Full Text Journal Articles by
Author Lisa Jane K Graham

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Plasma Cell-Free DNA Profiling of PTEN-PI3K-AKT Pathway Aberrations in Metastatic Castration-Resistant Prostate Cancer.

Edmond M Kwan, Chao Dai, Heidi Fettke, Christine Hauser, Maria M Docanto, Patricia Bukczynska, Nicole Ng, Siavash Foroughi, Lisa-Jane K Graham, Kate Mahon, Winston Tan, Xiaohong Wang, Zhixin Zhao, Tiantian Zheng, Kemin Zhou, Jianjun Yu, Pan Du, Lisa G Horvath, Shidong Jia, Manish Kohli, Arun A Azad,

Tumor tissue from metastatic castration-resistant prostate cancer (mCRPC) harbors frequent copy number variations (CNVs) in the PTEN-PI3K-AKT pathway. However, identifying CNVs in plasma cell-free DNA (cfDNA) has proven to be challenging. With emerging data supporting Akt inhibition in PTEN-deficient mCRPC, we profiled PTEN-PI3K-AKT pathway aberrations in patients with mCRPC using ... Read more >>

JCO Precis Oncol (JCO precision oncology)
[2021, 5:]

Cited: 0 times

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Whole blood GRHL2 expression as a prognostic biomarker in metastatic hormone-sensitive and castration-resistant prostate cancer.

Edmond M Kwan, Heidi Fettke, Megan Crumbaker, Maria M Docanto, Sarah Q To, Patricia Bukczynska, Andrew Mant, Nicole Ng, Siavash Foroughi, Lisa-Jane K Graham, Anne-Maree Haynes, Sarah Azer, Lisi Elizabeth Lim, Eva Segelov, Kate Mahon, Ian D Davis, Phillip Parente, Carmel Pezaro, Tilman Todenhöfer, Niranjan Sathianathen, Christine Hauser, Lisa G Horvath, Anthony M Joshua, Arun A Azad,

<h4>Background</h4>As potent systemic therapies transition earlier in the prostate cancer disease course, molecular biomarkers are needed to guide optimal treatment selection for metastatic hormone-sensitive prostate cancer (mHSPC). The value of whole blood RNA to detect candidate biomarkers in mHSPC remains largely undefined.<h4>Methods</h4>In this cohort study, we used a previously optimised ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(4):1688-1699]

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Combined Cell-free DNA and RNA Profiling of the Androgen Receptor: Clinical Utility of a Novel Multianalyte Liquid Biopsy Assay for Metastatic Prostate Cancer.

Heidi Fettke, Edmond M Kwan, Maria M Docanto, Patricia Bukczynska, Nicole Ng, Lisa-Jane K Graham, Kate Mahon, Christine Hauser, Winston Tan, Xiao Hong Wang, Zhixin Zhao, Tiantian Zheng, Kemin Zhou, Pan Du, Jianjun Yu, Yong Huang, Shidong Jia, Manish Kohli, Lisa G Horvath, Arun A Azad,

<h4>Background</h4>The androgen receptor (AR) remains a critical driver in metastatic castration-resistant prostate cancer (mCRPC). Profiling AR aberrations in both circulating DNA and RNA may identify key predictive and/or prognostic biomarkers in the context of contemporary systemic therapy.<h4>Objective</h4>To profile AR aberrations in circulating nucleic acids and correlate with clinical outcomes.<h4>Design, setting, ... Read more >>

Eur Urol (European urology)
[2020, 78(2):173-180]

Cited: 4 times

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Prognostic Utility of a Whole-blood Androgen Receptor-based Gene Signature in Metastatic Castration-resistant Prostate Cancer.

Edmond M Kwan, Heidi Fettke, Maria M Docanto, Sarah Q To, Patricia Bukczynska, Andrew Mant, David Pook, Nicole Ng, Lisa-Jane K Graham, Stefano Mangiola, Eva Segelov, Kate Mahon, Ian D Davis, Phillip Parente, Carmel Pezaro, Tilman Todenhöfer, Lisa G Horvath, Arun A Azad,

<h4>Background</h4>The treatment paradigm for metastatic castration-resistant prostate cancer (mCRPC) has evolved significantly in recent years. Identifying predictive and/or prognostic biomarkers in the context of this rapidly expanding therapeutic armamentarium remains a pressing and unmet clinical need.<h4>Objective</h4>To develop a prognostic whole-blood gene signature for mCRPC patients.<h4>Design, setting, and participants</h4>As part of ... Read more >>

Eur Urol Focus (European urology focus)
[2021, 7(1):63-70]

Cited: 2 times

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Expression of Androgen Receptor Splice Variant 7 or 9 in Whole Blood Does Not Predict Response to Androgen-Axis-targeting Agents in Metastatic Castration-resistant Prostate Cancer.

Sarah Q To, Edmond M Kwan, Heidi C Fettke, Andrew Mant, Maria M Docanto, Luciano Martelotto, Patricia Bukczynska, Nicole Ng, Lisa-Jane K Graham, Phillip Parente, Carmel Pezaro, Kate Mahon, Lisa Horvath, Tilman Todenhöfer, Arun A Azad,

In 2014, a landmark study was published demonstrating that the expression of androgen receptor splice variant (AR-V) 7 was a negative predictive biomarker for response to abiraterone acetate and enzalutamide in metastatic castration-resistant prostate cancer (mCRPC) patients. However, these results were not supported by the recently reported ARMOR3-SV phase III ... Read more >>

Eur Urol (European urology)
[2018, 73(6):818-821]

Cited: 8 times

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Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3).

Darby G Brooke, Ellen M van Dam, Colin K W Watts, Amanda Khoury, Marie A Dziadek, Hilary Brooks, Lisa-Jane K Graham, Jack U Flanagan, William A Denny,

High-throughput screening of a small-molecule library identified a 5-triazolo-2-arylpyridazinone as a novel inhibitor of the important glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3). Such inhibitors are of interest due to PFKFB3's control of the important glycolytic pathway used by cancer cells to generate ATP. A series of analogues was synthesized to study ... Read more >>

Bioorg Med Chem (Bioorganic & medicinal chemistry)
[2014, 22(3):1029-1039]

Cited: 15 times

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