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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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High-versus low-dose clonidine for sedation and analgesia in critically ill adults: A retrospective cohort study.

Elsa Purivatra, Melanie Guenette, Brenda Coleman, Alexandra Cheung, Lisa Burry,

<h4>What is known and objective</h4>Limited data suggest clonidine may be useful for sedation and analgesia in critically ill patients. Our objectives were to describe clonidine dosing regimens used for sedation and analgesia in critically ill adults, the associated adverse effects (i.e., hypotension), and whether clonidine dose was associated with dosage ... Read more >>

J Clin Pharm Ther (Journal of clinical pharmacy and therapeutics)
[2021, :]

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Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge cluster-randomized controlled trial.

Craig M Dale, Louise Rose, Sarah Carbone, Ruxandra Pinto, Orla M Smith, Lisa Burry, Eddy Fan, Andre Carlos Kajdacsy-Balla Amaral, Victoria A McCredie, Damon C Scales, Brian H Cuthbertson,

<h4>Purpose</h4>Oral chlorhexidine is used widely for mechanically ventilated patients to prevent pneumonia, but recent studies show an association with excess mortality. We examined whether de-adoption of chlorhexidine and parallel implementation of a standardized oral care bundle reduces intensive care unit (ICU) mortality in mechanically ventilated patients.<h4>Methods</h4>A stepped wedge cluster-randomized controlled ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, :]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

Cited: 0 times

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Mass Critical Care Surge Response during COVID-19: Implementation of Contingency Strategies A Preliminary Report of findings from the Task Force for Mass Critical Care.

Jeffrey R Dichter, Asha V Devereaux, Charles L Sprung, Vikramjit Mukherjee, Jason Persoff, Karyn D Baum, Douglas Ornoff, Amit Uppal, Tanzib Hossain, Kiersten N Henry, Marya Ghazipura, Kasey R Bowden, Henry J Feldman, Mitchell T Hamele, Lisa D Burry, Anne Marie O Martland, Meredith Huffines, Pritish K Tosh, James Downar, John L Hick, Michael D Christian, Ryan C Maves, ,

<h4>Background</h4>Following the publication of 2014 consensus statement regarding mass critical care during public health emergencies, much has been learned about surge responses and the care of overwhelming numbers of patients during the COVID-19 pandemic.<sup>1</sup> Gaps in prior pandemic planning were identified and require modification in the midst of ongoing surge ... Read more >>

Chest (Chest)
[2021, :]

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Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III.

Denham S Ward, Anthony R Absalom, Leanne M Aitken, Michele C Balas, David L Brown, Lisa Burry, Elizabeth Colantuoni, Douglas Coursin, John W Devlin, Franklin Dexter, Robert H Dworkin, Talmage D Egan, Doug Elliott, Ingrid Egerod, Pamela Flood, Gilles L Fraser, Timothy D Girard, David Gozal, Ramona O Hopkins, John Kress, Mervyn Maze, Dale M Needham, Pratik Pandharipande, Richard Riker, Daniel I Sessler, Steven L Shafer, Yahya Shehabi, Claudia Spies, Lena S Sun, Avery Tung, Richard D Urman,

<h4>Objectives</h4>Clinical trials evaluating the safety and effectiveness of sedative medication use in critically ill adults undergoing mechanical ventilation differ considerably in their methodological approach. This heterogeneity impedes the ability to compare results across studies. The Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research Recommendations convened a meeting ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(10):1684-1693]

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A Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS).

Louise Rose, Lisa Burry, Meera Agar, Noll L Campbell, Mike Clarke, Jacques Lee, John C Marshall, John W Devlin, Bronagh Blackwood, Dale M Needham, Najma Siddiqi, Valerie Page, ,

<h4>Objectives</h4>Delirium in critically ill adults is highly prevalent and has multiple negative consequences. To-date, trials of interventions to prevent or treat delirium report heterogenous outcomes. To develop international consensus among key stakeholders for a core outcome set for future trials of interventions to prevent and/or treat delirium in critically ill ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(9):1535-1546]

Cited: 3 times

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Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis.

Lisa D Burry, Wei Cheng, David R Williamson, Neill K Adhikari, Ingrid Egerod, Salmaan Kanji, Claudio M Martin, Brian Hutton, Louise Rose,

<h4>Purpose</h4>To compare the effects of prevention interventions on delirium occurrence in critically ill adults.<h4>Methods</h4>MEDLINE, Embase, PsychINFO, CINAHL, Web of Science, Cochrane Library, Prospero, and WHO international clinical trial registry were searched from inception to April 8, 2021. Randomized controlled trials of pharmacological, sedation, non-pharmacological, and multi-component interventions enrolling adult critically ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(9):943-960]

Cited: 0 times

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Addressing Barriers to Reducing Prescribing and Implementing Deprescribing of Sedative-Hypnotics in Primary Care.

Lisa Burry, Justin Turner, Timothy Morgenthaler, Cara Tannenbaum, Hyung J Cho, Evelyn Gathecha, Flora Kisuule, Abi Vijenthira, Christine Soong,

<h4>Objective</h4>To describe interventions that target patient, provider, and system barriers to sedative-hypnotic (SH) deprescribing in the community and suggest strategies for healthcare teams.<h4>Data sources</h4>Ovid MEDLINE ALL and EMBASE Classic + EMBASE (March 10, 2021).<h4>Study selection and data extraction</h4>English-language studies in primary care settings.<h4>Data synthesis</h4>20 studies were themed as patient-related and ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2021, :10600280211033022]

Cited: 0 times

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A core outcome set for studies evaluating interventions to prevent and/or treat delirium for adults requiring an acute care hospital admission: an international key stakeholder informed consensus study.

Louise Rose, Lisa Burry, Meera Agar, Bronagh Blackwood, Noll L Campbell, Mike Clarke, John W Devlin, Jacques Lee, John C Marshall, Dale M Needham, Najma Siddiqi, Valerie Page,

<h4>Background</h4>Trials of interventions to prevent or treat delirium in adults in an acute hospital setting report heterogeneous outcomes. Our objective was to develop international consensus among key stakeholders for a core outcome set (COS) for future trials of interventions to prevent and/or treat delirium in adults with an acute care ... Read more >>

BMC Med (BMC medicine)
[2021, 19(1):143]

Cited: 1 time

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Core outcome sets in intensive care-what are they and why do we need them? An example for delirium.

Louise Rose, Lisa Burry, Bronagh Blackwood, ,

Nurs Crit Care (Nursing in critical care)
[2021, 26(3):144-146]

Cited: 0 times

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Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context.

Federico Angriman, Bruno L Ferreyro, Lisa Burry, Eddy Fan, Niall D Ferguson, Shahid Husain, Shaf H Keshavjee, Enrico Lupia, Laveena Munshi, Samuele Renzi, Onion Gerald V Ubaldo, Bram Rochwerg, Lorenzo Del Sorbo,

The pleiotropic cytokine interleukin-6 (IL-6) has been implicated in the pathogenesis of COVID-19, but uncertainty remains about the potential benefits and harms of targeting IL-6 signalling in patients with the disease. The efficacy and safety of tocilizumab and sarilumab, which block the binding of IL-6 to its receptor, have been ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(6):655-664]

Cited: 5 times

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Advise non-pharmacological therapy as first line treatment for chronic insomnia.

Christine Soong, Lisa Burry, Maria Greco, Cara Tannenbaum,

BMJ (BMJ (Clinical research ed.))
[2021, 372:n680]

Cited: 0 times

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The Clinician Scientist.

David R Williamson, Salmaan Kanji, Lisa Burry,

Can J Hosp Pharm (The Canadian journal of hospital pharmacy)
[2021, 74(2):130-134]

Cited: 0 times

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Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.

Waleed Alhazzani, Laura Evans, Fayez Alshamsi, Morten Hylander Møller, Marlies Ostermann, Hallie C Prescott, Yaseen M Arabi, Mark Loeb, Michelle Ng Gong, Eddy Fan, Simon Oczkowski, Mitchell M Levy, Lennie Derde, Amy Dzierba, Bin Du, Flavia Machado, Hannah Wunsch, Mark Crowther, Maurizio Cecconi, Younsuck Koh, Lisa Burry, Daniel S Chertow, Wojciech Szczeklik, Emilie Belley-Cote, Massimiliano Greco, Malgorzata Bala, Ryan Zarychanski, Jozef Kesecioglu, Allison McGeer, Leonard Mermel, Manoj J Mammen, Sheila Nainan Myatra, Amy Arrington, Ruth Kleinpell, Giuseppe Citerio, Kimberley Lewis, Elizabeth Bridges, Ziad A Memish, Naomi Hammond, Frederick G Hayden, Muhammed Alshahrani, Zainab Al Duhailib, Greg S Martin, Lewis J Kaplan, Craig M Coopersmith, Massimo Antonelli, Andrew Rhodes,

<h4>Background</h4>The coronavirus disease 2019 pandemic continues to affect millions worldwide. Given the rapidly growing evidence base, we implemented a living guideline model to provide guidance on the management of patients with severe or critical coronavirus disease 2019 in the ICU.<h4>Methods</h4>The Surviving Sepsis Campaign Coronavirus Disease 2019 panel has expanded to ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):e219-e234]

Cited: 37 times

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Safety of dexmedetomidine for the control of agitation in critically ill traumatic brain injury patients: a descriptive study.

Véronique Bilodeau, Mar Saavedra-Mitjans, Anne Julie Frenette, Lisa Burry, Martin Albert, Francis Bernard, David R Williamson,

<h4>Background</h4>Behavioural disturbances such as agitation are common following traumatic brain injury and can interfere with treatments, cause self-harm and delay rehabilitation. As there is a lack of evidence on the optimal approach to manage agitation in recovering TBI patients, various pharmacological agents are used including antipsychotics, anticonvulsants and sedative agents. ... Read more >>

J Clin Pharm Ther (Journal of clinical pharmacy and therapeutics)
[2021, 46(4):1020-1026]

Cited: 1 time

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Agitation, confusion, and aggression in critically ill traumatic brain injury-a pilot cohort study (ACACIA-PILOT).

David R Williamson, Sofia Ihsenne Cherifa, Anne Julie Frenette, Mar Saavedra Mitjans, Emmanuel Charbonney, Gabrielle Cataford, Virginie Williams, Julia Lainer Palacios, Lisa Burry, Sangeeta Mehta, Caroline Arbour, Francis Bernard, ,

<h4>Background</h4>Agitated behaviors are problematic in intensive care unit (ICU) patients recovering from traumatic brain injury (TBI) as they create substantial risks and challenges for healthcare providers. To date, there have been no studies evaluating their epidemiology and impact in the ICU. Prior to planning a multicenter study, assessment of recruitment, ... Read more >>

Pilot Feasibility Stud (Pilot and feasibility studies)
[2020, 6(1):193]

Cited: 1 time

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In response to: The neuroprotective effect of quetiapine in critically ill traumatic brain injury patients.

Mar Saavedra Mitjans, Lisa Burry, David Williamson,

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2020, 89(6):e191-e192]

Cited: 0 times

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It Takes a Village…: Contending With Drug Shortages During Disasters.

Lisa D Burry, Jeffrey F Barletta, David Williamson, Salmaan Kanji, Ryan C Maves, Jeffrey Dichter, Michael D Christian, James Geiling, Brian L Erstad,

Critical drug shortages have been widely documented during the coronavirus disease 2019 (COVID-19) pandemic, particularly for IV sedatives used to facilitate mechanical ventilation. Surges in volume of patients requiring mechanical ventilation coupled with prolonged ventilator days and the high sedative dosing requirements observed quickly led to the depletion of "just-in-time" ... Read more >>

Chest (Chest)
[2020, 158(6):2414-2424]

Cited: 7 times

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Baricitinib: A Review of Pharmacology, Safety, and Emerging Clinical Experience in COVID-19.

Sarah C J Jorgensen, Christopher L Y Tse, Lisa Burry, Linda D Dresser,

A hyperinflammatory response to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection, reminiscent of cytokine release syndrome, has been implicated in the pathophysiology of acute respiratory distress syndrome and organ damage in patients with coronavirus disease 2019 (COVID-19). Agents that inhibit components of the pro-inflammatory cascade have garnered interest as potential ... Read more >>

Pharmacotherapy (Pharmacotherapy)
[2020, 40(8):843-856]

Cited: 22 times

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Baricitinib: Impact on COVID-19 coagulopathy?

Sarah C J Jorgensen, Lisa Burry, Christopher L Y Tse, Linda D Dresser,

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 1 time

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Strategies for the Prevention and Treatment of Iatrogenic Withdrawal from Opioids and Benzodiazepines in Critically Ill Neonates, Children and Adults: A Systematic Review of Clinical Studies.

Barbara Sneyers, Marc-Alexandre Duceppe, Anne Julie Frenette, Lisa D Burry, Philippe Rico, Annie Lavoie, Céline Gélinas, Sangeeta Mehta, Maryse Dagenais, David R Williamson, Marc M Perreault,

<h4>Background</h4>Critically ill patients are at high risk of iatrogenic withdrawal syndrome (IWS), due to exposure to high doses or prolonged periods of opioids and benzodiazepines.<h4>Purpose</h4>To examine pharmacological management strategies designed to prevent and/or treat IWS from opioids and/or benzodiazepines in critically ill neonates, children and adults.<h4>Methods</h4>We included non-randomised studies of ... Read more >>

Drugs (Drugs)
[2020, 80(12):1211-1233]

Cited: 2 times

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Therapeutic alternatives and strategies for drug conservation in the intensive care unit during times of drug shortage: a report of the Ontario COVID-19 ICU Drug Task Force.

Salmaan Kanji, Lisa Burry, David Williamson, Michelle Pittman, Samuel Dubinsky, Deep Patel, Sabrina Natarajan, Robert MacLean, Jin-Hyeun Huh, Damon C Scales, David Neilipovitz, ,

During the coronavirus disease (COVID-19) global pandemic, urgent strategies to alleviate shortages are required. Evaluation of the feasibility, practicality, and value of drug conservation strategies and therapeutic alternatives requires a collaborative approach at the provincial level. The Ontario COVID-19 ICU Drug Task Force was directed to create recommendations suggesting drug ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2020, 67(10):1405-1416]

Cited: 6 times

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Managing ICU surge during the COVID-19 crisis: rapid guidelines.

Shadman Aziz, Yaseen M Arabi, Waleed Alhazzani, Laura Evans, Giuseppe Citerio, Katherine Fischkoff, Jorge Salluh, Geert Meyfroidt, Fayez Alshamsi, Simon Oczkowski, Elie Azoulay, Amy Price, Lisa Burry, Amy Dzierba, Andrew Benintende, Jill Morgan, Giacomo Grasselli, Andrew Rhodes, Morten H Møller, Larry Chu, Shelly Schwedhelm, John J Lowe, Du Bin, Michael D Christian,

Given the rapidly changing nature of COVID-19, clinicians and policy makers require urgent review and summary of the literature, and synthesis of evidence-based guidelines to inform practice. The WHO advocates for rapid reviews in these circumstances. The purpose of this rapid guideline is to provide recommendations on the organizational management ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(7):1303-1325]

Cited: 63 times

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