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Opposite effects of miR-155 in the initial and later stages of lipopolysaccharide (LPS)-induced inflammatory response.

Yuhua Liu, Xiaopeng Wan, Yuan Yuan, Jingjing Huang, Yijia Jiang, Kaiyue Zhao, Yan Wang, Yang Liu, Qingqing Wang, Hongchuan Jin,

Although microRNA-155 (miR-155) is considered a pro-inflammatory mediator, cumulative evidence indicates that it also has anti-inflammatory effects in macrophages and dendritic cells. In this study, we identified the dramatic expression changes of more than half of potential miR-155-targeted genes upon lipopolysaccharide (LPS) stimulation; 223 genes were down-regulated and 85 genes ... Read more >>

J Zhejiang Univ Sci B (Journal of Zhejiang University. Science. B)
[2021, 22(7):590-598]

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Development of a pyrF-based counterselectable system for targeted gene deletion in Streptomyces rimosus.

Yiying Yang, Qingqing Sun, Yang Liu, Hanzhi Yin, Wenping Yang, Yang Wang, Ying Liu, Yuxian Li, Shen Pang, Wenxi Liu, Qian Zhang, Fang Yuan, Shiwen Qiu, Jiong Li, Xuefeng Wang, Keqiang Fan, Weishan Wang, Zilong Li, Shouliang Yin,

<i>Streptomyces</i> produces many valuable and important biomolecules with clinical and pharmaceutical applications. The development of simple and highly efficient gene editing tools for genetic modification of <i>Streptomyces</i> is highly desirable. In this study, we developed a screening system for targeted gene knockout using a uracil auxotrophic host (Δ<i>pyrF</i>) resistant to ... Read more >>

J Zhejiang Univ Sci B (Journal of Zhejiang University. Science. B)
[2021, 22(5):383-396]

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Quasispecies of SARS-CoV-2 revealed by single nucleotide polymorphisms (SNPs) analysis.

Rongsui Gao, Wenhong Zu, Yang Liu, Junhua Li, Zeyao Li, Yanling Wen, Haiyan Wang, Jing Yuan, Lin Cheng, Shengyuan Zhang, Yu Zhang, Shuye Zhang, Weilong Liu, Xun Lan, Lei Liu, Feng Li, Zheng Zhang,

New SARS-CoV-2 mutants have been continuously indentified with enhanced transmission ever since its outbreak in early 2020. As an RNA virus, SARS-CoV-2 has a high mutation rate due to the low fidelity of RNA polymerase. To study the single nucleotide polymorphisms (SNPs) dynamics of SARS-CoV-2, 158 SNPs with high confidence ... Read more >>

Virulence (Virulence)
[2021, 12(1):1209-1226]

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Synthesis, biological activities and docking studies of pleuromutilin derivatives with piperazinyl urea linkage.

Yuanyuan Zhang, Chuan Xie, Yang Liu, Feng Shang, Rushiya Shao, Jing Yu, Chunxia Wu, Xinghui Yao, Dongfang Liu, Zhouyu Wang,

Antibiotics resistance is becoming increasingly common, involving almost all antibiotics on the market. Diseases caused by drug resistant bacteria, such as MRSA, have high mortality and negatively affect public health. The development of new drugs would be an effective means of solving this problem. Modifications based on bioactive natural products ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):764-775]

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Identification of IGF2BP1-related lncRNA-miRNA-mRNA network in goat skeletal muscle satellite cells.

Xiaoli Xu, Junchen Leng, Xiao Zhang, Terence D Capellini, Yuan Chen, Liu Yang, Zitong Chen, Shuailong Zheng, Xujia Zhang, Siyuan Zhan, Linjie Wang, Tao Zhong, Jiazhong Guo, Lili Niu, Yan Wang, Dinghui Dai, Hongping Zhang, Li Li, Jiaxue Cao,

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) plays essential roles in the proliferation of skeletal muscle satellite cells (MuSCs). Increasing evidence has shown that IGF2BP1 regulates the expression of noncoding RNAs and mRNAs. However, the related molecular network remains to be fully understood. Therefore, we performed RNA sequencing and ... Read more >>

Anim Sci J (Animal science journal = Nihon chikusan Gakkaiho)
[2021, 92(1):e13631]

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M2 subtype tumor associated macrophages (M2-TAMs) infiltration predicts poor response rate of immune checkpoint inhibitors treatment for prostate cancer.

Zhou JiaWei, Dou ChunXia, Liu CunDong, Liu Yang, Yang JianKun, Duan HaiFeng, Yang Cheng, Huang ZhiPeng, Wang HongYi, Liao DeYing, Liang ZhiJian, Xie Xiao, Zhou QiZhao, Xue KangYi, Guo WenBing, Xia Ming, Zhou JunHao, Bao JiMing, Zhao ShanChao, Chen MingKun,

<h4>Background</h4>Prostate cancer (PCa) is poor response to the immunotherapy for its high heterogeneity of immune microenvironment. In this study, we aim to introduce a new immune subtype for PCa involving M2 tumour associated macrophages <b>(</b>M2-TAMs).<h4>Methods</h4>Three hundred and sixty-two PCa patients and matched normal prostate tissues were selected from the Cancer ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):730-740]

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Glucagon-like peptide (GLP) -2 improved colonizing bacteria and reduced severity of ulcerative colitis by enhancing the diversity and abundance of intestinal mucosa.

Dongyue Li, Youlin Yang, Xunhai Yin, Yang Liu, Hongyu Xu, Yu Ni, Ping Hang, Sijia Niu, Huichao Zhang, Wenbo Ding, Hongyu Kuang,

The global incidence of ulcerative colitis (UC) continues to increase while it's clinical cure rate remains low. Intestinal mucosal ulcers have segmental distribution and variable severity. Intestinal bacteria are closely related to intestinal immunity and metabolism; however, the relationship between intestinal microbiome profile and the occurrence of UC, as well ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):5195-5209]

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Silencing of let-7b-5p inhibits ovarian cancer cell proliferation and stemness characteristics by Asp-Glu-Ala-Asp-box helicase 19A.

Xiujuan Huang, Hongxia Dong, Yang Liu, Fen Yu, Shunshi Yang, Zhen Chen, Jueying Li,

The emergence and recurrence of ovarian cancer are associated with ovarian cancer stem cells. For cancer treatment, gene delivery of microbubbles (MB)-mediated microRNA (miRNA) is considered as a promising approach. In this study, our aim is to investigate the effects of MB-mediated let-7b-5p inhibitor on the proliferation and stemness characteristics ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):7666-7677]

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MicroRNA miR-502-5p inhibits ovarian cancer genesis by downregulation of GINS complex subunit 2.

Lili Zhan, Jing Yang, Yang Liu, Yanxiang Cheng, Hua Liu,

Ovarian cancer (OC) is one of the most common malignancies with high incidence and mortality and the eighth most common cancer-associated mortality in women worldwide. Aberrant expression of the GINS complex subunit 2 (GINS2) gene and miR-502-5p has been associated with cancer progression. This study aims to investigate the specific ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3336-3347]

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Effect of 3 NR3C1 Mutations in the Pathogenesis of Pituitary ACTH Adenoma.

Hui Miao, Yang Liu, Lin Lu, Fengying Gong, Linjie Wang, Lian Duan, Yong Yao, Renzhi Wang, Shi Chen, Xinxin Mao, Dongyun Zhang, Anthony P Heaney, Huijuan Zhu,

<h4>Context</h4>Glucocorticoids act through the glucocorticoid receptor (GR) encoded by the nuclear receptor subfamily 3 group C member 1 (NR3C1) gene.<h4>Objective</h4>This study aimed to examine the function of NR3C1 variants and their possible pathogenic role in Cushing disease (CD).<h4>Methods</h4>Next-generation sequencing was conducted in 49 CD patients. Corticotroph tumor GR protein expression ... Read more >>

Endocrinology (Endocrinology)
[2021, 162(11):]

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Evaluation of paraprobiotic applicability of Clostridium butyricum CBG01 in improving the growth performance, immune responses and disease resistance in Pacific white shrimp, Penaeus vannamei

Kai Luo, Xiangli Tian, Bo Wang, Cong Wei, Longbin Wang, Shengkun Zhang, Yang Liu, Tengfei Li, Shuanglin Dong,

The present study evaluated the growth performance, non-specific immunity and disease resistance in Penaeus vannamei fed diets supplemented with live or dead cells of Clostridium butyricum CBG01 (live cells, CB; sonication-killed cell-free extracts, UI; heat-killed whole-cell, HI; fermentation supernatant, FS; the control, the basal diet without C. butyricum, DZ) for ... Read more >>

Aquaculture (Aquaculture (Amsterdam, Netherlands))
[2021, 544:Not Available]

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SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation

Gang Xu, Ying Li, Shengyuan Zhang, Haoran Peng, Yunyun Wang, Dekang Li, Taijie Jin, Zhuohao He, Yilun Tong, Chunting Qi, Guowei Wu, Kangyun Dong, Jizhou Gou, Yang Liu, Tongyang Xiao, Jing Qu, Liang Li, Liang Liu, Ping Zhao, Zheng Zhang, Junying Yuan,

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the ongoing global pandemic that poses substantial challenges to public health worldwide. A subset of COVID-19 patients experience systemic inflammatory response, known as cytokine storm, which may lead to death. Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is ... Read more >>

Cell Res (Cell research)
[2021, :1-14]

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Dietary patterns and their associations with overweight/obesity among preschool children in Dongcheng District of Beijing: a cross-sectional study.

Kaiyuan Min, Jing Wang, Wei Liao, Thomas Astell-Burt, Xiaoqi Feng, Shuya Cai, Yang Liu, Peiwen Zhang, Fenghua Su, Kexin Yang, Liang Sun, Juan Zhang, Lianjun Wang, Zechen Liu, Yu Jiang,

<h4>Background</h4>Few studies investigated the associations between dietary patterns and overweight/obesity among Chinese preschool children. Thus, the study aims to explore dietary patterns and their associations with overweight/obesity among preschool children in the Dongcheng District of Beijing.<h4>Methods</h4>With a stratified proportionate cluster sampling, the study included 3373 pairs of preschool children and ... Read more >>

BMC Public Health (BMC public health)
[2021, 21(1):223]

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LncRNA LINC00152 promotes oral squamous cell carcinoma growth via enhancing Upstream Transcription Factor 1 mediated Mitochondrial Ribosomal Protein L52 transcription.

Xiuhe Zou, Xiaokun Hu, Fenghui He, Ming Zhang, Xiangyu Kong, Shu Rui, Yang Liu, Liying Wang, Xun Zheng, Jiaye Liu, Zhihui Li, Han Luo,

LINC00152 (long intergenic non-protein coding RNA 152) was identified as an oncogenic lncRNA in multiple cancers. In the current study, we aimed to explore the transcriptional profile of LINC00152 in oral squamous cell carcinoma (OSCC) and its regulations at the transcriptional level. Bioinformatic analysis was performed by extracting the OSCC ... Read more >>

J Oral Pathol Med (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology)
[2021, :]

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Comparative Proteomics Reveals the Effect of the Transcriptional Regulator Sp13016 on Butenyl-Spinosyn Biosynthesis in Saccharopolyspora pogona.

Jianli Tang, Haocheng He, Yunlong Li, Zhudong Liu, Ziyuan Xia, Li Cao, Zirong Zhu, Ling Shuai, Yang Liu, Qianqian Wan, Yuewen Luo, Youming Zhang, Jie Rang, Liqiu Xia,

Butenyl-spinosyn is a highly effective and broad-spectrum biopesticide produced by Saccharopolyspora pogona. However, the yield of this compound is difficult to increase because the regulatory mechanism of secondary metabolism is still unknown. Here, the transcriptional regulator Sp13016 was discovered to be highly associated with butenyl-spinosyn synthesis and bacterial growth. Overexpression ... Read more >>

J Agric Food Chem (Journal of agricultural and food chemistry)
[2021, :]

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Regulation of root secondary metabolites by partial root-associated microbiotas under the shaping of licorice ecotypic differentiation in northwest China.

Yang Liu, Hao Wang, Ziheng Peng, Da Li, Weimin Chen, Shuo Jiao, Gehong Wei,

It is becoming increasingly evident about interactions between plant hosts and their microbiotas, while the effects of plant communities on microbial communities in different geographic environments are poorly understood. Here, the differentiation of licorice plant ecotypes and the distribution of root-associated microbiotas were investigated across five sampling sites in northwest ... Read more >>

J Integr Plant Biol (Journal of integrative plant biology)
[2021, :]

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Global burden and attributable risk factors of acute lymphoblastic leukemia in 204 countries and territories in 1990-2019: estimation based on Global Burden of Disease Study 2019.

Yuefen Hu, Xiuping Zhang, Aijun Zhang, Yu Hou, Yang Liu, Qizhao Li, Yawen Wang, Yafei Yu, Ming Hou, Jun Peng, Xiaorong Yang, Shuqian Xu,

To provide a foundational guideline for policy-makers to efficiently allocate medical resources in the context of population aging and growth, the latest spatial distribution and temporal trend of acute lymphoblastic leukemia (ALL) along with attributable risk factors by sex and age were mapped. Based on the Global Burden of Disease ... Read more >>

Hematol Oncol (Hematological oncology)
[2021, :]

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SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation.

Gang Xu, Ying Li, Shengyuan Zhang, Haoran Peng, Yunyun Wang, Dekang Li, Taijie Jin, Zhuohao He, Yilun Tong, Chunting Qi, Guowei Wu, Kangyun Dong, Jizhou Gou, Yang Liu, Tongyang Xiao, Jing Qu, Liang Li, Liang Liu, Ping Zhao, Zheng Zhang, Junying Yuan,

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the ongoing global pandemic that poses substantial challenges to public health worldwide. A subset of COVID-19 patients experience systemic inflammatory response, known as cytokine storm, which may lead to death. Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is ... Read more >>

Cell Res (Cell research)
[2021, :]

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Irradiation-Induced Nasopharyngeal Necrosis in Newly Diagnosed Nasopharyngeal Carcinoma Treated by Intensity-Modulated Radiation Therapy: Clinical Characteristics and the Influence of Treatment Strategies

Yi Xu, Yang Liu, Zekun Wang, Jingbo Wang, Jianghu Zhang, Xuesong Chen, Runye Wu, Qingfeng Liu, Yuan Qu, Kai Wang, Xiaodong Huang, Jingwei Luo, Li Gao, Guozhen Xu, Ye Zhang, Junlin Yi,

<h4>Purpose: </h4> To define the clinical characteristics of irradiation-induced nasopharyngeal necrosis (INN) after intensity-modulated radiotherapy (IMRT) and identify the influence of treatment strategies on INN in primary nasopharyngeal carcinoma (NPC) patients. Patients and methods: From 2008 to 2019, NPC patients pathologically diagnosed with INN after primary IMRT were reviewed. Those ... Read more >>

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Deficiency of p38α-MAPK in myeloid cells ameliorates symptoms and pathology of APP-transgenic Alzheimer’s disease mice

Qinghua Luo, Laura Schnöder, Wenlin Hao, Kathrin Litzenburger, Yann Decker, Inge Tomic, Michael Menger, Klaus Fassbender, Yang Liu,

Microglial activation is a hall marker of Alzheimer’s disease (AD); its pathogenic role and regulating mechanisms are unclear. In APP-transgenic mice, we deleted p38α-MAPK in the myeloid cell lineage from birth or specifically in microglia from 9 months, and analysed the AD pathology at the age of 4, 9 and ... Read more >>

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DNA methylation-calling tools for Oxford Nanopore sequencing: a survey and human epigenome-wide evaluation.

Yang Liu, Wojciech Rosikiewicz, Ziwei Pan, Nathaniel Jillette, Ping Wang, Aziz Taghbalout, Jonathan Foox, Christopher Mason, Martin Carroll, Albert Cheng, Sheng Li,

Nanopore long-read sequencing technology greatly expands the capacity of long-range, single-molecule DNA-modification detection. A growing number of analytical tools have been developed to detect DNA methylation from nanopore sequencing reads. Here, we assess the performance of different methylation-calling tools to provide a systematic evaluation to guide researchers performing human epigenome-wide ... Read more >>

Genome Biol (Genome biology)
[2021, 22(1):295]

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FDG PET/CT Image of a Solitary Rib Hamartoma.

Liu Xiao, Liu Yang, Lin Li,

Hamartoma of the rib is very rare in adults. Herein, we report a 49-year-old woman who complained of chest pain for 1 month. FDG PET/CT revealed focal osteolytic bone destruction in the right 11th rib with elevated FDG uptake. The postoperative pathology supported the diagnosis of hamartoma. Our case shows ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, :]

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Deep neural network based CEST and AREX processing: Application in imaging a model of Alzheimer's disease at 3 T.

Jianpan Huang, Joseph H C Lai, Kai-Hei Tse, Gerald W Y Cheng, Yang Liu, Zilin Chen, Xiongqi Han, Lin Chen, Jiadi Xu, Kannie W Y Chan,

To optimize and apply deep neural network based CEST (deepCEST) and apparent exchange dependent-relaxation (deepAREX) for imaging the mouse brain with Alzheimer's disease (AD) at 3T MRI. CEST and T1 data of central and anterior brain slices of 10 AD mice and 10 age-matched wild type (WT) mice were acquired ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2021, :]

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Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes.

Tianyu Zheng, Jinrong Huang, Xi Xiang, Siyuan Li, Jiaying Yu, Kunli Qu, Zhe Xu, Peng Han, Zhanying Dong, Yang Liu, Fengping Xu, Huanming Yang, Marja Jäättelä, Yonglun Luo, Bin Liu,

The transcription factor cyclic-AMP response element-binding protein 1 (CREB1) responds to cAMP level and controls the expression of target genes, which regulates nutrition partitioning. The promoters of CREB1-targeted genes responsive to cAMP have been extensively investigated and characterized with the presence of both cAMP response element and TATA box. Compelling ... Read more >>

Cancer Cell Int (Cancer cell international)
[2021, 21(1):530]

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Integrative proteogenomic characterization of early esophageal cancer

Lingling Li, Dongxian Jiang, Qiao Zhang, Hui Liu, Zhaoyu Qin, Fujiang Xu, Dan Shen, Haixing Wang, Chunmei Guo, Jinwen Feng, Yang Liu, Weijie Chen, Xue Zhang, Lin Bai, Sha Tian, Subei Tan, Chen Xu, Qi Song, Yalan Liu, Yunshi Zhong, Tianyin Chen, Pinghong Zhou, Jian-Yuan Zhao, Yingyong Hou, Chen Ding,

We performed a comprehensive multi-omics analysis of 756 trace-tumor-samples from 124 esophageal squamous cell carcinoma phase (ESCC) patients, covering 9 histopathological stages in 3 phases as nontumor phase (NT phase), intraepithelial neoplasia phase (IEN phase), and ESCC phase. Proteogenomics elucidated the stage-specific molecular characterization and defined the cancer-driving waves along ... Read more >>

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