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Author Lingyun Wu

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Cystathionine gamma-lyase/H2 S signaling facilitates myogenesis under aging and injury condition.

Yanjie Zhang, Laura Masters, Yuehong Wang, Lingyun Wu, Yanxi Pei, Baoqing Guo, Amadeo Parissenti, Simon J Lees, Rui Wang, Guangdong Yang,

Hydrogen sulfide (H<sub>2</sub> S) can be endogenously produced and belongs to the class of signaling molecules known as gasotransmitters. Cystathionine gamma-lyase (CSE)-derived H<sub>2</sub> S is implicated in the regulation of cell differentiation and the aging process, but the involvements of the CSE/H<sub>2</sub> S system in myogenesis upon aging and injury ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21511]

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Evaluation of changes in shoulder balance and prediction of final shoulder imbalance during growing-rod treatment for early-onset scoliosis.

Ziyang Liu, Tie Liu, Yong Hai, Lingyun Wu, Junrui Jonathan Hai, Kang Gao, Xuanrong Guo, Honghao Yang, Nan Kang, Fan Zhao,

<h4>Background</h4>Obtaining and maintaining final shoulder balance after the entire treatment course is essential for early-onset scoliosis (EOS) patients. The relatively small number of growing-rod (GR) graduates who complete final fusion has resulted in an overall paucity of research on the GR treatment of EOS and a lack of research on ... Read more >>

BMC Musculoskelet Disord (BMC musculoskeletal disorders)
[2021, 22(1):354]

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AHR signaling pathway reshapes the metabolism of AML/MDS cells and potentially leads to cytarabine resistance.

Yan Jia, Juan Guo, Youshan Zhao, Zheng Zhang, Lei Shi, Ying Fang, Dong Wu, Lingyun Wu, Chunkang Chang,

Emerging evidence suggests that aryl hydrocarbon receptor (AHR) promotes the initiation, invasion, progression, and metastasis of cancer cells. However, its effects in patients with myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) remain undefined. In this study, we aimed to investigate the effects of AHR activation on malignant cells in patients with MDS/AML. ... Read more >>

Acta Biochim Biophys Sin (Shanghai) (Acta biochimica et biophysica Sinica)
[2021, 53(4):492-500]

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Linkages of surface air temperature variations over Central Asia with large-scale climate patterns

Yuanhuang Zhuang, Jingyong Zhang, Lingyun Wu,

In this study, we investigate the dominant modes of surface air temperature variations of the cold season (from November through to the next March) and the warm season (from May to September) over Central Asia, and their associations with large-scale climate patterns for the period of 1979–2016. The first two ... Read more >>

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The expression of microRNA-340 and cyclin D1 and its relationship with the clinicopathological characteristics and prognosis of lung cancer.

Li Fang, Xiuping Xu, Wenyan Zheng, Lingyun Wu, Haijun Wan,

<h4>Background</h4>To explore the expression of microribonucleic acid-340 (miR-340) and cyclin D1 (CCND1) in lung cancer (LC) tissues and its relationship with the clinicopathological characteristics and prognosis of LC.<h4>Methods</h4>Cancer tissues and paracancerous normal lung tissues of 65 patients with LC admitted to our hospital from January 2014 to March 2015 were ... Read more >>

Asian J Surg (Asian journal of surgery)
[2021, :]

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Interaction among estrogen, IGF-1, and H2S on smooth muscle cell proliferation.

Tian Shuang, Ming Fu, Guangdong Yang, Ying Huang, Zhongming Qian, Lingyun Wu, Rui Wang,

Both estrogen and hydrogen sulfide (H2S) inhibit the proliferation of vascular smooth muscle cells (SMCs) and development of atherosclerosis. In the absence of endogenous H2S as occurred in CSE-knockout (KO) mouse, however, estrogen stimulates the proliferation of vascular SMCs. The underlying mechanisms for this seemingly controversial vascular effect of estrogen ... Read more >>

J Endocrinol (The Journal of endocrinology)
[2021, 248(1):17-30]

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TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-κB pathways.

Yan Zhou, Tao Tao, Guangjie Liu, Xuan Gao, Yongyue Gao, Zong Zhuang, Yue Lu, Han Wang, Wei Li, Lingyun Wu, Dingding Zhang, Chunhua Hang,

Neuronal apoptosis has an important role in early brain injury (EBI) following subarachnoid hemorrhage (SAH). TRAF3 was reported as a promising therapeutic target for stroke management, which covered several neuronal apoptosis signaling cascades. Hence, the present study is aimed to determine whether downregulation of TRAF3 could be neuroprotective in SAH-induced ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(1):10]

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Gasotransmitter signaling in energy homeostasis and metabolic disorders.

Amr Ali, Yuehong Wang, Lingyun Wu, Guangdong Yang,

Gasotransmitters are small molecules of gases, including nitric oxide (NO), hydrogen sulfide (H<sub>2</sub>S), and carbon monoxide (CO). These three gasotransmitters can be endogenously produced and regulate a wide range of pathophysiological processes by interacting with specific targets upon diffusion in the biological media. By redox and epigenetic regulation of various ... Read more >>

Free Radic Res (Free radical research)
[2020, :1-23]

Cited: 1 time

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Identification of latent core genes and pathways associated with myelodysplastic syndromes based on integrated bioinformatics analysis.

Yuqian Zhu, Lingyun Wu,

<b>Background:</b> Myelodysplastic syndromes (MDS) are relatively common hematological malignancies characterized by dysplastic hematopoiesis in one or more of the lineages of the bone marrow. This study aimed to identify critical pathogenic biomarkers associated with the carcinogenesis and progression of MDS. <b>Methods:</b> To explore the candidate genes, the expression profiles of ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):299-308]

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Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation.

Yuehong Wang, Ruihuan Yu, Lingyun Wu, Guangdong Yang,

Recognized as a novel and important gasotransmitter, hydrogen sulfide (H<sub>2</sub>S) is widely present in various tissues and organs. Cystathionine gamma-lyase (CSE)-derived H<sub>2</sub>S has been shown to regulate oxidative stress and lipid metabolism. The aim of the present study is to examine the role of H<sub>2</sub>S in ferroptosis and lipid peroxidation ... Read more >>

Cell Signal (Cellular signalling)
[2021, 78:109870]

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Breast Cancer Cell-Neutrophil Interactions Enhance Neutrophil Survival and Pro-Tumorigenic Activities.

Lingyun Wu, Sugandha Saxena, Paran Goel, Dipakkumar R Prajapati, Cheng Wang, Rakesh K Singh,

Breast cancer remains the most prevalent cancer in women with limited treatment options for patients suffering from therapy-resistance and metastatic disease. Neutrophils play an important role in breast cancer progression and metastasis. We examined the pro-tumorigenic nature of the breast cancer cell-neutrophil interactions and delineated the differences in neutrophil properties ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(10):]

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Correction: Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.

Yuehong Wang, Ping Gao, Can Wei, Hongzhu Li, Li Zhang, Yajun Zhao, Bo Wu, Ye Tian, Weihua Zhang, Lingyun Wu, Rui Wang, Changqing Xu,

Since online publication of this article, the authors noticed that there was an error in Figs. 2 and 4. In Fig. 2c the samples were mislabelled, the correct labelling order is 'Control, HG, HG + NPS R568, HG + Calhex231'. In Fig. 4c, an incorrect image was used to compile the HG + NPS R568 group, ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(9):784]

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Comparison of computed tomography- and magnetic resonance imaging-based target delineation for cervical cancer brachytherapy.

Fang Wang, Luyi Bu, Qun Wu, Xue Jiang, Lingyun Wu, Yu Li, Bin Xi, Zhongjie Lu, Senxiang Yan,

<h4>Purpose</h4>The objective of this study was to compare and assess the accuracy of computed tomography (CT)-based target delineation with that of magnetic resonance imaging (MRI)-based on high-dose-rate brachytherapy (HDR-BT) for patients with cervical cancer.<h4>Material and methods</h4>Data of 20 patients with locally advanced cervical cancer were collected and evaluated. Dimensions, conformity, ... Read more >>

J Contemp Brachytherapy (Journal of contemporary brachytherapy)
[2020, 12(4):367-374]

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Osalmid, a Novel Identified RRM2 Inhibitor, Enhances Radiosensitivity of Esophageal Cancer.

Qiuying Tang, Lingyun Wu, Mengyou Xu, Danfang Yan, Jimin Shao, Senxiang Yan,

<h4>Purpose</h4>Esophageal cancer (EC) is an aggressive malignancy and is often resistant to currently available therapies. Inhibition of ribonucleotide reductase small subunit M2 (RRM2) in tumors is speculated to mediate chemosensitization. Previous studies have reported that Osalmid could act as an RRM2 inhibitor. We explored whether RRM2 was involved in radioresistance ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2020, 108(5):1368-1379]

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Hydrogen sulfide signaling in regulation of cell behaviors.

Yuehong Wang, Ruihuan Yu, Lingyun Wu, Guangdong Yang,

Recent advances in the biomedical importance of H<sub>2</sub>S have help us understand various cellular functions and pathophysiological processes from a new aspect. Specially, H<sub>2</sub>S has been demonstrated to play multiple roles in regulating cell behaviors, including cell survival, cell differentiation, cell senescence, cell hypertrophy, cell atrophy, cell metaplasia, and cell ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 103:9-19]

Cited: 3 times

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Identification of IFITM1 with prognostic value in pancreatic cancer using network module-based analysis

Lingyun Wu, Xinli Zhu, Mengmeng Tang, Lihong Wang, Chiyuan Ma, Tingbo Liang, Senxiang Yan,

<h4>Background: </h4> Despite improvements reported in diagnosis and treatments in recent decades, pancreatic cancer still characterized with poor prognosis and low survival rate among solid tumors. Intensive interests have grown in exploring novel predictive biomarkers, aiming to enhance the efficiency in early detection and treatment prognosis. <h4>Methods: </h4> In this ... Read more >>

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Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury

Han Wang, Xiaoming Zhou, Lingyun Wu, Guangjie Liu, Weidong Xu, Xiangsheng Zhang, Yongyue Gao, Tao Tao, Yan Zhou, Yue Lu, Juan Wang, Chulei Deng, Zong Zhuang, Chunhua Hang, Wei Li,

<h4>Background: </h4> Aucubin (Au), an iridoid glycoside from natural plants, has anti-oxidative and anti-inflammatory bioactivities; however, its effects on a traumatic brain injury (TBI) model remain unknown. We explored the potential role of Au in a H 2 O 2 -induced oxidant damage in primary cortical neurons and weight-drop induced-TBI ... Read more >>

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H2S-stimulated bioenergetics in chicken erythrocytes and the underlying mechanism.

Zhuping Jin, Quanxi Zhang, Eden Wondimu, Richa Verma, Ming Fu, Tian Shuang, Hassan Mustafa Arif, Lingyun Wu, Rui Wang,

The production of H2S and its effect on bioenergetics in mammalian cells may be evolutionarily preserved. Erythrocytes of birds, but not those of mammals, have a nucleus and mitochondria. In the present study, we report the endogenous production of H2S in chicken erythrocytes, which was mainly catalyzed by 3-mercaptopyruvate sulfur ... Read more >>

Am J Physiol Regul Integr Comp Physiol (American journal of physiology. Regulatory, integrative and comparative physiology)
[2020, 319(1):R69-R78]

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CXCR2 signaling promotes secretory cancer-associated fibroblasts in pancreatic ductal adenocarcinoma.

Mohammad Awaji, Sugandha Saxena, Lingyun Wu, Dipakkumar R Prajapati, Abhilasha Purohit, Michelle L Varney, Sushil Kumar, Satyanarayana Rachagani, Quan P Ly, Maneesh Jain, Surinder K Batra, Rakesh K Singh,

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging malignancies. Desmoplasia and tumor-supporting inflammation are hallmarks of PDAC. The tumor microenvironment contributes significantly to tumor progression and spread. Cancer-associated fibroblasts (CAFs) facilitate therapy resistance and metastasis. Recent reports emphasized the concurrence of multiple subtypes of CAFs with diverse roles, ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(7):9405-9418]

Cited: 2 times

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Cystathionine gamma-lyase/H2S system suppresses hepatic acetyl-CoA accumulation and nonalcoholic fatty liver disease in mice.

Amr Ali, Yanjie Zhang, Ming Fu, Yanxi Pei, Lingyun Wu, Rui Wang, Guangdong Yang,

AIMS:Hydrogen sulfide (H2S) as a novel gasotransmitter can be endogenously produced in liver by cystathionine gamma-lyase (CSE). The dysfunctions of CSE/H2S system have been linked to various liver diseases. Acetyl-CoA is the key intermediate from the metabolism of lipid. This study examined the roles of H2S in hepatic acetyl-CoA and ... Read more >>

Life Sci (Life sciences)
[2020, 252:117661]

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NPM1 mutation with DNMT3A wild type defines a subgroup of MDS with particularly favourable outcomes after decitabine therapy.

Lingyun Wu, Xiao Li, Feng Xu, Dong Wu, Qi He, Luxi Song, Chao Xiao, Youshan Zhao, Zheng Zhang, Juan Guo, Liyu Zhou, Jiying Su, Chunkang Chang,

Br J Haematol (British journal of haematology)
[2020, 189(5):982-984]

Cited: 1 time

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MFG-E8 attenuates neuro-inflammation in subarachnoid hemorrhage through driving microglial M2 polarization via modulating Integrin β3/SOCS3/STAT3 signaling pathway

Yongyue Gao, Zong Zhuang, Yue Lu, Lingyun Wu, Guangjie Liu, Yan Zhou, Dingding Zhang, Haibin Dai, Tao Tao, Han Wang, Wei Li, Chun-Hua Hang,

<h4>Background: </h4> Increasing evidence suggests microglial polarization plays an important role in the pathological processes of neuro-inflammation following subarachnoid hemorrhage (SAH). Previous studies indicated that milk fat globule-EGF factor-8 (MFG-E8) has the potential in anti-apoptosis and anti-inflammation in cerebral ischemia. However, the effects of MFG-E8 on microglial polarization have not ... Read more >>

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Golgi Stress Response, Hydrogen Sulfide Metabolism, and Intracellular Calcium Homeostasis.

Yanjie Zhang, Yuehong Wang, Ethan Read, Ming Fu, Yanxi Pei, Lingyun Wu, Rui Wang, Guangdong Yang,

<b><i>Aims:</i></b> The physiological and pathological importance of hydrogen sulfide (H<sub>2</sub>S) as a novel gasotransmitter has been widely recognized. Cystathionine gamma-lyase (CSE) is one of the major H<sub>2</sub>S-producing enzymes and it regulates diverse functions in connection with intracellular calcium (Ca<sup>2+</sup>). The aim of this study is to examine the role of ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2020, 32(9):583-601]

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The impact of NBUVB on microbial community profiling in the lesional skin of vitiligo subjects.

Xiangfeng Yuan, Linlin Wang, Dan Meng, Lingyun Wu, Xing Wang, Dong Zhang, Zengxiang Luo, Yunyan Pang, Guoyan Liu,

BACKGROUND:The impact of NBUVB on the cutaneous microbiota of vitiligo patients remains to be fully elucidated. METHODS:To characterize the cutaneous microbiota in vitiligo patients, cutaneous samples from 60 patients with vitiligo and after NBUVB irradiation were profiled using the Illumina MiSeq platform. Alpha diversity estimations revealed higher microbiota diversity in ... Read more >>

Microb Pathog (Microbial pathogenesis)
[2020, 140:103943]

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Neutrophils in the Tumor Microenvironment.

Lingyun Wu, Sugandha Saxena, Rakesh K Singh,

Neutrophils are the first responders to inflammation, infection, and injury. As one of the most abundant leukocytes in the immune system, neutrophils play an essential role in cancer progression, through multiple mechanisms, including promoting angiogenesis, immunosuppression, and cancer metastasis. Recent studies demonstrating elevated neutrophil to lymphocyte ratios suggest neutrophil as ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2020, 1224:1-20]

Cited: 3 times

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