as Parkinson’s disease, have the highest social and economic burden and increasing evidence show interrelations between them. Particularly, dysfunction of the cardiovascular nervous system is part of ... Read more >>

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Cardiac Noradrenaline Turnover and Heat Shock Protein 27 Phosphorylation in Dyskinetic Monkeys.

Pilar Almela, Lorena Cuenca-Bermejo, José E Yuste, Cristina Estrada, Vicente de Pablos, Víctor Bautista-Hernández, Emiliano Fernández-Villalba, María-Luisa Laorden, María-Trinidad Herrero,

<h4>Background</h4>Autonomic dysfunction is a well-known dominant symptom in the advanced stages of Parkinson's disease. However, the role of cardiac sympathetic nerves still needs to be elucidated.<h4>Objectives</h4>To evaluate cardiac sympathetic response in Parkinsonian and dyskinetic monkeys.<h4>Methods</h4>Adult male monkeys were divided into 1 of the following 3 groups: controls, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys, and ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2020, 35(4):698-703]

Cited: 1 time

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