Full Text Journal Articles by
Author Lisa D Boxer


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MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes.

Lisa D Boxer, William Renthal, Alexander W Greben, Tess Whitwam, Andrew Silberfeld, Hume Stroud, Emmy Li, Marty G Yang, Benyam Kinde, Eric C Griffith, Boyan Bonev, Michael E Greenberg,

Mutations in the methyl-DNA-binding repressor protein MeCP2 cause the devastating neurodevelopmental disorder Rett syndrome. It has been challenging to understand how MeCP2 regulates transcription because MeCP2 binds broadly across the genome and MeCP2 mutations are associated with widespread small-magnitude changes in neuronal gene expression. We demonstrate here that MeCP2 represses ... Read more >>

Mol Cell (Molecular cell)
[2020, 77(2):294-309.e9]

Cited: 11 times

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Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing.

William Renthal, Lisa D Boxer, Sinisa Hrvatin, Emmy Li, Andrew Silberfeld, M Aurel Nagy, Eric C Griffith, Thomas Vierbuchen, Michael E Greenberg,

In females with X-linked genetic disorders, wild-type and mutant cells coexist within brain tissue because of X-chromosome inactivation, posing challenges for interpreting the effects of X-linked mutant alleles on gene expression. We present a single-nucleus RNA sequencing approach that resolves mosaicism by using single-nucleotide polymorphisms in genes expressed in cis ... Read more >>

Nat Neurosci (Nature neuroscience)
[2018, 21(12):1670-1679]

Cited: 32 times

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Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation.

Adam J Rubin, Brook C Barajas, Mayra Furlan-Magaril, Vanessa Lopez-Pajares, Maxwell R Mumbach, Imani Howard, Daniel S Kim, Lisa D Boxer, Jonathan Cairns, Mikhail Spivakov, Steven W Wingett, Minyi Shi, Zhixin Zhao, William J Greenleaf, Anshul Kundaje, Michael Snyder, Howard Y Chang, Peter Fraser, Paul A Khavari,

Chromosome conformation is an important feature of metazoan gene regulation; however, enhancer-promoter contact remodeling during cellular differentiation remains poorly understood. To address this, genome-wide promoter capture Hi-C (CHi-C) was performed during epidermal differentiation. Two classes of enhancer-promoter contacts associated with differentiation-induced genes were identified. The first class ('gained') increased in ... Read more >>

Nat Genet (Nature genetics)
[2017, 49(10):1522-1528]

Cited: 79 times

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Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States.

Hume Stroud, Susan C Su, Sinisa Hrvatin, Alexander W Greben, William Renthal, Lisa D Boxer, M Aurel Nagy, Daniel R Hochbaum, Benyam Kinde, Harrison W Gabel, Michael E Greenberg,

In mammals, the environment plays a critical role inĀ promoting the final steps in neuronal developmentĀ during the early postnatal period. While epigenetic factors are thought to contribute to this process, the underlying molecular mechanisms remain poorly understood. Here, we show that in the brain during early life, the DNA methyltransferase DNMT3A ... Read more >>

Cell (Cell)
[2017, 171(5):1151-1164.e16]

Cited: 67 times

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CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation.

Bryan K Sun, Lisa D Boxer, Julia D Ransohoff, Zurab Siprashvili, Kun Qu, Vanessa Lopez-Pajares, S Tyler Hollmig, Paul A Khavari,

Outward migration of epidermal progenitors occurs with induction of hundreds of differentiation genes, but the identities of all regulators required for this process are unknown. We used laser capture microdissection followed by RNA sequencing to identify calmodulin-like 5 (CALML5) as the most enriched gene in differentiating outer epidermis. CALML5 mRNA ... Read more >>

Genes Dev (Genes & development)
[2015, 29(21):2225-2230]

Cited: 23 times

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A LncRNA-MAF:MAFB transcription factor network regulates epidermal differentiation.

Vanessa Lopez-Pajares, Kun Qu, Jiajing Zhang, Dan E Webster, Brook C Barajas, Zurab Siprashvili, Brian J Zarnegar, Lisa D Boxer, Eon J Rios, Shiying Tao, Markus Kretz, Paul A Khavari,

Progenitor differentiation requires remodeling of genomic expression; however, in many tissues, such as epidermis, the spectrum of remodeled genes and the transcription factors (TFs) that control them are not fully defined. We performed kinetic transcriptome analysis during regeneration of differentiated epidermis and identified gene sets enriched in progenitors (594 genes), ... Read more >>

Dev Cell (Developmental cell)
[2015, 32(6):693-706]

Cited: 82 times

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ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes.

Lisa D Boxer, Brook Barajas, Shiying Tao, Jiajing Zhang, Paul A Khavari,

ZNF750 controls epithelial homeostasis by inhibiting progenitor genes while inducing differentiation genes, a role underscored by pathogenic ZNF750 mutations in cancer and psoriasis. How ZNF750 accomplishes these dual gene regulatory impacts is unknown. Here, we characterized ZNF750 as a transcription factor that binds both the progenitor and differentiation genes that ... Read more >>

Genes Dev (Genes & development)
[2014, 28(18):2013-2026]

Cited: 64 times

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ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation.

George L Sen, Lisa D Boxer, Dan E Webster, Rose T Bussat, Kun Qu, Brian J Zarnegar, Danielle Johnston, Zurab Siprashvili, Paul A Khavari,

Disrupted epidermal differentiation characterizes numerous diseases that impact >25% of the population. In a search for dominant mediators of differentiation, we defined a requirement for ZNF750 in terminal epidermal differentiation. ZNF750 controlled genes mutated in numerous human skin diseases, including FLG, LOR, LCE3B, ALOXE3, and SPINK5. ZNF750 induced progenitor differentiation ... Read more >>

Dev Cell (Developmental cell)
[2012, 22(3):669-677]

Cited: 112 times

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Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

Eriko Michishita, Ronald A McCord, Lisa D Boxer, Matthew F Barber, Tao Hong, Or Gozani, Katrin F Chua,

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2009, 8(16):2664-2666]

Cited: 197 times

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SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

Tiara L A Kawahara, Eriko Michishita, Adam S Adler, Mara Damian, Elisabeth Berber, Meihong Lin, Ron A McCord, Kristine C L Ongaigui, Lisa D Boxer, Howard Y Chang, Katrin F Chua,

Members of the sirtuin (SIRT) family of NAD-dependent deacetylases promote longevity in multiple organisms. Deficiency of mammalian SIRT6 leads to shortened life span and an aging-like phenotype in mice, but the underlying molecular mechanisms are unclear. Here we show that SIRT6 functions at chromatin to attenuate NF-kappaB signaling. SIRT6 interacts ... Read more >>

Cell (Cell)
[2009, 136(1):62-74]

Cited: 547 times

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