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The SIOP-Renal Tumour Study Group consensus statement on flank target volume delineation for highly conformal radiotherapy.

Geert O Janssens, Patrick Melchior, Joeri Mul, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Line Claude, Kristin Gurtner, Kees P van de Ven, Martine van Grotel, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Xavier Muracciole, Tom Boterberg, Henry Mandeville, Jan Godzinski, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe,

For decades, radiotherapy with two opposing photon beams has been the standard technique used to cover the flank target volume in paediatric patients with renal tumours. Nowadays, many institutes are implementing advanced radiotherapy techniques that spare healthy tissue. To decrease the radiotherapy dose to healthy structures while preserving oncological efficacy, ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):846-852]

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[Influence of age on indications and modalities of radiation therapy: What to keep in mind for adolescents and young adults?]

Emmanuel Jouglar, Alexandre Escande, Valentine Martin, Charlotte Demoor-Goldschmidt, Christian Carrie, Line Claude, Valérie Bernier-Chastagner,

When using radiation therapy for adolescents and young adults (AYA), paediatricians, adults' oncologists and radiation oncologists need to keep in mind several particularities through the whole therapeutic process. They embrace the indication, target volumes, prescribed dose, treatment techniques and follow-up. Indeed, the young age and the cancer features that characterised ... Read more >>

Bull Cancer (Bulletin du cancer)
[2020, :]

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Osteosarcoma.

Bree R Eaton, Rudolf Schwarz, Ralph Vatner, Brian Yeh, Line Claude, Daniel J Indelicato, Nadia Laack,

Osteosarcoma is a rare tumor that requires complex multidisciplinary management. This paper reviews the general management and standard radiotherapy guidelines for osteosarcoma in both North America and Europe in a joined effort between the Children's Oncology Group and International Society of Pediatric Oncology. Standard treatment involves multiagent induction chemotherapy followed ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, :e28352]

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Exclusive Hyperfractionated Radiation Therapy and Reduced Boost Volume for Standard-Risk Medulloblastoma: Pooled Analysis of the 2 French Multicentric Studies MSFOP98 and MSFOP 2007 and Correlation With Molecular Subgroups.

Christian Carrie, Virginie Kieffer, Dominique Figarella-Branger, Julien Masliah-Planchon, Stéphanie Bolle, Valérie Bernier, Anne Laprie, Stéphane Supiot, Julie Leseur, Jean-Louis Habrand, Claire Alapetite, Christine Kerr, Christelle Dufour, Line Claude, Sophie Chapet, Aymeri Huchet, Pierre-Yves Bondiau, Alexandre Escande, Gilles Truc, Tan Dat Nguyen, Caroline Pasteuris, Céline Vigneron, Xavier Muracciole, Franck Bourdeaut, Romain Appay, Bernard Dubray, Carole Colin, Céline Ferlay, Sophie Dussart, Sylvie Chabaud, Laetitia Padovani, , ,

PURPOSE:Medulloblastoma has recently been characterized as a heterogeneous disease with 4 distinct molecular subgroups: wingless (WNT), sonic hedgehog (SHH), group 3, and group 4, with a new definition of risk stratification. We report progression-free survival, overall survival, and long-term cognitive effects in children with standard-risk medulloblastoma exclusively treated with hyperfractionated ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2020, 108(5):1204-1217]

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Testicular transposition in children before scrotal external radiotherapy.

Marielle Le Bon, Herve Lejeune, Sylvie Helfre, Stéphanie Bolle, Laetitia Padovani, Laurence Mengue, Nadege Corradini, Frédéric Hameury, Line Claude,

Testicular transposition (TT) before scrotal external radiotherapy (RT) is poorly reported in children with cancer, with only rare case reports published. TT surgical techniques, dosimetric parameters, and testicular functions are retrospectively reported in 12 children, median age 12.8 years, after scrotal RT for sarcomas. TT has low morbidity and allows ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(9):e28526]

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Brain metastases treated with hypofractionated stereotactic radiotherapy: 8 years experience after Cyberknife installation.

Laurence Mengue, Aurélie Bertaut, Louise Ngo Mbus, Mélanie Doré, Myriam Ayadi, Karen Clément-Colmou, Line Claude, Christian Carrie, Cécile Laude, Ronan Tanguy, Julie Blanc, Marie-Pierre Sunyach,

BACKGROUND:Hypofractionated stereotactic radiotherapy (HFSRT) is indicated for large brain metastases (BM) or proximity to critical organs (brainstem, chiasm, optic nerves, hippocampus). The primary aim of this study was to assess factors influencing BM local control after HFSRT. Then the effect of surgery plus HFSRT was compared with exclusive HFSRT on ... Read more >>

Radiat Oncol (Radiation oncology (London, England))
[2020, 15(1):82]

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Cerebellar lesions at a young age predict poorer long-term functional recovery.

Pierre-Aurélien Beuriat, Irene Cristofori, Nathalie Richard, Lara Bardi, Celia Loriette, Alexandru Szathmari, Federico Di Rocco, Pierre Leblond, Didier Frappaz, Cécile Faure-Conter, Line Claude, Carmine Mottolese, Michel Desmurget,

Early studies on long-term functional recovery after motor and premotor lesions showed better outcomes in younger monkeys than in older monkeys. This finding led to the widespread belief that brain injuries cause less impairment in children than adults. However, this view has limitations and a large body of evidence now ... Read more >>

(Brain communications)
[2020, 2(1):fcaa027]

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Pattern of loco-regional relapses and treatment in pediatric esthesioneuroblastoma: The French very rare tumors group (Fracture) contribution.

Benoît Dumont, Brice Fresneau, Line Claude, Anne-Sophie Defachelles, Vincent Couloigner, Stéphanie Puget, Hervé J Brisse, Paul Fréneaux, Brigitte Lacour, Daniel Orbach,

BACKGROUND:Esthesioneuroblastoma (ENB) is a rare neuroectodermal tumor that seldom occurs during childhood. Multimodal treatments are currently proposed, but the place of each therapy is still in debate. Our objective is to describe clinical evolution, especially the pattern of relapses and determine contributors to tumor progression. PROCEDURE:Medical charts of all children ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(4):e28154]

Cited: 1 time

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High-Dose Chemotherapy Compared With Standard Chemotherapy and Lung Radiation in Ewing Sarcoma With Pulmonary Metastases: Results of the European Ewing Tumour Working Initiative of National Groups, 99 Trial and EWING 2008.

Uta Dirksen, Bernadette Brennan, Marie-Cécile Le Deley, Nathalie Cozic, Henk van den Berg, Vivek Bhadri, Bénédicte Brichard, Line Claude, Alan Craft, Susanne Amler, Natalie Gaspar, Hans Gelderblom, Robert Goldsby, Richard Gorlick, Holcombe E Grier, Jean-Marc Guinbretiere, Peter Hauser, Lars Hjorth, Katherine Janeway, Heribert Juergens, Ian Judson, Mark Krailo, Jarmila Kruseova, Thomas Kuehne, Ruth Ladenstein, Cyril Lervat, Stephen L Lessnick, Ian Lewis, Claude Linassier, Perrine Marec-Berard, Neyssa Marina, Bruce Morland, Hélène Pacquement, Michael Paulussen, R Lor Randall, Andreas Ranft, Gwénaël Le Teuff, Keith Wheatley, Jeremy Whelan, Richard Womer, Odile Oberlin, Douglas S Hawkins, ,

PURPOSE:The R2Pulm trial was conducted to evaluate the effect of busulfan-melphalan high-dose chemotherapy with autologous stem-cell rescue (BuMel) without whole-lung irradiation (WLI) on event-free survival (main end point) and overall survival, compared with standard chemotherapy with WLI in Ewing sarcoma (ES) presenting with pulmonary and/or pleural metastases. METHODS:From 2000 to ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, 37(34):3192-3202]

Cited: 2 times

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Update in pediatric nasopharyngeal undifferentiated carcinoma.

Line Claude, Emmanuel Jouglar, Loig Duverge, Daniel Orbach,

Many of the principles established in adults with undifferentiated nasopharyngeal carcinoma (NPC) apply to children, adolescents and young adults. However, NPC in young patients should be distinguished from the adult form by several points. This review focuses mainly on differences between adult and pediatric NPC. The role of biology and ... Read more >>

Br J Radiol (The British journal of radiology)
[2019, 92(1102):20190107]

Cited: 1 time

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Healthcare system barriers of breast and thyroid screening for childhood and young adulthood cancer survivors in France A qualitative study of the DeNaCaPST programme at one year

charlotte demoor-goldschmidt, claire berger, isabelle guichard, STEPHANE SUPIOT, aliette dezellus, bruno filhon, piere-yves bondiau, maryline poiree, caroline oudot, line claude, gilles truc, claire briandet, laetitia padovani, carole coze, valerie bernier, christine kerr, yves reguerre, helene sudour-bonnange, jeremie gaudichon, celine vigneron, agnes dumas, florent de vathaire,

Abstract Purpose Childhood, adolescent and young adult cancer survivors (CAYACS) who were treated by radiotherapy have a significant risk of developing subsequent malignancies, particularly breast and thyroid cancers when the field of irradiation concerned these organs. Advice regarding their increased risk of developing secondary breast (SBC) and thyroid (STC) cancer ... Read more >>

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Adapted strategy to tumor response in childhood nasopharyngeal carcinoma: the French experience.

Anaïs Jouin, Sylvie Helfre, Stéphanie Bolle, Line Claude, Anne Laprie, Emilie Bogart, Céline Vigneron, Hélène Potet, Anne Ducassou, Audrey Claren, François Georges Riet, Marie Pierre Castex, Cécile Faure-Conter, Brice Fresneau, Anne Sophie Defachelles, Daniel Orbach,

PURPOSE:The aim of this study was to retrospectively study survival and long-term morbidities of children with nasopharyngeal carcinoma (NPC) treated by induction chemotherapy and concurrent chemoradiation (CRT). The total dose of radiation was adapted to the response following neoadjuvant chemotherapy. METHODS:Children with non-metastatic NPC treated in France between 1999 and ... Read more >>

Strahlenther Onkol (Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al])
[2019, 195(6):504-516]

Cited: 1 time

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Re-irradiation of locally recurrent pediatric intracranial ependymoma: Experience of the French society of children's cancer.

Elise Régnier, Anne Laprie, Anne Ducassou, Stéphanie Bolle, Stéphane Supiot, Xavier Muracciole, Line Claude, Sophie Chapet, Bernard Coche-Dequéant, Céline Vigneron, Julie Leseur, Pierre Y Bondiau, Jean L Habrand, Valérie Bernier,

PURPOSE:This study aimed to evaluate retrospectively the clinical results of re-irradiation for children with a locally recurrent brain ependymoma. METHODS:33 full-dose re-irradiations were delivered to 31 children with a recurrent brain ependymoma after a standard treatment. Each child was followed up with clinical and MRI examinations. We evaluated overall survival, ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2019, 132:1-7]

Cited: 2 times

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Pediatric Localized Intracranial Ependymomas: A Multicenter Analysis of the Société Française de lutte contre les Cancers de l'Enfant (SFCE) from 2000 to 2013.

Anne Ducassou, Laetitia Padovani, Leonor Chaltiel, Stéphanie Bolle, Jean-Louis Habrand, Line Claude, Christian Carrie, Xavier Muracciole, Bernard Coche-Dequeant, Claire Alapetite, Stéphane Supiot, Charlotte Demoor-Goldschmidt, Valerie Bernier-Chastagner, Aymeri Huchet, Julie Leseur, Elisabeth Le Prise, Christine Kerr, Gilles Truc, Tan Dat Nguyen, Anne-Isabelle Bertozzi, Didier Frappaz, Sergio Boetto, Annick Sevely, Fatima Tensaouti, Anne Laprie, ,

PURPOSE:The objective of this study was to analyze survival and prognostic factors for children, adolescents, and young adults treated with postoperative radiation therapy (RT) for intracranial ependymoma. METHODS AND MATERIALS:Between 2000 and 2013, 202 patients aged ≤25 years were treated in the 13 main French pediatric RT reference centers. Their ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2018, 102(1):166-173]

Cited: 4 times

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Clinical and histological features of second breast cancers following radiotherapy for childhood and young adult malignancy.

Charlotte Demoor-Goldschmidt, Stéphane Supiot, Marc-André Mahé, Odile Oberlin, Rodrigue Allodji, Nadia Haddy, Sylvie Helfre, Céline Vigneron, Victoire Brillaud-Meflah, Valérie Bernier, Anne Laprie, Anne Ducassou, Line Claude, Ibrahim Diallo, Florent de Vathaire,

OBJECTIVE:The purpose of this study was to determine the characteristics of early second breast cancer (SBC) among survivors of childhood and young adult malignancy treated with irradiation. METHODS:We conducted a multicenter retrospective study of women who presented with breast cancer aged 50 years or younger in nine French centers. RESULTS:121 ... Read more >>

Br J Radiol (The British journal of radiology)
[2018, 91(1086):20170824]

Cited: 3 times

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Imaging biomarkers of outcome after radiotherapy for pediatric ependymoma.

Fatima Tensaouti, Anne Ducassou, Léonor Chaltiel, Annick Sevely, Stéphanie Bolle, Laetitia Padovani, Anais Jouin, Claire Alapetite, Stéphane Supiot, Aymeri Huchet, Valérie Bernier, Line Claude, Christine Kerr, Elisabeth Le Prisé, Anne-Isabelle Bertozzi-Salamon, Samuel Liceaga, Jean Albert Lotterie, Patrice Péran, Anne Laprie, ,

BACKGROUND AND PURPOSE:Ependymoma is the third most common brain tumor in children. Radiation therapy (RT) is systematically administered after maximum surgical resection, utilizing recent advances in radiation delivery. Imaging can make a significant contribution to improving treatment outcome. This prompted us to look for significant preoperative and postoperative imaging markers ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2018, 127(1):103-107]

Cited: 1 time

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Childhood Nasopharyngeal Carcinoma: State-of-the-Art, and Questions for the Future.

Marie-Emilie Dourthe, Stéphanie Bolle, Stéphane Temam, Anais Jouin, Line Claude, Yves Reguerre, Anne-Sophie Defachelles, Daniel Orbach, Brice Fresneau,

In children, nasopharyngeal carcinoma (NPC) is a very rare tumor, mostly Epstein-Barr Virus related and quite always diagnosed at a locally advanced stage. With current protocols associating induction cisplatin-based chemotherapy and concomitant chemoradiotherapy, prognosis is excellent with overall survival higher than 85%. However, long-term toxicities are frequent. Improvement in radiation ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2018, 40(2):85-92]

Cited: 2 times

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Hippocampal Sparing During Craniospinal Irradiation: What Did We Learn About the Incidence of Perihippocampus Metastases?

Laetitia Padovani, Frédérique Chapon, Nicolas André, Mohamed Boucekine, Anne Geoffray, Franck Bourdeau, Julien Masliah-Planchon, Line Claude, Aymeri Huchet, Anne Laprie, Stephane Supiot, Bernard Coche-Dequéant, Christine Kerr, Claire Alapetite, Julie Leseur, Tandat Nguyen, Sophie Chapet, Valerie Bernier, Pierre-Yves Bondiau, Georges Noel, Jean Louis Habrand, Stephanie Bolle, François Doz, Christelle Dufour, Xavier Muracciole, Christian Carrie,

PURPOSE:To identify the incidence of patients with perihippocampal metastases to assess the risk of brain relapse when sparing the hippocampal area. Medulloblastoma (MB) represents 20% of pediatric brain tumors. For high-risk MB patients, the 3- to 5-year event-free survival rate has recently improved from 50% to >76%. Many survivors, however, ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2018, 100(4):980-986]

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Patterns of locoregional failure in locally advanced non-small cell lung cancer treated with definitive conformal radiotherapy: Results from the Gating 2006 trial.

Emmanuel Jouglar, Vanina Isnardi, Dorothée Goulon, Céline Ségura-Ferlay, Myriam Ayadi, Claire Dupuy, Jean-Yves Douillard, Marc-André Mahé, Line Claude,

PURPOSE:To determine the patterns of locoregional failure (LRF) in patients with locally advanced non-small cell lung cancer treated with definitive radiotherapy (RT). PATIENTS AND METHODS:One hundred and fifty-four patients from the Gating 2006 prospective randomized trial were treated with conformal RT with or without respiratory motion management. For patients with ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2018, 126(2):291-299]

Cited: 2 times

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Patterns of failure after radiotherapy for pediatric patients with intracranial ependymoma.

Fatima Tensaouti, Anne Ducassou, Léonor Chaltiel, Stéphanie Bolle, Xavier Muracciole, Bernard Coche-Dequeant, Claire Alapetite, Valérie Bernier, Line Claude, Stéphane Supiot, Aymeri Huchet, Christine Kerr, Elisabeth le Prisé, Anne Laprie, ,

To investigate the patterns of failure after radiotherapy for pediatric intracranial ependymoma and their correlation with dose parameters.Between 2000 and 2013, 206 patients were treated in France. MRI scans at relapse were registered to the original planning CTs for topographic analysis of failure patterns. To compare relapse patients (RP) with ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2017, 122(3):362-367]

Cited: 7 times

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[Use of hypnosis in radiotherapy as an alternative to general anesthesia in pediatric radiation oncology].

Line Claude, Magali Morelle, Sandrine Mancini, Anita Duncan, Henri Sebban, Christian Carrie, Perrine Marec-Berard,

General anesthesia (GA) is often needed for radiotherapy (RT) in young children. This study aimed to evaluate the place of the rituals and/or hypnosis in pediatric in a reference center in pediatric radiation oncology in Rhône-Alpes Auvergne.This observational study retrospectively collected data on AG in children<5 years treated by RT in ... Read more >>

Bull Cancer (Bulletin du cancer)
[2016, 103(11):921-927]

Cited: 1 time

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Prognostic and predictive values of diffusion and perfusion MRI in paediatric intracranial ependymomas in a large national study.

Fatima Tensaouti, Anne Ducassou, Léonor Chaltiel, Annick Sevely, Stéphanie Bolle, Xavier Muracciole, Bernard Coche-Dequant, Claire Alapetite, Stéphane Supiot, Aymeri Huchet, Valérie Bernier, Line Claude, Anne-Isabelle Bertozzi-Salamon, Samuel Liceaga, Jean Albert Lotterie, Patrice Péran, Pierre Payoux, Anne Laprie, ,

To assess the relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC) derived, respectively, from perfusion and diffusion pre-operative MRI of intracranial ependymomas and their predictive and prognostic values.Pre-operative MRI and clinical data for intracranial ependymomas diagnosed between January 2000 and December 2013 were retrospectively retrieved from a web-based ... Read more >>

Br J Radiol (The British journal of radiology)
[2016, 89(1066):20160537]

Cited: 4 times

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MB-47RISK OF HIPPOCAMPAL REGION METASTASIS IN HIGH RISK MEDULLOBLASTOMA: SUFFICIENT RATIONAL FOR HIPPOCAMPAL SPARING DURING CRANIOSPINAL IRRADIATION?

Laetitia Padovani, Frederique Chapon, Anne Geoffray, Line Claude, Aymeri Huchet, Anne Laprie, Bernard Coche Dequeant, Chrisitne Kerr, Claire Alapetite, Julie Leseur, Sophie Chapet, Valerie Bernier, Pierre Yves Bondiau, Georges Noel, Nicolas Andre, François Doz, Christian Carrie, Christelle Dufour, Xavier Muracciole,

Neuro Oncol (Neuro-oncology)
[2016, 18(Suppl 3):iii107-iii107]

Cited: 0 times

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Paediatric radiation oncology in the care of childhood cancer: A position paper by the International Paediatric Radiation Oncology Society (PROS).

Rolf-Dieter Kortmann, Carolyn Freeman, Karen Marcus, Line Claude, Karin Dieckmann, Edward Halperin, Natia Esiashvili, Arnold Paulino, Anita Mahajan, Klaus Seiersen, Verity Ahern, Umberto Ricardi, Christian Carrie,

Paediatric malignancies are a challenge for the radiation oncologist due to their rarity, the great variety of histological types, and the complexity of treatment concepts that evolve over time. The Paediatric Radiation Oncology Society (PROS) is the only internationally operating society for paediatric radiation oncology. The objectives of PROS are ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2016, 119(2):357-360]

Cited: 5 times

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Can postoperative radiotherapy be omitted in localised standard-risk Ewing sarcoma? An observational study of the Euro-E.W.I.N.G group.

Stéphanie Foulon, Bernadette Brennan, Nathalie Gaspar, Uta Dirksen, Lee Jeys, Anna Cassoni, Line Claude, Beatrice Seddon, Perrine Marec-Berard, Jeremy Whelan, Michael Paulussen, Arne Streitbuerger, Odile Oberlin, Heribert Juergens, Robert Grimer, Marie-Cécile Le Deley,

The role of postoperative radiotherapy (PORT) in Ewing sarcoma (ES) is unclear. We assessed the impact of PORT on local control in patients with localised ES and good histological response to chemotherapy (<10% cells).All randomised patients in the EE99-R1 trial (comparing two consolidation chemotherapy regimens) undergoing surgery after induction chemotherapy were ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2016, 61:128-136]

Cited: 19 times

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