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Bupivacaine inhibits the malignant biological behavior of oral squamous cell carcinoma cells by inhibiting the activation of ERK1/2 and STAT3.

Zhongchao Wang, Jie Zhang, Yongmei Wen, Pin Wang, Liyuan Fan,

<h4>Background</h4>Oral squamous cell carcinoma (OSCC) is an aggressive malignant tumor. Bupivacaine (Bupi), a local anesthetic drug, has been shown to display anti-tumor activity against a variety of tumors.<h4>Methods</h4>We selected OSCC CAL-27 cells as the <i>in vitro</i> model. Cell toxicity, proliferation, apoptosis, and stemness were conducted, respectively. The protein levels of ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2021, 9(10):839]

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Analysis of 12 GWAS-Linked Loci With Parkinson's Disease in the Chinese Han Population.

Liyuan Fan, Changhe Shi, Xinchao Hu, Zhongxian Zhang, Huimin Zheng, Haiyang Luo, Yu Fan, Shuo Zhang, Zhengwei Hu, Jing Yang, Chengyuan Mao, Yuming Xu,

A recent large-scale European-originated genome-wide association study identified 38 novel independent risk signals in 37 loci for Parkinson's disease (PD). However, whether these new loci are associated with PD in Asian populations remains elusive. The present study aimed to explore the relationship between the 12 most relevant loci with larger ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:623913]

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Generation of induced pluripotent stem cell line (ZZUi0021-A) from a patient with spinocerebellar ataxia type 19.

Fen Liu, Yu Fan, Liyuan Fan, Mengjie Li, Qimeng Zhang, Chengyuan Mao, Jun Wu, Shuo Zhang, Zhengwei Hu, Changhe Shi, Yuming Xu,

Spinocerebellar ataxia type 19 (SCA19) is an extremely rare autosomal dominant cerebellar ataxia hereditary that caused by the KCND3 gene mutation. And has a complex pathogenesis. At present, its pathogenesis is still unclear, and there is no effective treatment for SCA19. So, to study its pathogenesis and find effective treatments, ... Read more >>

Stem Cell Res (Stem cell research)
[2021, 53:102320]

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Neuroinflammation in Parkinson's Disease: Triggers, Mechanisms, and Immunotherapies.

Tai Wang, Changhe Shi, Haiyang Luo, Huimin Zheng, Liyuan Fan, Mibo Tang, Yun Su, Jing Yang, Chengyuan Mao, Yuming Xu,

Parkinson's disease (PD) is a heterogeneous neurodegenerative disease involving multiple etiologies and pathogenesis, in which neuroinflammation is a common factor. Both preclinical experiments and clinical studies provide evidence for the involvement of neuroinflammation in the pathophysiology of PD, although there are a number of key issues related to neuroinflammatory processes ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421991066]

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Generation of an induced pluripotent stem cell line (ZZUi022-A) from a paroxysmal kinesigenic dyskinesia individual carrying the PRRT2 gene mutation.

Liyuan Fan, Chengyuan Mao, Changhe Shi, Yu Fan, Fen Liu, Huimin Zheng, Yun Su, Han Liu, Yanlin Wang, Yu-Tao Liu, Jing Yang, Yuming Xu,

Paroxysmal kinesigenic dyskinesia (PKD), the most common type of paroxysmal movement disorders, is caused by mutations in PRRT2 gene. We identified an unreported PRRT2 c. 535 C > T (p. Q 1 7 9 *) pathogenic mutation in a Chinese Han family with PKD and generated an induced pluripotent stem cell (iPSC) ... Read more >>

Stem Cell Res (Stem cell research)
[2021, 51:102210]

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CHIP protects against MPP+/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease.

Zhengwei Hu, Chengyuan Mao, Hui Wang, Zhongxian Zhang, Shuo Zhang, Haiyang Luo, Mibo Tang, Jing Yang, Yanpeng Yuan, Yanlin Wang, Yutao Liu, Liyuan Fan, Qimeng Zhang, Dabao Yao, Fen Liu, Jonathan C Schisler, Changhe Shi, Yuming Xu,

Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD). Carboxyl terminus of Hsp70-interacting protein (CHIP) is a key regulator of mitochondrial dynamics, and mutations in CHIP or deficits in its expression have been associated with various neurological diseases. This study explores the protective role of CHIP in ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(1):1458-1472]

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α-Synuclein in Parkinson's Disease: Does a Prion-Like Mechanism of Propagation from Periphery to the Brain Play a Role?

Huimin Zheng, Changhe Shi, Haiyang Luo, Liyuan Fan, Zhihua Yang, Xinchao Hu, Zhongxian Zhang, Shuo Zhang, Zhengwei Hu, Yu Fan, Jing Yang, Chengyuan Mao, Yuming Xu,

Parkinson's disease (PD) is one of the most common neurodegenerative diseases, defined as motor and non-motor symptoms associated with the loss of dopaminergic neurons and a decreased release of dopamine (DA). Currently, PD patients are believed to have a neuropathological basis denoted by the presence of Lewy bodies (LBs) or ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, 27(4):367-387]

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Correction to: Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis.

Liyuan Fan, Qiang Cao, Jia Liu, Junpeng Zhang, Baosheng Li,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

Mol Cancer (Molecular cancer)
[2020, 19(1):113]

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Radiotranscriptomics signature-based predictive nomograms for radiotherapy response in patients with nonsmall cell lung cancer: Combination and association of CT features and serum miRNAs levels.

Liyuan Fan, Qiang Cao, Xiuping Ding, Dongni Gao, Qiwei Yang, Baosheng Li, Baosheng Li,

<h4>Purpose</h4>We aimed to establish radiotranscriptomics signatures based on serum miRNA levels and computed tomography (CT) texture features and develop nomogram models for predicting radiotherapy response in patients with nonsmall cell lung cancer (NSCLC).<h4>Methods</h4>We first used established radioresistant NSCLC cell lines for miRNA selection. At the same time, patients (103 for ... Read more >>

Cancer Med (Cancer medicine)
[2020, 9(14):5065-5074]

Cited: 2 times

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Modeling Parkinson's Disease Using Induced Pluripotent Stem Cells.

Xinchao Hu, Chengyuan Mao, Liyuan Fan, Haiyang Luo, Zhengwei Hu, Shuo Zhang, Zhihua Yang, Huimin Zheng, Huifang Sun, Yu Fan, Jing Yang, Changhe Shi, Yuming Xu,

Parkinson's disease (PD) is the second most common neurodegenerative disease. The molecular mechanisms of PD at the cellular level involve oxidative stress, mitochondrial dysfunction, autophagy, axonal transport, and neuroinflammation. Induced pluripotent stem cells (iPSCs) with patient-specific genetic background are capable of directed differentiation into dopaminergic neurons. Cell models based on ... Read more >>

Stem Cells Int (Stem cells international)
[2020, 2020:1061470]

Cited: 8 times

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Using Real-world Historical Controls to Evaluate Radiation Dose Escalation in Esophageal Cancer.

Liyuan Fan, Baosheng Li, Chen Hu,

JAMA Oncol (JAMA oncology)
[2020, 6(4):583]

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Association analysis of 15 GWAS-linked loci with Parkinson's disease in Chinese Han population.

Xinchao Hu, Chengyuan Mao, Zhengwei Hu, Zhongxian Zhang, Shuo Zhang, Zhihua Yang, Yu Fan, Liyuan Fan, Huimin Zheng, Jing Yang, Yutao Liu, Yanpeng Yuan, Yaohe Wang, Changhe Shi, Yuming Xu,

Genetic factors play an important role in Parkinson's disease (PD) and vary from different races. A previous genome-wide association study (GWAS) identified 17 novel risk loci that were associated with PD in Caucasians. Several subsequent studies investigated the association between these loci and PD in Chinese populations. However, the results ... Read more >>

Neurosci Lett (Neuroscience letters)
[2020, 725:134867]

Cited: 1 time

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Aberrant miR-1246 expression promotes radioresistance in non-small cell lung cancer: a potential prognostic biomarker and radiotherapy sensitization target.

Liyuan Fan, Juan Wang, Qiang Cao, Xiuping Ding, Baosheng Li,

Radiosensitivity varies among patients with non-small cell lung cancer (NSCLC). In this work, we aimed to investigate microRNAs associated with this heterogeneity among individuals. We selected miR-1246 from the microRNAs that were revealed by microarray experiments to be differentially expressed between radioresistant and parental cell lines. Both intracellular and extracellular ... Read more >>

Am J Cancer Res (American journal of cancer research)
[2020, 10(1):314-335]

Cited: 4 times

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Coronin3 Promotes Nasopharyngeal Carcinoma Migration And Invasion By Induction Of Epithelial-To-Mesenchymal Transition.

Liyuan Fan, Yumei Wei, Xiuping Ding, Baosheng Li, Baosheng Li,

Purpose:Coronin3 is a cytoskeletal protein that has been implicated in metastasis in many cancer types. Here, we demonstrate its effect in nasopharyngeal carcinoma (NPC) and propose a new probable mechanism of CORO1C-mediated cell migration and invasion by regulation of epithelial-to-mesenchymal transition (EMT) and CDH11. Patients and methods:First, we measured the ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2019, 12:9585-9598]

Cited: 3 times

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Correction to: Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis.

Liyuan Fan, Qiang Cao, Jia Liu, Junpeng Zhang, Baosheng Li,

After publication of the article [1], the author reported that this article contained error. In Funding section, the funding number provided 2016YFC0105100 should have been 2016YFC0105106. ... Read more >>

Mol Cancer (Molecular cancer)
[2019, 18(1):121]

Cited: 1 time

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The role of non-covalent interactions in the alkaline dissolution of heat-set whey protein hydrogels made at gelation pH 2–11

Liyuan Fan, Anlei Ge, Ruben Mercadé-Prieto, Xiao Dong Chen,

The alkaline dissolution of protein hydrogels occurs during the cleaning of protein-rich fouling deposits common in the food industry, as in the cleaning of whey protein deposits in dairy processing. Here we seek to identify which are the dissolution rate limiting mechanisms by systematically studying whey protein isolate (WPI) heat-set ... Read more >>

(Food hydrocolloids.)
[2019, 89:100-110]

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On the nature of the optimum cleaning concentration for dairy fouling: High NaOH concentrations inhibit the cleavage of non-covalent interactions in whey protein aggregates

Liyuan Fan, Ruben Mercadé-Prieto, Xiao Dong Chen,

The dairy industry has long known that highly concentrated alkaline solutions should not be used to clean whey protein rich fouling deposits. At >0.1 mol L−1 NaOH dissolution and cleaning rates decrease markedly to very low values, particularly at low-mid temperatures. It is shown here that it is caused by ... Read more >>

Lebensm Wiss Technol (Lebensmittel-Wissenschaft + [i.e. und] Technologie.)
[2019, 101:519-525]

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Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis.

Liyuan Fan, Qiang Cao, Jia Liu, Junpeng Zhang, Baosheng Li,

Esophageal squamous cell cancer (ESCC) is a high incidence and mortality disease worldwide. However, specificity and sensitivity of its diagnostic and prognostic biomarkers are still unsatisfactory. Recently, circular RNAs (circRNAs) as biomarkers have been studied extensively while the expression profile and clinical significance of circRNAs in ESCC have rarely been ... Read more >>

Mol Cancer (Molecular cancer)
[2019, 18(1):16]

Cited: 36 times

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New Insights Into the Pathogenesis of Alzheimer's Disease.

Liyuan Fan, Chengyuan Mao, Xinchao Hu, Shuo Zhang, Zhihua Yang, Zhengwei Hu, Huifang Sun, Yu Fan, Yali Dong, Jing Yang, Changhe Shi, Yuming Xu,

Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most prevalent cause of dementia, is characterized by progressive cognitive impairment. The prevalence of AD continues to increase worldwide, becoming a great healthcare challenge of the twenty-first century. In the more than 110 years since AD was discovered, ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:1312]

Cited: 21 times

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Magnetic resonance imaging (MRI) to quantify the swelling and drying of whey protein hydrogels

Liyuan Fan, Jinxin Yang, Roger Armengol Casali, Ruben Mercadé-Prieto, Xiao Dong Chen, Xin Jin,

Magnetic resonance imaging (MRI) is a very powerful technique increasingly used in food engineering, yet examples where the local water content is quantified are scarce. Homogeneous whey protein hydrogels were utilized as a model system, far simpler than most foods. The normalized proton density intensity of hydrogels was predicted using ... Read more >>

(Journal of food engineering.)
[2017, 214:97-103]

Cited: 1 time

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[Therapeutic effect of enhancer of Zeste homolog 2 inhibitor GSK343 on periodontitis by regulating macrophage differentiation].

Wang Zhongchao, Fan Liyuan, Tan Dan, Zhou Cong, Luo Shijun,

<h4>Objective</h4>To explore the therapeutic effect of enhancer of Zeste homolog 2 (EZH2) inhibitor GSK343 on periodontitis by regulating microphage differentiation.<h4>Methods</h4>Macrophage RAW264.7 cells were divided into the blank (A group), control (B group), lipopolysaccharide (LPS) stimulation (C group), and LPS+GSK343 (D group) groups. Phenotype transformations was determined through Western blot analysis ... Read more >>

Hua Xi Kou Qiang Yi Xue Za Zhi (Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology)
[2017, 35(3):264-268]

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Synthetic treatment of intracranial peripheral primitive neuroectodermal tumor with multiple metastasis: a case report.

Yang Zhang, Hongsheng Li, Zongjuan Li, Ming Liu, Linke Yang, Liyuan Fan, Chengsuo Huang, Baosheng Li,

Ewing sarcomas (ES) and peripheral primitive neuroectodermal tumors (pPNET) are now thought to belong to the same tumor family. Ewing sarcoma family tumor (ESFT) members commonly originate in bones and soft tissues. However, a few published articles describe ESFT arising from cranial cavities. Pathologically, ES/pPNET are composed of small round ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2016, 9:3327-3333]

Cited: 1 time

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A method for synthesis of homoallylic bromide.

Wenke Qi, Peipei Wang, Liyuan Fan, Songlin Zhang,

Cyclopropyl Grignard reagents react with carbonyl compounds in the presence of diethyl phosphite to give homoallylic bromides. The reaction is effectively carried out under mild conditions in a one-pot fashion with moderate to good yields. ... Read more >>

J Org Chem (The Journal of organic chemistry)
[2013, 78(12):5918-5924]

Cited: 1 time

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An efficient synthetic method for allyl-epoxides via allylation of α-haloketones or esters with allylmagnesium bromide.

Liyuan Fan, Min Zhang, Songlin Zhang,

A simple, efficient, and non-metal-catalyzed synthetic method for allyl-epoxides and diallyl-epoxides by allylation of α-haloketones and esters with allylmagnesium bromide in mild conditions is reported in this article. It inherited some advantages of the organomagnesium reagents such as availability, operational simplicity and low toxicity. ... Read more >>

Org Biomol Chem (Organic & biomolecular chemistry)
[2012, 10(16):3182-3184]

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