Full Text Journal Articles by
Author Linhao You


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An Extendable Star-Like Nanoplatform for Functional and Anatomical Imaging-Guided Photothermal Oncotherapy.

Xuexiang Han, Ying Xu, Yiye Li, Xiao Zhao, Yinlong Zhang, Huan Min, Yingqiu Qi, Gregory J Anderson, Linhao You, Yuliang Zhao, Guangjun Nie,

Combining informative imaging methodologies with effective treatments to destroy tumors is of great importance for oncotherapy. Versatile nanotheranostic agents that inherently possess both diagnostic imaging and therapeutic capabilities are highly desirable to meet these requirements. Here, a simple but powerful nanoplatform based on polydopamine-coated gold nanostar ([email protected]), which can be ... Read more >>

ACS Nano (ACS nano)
[2019, 13(4):4379-4391]

Cited: 11 times

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Polymeric Nanoparticles Enhance the Ability of Deferoxamine To Deplete Hepatic and Systemic Iron.

Shanshan Guo, Gang Liu, David M Frazer, Tianqing Liu, Linhao You, Jiaqi Xu, Yongwei Wang, Gregory J Anderson, Guangjun Nie,

Chelators are commonly used to remove excess iron in iron-loading disorders. Deferoxamine (DFO) is an effective and safe iron chelator but an onerous parenteral administration regimen limits its routine use. To develop more effective methods for delivering iron chelators, we examined whether amphiphilic copolymer nanoparticles (NPs) could deliver DFO more ... Read more >>

Nano Lett (Nano letters)
[2018, 18(9):5782-5790]

Cited: 2 times

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Suppression of Tumor Energy Supply by Liposomal Nanoparticle-Mediated Inhibition of Aerobic Glycolysis.

Yinlong Zhang, Jingyan Wei, Jiaqi Xu, Wei Sun Leong, Guangna Liu, Tianjiao Ji, Zhiqiang Cheng, Jing Wang, Jiayan Lang, Ying Zhao, Linhao You, Xiao Zhao, Taotao Wei, Greg J Anderson, Sheng Qi, Jing Kong, Guangjun Nie, Suping Li,

Aerobic glycolysis enables cancer cells to rapidly take up nutrients (e.g., nucleotides, amino acids, and lipids) and incorporate them into the biomass needed to produce a new cell. In contrast to existing chemotherapy/radiotherapy strategies, inhibiting aerobic glycolysis to limit the adenosine 5'-triphosphate (ATP) yield is a highly efficient approach for ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2018, 10(3):2347-2353]

Cited: 8 times

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Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice.

Linhao You, Jing Wang, Tianqing Liu, Yinlong Zhang, Xuexiang Han, Ting Wang, Shanshan Guo, Tianyu Dong, Junchao Xu, Gregory J Anderson, Qiang Liu, Yan-Zhong Chang, Xin Lou, Guangjun Nie,

Excess iron deposition in the brain often causes oxidative stress-related damage and necrosis of dopaminergic neurons in the substantia nigra and has been reported to be one of the major vulnerability factors in Parkinson's disease (PD). Iron chelation therapy using deferoxamine (DFO) may inhibit this nigrostriatal degeneration and prevent the ... Read more >>

ACS Nano (ACS nano)
[2018, 12(5):4123-4139]

Cited: 20 times

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The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss.

Zi Xu, Weijia Sun, Yuheng Li, Shukuan Ling, Chenyang Zhao, Guohui Zhong, Dingsheng Zhao, Jinping Song, Hailin Song, Jinqiao Li, Linhao You, Guangjun Nie, Yanzhong Chang, Yingxian Li,

Iron overload inhibits osteoblast function and promotes osteoclastogenesis. Hepcidin plays an important role in this process. The changes in iron content and the regulation of hepcidin under unloading-induced bone loss remain unknown. A hindlimb suspension model was adopted to simulate unloading-induced bone loss in mice. The results showed that iron ... Read more >>

Bone (Bone)
[2017, 94:152-161]

Cited: 16 times

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The effect of anti-inflammatory properties of ferritin light chain on lipopolysaccharide-induced inflammatory response in murine macrophages.

Yumei Fan, Jie Zhang, Linlin Cai, Shengnan Wang, Caizhi Liu, Yongze Zhang, Linhao You, Yujian Fu, Zhenhua Shi, Zhimin Yin, Lan Luo, Yanzhong Chang, Xianglin Duan,

Ferritin light chain (FTL) reduces the free iron concentration by forming ferritin complexes with ferritin heavy chain (FTH). Thus, FTL competes with the Fenton reaction by acting as an antioxidant. In the present study, we determined that FTL influences the lipopolysaccharide (LPS)-induced inflammatory response. FTL protein expression was regulated by ... Read more >>

Biochim Biophys Acta (Biochimica et biophysica acta)
[2014, 1843(11):2775-2783]

Cited: 14 times

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