Full Text Journal Articles by
Author Liqiang Shen


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CueR activates transcription through a DNA distortion mechanism.

Chengli Fang, Steven J Philips, Xiaoxian Wu, Kui Chen, Jing Shi, Liqiang Shen, Juncao Xu, Yu Feng, Thomas V O'Halloran, Yu Zhang,

The MerR-family transcription factors (TFs) are a large group of bacterial proteins responding to cellular metal ions and multiple antibiotics by binding within central RNA polymerase-binding regions of a promoter. While most TFs alter transcription through protein-protein interactions, MerR TFs are capable of reshaping promoter DNA. To address the question ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Accumulation of the RNA polymerase subunit RpoB depends on RNA editing by OsPPR16 and affects chloroplast development during early leaf development in rice.

Weifeng Huang, Yang Zhang, Liqiang Shen, Qian Fang, Qun Liu, Chenbo Gong, Chen Zhang, Yong Zhou, Cui Mao, Yongli Zhu, Jinghong Zhang, Hongping Chen, Yu Zhang, Yongjun Lin, Ralph Bock, Fei Zhou,

Plastid-encoded genes are coordinately transcribed by the nucleus-encoded RNA polymerase (NEP) and the plastid-encoded RNA polymerase (PEP). Resulting primary transcripts are frequently subject to RNA editing by cytidine-to-uridine conversions at specific sites. The physiological role of many editing events is largely unknown. Here, we have used the CRISPR/Cas9 technique in ... Read more >>

New Phytol (The New phytologist)
[2020, :]

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Crl activates transcription by stabilizing the active conformation of the master stress factor σS

Juncao Xu, Kaijie Cui, Liqiang Shen, Jing Shi, Lingting Li, Linlin You, Chengli Fang, Guoping Zhao, Yu Feng, Bei Yang, Yu Zhang,

SUMMARY σ S is a master transcription initiation factor that protects bacterial cells from various harmful environmental stresses and antibiotic pressure. Although its mechanism remains unclear, it is known that full activation of σ S -mediated transcription requires a σ S -specific activator, Crl. In this study, we determined a ... Read more >>

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Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.

Xiaoxian Wu, Diane L Haakonsen, Allen G Sanderlin, Yue J Liu, Liqiang Shen, Ningning Zhuang, Michael T Laub, Yu Zhang,

Canonical bacterial transcription activators bind to non-transcribed promoter elements to increase transcription of their target genes. Here we report crystal structures of binary complexes comprising domains of Caulobacter crescentus GcrA, a noncanonical bacterial transcription factor, that support a novel mechanism for transcription activation through the preferential binding of methylated cis-regulatory ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2018, 46(6):3245-3256]

Cited: 4 times

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Cyclic AMP Inhibits the Activity and Promotes the Acetylation of Acetyl-CoA Synthetase through Competitive Binding to the ATP/AMP Pocket.

Xiaobiao Han, Liqiang Shen, Qijun Wang, Xufeng Cen, Jin Wang, Meng Wu, Peng Li, Wei Zhao, Yu Zhang, Guoping Zhao,

The high-affinity biosynthetic pathway for converting acetate to acetyl-coenzyme A (acetyl-CoA) is catalyzed by the central metabolic enzyme acetyl-coenzyme A synthetase (Acs), which is finely regulated both at the transcriptional level via cyclic AMP (cAMP)-driven trans-activation and at the post-translational level via acetylation inhibition. In this study, we discovered that ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2017, 292(4):1374-1384]

Cited: 5 times

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PAQR3 modulates H3K4 trimethylation by spatial modulation of the regulatory subunits of COMPASS-like complexes in mammalian cells.

Chunchun Liu, Yuxue Zhang, Yongfan Hou, Liqiang Shen, Yinlong Li, Weiwei Guo, Daqian Xu, Gaigai Liu, Zilong Zhao, Kaiyang Man, Yi Pan, Zhenzhen Wang, Yan Chen,

Histone modification plays important roles in many biological processes such as development and carcinogenesis. Methylation of histone H3 lysine 4 (H3K4) is commonly associated with transcriptional activation of genes. H3K4 methylation in mammalian cells is carried out by COMPASS (complex of proteins associated with Set1)-like complexes that are composed of ... Read more >>

Biochem. J. (The Biochemical journal)
[2015, 467(3):415-424]

Cited: 7 times

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Cloning, expression, purification, crystallization and preliminary crystallographic analysis of the kinase domain of AtMAP4Kalpha2 from Arabidopsis thaliana.

Liqiang Shen, Xiaoli Du, Qing Su, Mingxia Li, Zhiqin Zhou,

Arabidopsis thaliana (At) MAP4Kalpha2, a member of the Ste20/PAK-like protein kinase family, is an essential component of the septum initiation network involved in cell division. To better understand the mode of action of AtMAP4Kalpha2, a structural biology approach has been pursued. In this study, the kinase domain of AtMAP4Kalpha2 was ... Read more >>

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (Acta crystallographica. Section F, Structural biology and crystallization communications)
[2013, 69(Pt 7):788-791]

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