Full Text Journal Articles by
Author Ling Wang

Advertisement

Find full text journal articles






Heck reaction prediction using a transformer model based on a transfer learning strategy.

Ling Wang, Chengyun Zhang, Renren Bai, Jianjun Li, Hongliang Duan,

A proof-of-concept methodology for addressing small amounts of chemical data using transfer learning is presented. We demonstrate this by applying transfer learning combined with the transformer model to small-dataset Heck reaction prediction. Introducing transfer learning significantly improved the accuracy of the transformer-transfer learning model (94.9%) over that of the transformer-baseline ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(65):9368-9371]

Cited: 0 times

View full text PDF listing >>



Nuclear delivery of dual anticancer drug-based nanomedicine constructed by cisplatinum-induced peptide self-assembly.

Tengyan Xu, Chunhui Liang, Debin Zheng, Xiaorong Yan, Yaoxia Chen, Yumiao Chen, Xinxin Li, Yang Shi, Ling Wang, Zhimou Yang,

Nuclear delivery of anticancer drugs, particularly dual complementary anticancer drugs, can significantly improve chemotherapy efficacy. However, successful examples are rare. We reported a novel dual anticancer drug-based nanomedicine with nuclear accumulation properties. The nanomedicine was formed by chelation between a drug peptide amphiphile Rh-GFFYERGD (Rh represents Rhein, 1,8-dihydroxy-3-carboxy anthraquinonea) and ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(28):15275-15282]

Cited: 2 times

View full text PDF listing >>



Advertisement

The miR-455-3p/HDAC2 axis plays a pivotal role in the progression and reversal of liver fibrosis and is regulated by epigenetics.

Hongmei You, Ling Wang, Fangtian Bu, Hongwu Meng, Xueyin Pan, Juanjuan Li, Yafei Zhang, Ao Wang, Nana Yin, Cheng Huang, Jun Li,

Histone deacetylases (HDACs), especially HDAC2, play a role in alleviating liver fibrosis; however, the specific upstream regulation mechanism is unknown. Herein, TargetScan was used to predict the potential upstream targets of HDAC2, and the role of miR-455-3p was explored. The dual luciferase reporter assay showed that miR-455-3p binds to the ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21700]

Cited: 0 times

View full text PDF listing >>



Tandem molecular self-assembly for selective lung cancer therapy with an increase in efficiency by two orders of magnitude.

Debin Zheng, Jingfei Liu, Yinghao Ding, Limin Xie, Yingying Zhang, Yaoxia Chen, Rong Peng, Miao Cai, Ling Wang, Huaimin Wang, Jie Gao, Zhimou Yang,

In situ self-assembly of prodrug molecules into nanomedicine can elevate the therapeutic efficacy of anticancer medications by enhancing the targeting and enrichment of anticancer drugs at tumor sites. However, the disassembly and biodegradation of nanomedicine after enrichment prevents the further improvement of the efficiency, and avoiding such disassembly and biodegradation ... Read more >>

Nanoscale (Nanoscale)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Oxidative stress in oocyte aging and female reproduction.

Ling Wang, Jinhua Tang, Lei Wang, Feng Tan, Huibin Song, Jiawei Zhou, Fenge Li,

In a healthy body, reactive oxygen species (ROS) and antioxidants remain balanced. When the balance is broken toward an overabundance of ROS, oxidative stress appears and may lead to oocyte aging. Oocyte aging is mainly reflected as the gradual decrease of oocyte quantity and quality. Here, we aim to review ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Development of new self-assembled cationic amino liposomes for efficient gene delivery.

Yihang Wu, Yue Xiong, Ling Wang, Quanming Zhou, Linxian Li, Pavel A Levkin, Gary Davidson, Liqian Gao, Wenbin Deng,

A library of 83 structurally diverse cationic amino liposomes is rationally designed and parallelly synthesized for the transfection of plasmid DNA and siRNA. Our designed self-assembled liposomes not only exhibit excellent transfection efficiency in HEK 293T cells and mouse embryonic stem cells, but also show low cytotoxicity. ... Read more >>

Biomater Sci (Biomaterials science)
[2020, 8(11):3021-3025]

Cited: 3 times

View full text PDF listing >>



Hierarchical Two-Level Supramolecular Chirality of an Achiral Anthracene-Based Tetracationic Nanotube in Water.

Hao Nian, Lin Cheng, Ling Wang, Haiyang Zhang, Pinpin Wang, Yawen Li, Liping Cao,

Herein, we report an achiral anthracene-based tetracationic nanotube (1⋅4Cl<sup>-</sup> ) that shows two levels of supramolecular chirality: namely, conformationally adaptive host-guest complexation with nucleoside triphosphates (e.g. ATP, GTP, CTP, and UTP) and twisted packing of the chiral host-guest complexes in water. Interestingly, achiral 1⋅4Cl<sup>-</sup> exhibits chiral recognition for ATP/GTP and ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2021, :]

Cited: 0 times

View full text PDF listing >>



CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients.

Mengying Ke, Liqing Kang, Ling Wang, Shu Yang, Yajun Wang, Haiyan Liu, Chunyan Gu, Hongming Huang, Ye Yang,

The chimera antigen receptor (CAR) T cell therapy is a novel and potential targeted therapy and has achieved satisfactory efficacy in patients with relapsed or refractory multiple myeloma (MM) in recent years. However, cytokine release syndrome (CRS) and clinical efficacy have become the major obstacles which limit the application of ... Read more >>

J Hematol Oncol (Journal of hematology & oncology)
[2021, 14(1):90]

Cited: 0 times

View full text PDF listing >>



Safety improvements by intelligent connected vehicle technologies: A meta-analysis considering market penetration rates.

Guiming Xiao, Jaeyoung Lee, Qianshan Jiang, Helai Huang, Mohamed Abdel-Aty, Ling Wang,

As the era of intelligent connected vehicles (ICVs) is approaching, a number of studies have investigated the potential benefits of ICVs, including the safety effects. Although previous studies agree that ICVs would significantly improve traffic safety, its quantified safety effects at different stages are still being debated. This study aims ... Read more >>

Accid Anal Prev (Accident; analysis and prevention)
[2021, 159:106234]

Cited: 0 times

View full text PDF listing >>



SfABCC2 transporter extracellular loops 2 and 4 are responsible for the Cry1Fa insecticidal specificity against Spodoptera frugiperda.

Yuanyuan Liu, Minghui Jin, Ling Wang, Haixia Wang, Zhichao Xia, Yongbo Yang, Alejandra Bravo, Mario Soberón, Yutao Xiao, Kaiyu Liu,

Bacillus thuringiensis (Bt) bacteria produce Cry toxins that kill insect pests. Insect specificity of Cry toxins relies on their binding to larval gut membrane proteins such as cadherin and ATP-binding cassette (ABC) transporter proteins. Mutations in ABC transporters have been implicated in high levels of resistance to Cry toxins in ... Read more >>

Insect Biochem Mol Biol (Insect biochemistry and molecular biology)
[2021, :103608]

Cited: 0 times

View full text PDF listing >>



Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury.

Xue-Yin Pan, Ling Wang, Hong-Mei You, Miao Cheng, Yang Yang, Cheng Huang, Jun Li,

Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide. Macrophages exhibit different functional states and are classified as classically activated (M1) and alternatively activated (M2) macrophages. However, the mechanisms that govern M1/M2 polarization in chronic ALD remain to be elucidated. Prostacyclin (PGI<sub>2</sub>) synthase (PTGIS) is an ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Immune activation induces telomeric DNA damage and promotes short-lived effector T cell differentiation in chronic HCV infection.

Lam Nhat Nguyen, Lam Ngoc Thao Nguyen, Juan Zhao, Madison Schank, Xindi Dang, Dechao Cao, Sushant Khanal, Bal Krishna Chand Thakuri, Jinyu Zhang, Zeyuan Lu, Xiao Y Wu, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P Moorman, Zhi Q Yao,

<h4>Background and aims</h4>Hepatitis C virus (HCV) leads to a high rate of chronic infection and T cell dysfunction. While it is well-known that chronic antigenic stimulation is a driving force for impaired T cell functions, the precise mechanisms underlying immune activation-induced T cell dysfunctions during HCV infection remain elusive.<h4>Approach and ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, :]

Cited: 0 times

View full text PDF listing >>



A Panel Regression Analysis for the COVID-19 Epidemic in the United States: From the Quarantine Policy and Environmental Perspective

Yinpei Guo, Bo Li, Tonghua Duan, Nan Yao, Han Wang, Yixue Yang, Shoumeng Yan, Mengzi Sun, Ling Wang, Yan Yao, Yuchen Sun, Jiwei Jia, Siyu Liu,

<h4>Background: </h4> The COVID-19 epidemic has had an extreme impact on society. This study aimed to discuss this epidemic in the U.S. and explore the association between COVID-19 daily incidence rate and influencing factors including people’s implementation of states’ quarantine policy and environmental factors including temperature, humidity and so on. ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Preemptive Intravenous Nalbuphine for the Treatment of Post-Operative Visceral Pain: A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial.

Xiaofen Liu, Jun Hu, Xianwen Hu, Rui Li, Yun Li, Gordon Wong, Ye Zhang, ,

<h4>Introduction</h4>Post-operative visceral pain is common in early postoperative period after laparoscopic surgery. As a kappa opioid receptor agonist, the antinociceptive effects of nalbuphine in visceral pain are consistent across a multitude of experimental conditions irrespective of species. We hypothesized that preemptive nalbuphine can decrease the visceral pain for patients with ... Read more >>

Pain Ther (Pain and therapy)
[2021, :]

Cited: 0 times

View full text PDF listing >>



The effect of lysophosphatidic acid-supplemented culture medium on human immature oocytes matured in vitro.

Qigui Xie, Yaxin Xing, Jianhong Zhou, Ling Wang, Jie Wu, Ri-Cheng Chian,

<h4>Background</h4>Lysophosphatidic acid-supplemented culture medium significantly increases the oocyte maturation rate in vitro. However, potential targets and pathways involved remain unknown.<h4>Methods</h4>A total of 43 women, who underwent cesarean section and aged between 18 and 35 years with good health, were included in this study. Immature oocytes were obtained and cultured with ... Read more >>

Reprod Biol Endocrinol (Reproductive biology and endocrinology : RB&E)
[2021, 19(1):83]

Cited: 0 times

View full text PDF listing >>



Quantitative Proteomics by iTRAQ-PRM based Reveals the New Characterization for Gout.

Guangqi Chen, Jiafen Cheng, Hanjie Yu, Xiao Huang, Hui Bao, Ling Qin, Ling Wang, Yaxiang Song, Xinying Liu, Ai Peng,

<h4>Background: </h4> Gout is a common and complex form of immunoreactive arthritis based on hyperuricemia, while the symptoms would turn to remission or even got worse. So, it is hard to early identify whether an asymptomatic hyperuricemia (AHU) patient will be susceptible to get acute gout attack and it is ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Hsa_circ_0001982 promotes the progression of breast cancer through miR-1287-5p/MUC19 axis under hypoxia.

Zhimin Qiu, Ling Wang, Huaidong Liu,

<h4>Background</h4>Breast cancer (BC) is the most commonly malignant tumor among women worldwide. Many studies have reported that circular RNAs (circRNAs) were participated in the regulation of multiple cancers development. However, the mechanism underlying hsa_circ_0001982 in breast cancer development is still unclear.<h4>Methods</h4>Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect ... Read more >>

World J Surg Oncol (World journal of surgical oncology)
[2021, 19(1):161]

Cited: 0 times

View full text PDF listing >>



Functional Reorganizations Outside the Sensorimotor Regions Following Complete Thoracolumbar Spinal Cord Injury.

Weimin Zheng, Ling Wang, Qian Chen, Xuejing Li, Xin Chen, Wen Qin, Kuncheng Li, Jie Lu, Nan Chen,

<h4>Background</h4>Studies have shown that loss of sensorimotor function in spinal cord injury (SCI) leads to brain functional reorganization, which may play important roles in motor function recovery. However, the specific functional changes following SCI are still poorly understood.<h4>Purpose</h4>To investigate whether there are functional reorganizations outside the sensorimotor regions after complete ... Read more >>

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2021, :]

Cited: 0 times

View full text PDF listing >>



The association between carotenoids and subjects with overweight or obesity: a systematic review and meta-analysis.

Nan Yao, Shoumeng Yan, Yinpei Guo, Han Wang, Xiaotong Li, Ling Wang, Wenyu Hu, Bo Li, Weiwei Cui,

<h4>Background</h4>Excess body weight, including overweight and obesity, is one of the major factors influencing human health, and plays an important role in the global burden of disease. Carotenoids serve as precursors of vitamin A-related retinoids, and are considered to have potential effects on many diseases. However, the influence of carotenoids ... Read more >>

Food Funct (Food & function)
[2021, 12(11):4768-4782]

Cited: 0 times

View full text PDF listing >>



The Association of Lumbar Disc Herniation with Lumbar Volumetric Bone Mineral Density in a Cross-Sectional Chinese Study.

Jian Geng, Ling Wang, Qing Li, Pengju Huang, Yandong Liu, Glen M Blake, Wei Tian, Xiaoguang Cheng,

Little is known about the effect of lumbar intervertebral disc herniation (LDH) on lumbar bone mineral density (BMD), and few previous studies have used quantitative computed tomography (QCT) to assess whether the staging of LDH correlates with lumbar vertebral trabecular volumetric bone mineral density (Trab.vBMD). To explore the relationship between ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(6):]

Cited: 0 times

View full text PDF listing >>



Gibberellic acid application on biomass, oxidative stress response, and photosynthesis in spinach (Spinacia oleracea L.) seedlings under copper stress.

Qin Gong, Zhao-Hua Li, Ling Wang, Jing-Yi Zhou, Qun Kang, Duan-Dan Niu,

The mechanism of Cu tolerance in plants and its control measures are of considerable significance for the remediation of Cu-contaminated soils. Gibberellic acid (GA<sub>3</sub>) is involved in plant growth and development and in the response to heavy metal stress. In the present study, changes in the biomass, oxidative stress response ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Disrupted functional brain network topology in Parkinson's disease patients with freezing of gait.

Nannan Li, Xueling Suo, Jinhong Zhang, Du Lei, Ling Wang, Junying Li, Jiaxin Peng, Liren Duan, Qiyong Gong, Rong Peng,

<h4>Background</h4>Freezing of gait (FOG) is a common and debilitating gait disturbance in patients with Parkinson's disease (PD), but the potential mechanisms are still unclear. This study aimed to explore alterations in the topological organization of whole-brain functional networks in PD patients with FOG.<h4>Methods</h4>We recruited 75 patients with PD, 37 patients ... Read more >>

Neurosci Lett (Neuroscience letters)
[2021, 759:135970]

Cited: 0 times

View full text PDF listing >>



Choosing an appropriate glomerular filtration rate estimating equation: role of body mass index.

Jiayong Li, Xiang Xu, Jialing Luo, Wenjing Chen, Man Yang, Ling Wang, Nan Zhu, Weijie Yuan, Lijie Gu,

<h4>Background</h4>We aimed to investigate the accuracy of different equations in evaluating estimated glomerular filtration rate (eGFR) in a Chinese population with different BMI levels.<h4>Methods</h4>A total of 837 Chinese patients were enrolled, and the eGFRs were calculated by three Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, three full-age spectrum (FAS) equations ... Read more >>

BMC Nephrol (BMC nephrology)
[2021, 22(1):197]

Cited: 0 times

View full text PDF listing >>



An Improved Parameter-Estimating Method in Bayesian Networks Applied for Cognitive Diagnosis Assessment.

Ling Ling Wang, Tao Xin, Liu Yanlou,

Bayesian networks (BNs) can be employed to cognitive diagnostic assessment (CDA). Most of the existing researches on the BNs for CDA utilized the MCMC algorithm to estimate parameters of BNs. When EM algorithm and gradient descending (GD) learning method are adopted to estimate the parameters of BNs, some challenges may ... Read more >>

Front Psychol (Frontiers in psychology)
[2021, 12:665441]

Cited: 0 times

View full text PDF listing >>



Development and validation of a novel diagnostic nomogram model to predict primary aldosteronism in patients with hypertension.

Meng-Hui Wang, Nan-Fang Li, Qin Luo, Guo-Liang Wang, Mulalibieke Heizhati, Ling Wang, Lei Wang, Wei-Wei Zhang,

<h4>Purpose</h4>Primary aldosteronism (PA) remains, to a large extent, an under-diagnosed disease. We aimed to develop and validate a novel clinical nomogram to predict PA based on routine biochemical variables including new ones, calcium-phosphorus product.<h4>Methods</h4>Records from 806 patients with hypertension were randomly divided into 70% (n = 564) as the training set and ... Read more >>

Endocrine (Endocrine)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
0.9321 s