Full Text Journal Articles by
Author Lindsay McKenna

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Access to paediatric formulations for the treatment of childhood tuberculosis.

Madlen Nash, Christophe Perrin, James A Seddon, Jennifer Furin, Janika Hauser, Ben Marais, Ian Kitai, Jeffrey Starke, Lindsay McKenna,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(12):855-857]

Cited: 0 times

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Public investments in the clinical development of bedaquiline.

Dzintars Gotham, Lindsay McKenna, Mike Frick, Erica Lessem,

INTRODUCTION:In 2012, bedaquiline became the first new treatment from a novel class to be approved for tuberculosis in nearly five decades and is now a core component of the standard of care for multidrug-resistant tuberculosis. In addition to the originator pharmaceutical company, Janssen, a range of governmental and non-profit entities ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0239118]

Cited: 0 times

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Challenges in TB regimen development: preserving evidentiary standards for regulatory decisions and policymaking.

Lorenzo Guglielmetti, Marcus Low, Lindsay McKenna,

Expert Rev Anti Infect Ther (Expert review of anti-infective therapy)
[2020, 18(8):701-704]

Cited: 0 times

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Are pretomanid-containing regimens for tuberculosis a victory or a victory narrative?

Lindsay McKenna, Jennifer Furin,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2019, 7(12):999-1000]

Cited: 0 times

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Alternative dosing guidelines to improve outcomes in childhood tuberculosis: a mathematical modelling study.

Kendra K Radtke, Kelly E Dooley, Peter J Dodd, Anthony J Garcia-Prats, Lindsay McKenna, Anneke C Hesseling, Radojka M Savic,

BACKGROUND:Malnourished and young children are particularly susceptible to severe forms of tuberculosis and poor treatment response. WHO dosing guidelines for drugs for tuberculosis treatment are based only on weight, which might lead to systematic underdosing and poor outcomes in these children. We aimed to assess and quantify the population effect ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2019, 3(9):636-645]

Cited: 0 times

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Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.

Payam Nahid, Sundari R Mase, Giovanni Battista Migliori, Giovanni Sotgiu, Graham H Bothamley, Jan L Brozek, Adithya Cattamanchi, J Peter Cegielski, Lisa Chen, Charles L Daley, Tracy L Dalton, Raquel Duarte, Federica Fregonese, C Robert Horsburgh, Faiz Ahmad Khan, Fayez Kheir, Zhiyi Lan, Alfred Lardizabal, Michael Lauzardo, Joan M Mangan, Suzanne M Marks, Lindsay McKenna, Dick Menzies, Carole D Mitnick, Diana M Nilsen, Farah Parvez, Charles A Peloquin, Ann Raftery, H Simon Schaaf, Neha S Shah, Jeffrey R Starke, John W Wilson, Jonathan M Wortham, Terence Chorba, Barbara Seaworth,

Background: The American Thoracic Society, U.S. Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America jointly sponsored this new practice guideline on the treatment of drug-resistant tuberculosis (DR-TB). The document includes recommendations on the treatment of multidrug-resistant TB (MDR-TB) as well as isoniazid-resistant but ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 200(10):e93-e142]

Cited: 13 times

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Key features to consider in revising the Model List of Essential In Vitro Diagnostics: a TB perspective.

Khairunisa Suleiman, Kathleen England, Erica Lessem, Lindsay McKenna,

Int J Tuberc Lung Dis (The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease)
[2019, 23(2):272]

Cited: 0 times

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Time to act on injectable-free regimens for children with multidrug-resistant tuberculosis.

James A Seddon, H Simon Schaaf, Ben J Marais, Lindsay McKenna, Anthony J Garcia-Prats, Anneke C Hesseling, Jennifer Hughes, Pauline Howell, Anne Detjen, Farhana Amanullah, Urvashi Singh, Iqbal Master, Carlos M Perez-Velez, Nirupa Misra, Mercedes C Becerra, Jennifer J Furin,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2018, 6(9):662-664]

Cited: 3 times

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The upcoming UN general assembly resolution on tuberculosis must also benefit children.

Anne K Detjen, Lindsay McKenna, Stephen M Graham, Ben J Marais, Farhana Amanullah, ,

Lancet Glob Health (The Lancet. Global health)
[2018, 6(5):e485-e486]

Cited: 1 time

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Challenges of using new and repurposed drugs for the treatment of multidrug-resistant tuberculosis in children.

H Simon Schaaf, Anthony J Garcia-Prats, Lindsay McKenna, James A Seddon,

New and repurposed antituberculosis drugs are urgently needed to more safely and effectively treat multidrug-resistant (MDR) tuberculosis (TB) in children. Multiple challenges limit timely access to new MDR-TB treatments in children. Areas covered: Diagnosis of MDR-TB in children remains a barrier, with few children with MDR-TB diagnosed and treated. Other ... Read more >>

Expert Rev Clin Pharmacol (Expert review of clinical pharmacology)
[2018, 11(3):233-244]

Cited: 2 times

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A Community Perspective on the Inclusion of Pregnant Women in Tuberculosis Drug Trials.

Lindsay McKenna, Mike Frick, Cynthia Lee, Dorothy Namutamba, Liani Smit, Marie Theunissen, Wim Vandevelde, Suraj Madoori, Kathryn Snow, Barbara Seaworth,

Affecting both mother and the existing pregnancy, tuberculosis (TB) increases the likelihood of poor birth outcomes. Despite substantial clinical need for TB prevention and treatment, pregnant women remain neglected by research initiatives. As members of 3 community advisory boards that provide input into TB drug trials, we offer a community ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2017, 65(8):1383-1387]

Cited: 5 times

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New and Repurposed Drugs for Pediatric Multidrug-Resistant Tuberculosis. Practice-based Recommendations.

Elizabeth P Harausz, Anthony J Garcia-Prats, James A Seddon, H Simon Schaaf, Anneke C Hesseling, Jay Achar, Jonathan Bernheimer, Andrea T Cruz, Lia D'Ambrosio, Anne Detjen, Stephen M Graham, Jennifer Hughes, Sylvie Jonckheere, Ben J Marais, Giovanni Battista Migliori, Lindsay McKenna, Alena Skrahina, Marina Tadolini, Peyton Wilson, Jennifer Furin, ,

It is estimated that 33,000 children develop multidrug-resistant tuberculosis (MDR-TB) each year. In spite of these numbers, children and adolescents have limited access to the new and repurposed MDR-TB drugs. There is also little clinical guidance for the use of these drugs and for the shorter MDR-TB regimen in the ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2017, 195(10):1300-1310]

Cited: 17 times

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Paediatric study of bedaquiline remains an "open issue".

Lindsay McKenna, Laia Ruiz Mingote,

Eur. Respir. J. (The European respiratory journal)
[2016, 48(3):956-957]

Cited: 0 times

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Recent Developments and Future Opportunities in the Treatment of Tuberculosis in Children.

James A Seddon, Lindsay McKenna, Tejshri Shah, Beate Kampmann,

Tuberculosis in children accounts for a significant proportion of the overall burden of disease, and yet for many years research into pediatric treatment has been neglected. Recently, there have been major developments in our understanding of pediatric tuberculosis, and a large number of studies are under way or planned. New ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2015, 61Suppl 3:S188-99]

Cited: 2 times

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Access to new medications for the treatment of drug-resistant tuberculosis: patient, provider and community perspectives.

Erica Lessem, Helen Cox, Colleen Daniels, Jennifer Furin, Lindsay McKenna, Carole D Mitnick, Thato Mosidi, Caitlin Reed, Barbara Seaworth, Jonathan Stillo, Phumeza Tisile, Dalene von Delft,

Multidrug-resistant tuberculosis (MDR-TB) is on the rise, and is difficult to treat. The approval of two new drugs, bedaquiline and delamanid, and growing evidence for the use of linezolid, offer renewed hope for addressing MDR-TB. However, access to these medicines remains a significant challenge. These drugs have not been registered ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2015, 32:56-60]

Cited: 21 times

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The 'invisibility' of children with tuberculosis.

Lindsay McKenna, Mike Frick, Barbara Seaworth, Jennifer Furin,

J Public Health Policy (Journal of public health policy)
[2015, 36(1):123-125]

Cited: 1 time

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Cost-effectiveness of 12-dose LTBI regimen improved following advocacy to lower the price of rifapentine.

Mike Frick, Barbara Seaworth, Lindsay McKenna, Taharqa Elnour, Cynthia Lee,

Int J Tuberc Lung Dis (The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease)
[2014, 18(11):1386]

Cited: 1 time

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The diabetes gene Hhex maintains δ-cell differentiation and islet function.

Jia Zhang, Lindsay B McKenna, Clifford W Bogue, Klaus H Kaestner,

The homeodomain transcription factor HHEX (hematopoietically expressed homeobox) has been repeatedly linked to type 2 diabetes mellitus (T2DM) using genome-wide association studies. We report here that within the adult endocrine pancreas, Hhex is selectively expressed in the somatostatin-secreting δ cell. Using two mouse models with Hhex deficiency in the endocrine ... Read more >>

Genes Dev. (Genes & development)
[2014, 28(8):829-834]

Cited: 42 times

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Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.

Vasumathi Kameswaran, Nuria C Bramswig, Lindsay B McKenna, Melinda Penn, Jonathan Schug, Nicholas J Hand, Ying Chen, Inchan Choi, Anastassios Vourekas, Kyoung-Jae Won, Chengyang Liu, Kumar Vivek, Ali Naji, Joshua R Friedman, Klaus H Kaestner,

Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing β cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from ... Read more >>

Cell Metab (Cell metabolism)
[2014, 19(1):135-145]

Cited: 130 times

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Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver.

Jonathan Schug, Lindsay B McKenna, Gabriel Walton, Nicholas Hand, Sarmistha Mukherjee, Kow Essuman, Zhongjie Shi, Yan Gao, Karen Markley, Momo Nakagawa, Vasumathi Kameswaran, Anastassios Vourekas, Joshua R Friedman, Klaus H Kaestner, Linda E Greenbaum,

Validation of physiologic miRNA targets has been met with significant challenges. We employed HITS-CLIP to identify which miRNAs participate in liver regeneration, and to identify their target mRNAs.miRNA recruitment to the RISC is highly dynamic, changing more than five-fold for several miRNAs. miRNA recruitment to the RISC did not correlate ... Read more >>

BMC Genomics (BMC genomics)
[2013, 14:264]

Cited: 31 times

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Tissue-specific regulation of mouse microRNA genes in endoderm-derived tissues.

Yan Gao, Jonathan Schug, Lindsay B McKenna, John Le Lay, Klaus H Kaestner, Linda E Greenbaum,

MicroRNAs fine-tune the activity of hundreds of protein-coding genes. The identification of tissue-specific microRNAs and their promoters has been constrained by the limited sensitivity of prior microRNA quantification methods. Here, we determine the entire microRNAome of three endoderm-derived tissues, liver, jejunum and pancreas, using ultra-high throughput sequencing. Although many microRNA ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2011, 39(2):454-463]

Cited: 36 times

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MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function.

Lindsay B McKenna, Jonathan Schug, Anastassios Vourekas, Jaime B McKenna, Nuria C Bramswig, Joshua R Friedman, Klaus H Kaestner,

Whereas the importance of microRNA (miRNA) for the development of several tissues is well established, its role in the intestine is unknown. We aimed to quantify the complete miRNA expression profile of the mammalian intestinal mucosa and to determine the contribution of miRNAs to intestinal homeostasis using genetic means.We determined ... Read more >>

Gastroenterology (Gastroenterology)
[2010, 139(5):1654-64, 1664.e1]

Cited: 141 times

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FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine.

Blair B Madison, Lindsay B McKenna, Diane Dolson, Douglas J Epstein, Klaus H Kaestner,

The hedgehog (Hh) signaling pathway is a key component of cross-talk during vertebrate gut development, involving endodermally secreted Sonic (Shh) and Indian hedgehog (Ihh) proteins that directly signal to adjacent mesoderm. Here we show that the closely linked mesenchymal forkhead transcription factors Foxf1 and Foxl1 are part of this signaling ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2009, 284(9):5936-5944]

Cited: 70 times

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