Full Text Journal Articles by
Author Lisa Coles

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The association of patient weight and dose of fosphenytoin, levetiracetam, and valproic acid with treatment success in status epilepticus.

Abhishek G Sathe, Jordan J Elm, James C Cloyd, James M Chamberlain, Robert Silbergleit, Jaideep Kapur, Hannah R Cock, Nathan B Fountain, Shlomo Shinnar, Daniel H Lowenstein, Robin A Conwit, Thomas P Bleck, Lisa D Coles,

The Established Status Epilepticus Treatment Trial was a blinded, comparative-effectiveness study of fosphenytoin, levetiracetam, and valproic acid in benzodiazepine-refractory status epilepticus. The primary outcome was clinical seizure cessation and increased responsiveness without additional anticonvulsant medications. Weight-based dosing was capped at 75 kg. Hence, patients weighing >75 kg received a lower mg/kg dose. ... Read more >>

Epilepsia (Epilepsia)
[2020, 61(6):e66-e70]

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Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial.

James M Chamberlain, Jaideep Kapur, Shlomo Shinnar, Jordan Elm, Maija Holsti, Lynn Babcock, Alex Rogers, William Barsan, James Cloyd, Daniel Lowenstein, Thomas P Bleck, Robin Conwit, Caitlyn Meinzer, Hannah Cock, Nathan B Fountain, Ellen Underwood, Jason T Connor, Robert Silbergleit, , ,

BACKGROUND:Benzodiazepine-refractory, or established, status epilepticus is thought to be of similar pathophysiology in children and adults, but differences in underlying aetiology and pharmacodynamics might differentially affect response to therapy. In the Established Status Epilepticus Treatment Trial (ESETT) we compared the efficacy and safety of levetiracetam, fosphenytoin, and valproate in established ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10231):1217-1224]

Cited: 1 time

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Pharmacokinetics, Safety, and Tolerability of Orally Administered Ursodeoxycholic Acid in Patients With Parkinson's Disease-A Pilot Study.

Abhishek G Sathe, Paul Tuite, Chi Chen, Yiwei Ma, Wei Chen, James Cloyd, Walter C Low, Clifford J Steer, Byeong-Yeul Lee, Xiao-Hong Zhu, Lisa D Coles,

Mitochondrial dysfunction is implicated in the pathogenesis of Parkinson's disease. Preliminary data have shown lower brain adenosine triphosphate (ATP) levels in Parkinson's disease versus age-matched healthy controls. Ursodeoxycholic acid (UDCA) may improve impaired mitochondrial function. Our objective was to evaluate UDCA tolerability, pharmacokinetics, and its effect on brain bioenergetics in ... Read more >>

J Clin Pharmacol (Journal of clinical pharmacology)
[2020, 60(6):744-750]

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Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus.

Jaideep Kapur, Jordan Elm, James M Chamberlain, William Barsan, James Cloyd, Daniel Lowenstein, Shlomo Shinnar, Robin Conwit, Caitlyn Meinzer, Hannah Cock, Nathan Fountain, Jason T Connor, Robert Silbergleit, ,

BACKGROUND:The choice of drugs for patients with status epilepticus that is refractory to treatment with benzodiazepines has not been thoroughly studied. METHODS:In a randomized, blinded, adaptive trial, we compared the efficacy and safety of three intravenous anticonvulsive agents - levetiracetam, fosphenytoin, and valproate - in children and adults with convulsive ... Read more >>

N Engl J Med (The New England journal of medicine)
[2019, 381(22):2103-2113]

Cited: 6 times

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Lessons from the Established Status Epilepticus Treatment Trial.

Hannah R Cock, Lisa D Coles, Jordan Elm, Robert Silbergleit, James M Chamberlain, James C Cloyd, Nathan Fountain, Shlomo Shinnar, Dan Lowenstein, Robin Conwit, Thomas P Bleck, Jaideep Kapur,

Convulsive status epilepticus (SE) is a relatively common emergency condition affecting individuals of all ages. The primary goal of treatment is prompt termination of seizures. Where first-line treatment with benzodiazepine has failed to achieve this, a condition known as established SE (ESE), there is uncertainty about which agent to use ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2019, 101(Pt B):106296]

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Underdosing of Benzodiazepines in Patients With Status Epilepticus Enrolled in Established Status Epilepticus Treatment Trial.

Abhishek G Sathe, Holly Tillman, Lisa D Coles, Jordan J Elm, Robert Silbergleit, James Chamberlain, Jaideep Kapur, Hannah R Cock, Nathan B Fountain, Shlomo Shinnar, Daniel H Lowenstein, Robin A Conwit, Thomas P Bleck, James C Cloyd,

Acad Emerg Med (Academic emergency medicine : official journal of the Society for Academic Emergency Medicine)
[2019, 26(8):940-943]

Cited: 0 times

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CPNP 2019 Annual Meeting Poster Abstracts.

(The mental health clinician)
[2019, 9(3):141-257]

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Pilot randomized controlled trial of a Spanish-language Behavioral Activation mobile app (¡Aptívate!) for the treatment of depressive symptoms among united states Latinx adults with limited English proficiency.

Jennifer Dahne, Anahi Collado, C W Lejuez, Cristina M Risco, Vanessa A Diaz, Lisa Coles, Jacob Kustanowitz, Michael J Zvolensky, Matthew J Carpenter,

BACKGROUND:To address the need for disseminable, evidence-based depression treatment options for Latinx adults with limited English proficiency (LEP), our team developed ¡Aptívate!, a Spanish-language Behavioral Activation self-help mobile application. Primary aims of this study were to: 1) examine feasibility and uptake of ¡Aptívate! among depressed Latinx adults with LEP and ... Read more >>

J Affect Disord (Journal of affective disorders)
[2019, 250:210-217]

Cited: 1 time

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Rescue therapies for seizure emergencies: New modes of administration.

Patricia D Maglalang, Davin Rautiola, Ronald A Siegel, Jared M Fine, Leah R Hanson, Lisa D Coles, James C Cloyd,

A subgroup of patients with drug-resistant epilepsy have seizure clusters, which are a part of the continuum of seizure emergencies that includes prolonged episodes and status epilepticus. When the patient or caregiver can identify the beginning of a cluster, the condition is amenable to certain treatments, an approach known as ... Read more >>

Epilepsia (Epilepsia)
[2018, 59 Suppl 2:207-215]

Cited: 4 times

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Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study.

Meral A Tubi, Evan Lutkenhoff, Manuel Buitrago Blanco, David McArthur, Pablo Villablanca, Benjamin Ellingson, Ramon Diaz-Arrastia, Paul Van Ness, Courtney Real, Vikesh Shrestha, Jerome Engel, Paul M Vespa,

OBJECTIVE:Injury severity after traumatic brain injury (TBI) is a well-established risk factor for the development of post-traumatic epilepsy (PTE). However, whether lesion location influences the susceptibility of seizures and development of PTE longitudinally has yet to be defined. We hypothesized that lesion location, specifically in the temporal lobe, would be ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2019, 123:115-121]

Cited: 4 times

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A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics.

Natalie S Schmitz, Linda E Krach, Lisa D Coles, Usha Mishra, Suresh K Agarwal, James C Cloyd, Robert L Kriel,

Abrupt discontinuation of baclofen can result in a potentially severe withdrawal syndrome. The current treatment for baclofen withdrawal is inadequate, resulting in a critical need to develop an alternative method to prevent or treat this withdrawal syndrome.To evaluate the safety profile and pharmacokinetics of oral (PO) and investigational intravenous (IV) ... Read more >>

PM R (PM & R : the journal of injury, function, and rehabilitation)
[2017, 9(8):743-750]

Cited: 3 times

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Intravenous Topiramate: Pharmacokinetics in Dogs with Naturally Occurring Epilepsy.

Irene Vuu, Lisa D Coles, Patricia Maglalang, Ilo E Leppik, Greg Worrell, Daniel Crepeau, Usha Mishra, James C Cloyd, Edward E Patterson,

RATIONALE:Barriers to developing treatments for human status epilepticus include the inadequacy of experimental animal models. In contrast, naturally occurring canine epilepsy is similar to the human condition and can serve as a platform to translate research from rodents to humans. The objectives of this study were to characterize the pharmacokinetics ... Read more >>

(Frontiers in veterinary science)
[2016, 3:107]

Cited: 0 times

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Intravenous Administration of Stable-Labeled N-Acetylcysteine Demonstrates an Indirect Mechanism for Boosting Glutathione and Improving Redox Status.

Jie Zhou, Lisa D Coles, Reena V Kartha, Nardina Nash, Usha Mishra, Troy C Lund, James C Cloyd,

There is an increasing interest in using N-acetylcysteine (NAC) as a treatment for neurodegenerative disorders to increase glutathione (GSH) levels and its redox status. The purpose of this study was to characterize the biosynthesis of NAC to GSH using a novel stable isotope-labeled technique, and investigate the pharmacodynamics of NAC ... Read more >>

J Pharm Sci (Journal of pharmaceutical sciences)
[2015, 104(8):2619-2626]

Cited: 15 times

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Use of IV fosphenytoin pharmacokinetics to determine the loading dose for a clinical trial of canine status epilepticus.

Lisa D Coles, Ilo E Leppik, Edward E Patterson, Zachary Rivers, Usha Mishra, James C Cloyd,

OBJECTIVE: Canine status epilepticus (CSE) has potential as a translational platform to evaluate the safety and efficacy of novel compounds and inform human status epilepticus trials. The aim of this study was to determine the intravenous dose of fosphenytoin (FOS) needed for dogs in a CSE clinical trial to attain ... Read more >>

Epilepsia (Epilepsia)
[2015, 56(6):888-894]

Cited: 1 time

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Canine status epilepticus treated with fosphenytoin: A proof of principle study.

Edward E Patterson, Ilo E Leppik, Lisa D Coles, Michael Podell, Charles H Vite, William Bush, James C Cloyd,

There are a limited number of marketed intravenous antiepileptic drugs (AEDs) available to treat status epilepticus (SE). All were first developed for chronic therapy of epilepsy, not specifically for SE. Epilepsy and canine SE (CSE) occur naturally in dogs, with prevalence, presentation, and percentage of refractory cases similar to human ... Read more >>

Epilepsia (Epilepsia)
[2015, 56(6):882-887]

Cited: 6 times

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A pilot study assessing pharmacokinetics and tolerability of oral and intravenous baclofen in healthy adult volunteers.

Suresh K Agarwal, Robert L Kriel, James C Cloyd, Lisa D Coles, Lisa A Scherkenbach, Michael H Tobin, Linda E Krach,

Our objective was to characterize baclofen pharmacokinetics and safety given orally and intravenously. Twelve healthy subjects were enrolled in a randomized, open-label, crossover study and received single doses of baclofen: 3 or 5 mg given intravenously and 5 or 10 mg taken orally with a 48-hour washout. Blood samples for ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2015, 30(1):37-41]

Cited: 7 times

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Pharmacokinetics and pharmacodynamics of intravenous baclofen in dogs: a preliminary study.

Lisa A Scherkenbach, Lisa D Coles, Edward E Patterson, James C Cloyd, Linda E Krach, Robert L Kriel,

Abrupt discontinuation of baclofen therapy is associated with a clinically serious withdrawal syndrome. Current treatment modalities are often ineffective. Intravenous (IV) baclofen is a potential method for preventing or treating baclofen withdrawal syndrome.To complete a preliminary study of IV baclofen in dogs.Single bolus IV doses (0.5, 2 and 3 mg/kg) ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2014, 66(7):935-942]

Cited: 3 times

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Feasibility study of a caregiver seizure alert system in canine epilepsy.

Lisa D Coles, Edward E Patterson, W Douglas Sheffield, Jaideep Mavoori, Jason Higgins, Bland Michael, Kent Leyde, James C Cloyd, Brian Litt, Charles Vite, Gregory A Worrell,

A device capable of detecting seizures and alerting caregivers would be a major advance for epilepsy management, and could be used to guide early intervention and prevent seizure-related injuries. The objective of this work was to evaluate a seizure advisory system (SAS) that alerts caregivers of seizures in canines with ... Read more >>

Epilepsy Res (Epilepsy research)
[2013, 106(3):456-460]

Cited: 11 times

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Interaction of N-acetylcysteine and cysteine in human plasma.

Kendra K Radtke, Lisa D Coles, Usha Mishra, Paul J Orchard, Mary Holmay, James C Cloyd,

N-acetyl-L-cysteine (NAC), a well-known antioxidant, has been successfully used as adjuvant therapy for late-stage childhood cerebral adrenoleukodystrophy (c-ALD); however, the mechanisms of NAC action are poorly understood. Previous research indicates that NAC serves as a precursor to L-cysteine (Cys), the rate-limiting substrate in the biosynthesis of glutathione (GSH), a potent, ... Read more >>

J Pharm Sci (Journal of pharmaceutical sciences)
[2012, 101(12):4653-4659]

Cited: 11 times

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Clinical tolerance and toxicity of intravenous baclofen: a pilot study in a canine model.

Linda E Krach, Robert L Kriel, Edward E Patterson, Lisa A Scherkenbach, Lisa D Coles, James C Cloyd,

OBJECTIVE: Assess safety and tolerance of intravenous (IV) baclofen using a dog model. DESIGN: Prospective pharmacokinetic study involving 6 adult dogs. Two dogs received baclofen 10 mg oral and IV bolus doses. Subsequent 4 dogs were given IV boluses of 0.5, 1.0 and 1.5 mg/kg followed by constant infusion of ... Read more >>

J Pediatr Rehabil Med (Journal of pediatric rehabilitation medicine)
[2011, 4(2):89-98]

Cited: 5 times

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Canine status epilepticus: a translational platform for human therapeutic trials.

Ilo E Leppik, Edward N Patterson, Lisa D Coles, Elise M Craft, James C Cloyd,

Current treatment of human status epilepticus (SE) relies on drugs developed for chronic treatment of epilepsy. Many potent compounds have been discovered in animal models of SE. But they may never be useful for chronic treatment of epilepsy and thus not available for human use. Naturally occurring canine SE may ... Read more >>

Epilepsia (Epilepsia)
[2011, 52 Suppl 8:31-34]

Cited: 14 times

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Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells (NCI-ADR-RES) and placental cells (JAR).

Lisa D Coles, Insong J Lee, Pamela J Voulalas, Natalie D Eddington,

The effect of progesterone and estrogen treatment on the expression and function of P-glycoprotein (P-gp) was evaluated in JAR cells and a P-gp overexpressing cell line, NCI-ADR-RES. Western blot analysis and real-time Q-PCR were used to evaluate P-gp protein and MDR1 mRNA expression respectively in the cells following incubation with ... Read more >>

Mol. Pharm. (Molecular pharmaceutics)
[2009, 6(6):1816-1825]

Cited: 13 times

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Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice.

Lisa D Coles, Insong J Lee, Hazem E Hassan, Natalie D Eddington,

Efflux transporters such as P-glycoprotein (P-gp) play a critical role in the maternal-to-fetal and blood-to-brain transfer of many drugs. Using a mouse model, the effects of gestational age on P-gp and MRP expression in the placenta and brain were evaluated. P-gp protein levels in the placenta and brain were greater ... Read more >>

J Pharm Sci (Journal of pharmaceutical sciences)
[2009, 98(8):2832-2846]

Cited: 13 times

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Including fathers in preventing non-accidental head injury.

Lisa Coles, Lynne Collins,

Health visitors identified fathers as a marginalised, difficult-to-reach group when aiming for universal implementation of a public health programme to prevent non-accidental head injury (NAHI) in babies. Follow-on research with 30 fathers from disadvantaged backgrounds, including some in prison, explored barriers and facilitating factors to preventing NAHI through focus groups ... Read more >>

Community Pract (Community practitioner : the journal of the Community Practitioners' & Health Visitors' Association)
[2009, 82(4):20-23]

Cited: 2 times

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Prevention of physical child abuse: concept, evidence and practice.

Lisa Coles,

Given a lack of standardised procedures for preventing child abuse, what can be done in terms of thinking and action about the prevention of physical child abuse in health visiting and community practice? This paper reflects on knowledge gained while undertaking case series research into non-accidental head injury (NAHI), qualitative ... Read more >>

Community Pract (Community practitioner : the journal of the Community Practitioners' & Health Visitors' Association)
[2008, 81(6):18-22]

Cited: 0 times

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