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Tuberculosis-Associated Hospitalizations and Deaths after COVID-19 Shelter-In-Place, San Francisco, California, USA.

Janice K Louie, Rocio Agraz-Lara, Laura Romo, Felix Crespin, Lisa Chen, Susannah Graves,

A mandated shelter-in-place and other restrictions associated with the coronavirus disease pandemic precipitated a decline in tuberculosis diagnoses in San Francisco, California, USA. Several months into the pandemic, severe illness resulting in hospitalization or death increased compared with prepandemic levels, warranting heightened vigilance for tuberculosis in at-risk populations. ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(8):2227-2229]

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Reversal of thoracic sympathectomy through robot-assisted microsurgical sympathetic trunk reconstruction with sural nerve graft and additional end-to-side coaptation of the intercostal nerves: A case report.

Tommy Nai-Jen Chang, Bassem W Daniel, Angela Ting-Wei Hsu, Lisa Wen-Yu Chen, Cheyenne Wei-Hsuan Sung, David Chwei-Chin Chuang, Yin-Kai Chao,

Thoracic sympathectomy to treat palmar hyperhidrosis (PH) has widely been performed. Many patients regret the surgery due to compensatory hyperhidrosis (CH), gustatory hyperhidrosis, arrhythmia, hypertension, gastrointestinal disturbances, and emotional distress. Robotic applications in microsurgery are very limited. We report the technique and long-term patient-reported outcomes of bilateral robot-assisted microsurgical sympathetic ... Read more >>

Microsurgery (Microsurgery)
[2021, :]

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Targeting the metabolic vulnerability of acute myeloid leukemia blasts with a combination of venetoclax and 8-chloro-adenosine.

Ralf Buettner, Le Xuan Truong Nguyen, Corey Morales, Min-Hsuan Chen, Xiwei Wu, Lisa S Chen, Dinh Hoa Hoang, Servando Hernandez Vargas, Vinod Pullarkat, Varsha Gandhi, Guido Marcucci, Steven T Rosen,

<h4>Background</h4>BCL-2 inhibition through venetoclax (VEN) targets acute myeloid leukemia (AML) blast cells and leukemic stem cells (LSCs). Although VEN-containing regimens yield 60-70% clinical response rates, the vast majority of patients inevitably suffer disease relapse, likely because of the persistence of drug-resistant LSCs. We previously reported preclinical activity of the ribonucleoside ... Read more >>

J Hematol Oncol (Journal of hematology & oncology)
[2021, 14(1):70]

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Mixed-Halide Triphenyl Methyl Radicals for Site-Selective Functionalization and Polymerization

Lisa Chen, Mona Arnold, Rémi Blinder, Fedor Jelezko, Alexander Kuehne,

<p>Derivatives of the stable, luminescent tris-2,4,6-trichlorophenylmethyl (TTM) radical exhibit unique doublet spin properties that are of interest for applications in optoelectronics, spintronics, and energy storage. However, the synthesis and variety of TTM-type donor-acceptor molecules with high quantum yields are limited by the symmetric chloride decoration and poor reactivity of chlorides ... Read more >>

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The Right Dose: From Phase I to Clinical Practice.

Stefanie L Groenland, Mark J Ratain, Lisa S Chen, Varsha Gandhi,

To realize the full potential of promising new anticancer drugs, it is of paramount importance to administer them at the right dose. The aim of this educational article is to provide several opportunities to optimize anticancer drug dosing, focusing on oral targeted therapies. First, therapeutic drug monitoring can optimize exposure ... Read more >>

Am Soc Clin Oncol Educ Book (American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting)
[2021, 41:92-106]

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Minicell-based fungal RNAi delivery for sustainable crop protection.

Md Tabibul Islam, Zachery Davis, Lisa Chen, Jacob Englaender, Sepehr Zomorodi, Joseph Frank, Kira Bartlett, Elisabeth Somers, Sergio M Carballo, Mark Kester, Ameer Shakeel, Payam Pourtaheri, Sherif M Sherif,

Spray-induced gene silencing (SIGS) using topical dsRNA applications has risen as a promising, target-specific, and environmentally friendly disease management strategy against phytopathogenic fungi. However, dsRNA stability, efficacy, and scalability are still the main constraints facing SIGS broader application. Here we show that Escherichia coli-derived anucleated minicells can be utilized as ... Read more >>

Microb Biotechnol (Microbial biotechnology)
[2021, 14(4):1847-1856]

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Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2-/- Mice.

Bridget L Morse, Lisa Hong Chen, John T Catlow, John K Fallon, Philip C Smith, Kathleen M Hillgren,

The role of organic cation transporter 1 (OCT1) in humans is gaining attention as data emerges regarding its role in physiology, drug exposure, and drug response. OCT1 variants with decreased <i>in vitro</i> function correlate well with altered exposure of multiple OCT1 substrates in variant carriers. In the current research, we ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:631793]

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Room-Temperature Phosphorescence Enabled through Nacre-Mimetic Nanocomposite Design.

Xuyang Yao, Jie Wang, Dejin Jiao, Zizhao Huang, Oumaima Mhirsi, Francisco Lossada, Lisa Chen, Bastian Haehnle, Alexander J C Kuehne, Xiang Ma, He Tian, Andreas Walther,

A generic, facile, and waterborne strategy is introduced to fabricate flexible, low-cost nanocomposite films with room-temperature phosphorescence (RTP) by incorporating waterborne RTP polymers into self-assembled bioinspired polymer/nanoclay nanocomposites. The excellent oxygen barrier of the lamellar nanoclay structure suppresses the quenching effect from ambient oxygen (k<sub>q</sub> ) and broadens the choice ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2021, 33(5):e2005973]

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Robotic-Assisted Peripheral Nerve Surgery: A Systematic Review.

Lisa Wen-Yu Chen, Mei Goh, Raymond Goh, Yin-Kai Chao, Jung-Ju Huang, Wen-Ling Kuo, Cheyenne Wei-Hsuan Sung, Johnny Chuieng-Yi Lu, David Chwei-Chin Chuang, Tommy Nai-Jen Chang,

<h4>Background</h4> Robotic-assisted techniques are a tremendous revolution in modern surgery, and the advantages and indications were well discussed in different specialties. However, the use of robotic technique in plastic and reconstructive surgery is still very limited, especially in the field of peripheral nerve reconstruction. This study aims to identify current clinical ... Read more >>

J Reconstr Microsurg (Journal of reconstructive microsurgery)
[2021, 37(6):503-513]

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Holistic reconstruction of mandible defect, lower lip and chin sensation, and smile reanimation in an advanced gum cancer patient: A case report.

Lisa Wen-Yu Chen, Chrisovalantis Lakhiani, Jung-Ju Huang, Mohamed Abdelrahman, Shiang-Fu Huang, Tommy Nai-Jen Chang,

Facial deformity, facial paralysis, and sensory loss are inevitable after some head and neck tumor resection and reconstruction, especially in high stage cancer. To overcome these obstacles, we present a case of T4a gum cancer patient (41-year-old) who received holistic reconstruction of the mandible defect via an osteo-peroneal-artery-perforator combined flap ... Read more >>

Microsurgery (Microsurgery)
[2021, 41(4):361-365]

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Addressing the drug-resistant tuberculosis challenge through implementing a mixed model of care in Uganda.

Samuel Kasozi, Nicholas Sebuliba Kirirabwa, Derrick Kimuli, Henry Luwaga, Enock Kizito, Stavia Turyahabwe, Deus Lukoye, Raymond Byaruhanga, Lisa Chen, Pedro Suarez,

Worldwide, Drug-resistant Tuberculosis (DR-TB) remains a big problem; the diagnostic capacity has superseded the clinical management capacity thereby causing ethical challenges. In Sub-Saharan Africa, treatment is either inadequate or lacking and some diagnosed patients are on treatment waiting lists. In Uganda, various health system challenges impeded scale-up of DR-TB care ... Read more >>

PLoS One (PloS one)
[2020, 15(12):e0244451]

Cited: 2 times

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Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells.

Redouane Aherrahrou, Liang Guo, V Peter Nagraj, Aaron Aguhob, Jameson Hinkle, Lisa Chen, Joon Yuhl Soh, Dillon Lue, Gabriel F Alencar, Arjan Boltjes, Sander W van der Laan, Emily Farber, Daniela Fuller, Rita Anane-Wae, Ngozi Akingbesote, Ani W Manichaikul, Lijiang Ma, Minna U Kaikkonen, Johan L M Björkegren, Suna Önengüt-Gümüşcü, Gerard Pasterkamp, Clint L Miller, Gary K Owens, Aloke Finn, Mohamad Navab, Alan M Fogelman, Judith A Berliner, Mete Civelek,

<h4>Rationale</h4>Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. Recent genome-wide association studies revealed 163 loci associated with CAD. However, the precise molecular mechanisms by which the majority of these loci increase CAD risk are not known. Vascular smooth muscle cells (VSMCs) are critical in the ... Read more >>

Circ Res (Circulation research)
[2020, 127(12):1552-1565]

Cited: 1 time

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A Prospective Comparison of Wavefront-Guided LASIK versus Wavefront-Guided PRK After Previous Keratorefractive Surgery.

Michele D Lee, Lisa Y Chen, Elaine M Tran, Edward E Manche,

<h4>Purpose</h4>To compare the results of retreatment with wavefront-guided LASIK versus wavefront-guided PRK for residual refractive error following previous myopic keratorefractive surgery.<h4>Methods</h4>In this prospective study, 32 eyes of 28 patients after prior myopic keratorefractive surgery underwent retreatment with flap-lift wavefront-guided LASIK (n = 12) or wavefront-guided PRK (n = 20) for ... Read more >>

Clin Ophthalmol (Clinical ophthalmology (Auckland, N.Z.))
[2020, 14:3411-3419]

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Microsurgical robotic suturing of sural nerve graft for sympathetic nerve reconstruction: a technical feasibility study.

Tommy Nai-Jen Chang, Lisa Wen-Yu Chen, Chin-Pang Lee, Kuo-Hsuan Chang, David Chwei-Chin Chuang, Yin-Kai Chao,

Background:Endoscopic thoracic sympathectomy (ETS) may provide a permanent surgical cure for primary palmar hyperhidrosis. Unfortunately, some patients can experience intensive post-operative compensatory sweating (CS) that ultimately impairs quality of life. Sympathetic nerve reconstruction (SNR) may be used to counteract severe post-operative CS through the restoration of sympathetic pathways. In this ... Read more >>

J Thorac Dis (Journal of thoracic disease)
[2020, 12(2):97-104]

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Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.

Bridget L Morse, Anil Kolur, Loyd R Hudson, Andrew T Hogan, Lisa Hong Chen, Ryan M Brackman, Geri A Sawada, John K Fallon, Philip C Smith, Kathleen M Hillgren,

Organic cation transporter 1 (OCT1) plays a role in hepatic uptake of drugs, affecting in vivo exposure, distinguished primarily through pharmacogenetics of the <i>SLC22A1</i> gene. The role of OCT1 in vivo has not been confirmed, however, via drug-drug interactions that similarly affect exposure. In the current research, we used Oct1/2 ... Read more >>

Drug Metab Dispos (Drug metabolism and disposition: the biological fate of chemicals)
[2020, 48(2):93-105]

Cited: 8 times

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Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.

Payam Nahid, Sundari R Mase, Giovanni Battista Migliori, Giovanni Sotgiu, Graham H Bothamley, Jan L Brozek, Adithya Cattamanchi, J Peter Cegielski, Lisa Chen, Charles L Daley, Tracy L Dalton, Raquel Duarte, Federica Fregonese, C Robert Horsburgh, Faiz Ahmad Khan, Fayez Kheir, Zhiyi Lan, Alfred Lardizabal, Michael Lauzardo, Joan M Mangan, Suzanne M Marks, Lindsay McKenna, Dick Menzies, Carole D Mitnick, Diana M Nilsen, Farah Parvez, Charles A Peloquin, Ann Raftery, H Simon Schaaf, Neha S Shah, Jeffrey R Starke, John W Wilson, Jonathan M Wortham, Terence Chorba, Barbara Seaworth,

<b>Background:</b> The American Thoracic Society, U.S. Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America jointly sponsored this new practice guideline on the treatment of drug-resistant tuberculosis (DR-TB). The document includes recommendations on the treatment of multidrug-resistant TB (MDR-TB) as well as isoniazid-resistant but ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 200(10):e93-e142]

Cited: 35 times

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General Medical Clinicians' Attitudes Toward People with Serious Mental Illness: A Scoping Review.

Elizabeth M Stone, Lisa Nawei Chen, Gail L Daumit, Sarah Linden, Emma E McGinty,

Individuals with serious mental illness (SMI) experience significant premature mortality due to somatic conditions but often receive sub-optimal somatic care, but little research has been done to understand how general medical clinicians' attitudes may affect care provision or health outcomes. This review describes general medical clinicians' attitudes toward people with ... Read more >>

J Behav Health Serv Res (The journal of behavioral health services & research)
[2019, 46(4):656-679]

Cited: 3 times

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Tuberculosis Regional Training and Medical Consultation Centers in the United States: Characteristics, outcomes, and quality of medical consultations, June 1, 2010 - May 31, 2014.

Sundari R Mase, Ratima Samron, David Ashkin, Kenneth G Castro, Stephen Ryan, Barbara Seaworth, Lisa Chen, Alfred Lardizabal, Dawn Tuckey, Amera Khan, Drew L Posey, Courtney Chappelle, Zelalem Temesgen,

<h4>Background</h4>Tuberculosis (TB) Regional Training and Medical Consultation Centers (RTMCCs) were established in 2005 for TB medical consultation, training and education in the United States. A medical consultation database (MCD) captured all consultations provided by RTMCCs; we report on those provided from June 1, 2010 to May 31, 2014.<h4>Methods</h4>All MCD consultations ... Read more >>

J Clin Tuberc Other Mycobact Dis (Journal of clinical tuberculosis and other mycobacterial diseases)
[2019, 17:100114]

Cited: 1 time

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Addressing the drug resistant tuberculosis challenge through implementing a mixed model of care in Uganda, 2012- 2017

Samuel Kasozi, Nicholas Sebuliba Kirirabwa, Derrick Kimuli, Henry Luwaga, Enock Kizito, Stavia Turyahabwe, Deus Lukoye, Raymond Byaruhanga, Chen Lisa, Pedro Suarez,

<h4>Background: </h4> Worldwide, Drug resistant Tuberculosis (DR-TB) remains a big problem; the diagnostic capacity has superseded the DR-TB clinical management capacity thereby causing ethical challenges. In Sub-Saharan Africa, treatment is either inadequate or lacking and some diagnosed patients are on treatment waiting lists. In Uganda, various health system challenges impeded ... Read more >>

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Patterns of response with talimogene laherparepvec in combination with ipilimumab or ipilimumab alone in metastatic unresectable melanoma.

Jason Chesney, Igor Puzanov, Frances Collichio, Mohammed M Milhem, Axel Hauschild, Lisa Chen, Anjali Sharma, Claus Garbe, Parminder Singh, Janice M Mehnert,

Talimogene laherparepvec (T-VEC) has demonstrated efficacy for unresectable melanoma. We explored response patterns from a phase 2 study evaluating patients with unresectable stage IIIB-IVM1c malignant melanoma who received T-VEC plus ipilimumab or ipilimumab alone. Patients with objective response per modified irRC were evaluated for pseudo-progression (single ≥25% increase in tumour ... Read more >>

Br J Cancer (British journal of cancer)
[2019, 121(5):417-420]

Cited: 6 times

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Tuberculosis in the United States: Medical Consultation Services Provided by 5 Tuberculosis Regional Training and Medical Consultation Centers, 2013-2017.

Neela D Goswami, Sundari Mase, David Griffith, Rajita Bhavaraju, Alfred Lardizabal, Michael Lauzardo, Lisa Chen, John Wilson, Courtney Chappelle, Connie A Haley,

With only 9105 new US tuberculosis (TB) cases reported in 2017, expert consultation is essential for TB care. Data were captured 2013-2017 from consultations by 5 CDC-funded centers, now the TB Centers of Excellence (COEs). 14 586 consultations were provided to TB providers, most related to TB disease and treatment ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(6):ofz167]

Cited: 3 times

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Induction of apoptosis by MCL-1 inhibitors in chronic lymphocytic leukemia cells.

Lisa S Chen, Michael J Keating, William G Wierda, Varsha Gandhi,

Leuk Lymphoma (Leukemia & lymphoma)
[2019, 60(12):3063-3066]

Cited: 1 time

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8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia.

Ralf Buettner, Le Xuan Truong Nguyen, Bijender Kumar, Corey Morales, Chao Liu, Lisa S Chen, Tea Pemovska, Timothy W Synold, Joycelynne Palmer, Ryan Thompson, Ling Li, Dinh Hoa Hoang, Bin Zhang, Lucy Ghoda, Claudia Kowolik, Mika Kontro, Calum Leitch, Krister Wennerberg, Xiaochun Yu, Ching-Cheng Chen, David Horne, Varsha Gandhi, Vinod Pullarkat, Guido Marcucci, Steven T Rosen,

Nucleoside analogs represent the backbone of several distinct chemotherapy regimens for acute myeloid leukemia (AML) and combination with tyrosine kinase inhibitors has improved survival of AML patients, including those harboring the poor-risk FLT3-ITD mutation. Although these compounds are effective in killing proliferating blasts, they lack activity against quiescent leukemia stem ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2019, :]

Cited: 5 times

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Ibrutinib dose and clinical outcome in chronic lymphocytic leukemia - learning from the 'real world'.

Prithviraj Bose, Lisa S Chen, Varsha Gandhi,

Leuk Lymphoma (Leukemia & lymphoma)
[2019, 60(7):1603-1605]

Cited: 1 time

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Management of Complex Epithelial Ingrowth After Laser In Situ Keratomileusis Using Fibrin Tissue Glue.

Lisa Y Chen, Jennifer S Kung, Edward E Manche,

<h4>Objectives</h4>To evaluate the efficacy and safety of adjunctive fibrin tissue glue in the treatment of complex epithelial ingrowth after laser in situ keratomileusis (LASIK).<h4>Methods</h4>A retrospective review was performed of 12 eyes in 12 patients treated for clinically significant epithelial ingrowth after LASIK with mechanical debridement of the ingrowth and placement ... Read more >>

Eye Contact Lens (Eye & contact lens)
[2018, 44 Suppl 2:S210-S214]

Cited: 1 time

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