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Author Long Qian

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Do Quarantine Experiences and Attitudes Towards COVID-19 Affect the Distribution of Mental Health in China? A Quantile Regression Analysis.

Haiyang Lu, Peng Nie, Long Qian,

While quarantine has become a widely used control strategy during the outbreak of the 2019 novel coronavirus disease (COVID-19), empirical research on whether and to what extent quarantine and attitudes towards COVID-19 affect mental health is scant. Using a cross-sectional online survey, this paper is the first from the Chinese ... Read more >>

(Applied Research in Quality of Life)
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How and to What Extent Can Pensions Facilitate Increased Use of Health Services by Older People: Evidence From Social Pension Expansion in Rural China

shanquan chen, Xi Chen, Stephen Law, Henry Lucas, Shenlan Tang, Qian Long, Lei Xue, Zheng Wang,

Abstract Background : The proportion of people aged 60 years or over is growing faster than other age groups. Traditionally, retirement has been considered as both a loss to the labour market and an additional economic burden on the nation. More recently, it is widely accepted that retired people can ... Read more >>

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A Systematic Review and Meta-Analysis Of Outcomes for Patients with COVID-19 and Acute Kidney Injury.

Shelief Y. Robbins-Juarez, Long Qian, Kristen L. King, Jacob S. Stevens, S. Ali Husain, Jai Radhakrishnan, Sumit Mohan,

Graphical abstract ... Read more >>

Kidney Int Rep (Kidney international reports)
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Hsp70 Gene Polymorphisms Are Associated With Disease Susceptibility and HRQOL Improvement in Chinese Han Population With Systemic Lupus Erythematosus.

Qiao-Mei Xie, Qiu-Yue Lou, Shun-Wei Huang, Hua-Qing Hu, Su-Su Li, Man Zhang, Xiu-Xiu Sun, Jian-Hua Xu, Shan-Qun Jiang, Sheng-Xiu Liu, Sheng-Qian Xu, Jing Cai, Shuang Liu, Fa-Ming Pan, Jin-Hui Tao, Long Qian, Chun-Huai Wang, Chun-Mei Liang, Hai-Liang Huang, Hai-Feng Pan, Hong Su, Yan-Feng Zou,

OBJECTIVES:The aim of this study is to investigate whether heat shock protein 70 (Hsp70) gene polymorphisms are implicated in systemic lupus erythematous (SLE) susceptibility, the efficacy of glucocorticoids (GCs) treatment, and improvement of health-related quality of life. METHODS:A total of 499 SLE patients and 499 controls were included in a ... Read more >>

J Clin Rheumatol (Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases)
[2020, 26(4):134-141]

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Regional heterogeneities of health literacy in China: a population-based study

Zhenhua Li, Yongquan Tian, Shuiyuan Xiao, Zhicheng Gong, Long Qian,

Abstract Background: Few studies have described the geographic variation in health literacy in China. This study aimed to investigate the regional heterogeneities in health literacy levels in the Chinese population, in order to formulate targeted health literacy promotion strategies in different economic and cultural contexts. Methods: Multi-stage stratification, clustering, and ... Read more >>

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KMT2A regulates cervical cancer cell growth through targeting VDAC1.

Changlin Zhang, Yijun Hua, Huijuan Qiu, Tianze Liu, Qian Long, Wei Liao, Jiehong Qiu, Nang Wang, Miao Chen, Dingbo Shi, Yue Yan, Chuanbo Xie, Wuguo Deng, Tian Li, Yizhuo Li,

Cervical cancer is an aggressive cutaneous malignancy, illuminating the molecular mechanisms of tumorigenesis and discovering novel therapeutic targets are urgently needed. KMT2A is a transcriptional co-activator regulating gene expression during early development and hematopoiesis, but the role of KMT2A in cervical cancer remains unknown. Here, we demonstrated that KMT2A regulated ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(10):9604-9620]

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Investigation of the role and mechanism of ARHGAP5-mediated colorectal cancer metastasis.

Tian Tian, Zhan-Hong Chen, Zongheng Zheng, Yubo Liu, Qi Zhao, Yuying Liu, Huijun Qiu, Qian Long, Miao Chen, Liren Li, Fangyun Xie, Guangyu Luo, Xiaojun Wu, Wuguo Deng,

Background: Metastatic colorectal cancer (CRC) is a lethal disease; however, the underlying molecular mechanisms remain unclear and require further study. Methods: RNA-Seq, PCR, Western blotting, immunohistochemistry, ChIP and RNAi assays were performed to investigate Rho GTPase-activating protein 5 (ARHGAP5, aslo known as p190RhoGAP-B, p190-B) expression and the clinical relevance, functional ... Read more >>

Theranostics (Theranostics)
[2020, 10(13):5998-6010]

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Inoculation concentration modulating the secretion and accumulation pattern of exopolysaccharides in desert cyanobacterium Microcoleus vaginatus.

Long Qian, Li Wu, Lie Yang, Zulin Zhang,

Cyanobacterial exopolysaccharides (EPS) accumulated during microalgal cultivation have significant application potential in antioxidation, pharmaceutical products, and so on. Inoculation concentration strongly affects the cultivation cost, biomass, and EPS accumulation. In this study, a high-EPS-excreted desert cyanobacterium Microcoleus vaginatus was isolated, and the effects of inoculation concentration on biomass, photosynthetic activity, ... Read more >>

Biotechnol. Appl. Biochem. (Biotechnology and applied biochemistry)
[2020, :]

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CircRNACCDC66 regulates cisplatin resistance in gastric cancer via the miR-618/BCL2 axis.

Qiang Zhang, Yongchang Miao, Qingsheng Fu, Hao Hu, Hao Chen, Ailiang Zeng, Yan Jin, Yangfan Jiang, Long Qian, Longchao Wu, Li Xu, Gang Wang, Lei Qiu, Xiaoxu Huang, Yabin Xia,

Gastric cancer (GC) remains a serious threat to human health with a high cancer-related death rate and unsatisfactory treatment effects after curative resection, especially with advanced GC. Thus, exploration of the molecular mechanism of cisplatin (CDDP) resistance in GC is crucial. circCCDC66 (hsa_circ_0001313) expression was detected by quantitative reverse-transcription PCR ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2020, 526(3):713-720]

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Natural orifice specimen extraction with a modified reverse puncture device technique for total laparoscopic colorectal resection: feasibility and efficacy.

Li Xu, Hao Chen, Hao Hu, Kaifeng Hu, Qiang Zhang, Yan Jin, Qingsheng Fu, Yangfan Jiang, Long Qian, Longchao Wu, Xiaoxu Huang, Yabin Xia,

Objective: To evaluate the feasibility and efficacy of the modified reverse puncture device (mRPD) technique for transanal anastomosis in total laparoscopic colorectal resection with natural orifice specimen extraction surgery (NOSES).Methods: From August 2015 to September 2017, 34 patients underwent laparoscopic colorectal resection using the mRPD technique to place the anvil ... Read more >>

Scand. J. Gastroenterol. (Scandinavian journal of gastroenterology)
[2020, 55(3):376-382]

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A novel method for the stabilization of soluble contaminants in electrolytic manganese residue: Using low-cost phosphogypsum leachate and magnesia/calcium oxide.

Hongliang Chen, Qian Long, Yutao Zhang, Shangkun Wang, Feizhou Deng,

Electrolytic manganese residue (EMR) contains a large amount of NH4+-N and Mn2+ and can negatively impact the environment. A stabilization treatment of soluble contaminants in the EMR is necessary for its reuse and safe stacking. This study presents experimental results for the stabilization of NH4+-N and Mn2+ in the EMR ... Read more >>

Ecotoxicol. Environ. Saf. (Ecotoxicology and environmental safety)
[2020, 194:110384]

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A New Financing Model for Tuberculosis (TB) Care in China: Challenges of Policy Development and Lessons Learned from the Implementation.

Qian Long, Weixi Jiang, Di Dong, Jiaying Chen, Li Xiang, Qiang Li, Fei Huang, Henry Lucas, Shenglan Tang,

Background: With support from the Gates Foundation, the Chinese Center for Disease Control and Prevention (China CDC) introduced a new financing model for tuberculosis (TB) care. This paper reviews the development of the associated financing policies and payment methods in three project sites and analyzes the factors impacting on policy ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(4):]

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Frequency-Specific Changes of Resting Brain Activity in Parkinson's Disease: A Machine Learning Approach.

Zhi-Yao Tian, Long Qian, Lei Fang, Xue-Hua Peng, Xiao-Hu Zhu, Min Wu, Wen-Zhi Wang, Wen-Han Zhang, Bai-Qi Zhu, Miao Wan, Xin Hu, Jianbo Shao,

The application of resting state functional MRI (RS-fMRI) in Parkinson's disease (PD) was widely performed using standard statistical tests, however, the machine learning (ML) approach has not yet been investigated in PD using RS-fMRI. In current study, we utilized the mean regional amplitude values as the features in patients with ... Read more >>

Neuroscience (Neuroscience)
[2020, 436:170-183]

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Regional heterogeneities of health literacy in China: a population-based study

Zhenhua Li, Yongquan Tian, Shuiyuan Xiao, Zhicheng Gong, Long Qian,

Abstract Background: Few studies described the geographic variations of health literacy in China. This study aimed to investigate the regional heterogeneities of health literacy level in Chinese population, in order to formulate targeted health literacy promotion strategies in different economic and cultural contexts.Methods: Multi-stage stratification, clustering, and random sampling methods ... Read more >>

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Temperature modulating sand-consolidating cyanobacterial biomass, nutrients removal and bacterial community dynamics in municipal wastewater.

Li Wu, Long Qian, Zhikang Deng, Xiaolong Zhou, Bolin Li, Shubin Lan, Lie Yang, Zulin Zhang,

Cultivating sand-consolidating cyanobacteria using wastewater has unique advantages on both nutrients recycling and ecological restoration by transferring excessive nutrients from wastewaters to desert areas. Although previous study showed that sand-consolidating cyanobacterium well adapted to synthetic domestic wastewater, no study has been carried out on actual wastewater. This study aims to ... Read more >>

Bioresour. Technol. (Bioresource technology)
[2020, 301:122758]

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Topological changes in white matter connectivity network in patients with Parkinson's disease and depression.

Xiao Hu, Long Qian, Yaoyu Zhang, Yuanyuan Xu, Li Zheng, Yijun Liu, Xiangrong Zhang, Yi Zhang, Weiguo Liu,

Depression is the most common non-motor symptom accompanying Parkinson's disease (PD) with high prevalence but unclear pathophysiological mechanism. Relatively little is known about the topological patterns of white matter structural networks in depressed patients with PD. In this study, we used diffusion-tensor imaging (DTI) and graph theory approaches to explore ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
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CTLA4 blockade promotes vessel normalization in breast tumors via the accumulation of eosinophils.

Xichen Zheng, Naidong Zhang, Long Qian, Xuexiang Wang, Peng Fan, Jiajie Kuai, Siyang Lin, Changpeng Liu, Wen Jiang, Songbing Qin, Haifeng Chen, Yuhui Huang,

Immune checkpoint blockade (ICB) has shown long-term survival benefits, but only in a small fraction of cancer patients. Recent studies suggest that improved vessel perfusion by ICB positively correlates with its therapeutic outcomes. However, the underlying mechanism of such a process remains unclear. Here, we show that anti-cytotoxic T-lymphocyte-associated protein ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, 146(6):1730-1740]

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SPION decorated exosome delivery of TNF-α to cancer cell membranes through magnetism.

Manjiao Zhuang, Xuelian Chen, Dan Du, Jiamei Shi, Mian Deng, Qian Long, Xiaofei Yin, Yayu Wang, Lei Rao,

Tumor necrosis factor (TNF-α) is capable of inducing apoptosis and is a promising candidate for genetic engineering drugs in cancer therapy; however, the serious side-effects of TNF-α hinder their clinical application. In the present study, a method for preparing fusion proteins of cell-penetrating peptides (CPP) and TNF-α (CTNF-α)-anchored exosomes coupled ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(1):173-188]

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Prognostic value of interim 18F-FDG PET/CT in T-cell lymphomas.

Long Qian, Miaoming Yan, Wei Zhang, Daobin Zhou, Yan Zhang, Li Huo, Yaping Luo, Yingqiang Zhang, Shaoxuan Hu,

18F-FDG PET/CT is recommended for staging and response assessment in FDG-avid lymphomas, such as HL and DLBCL. But evidence of PET/CT regarding T-cell lymphomas (TCLs) was limited. In this retrospective study, we conducted survival analysis using interim PET/CT in 51 TCLs patients. PET/CT were reported using the Deauville 5-point score ... Read more >>

Leuk. Lymphoma (Leukemia & lymphoma)
[2020, 61(4):927-933]

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SPION-Decorated Exosome Delivered BAY55-9837 Targeting the Pancreas through Magnetism to Improve the Blood GLC Response.

Manjiao Zhuang, Dan Du, Lingling Pu, Haixing Song, Mian Deng, Qian Long, Xiaofei Yin, Yayu Wang, Lei Rao,

BAY55-9837, a potential therapeutic peptide in the treatment of type 2 diabetes mellitus (T2DM), is capable of inducing glucose (GLC)-dependent insulin secretion. However, the therapeutic benefit of BAY55-9837 is limited by its short half-life, lack of targeting ability, and poor blood GLC response. How to improve the blood GLC response ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2019, 15(52):e1903135]

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Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma.

Jie Wei, Zhijie Xu, Xi Chen, Xiang Wang, Shuangshuang Zeng, Long Qian, Xue Yang, Chunlin Ou, Wei Lin, Zhicheng Gong, Yuanliang Yan,

The gasdermin (GSDM) superfamily has been demonstrated to consist of several important molecules that modulate multifunctional signal processes, such as cell pyroptosis. In this research, the roles of the GSDM superfamily on the occurrence and prognosis of lung adenocarcinoma (LUAD) were evaluated using integrative bioinformatic analyses and in vitro methods. Here, ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2020, 21(1):360-370]

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Corrigendum: SCD1 Confers Temozolomide Resistance to Human Glioma Cells Via the Akt/GSK3β/β-Catenin Signaling Axis.

Shuang Dai, Yuanliang Yan, Zhijie Xu, Shuangshuang Zeng, Long Qian, Lei Huo, Xuejun Li, Lunquan Sun, Zhicheng Gong,

[This corrects the article DOI: 10.3389/fphar.2017.00960.]. ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:1358]

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Prevalence and risk factors for postpartum depression in Sri Lanka: A population-based study.

Qiping Fan, Qian Long, Vijitha De Silva, Nishan Gunarathna, Upul Jayathilaka, Thushani Dabrera, Henry Lynn, Truls Østbye,

BACKGROUND:Previous studies in Sri Lanka have shown a high prevalence of postpartum depression (PPD). Postpartum depression screening using the Edinburgh Postnatal Depression Scale (EPDS) has been validated and included in routine postnatal care in 2012. OBJECTIVES:This study aimed to estimate the prevalence of PPD at 10 days and 4 weeks ... Read more >>

Asian J Psychiatr (Asian journal of psychiatry)
[2020, 47:101855]

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Non-invasive assessment of early stage diabetic nephropathy by DTI and BOLD MRI.

You-Zhen Feng, Yao-Jiang Ye, Zhong-Yuan Cheng, Jun-Jiao Hu, Chuang-Biao Zhang, Long Qian, Xiao-Hua Lu, Xiang-Ran Cai,

OBJECTIVE:Patients with diabetes mellitus, diabetic nephropathy (DN) and healthy donor were analyzed to test whether the early DN patients can be detected using both blood oxygenation level dependent (BOLD) and diffusion tensor imaging. METHODS:This study was approved by the Ethics Committee of our hospital. MR images were acquired on a ... Read more >>

Br J Radiol (The British journal of radiology)
[2020, 93(1105):20190562]

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Radiofrequency ablation versus laparoscopic hepatectomy for hepatocellular carcinoma: A real world single center study.

Yang-Xun Pan, Qian Long, Min-Jiang Yi, Jin-Bin Chen, Jian-Cong Chen, Yao-Jun Zhang, Li Xu, Min-Shan Chen, Zhong-Guo Zhou,

BACKGROUND:Both radiofrequency ablation (RFA) and laparoscopic hepatectomy (LH) are minimally invasive approach for hepatocellular carcinoma (HCC) at early stage. This study aimed to compare the efficacy of RFA and LH for treating HCC with a large cohort. METHODS:From March 2014 to July 2016, 477 patients who underwent RFA (n = 314) or ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2020, 46(4 Pt A):548-559]

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