Full Text Journal Articles by
Author Ling Li

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An organocatalytic asymmetric Friedel-Crafts reaction of 2-substituted indoles with aldehydes: enantioselective synthesis of α-hydroxyl ketones by low loading of chiral phosphoric acid.

Xiong-Fei Deng, Ying-Wei Wang, Shi-Qi Zhang, Ling Li, Guang-Xun Li, Gang Zhao, Zhuo Tang,

Hydroxyl alkylation of indoles by Friedel-Crafts reaction with a carbonyl compound is a useful strategy. However, the reaction was restricted to ketones due to the easy formation of a bisindole byproduct. Therefore, hydroxyl alkylation of an aldehyde with indole is confronted with great challenges. Here, we report an efficient strategy ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(16):2499-2502]

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Spatially resolved electrochemical reversibility of a conducting polymer thin film imaged by oblique-incidence reflectivity difference.

Changyin Zhong, Ling Li, Nan Chen, Zeping Peng, Weihua Hu,

The spatially resolved electrochemical reversibility of a polyaniline (PANI) thin film is successfully imaged by an oblique-incidence reflectivity difference (OIRD) technique. The electrochemical conversion of the PANI thin film from its completely reduced state to partially oxidized state gives rise to a considerable OIRD signal while upon the deterioration of ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(13):1972-1975]

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Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source.

Wanrong Meng, Chanshi He, Yaying Hao, Linlin Wang, Ling Li, Guiquan Zhu,

Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are nanosized membrane vesicles derived from most cell types. Carrying diverse biomolecules from their parent cells, EVs are important mediators of intercellular communication and thus play significant roles in physiological and pathological processes. Owing to their natural biogenesis process, EVs are ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):585-598]

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Recent advances in covalent organic frameworks (COFs) as a smart sensing material.

Xigui Liu, Danlian Huang, Cui Lai, Guangming Zeng, Lei Qin, Han Wang, Huan Yi, Bisheng Li, Shiyu Liu, Mingming Zhang, Rui Deng, Yukui Fu, Ling Li, Wenjing Xue, Sha Chen,

As a newly emerging kind of porous material, covalent organic frameworks (COFs) have drawn much attention because of their fascinating structural features (e.g., divinable structure, adjustable porosity and total organic backbone). Since the seminal work of Yaghi and co-workers reported in 2005, the COF materials have shown superior potential in ... Read more >>

Chem Soc Rev (Chemical Society reviews)
[2019, 48(20):5266-5302]

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Low Incidence of Venous Thrombosis But High Incidence of Arterial Thrombotic Complications Among Critically Ill COVID-19 Patients in Singapore

Chuen Wen Tan, Bingwen Eugene Fan, Winnie Z.Y. Teo, Moon Ley Tung, Humaira Shafi, Dheepa Christopher, Shuwei Zheng, Wee Ming Peh, Stephrene Seok Wei Chan, Vanessa Cui Lian Chong, Christian Aledia Gallardo, Cheng Chieh Ray Chang, Li Min Ling, Jing Yuan Tan, Ken Cheah Hooi Lee, Ghee Chee Phua, Benjamin Pei Zhi Cherng, Jenny Guek Hong Low, Vui Kian Ho, Vishnu Prasad, Lester Jung Long Wong, Cheryl Xiu Qi Lim, Yen Lin Chee, Kiat Hoe Ong, Lai Heng Lee, Heng Joo Ng, Eng Soo Yap,

Abstract Background: Arterial and venous thrombosis are reported to be common in critically ill COVID-19 patients. Method and Results: This is a national multicenter retrospective observational study involving all consecutive adult COVID-19 patients who required intensive care units (ICU) admission between 23 January 2020 and 30 April 2020 in Singapore. ... Read more >>

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Constructing colorful surfaces with mechanical robustness for magnesium alloys via a reagent-free method.

Lei Liu, Jing Lei Lei, Ling Jie Li, Xueping Zhang, Nian Bing Li, Fusheng Pan,

The colorful and mechanically robust surfaces of metallic materials are important for their applications of electronics, automobile, aerospace and so on, but it is challenging to prepare them at reasonable cost. Herein, we propose a simple, environment-friendly and cost-effective method, reagent-free hydrothermal treatment, to prepare the colorful surfaces of magnesium ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, :]

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A multicenter prospective phase III clinical randomized study of simultaneous integrated boost intensity-modulated radiotherapy with or without concurrent chemotherapy in patients with esophageal cancer: 3JECROG P-02 study protocol.

Lin-Rui Gao, Xin Wang, Weiming Han, Wei Deng, Chen Li, Xiaomin Wang, Yidian Zhao, Wenjie Ni, Xiao Chang, Zongmei Zhou, Lei Deng, Wenqing Wang, Wenyang Liu, Jun Liang, Tao Zhang, Nan Bi, Jianyang Wang, Yirui Zhai, Qinfu Feng, Jima Lv, Ling Li, Zefen Xiao,

BACKGROUND:Since the development of three-dimensional conformal radiotherapy and intensity-modulated radiotherapy (IMRT), no prospective study has investigated whether concurrent chemoradiotherapy (SIB-IMRT with 60 Gy) remains superior to radiotherapy (SIB-IMRT) alone for unresectable esophageal cancer (EC). Furthermore, the optimal therapeutic regimen for patients who cannot tolerate concurrent chemoradiotherapy is unclear. We recently completed ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):901]

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A gas pressure and colorimetric signal dual-mode strategy for sensitive detection of spermine using ssDNA-coated [email protected] nanoparticles as the probe.

Huan Jiang, Xinyue Rao, Ling Li, Zhongde Liu,

The naturally occurring spermine (Spm), as one of the many cationic polyamines, plays a key role in biological processes and is involved in a variety of diseases. The very similar structures among biogenic polyamines present a major challenge to achieve discriminative testing among them. In this contribution, using arbitrary ssDNA-coated ... Read more >>

Analyst (The Analyst)
[2020, :]

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Prevalence Patterns of Allergen Sensitization by Region, Gender, Age and Season among Patients with Allergic Symptoms in Mainland China: A Four-Year Multicenter Study.

Wenting Luo, Dandan Wang, Teng Zhang, Peiyan Zheng, Dongliang Leng, Ling Li, Yong Liu, Baoqinq Sun, Xiaohua Douglas Zhang,

Allergy (Allergy)
[2020, :]

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Co-editing PINK1 and DJ-1 genes via AAV-delivered CRISPR/Cas9 system in adult monkey brains elicits classic Parkinsonian phenotypes

Hao Li, Shihao Wu, Xia Ma, Xiao Li, Tianlin Cheng, Zhifang Chen, Jing Wu, Longbao Lv, Ling Li, Liqi Xu, Wenchao Wang, Yingzhou Hu, Haisong Jiang, Yong Yin, Zilong Qiu, Xintian Hu,

Abstract Whether direct manipulation of Parkinson’s disease (PD) risk genes in monkey brain can elicit Parkinsonian phenotypes remains an unsolved issue. Here, we employed an adeno-associated virus (AAV)-delivered CRISPR/Cas9 system to directly co-edit PINK1 and DJ-1 genes in the substantia nigra (SN) region of four adult monkey brains. After the ... Read more >>

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Prognosis Value of Low microRNA-34a Expression in Human Gastrointestinal Cancer: A Meta-Analysis

Yan-Ling Chen, Xiao-Lin Liu, Ling Li,

Abstract Background: Mounting evidence shows that microRNA-34a (miR-34a) is involved in cancer prognosis. Therefore, we summarize the predictive role of miR-34a for survival in patients with gastrointestinal cancers (GICs). Methods: All the eligible studies were searched by PubMed, Web of Science and EMBASE and survival results were extracted. Then, the ... Read more >>

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Impact of temperature variability on childhood allergic rhinitis in a subtropical city of China.

Xu Wang, Jian Cheng, Li Ling, Hong Su, Desheng Zhao, Hong Ni,

BACKGROUND:Many studies have shown an association of childhood respiratory diseases with short-term temperature variability such as diurnal temperature range (DTR) and temperature change between two neighboring days (TCN). However, the impact of temperature variability on allergic rhinitis (AR) has not been investigated so far. This study sought to evaluate the ... Read more >>

BMC Public Health (BMC public health)
[2020, 20(1):1418]

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Protective effects of HY1702 on lipopolysaccharide-induced mild acute respiratory distress syndrome in mice.

Mengfei Wang, Tong Zhang, Ling Li, Qing Xie, Yanping Wang, Yunsen Li, Zijun Chen,

Acute respiratory distress syndrome is an inflammatory disease with no effective pharmacological treatment. We investigated the therapeutic effect of HY1702, a new small molecule diterpene obtained from the processing and modification of Glaucocalyxin A and may exhibit anti-inflammatory activity. Specifically, we studied the anti-inflammatory effects of HY1702 on lipopolysaccharide-induced inflammatory ... Read more >>

Eur. J. Pharmacol. (European journal of pharmacology)
[2020, :173563]

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Analyzing and Accelerating the Bottlenecks of Training Deep SNNs with Backpropagation.

Ruizhi Chen, Ling Li,

Spiking neural networks (SNNs) with the event-driven manner of transmitting spikes consume ultra-low power on neuromorphic chips. However, training deep SNNs is still challenging compared to convolutional neural networks (CNNs). The SNN training algorithms have not achieved the same performance as CNNs. In this letter, we aim to understand the ... Read more >>

Neural Comput (Neural computation)
[2020, :1-44]

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Impact of temperature variability on childhood allergic rhinitis in a subtropical city of China

Xu Wang, Jian Cheng, Li Ling, Hong Su, Desheng Zhao, Hong Ni,

Abstract Background: Many studies have shown an association of childhood respiratory diseases with short-term temperature variability such as diurnal temperature range (DTR) and temperature change between two neighboring days (TCN). However, the impact of temperature variability on allergic rhinitis (AR) has not been investigated so far. This study sought to ... Read more >>

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Simulated microgravity suppresses MAPK pathway-mediated innate immune response to bacterial infection and induces gut microbiota dysbiosis.

Jing Wang, Conghui Han, Zhe Lu, Pupu Ge, Yu Cui, Dongdong Zhao, Xi Yang, Bo Wu, Lihua Qiang, Yong Zhang, Qiyao Chai, Zehui Lei, Ling Li, Cui Hua Liu, Lingqiang Zhang,

During spaceflight, astronauts are subjected to various physical stressors including microgravity, which could cause immune dysfunction and thus potentially predispose astronauts to infections and illness. However, the mechanisms by which microgravity affects innate immunity remain largely unclear. In this study, we conducted RNA-sequencing analysis to show that simulated microgravity (SMG) ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, :]

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Methylation pattern and expression dynamics of methylase and photosystem genes under varied light intensities in Fugacium kawagutii (Symbiodiniaceae).

Feng Yang, Ling Li, Senjie Lin,

Previous studies have indicated extensive methylation of CpG islands and abundant methyltransferase gene (DNMT) in Fugacium kawagutii (formerly Symbiodinium kawagutii) genome. However, whether DNA methylation plays a role in regulating gene expression in this and other dinoflagellates remains unclear. Here we characterized gene body methylation levels using methylation-specific PCR (MS-PCR) ... Read more >>

J. Phycol. (Journal of phycology)
[2020, :]

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Mechanical design of the highly porous cuttlebone: A bioceramic hard buoyancy tank for cuttlefish.

Ting Yang, Zian Jia, Hongshun Chen, Zhifei Deng, Wenkun Liu, Liuni Chen, Ling Li,

Cuttlefish, a unique group of marine mollusks, produces an internal biomineralized shell, known as cuttlebone, which is an ultra-lightweight cellular structure (porosity, ∼93 vol%) used as the animal's hard buoyancy tank. Although cuttlebone is primarily composed of a brittle mineral, aragonite, the structure is highly damage tolerant and can withstand ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(38):23450-23459]

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Follistatin-like 1 as a novel adipo-myokine related to insulin resistance and physical activity.

Xiaohui Xu, Tingran Zhang, Mani Mokou, Ling Li, Peng Li, Jinlin Song, Hua Liu, Zhiming Zhu, Dongfang Liu, Mengliu Yang, Gangyi Yang,

BACKGROUND AND AIMS:FSTL-1 is considered to be an adipokine or myokine that could be a potential regulator of metabolism. Our purpose is to investigate the relationship between circulating FSTL-1 levels and insulin resistance (IR) in type 2 diabetes mellitus (T2DM) and to identify the regulatory factors. METHODS:FSTL-1 expression in C57BL/6J ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, :]

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Mining Listeria monocytogenes single nucleotide polymorphism sites to identify the major serotypes using allele-specific multiplex PCR.

Xu Zhang, Li Ling, Zhiyong Li, Jufang Wang,

Worldwide, Listeria monocytogenes is a common foodborne pathogen and serotyping is necessary for traceability and surveillance. Due to high accuracy and speed, PCR is commonly used for serotyping by targeting specific genes, such as lmo1118 and ORF2110 for 1/2c-3c and 4b-4d-4e, respectively. Single nucleotide polymorphisms (SNPs) are single base alterations ... Read more >>

Int. J. Food Microbiol. (International journal of food microbiology)
[2020, 335:108885]

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mTOR - Mediated protein synthesis by inhibiting protein catabolism in Chinese perch (Siniperca chuatsi).

Jiao Li, Yanpeng Zhang, Xu-Fang Liang, Shan He, Shulin Tang, Ling Li, Xu Chen,

Activation of the mechanistic target of rapamycin (mTOR) pathway is known to promote protein synthesis by enhancing mRNA translation. However, there have been few literatures on the effect of mTOR on protein metabolism in non-mammals. The main source of ammonia in fish comes from protein catabolism. The key step of ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2020, :]

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Disturbed temporal dynamics of episodic retrieval activity with preserved spatial activity pattern in amnestic mild cognitive impairment: A simultaneous EEG-fMRI study

Hao Shu, Lihua Gu, Ping Yang, Molly Lucas, Lijuan Gao, Hongxing Zhang, Haisan Zhang, Zhan Xu, Wei Wu, Ling Li, Zhijun Zhang,

Abstract Background Episodic memory (EM) deficit is the core cognitive dysfunction of amnestic mild cognitive impairment (aMCI). However, the episodic retrieval circuit detected by functional MRI (fMRI) appears preserved in aMCI subjects. To address this discrepancy, this study employed simultaneous electroencephalography (EEG)-fMRI recording to determine whether temporal dynamics of ... Read more >>

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Synthesis of bio-inspired guanine microplatelets: morphological and crystallographic control.

Ling Li, Fenghua Chen, Yanan Liu, Limin Qi, Yurong Ma,

β-phase anhydrous guanine (β-AG) crystals are one of the most widespread organic crystals to construct optical structures in organisms. Currently no synthetic method is available that allows for producing guanine crystals with similar control in size, morphology and crystallography as in biological ones. Here we report a facile one-step synthesis ... Read more >>

Chemistry (Chemistry (Weinheim an der Bergstrasse, Germany))
[2020, :]

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Diagnostic Models for Screening of Chronic Periodontitis with Cytokines and Microbiologic Profiles in Saliva

Jungwon Lee, Jun-Beom Lee, Hyun-Young Song, Min Jung Son, Ling Li, In-Chul Rhyu, Yong-Moo Lee, Ki-Tae Koo, Jung-Sub An, Jin Sup Kim, Eunkyung Kim,

This study was to investigate and assess salivary biomarkers as a means of diagnosing periodontitis. A total of 121 subjects were included: 28 periodontally healthy subjects, 24 with stage I, 24 with stage II, 23 with stage III, and 22 with stage IV periodontitis. Salivary proteins including active matrix metalloproteinase-8 ... Read more >>

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An improved method for preparation of mouse retinal cryosections.

Ling Li, Yongqiong Lin, Fang Yang, Tongdan Zou, Jialiang Yang, Houbin Zhang,

Immunohistochemistry using mouse retinal cryosections is a routine assay used in vision research. However, retinal tissues are fragile, and it is difficult to obtain an ideal retinal cryosection. Here, we developed a modified method for preparing retinal cryosection. Super Glue was applied on the surface of the sclera before the cornea ... Read more >>

Eur J Histochem (European journal of histochemistry : EJH)
[2020, 64(3):]

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