Full Text Journal Articles by
Author Linda E Sousse

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What's New in Shock, February 2021?

Linda E Sousse, Teresa A Zimmers,

Shock (Shock (Augusta, Ga.))
[2021, 55(2):143-146]

Cited: 0 times

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Effect of N-(2-aminoethyl) ethanolamine on hypertrophic scarring changes in vitro: Finding novel anti-fibrotic therapies.

Zhenping Chen, Jianhua Gu, Amina El Ayadi, Andres F Oberhauser, Jia Zhou, Linda E Sousse, Celeste C Finnerty, David N Herndon, Paul J Boor,

Hypertrophic scars (HS) limit movement, decrease quality of life, and remain a major impediment to rehabilitation from burns. However, no effective pharmacologic therapies for HS exist. Here we tested the in vitro anti-fibrotic effects of the novel chemical N-(2-aminoethyl) ethanolamine (AEEA) at non-toxic concentrations. Scanning electron microscopy showed that AEEA ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2019, 362:9-19]

Cited: 2 times

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Reduced Postburn Hypertrophic Scarring and Improved Physical Recovery With Yearlong Administration of Oxandrolone and Propranolol.

David Herndon, Karel D Capek, Evan Ross, Jayson W Jay, Anesh Prasai, Amina El Ayadi, Guillermo Foncerrada-Ortega, Elizabeth Blears, Christian Sommerhalder, Kara McMullen, Dagmar Amtmann, Robert Cox, Gabriel Hundeshagen, Kristofer Jennings, Linda E Sousse, Oscar E Suman, Walter J Meyer, Celeste C Finnerty,

<h4>Background</h4>Massive burns induce a hypermetabolic response that leads to total body wasting and impaired physical and psychosocial recovery. The administration of propranolol or oxandrolone positively affects postburn metabolism and growth. The combined administration of oxandrolone and propranolol (OxProp) for 1 year restores growth in children with large burns. Here, we ... Read more >>

Ann Surg (Annals of surgery)
[2018, 268(3):431-441]

Cited: 2 times

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Bone metabolism in pediatric burned patients: A review.

Eric Schryver, Gordon L Klein, David N Herndon, Oscar E Suman, Ludwik K Branski, Linda E Sousse,

Severe burns in children can lead to growth delays, bone loss, and wasting of lean body mass and muscle with subsequent long-term effects such as osteoporosis. The following review examines 11 randomized, placebo-controlled, prospective clinical trials in pediatric burns between 1995 and 2017. These studies included approximately 250 burned children, ... Read more >>

Burns (Burns : journal of the International Society for Burn Injuries)
[2018, 44(8):1863-1869]

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Contemporary Burn Survival.

Karel D Capek, Linda E Sousse, Gabriel Hundeshagen, Charles D Voigt, Oscar E Suman, Celeste C Finnerty, Kristofer Jennings, David N Herndon,

BACKGROUND:The standard of burn treatment today reflects major advances. We sought to quantitate the impact of these advances on burn survival via age-stratified mortality ratios compared with other reported mortality analyses in burns. STUDY DESIGN:Age, percent of the total body surface area (TBSA) burned, presence of inhalation injury, length of ... Read more >>

J Am Coll Surg (Journal of the American College of Surgeons)
[2018, 226(4):453-463]

Cited: 2 times

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Correlation Between PaO2/FIO2 and Peripheral Capillary Oxygenation/FIO2 in Burned Children With Smoke Inhalation Injury.

Janos Cambiaso-Daniel, Charles D Voigt, Eric Rivas, Gabriel Hundeshagen, Omar Nunez-Lopez, Lars-Peter Kamolz, Michaela Sljivich, Linda E Sousse, David N Herndon, Oscar E Suman, Michael P Kinsky, Ronald P Mlcak,

<h4>Objectives</h4>Determine whether the peripheral capillary oxygenation/FIO2 ratio correlates with the PaO2/FIO2 ratio in burned children with smoke inhalation injury, with the goal of understanding if the peripheral capillary oxygenation/FIO2 ratio can serve as a surrogate for the PaO2/FIO2 ratio for the diagnosis of acute respiratory distress syndrome.<h4>Design</h4>Retrospective chart review.<h4>Setting</h4>Shriners Hospitals ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2017, 18(10):e472-e476]

Cited: 0 times

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The P50 Research Center in Perioperative Sciences: How the investment by the National Institute of General Medical Sciences in team science has reduced postburn mortality.

Celeste C Finnerty, Karel D Capek, Charles Voigt, Gabriel Hundeshagen, Janos Cambiaso-Daniel, Craig Porter, Linda E Sousse, Amina El Ayadi, Ramon Zapata-Sirvent, Ashley N Guillory, Oscar E Suman, David N Herndon,

Since the inception of the P50 Research Center in Injury and Peri-operative Sciences (RCIPS) funding mechanism, the National Institute of General Medical Sciences has supported a team approach to science. Many advances in critical care, particularly burns, have been driven by RCIPS teams. In fact, burns that were fatal in ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2017, 83(3):532-542]

Cited: 3 times

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Interactions of Phosphate Metabolism With Serious Injury, Including Burns.

Craig Porter, Linda E Sousse, Ryan Irick, Eric Schryver, Gordon L Klein,

Approximately 85% of the body's phosphate pool resides within the skeleton. The remaining 15% is stored as high-energy phosphates or in its free form, where it acts as a substrate for adenosine triphosphate (ATP) production. Accordingly, phosphate plays a crucial role in energy metabolism. Trauma and critical illness result in ... Read more >>

JBMR Plus (JBMR plus)
[2017, 1(2):59-65]

Cited: 2 times

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Long-Term Administration of Oxandrolone Improves Lung Function in Pediatric Burned Patients.

Linda E Sousse, David N Herndon, Ronald P Mlcak, Jong O Lee, Clark R Andersen, Andrew J Zovath, Celeste C Finnerty, Oscar E Suman,

Pulmonary dysfunction is a significant contributor to morbidity and mortality in the pediatric burned population. We have previously reported that the administration of a synthetic testosterone derivative, oxandrolone, significantly reduced hypermetabolism, and significantly increased height percentile, bone mineral content, lean body mass, and strength in pediatric burned patients. We hypothesize ... Read more >>

J Burn Care Res (Journal of burn care & research : official publication of the American Burn Association)
[2016, 37(5):273-277]

Cited: 4 times

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Reversal of Growth Arrest With the Combined Administration of Oxandrolone and Propranolol in Severely Burned Children.

David N Herndon, Charles D Voigt, Karel D Capek, Paul Wurzer, Ashley Guillory, Andrea Kline, Clark R Andersen, Gordon L Klein, Ronald G Tompkins, Oscar E Suman, Celeste C Finnerty, Walter J Meyer, Linda E Sousse,

<h4>Background</h4>The hypercatabolic response in severely burned pediatric patients is associated with increased production of catecholamines and corticosteroids, decreased formation of testosterone, and reduced strength alongside growth arrest for up to 2 years after injury. We have previously shown that, in the pediatric burned population, the administration of the testosterone analog ... Read more >>

Ann Surg (Annals of surgery)
[2016, 264(3):421-428]

Cited: 16 times

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High tidal volume decreases adult respiratory distress syndrome, atelectasis, and ventilator days compared with low tidal volume in pediatric burned patients with inhalation injury.

Linda E Sousse, David N Herndon, Clark R Andersen, Arham Ali, Nicole C Benjamin, Thomas Granchi, Oscar E Suman, Ronald P Mlcak,

<h4>Background</h4>Inhalation injury, which is among the causes of acute lung injury and acute respiratory distress syndrome (ARDS), continues to represent a significant source of mortality in burned patients. Inhalation injury often requires mechanical ventilation, but the ideal tidal volume strategy is not clearly defined in burned pediatric patients. The aim ... Read more >>

J Am Coll Surg (Journal of the American College of Surgeons)
[2015, 220(4):570-578]

Cited: 13 times

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Pulmonary histopathologic abnormalities and predictor variables in autopsies of burned pediatric patients.

Linda E Sousse, David N Herndon, Clark R Andersen, Andrew Zovath, Celeste C Finnerty, Ronald P Mlcak, Robert A Cox, Daniel L Traber, Hal K Hawkins,

<h4>Unlabelled</h4>Pulmonary abnormalities occur in 30-80% of fatalities after burn. The objective of our study is to investigate lung pathology in autopsy tissues of pediatric burn patients.<h4>Methods</h4>Three scientists with pathology training in pediatric burn care reviewed masked autopsy slides of burned children who died after admission to a burn center from ... Read more >>

Burns (Burns : journal of the International Society for Burn Injuries)
[2015, 41(3):519-527]

Cited: 2 times

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Advantages and pitfalls of combining intravenous antithrombin with nebulized heparin and tissue plasminogen activator in acute respiratory distress syndrome.

Sebastian Rehberg, Yusuke Yamamoto, Linda E Sousse, Collette Jonkam, Robert A Cox, Donald S Prough, Perenlei Enkhbaatar,

<h4>Background</h4>Pulmonary coagulopathy has become an important therapeutic target in adult respiratory distress syndrome (ARDS). We hypothesized that combining intravenous recombinant human antithrombin (rhAT), nebulized heparin, and nebulized tissue plasminogen activator (TPA) more effectively improves pulmonary gas exchange compared with a single rhAT infusion, while maintaining the anti-inflammatory properties of rhAT ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2014, 76(1):126-133]

Cited: 4 times

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Antithrombin attenuates vascular leakage via inhibiting neutrophil activation in acute lung injury.

Sebastian Rehberg, Yusuke Yamamoto, Linda E Sousse, Collette Jonkam, Yong Zhu, Lillian D Traber, Robert A Cox, Donald S Prough, Daniel L Traber, Perenlei Enkhbaatar,

<h4>Objective</h4>To test the hypothesis that restoration of antithrombin plasma concentrations attenuates vascular leakage by inhibiting neutrophil activation through syndecan-4 receptor inhibition in an established ovine model of acute lung injury.<h4>Design</h4>Randomized controlled laboratory experiment.<h4>Setting</h4>University animal research facility.<h4>Subjects</h4>Eighteen chronically instrumented sheep.<h4>Interventions</h4>Following combined burn and smoke inhalation injury (40% of total body surface ... Read more >>

Crit Care Med (Critical care medicine)
[2013, 41(12):e439-46]

Cited: 16 times

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Antithrombin attenuates myocardial dysfunction and reverses systemic fluid accumulation following burn and smoke inhalation injury: a randomized, controlled, experimental study.

Sebastian Rehberg, Yusuke Yamamoto, Eva Bartha, Linda E Sousse, Collette Jonkam, Yong Zhu, Lillian D Traber, Robert A Cox, Daniel L Traber, Perenlei Enkhbaatar,

<h4>Introduction</h4>We hypothesized that maintaining physiological plasma levels of antithrombin attenuates myocardial dysfunction and inflammation as well as vascular leakage associated with burn and smoke inhalation injury. Therefore, the present prospective, randomized experiment was conducted using an established ovine model.<h4>Methods</h4>Following 40% of total body surface area, third degree flame burn and ... Read more >>

Crit Care (Critical care (London, England))
[2013, 17(3):R86]

Cited: 5 times

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γ-tocopherol nebulization decreases oxidative stress, arginase activity, and collagen deposition after burn and smoke inhalation in the ovine model.

Yusuke Yamamoto, Linda E Sousse, Perenlei Enkhbaatar, Edward R Kraft, Donald J Deyo, Charlotte L Wright, Alan Taylor, Maret G Traber, Robert A Cox, Hal K Hawkins, Sebastian W Rehberg, Lillian D Traber, David N Herndon, Daniel L Traber,

More than 20,000 burn injury victims suffer from smoke inhalation injury in the United States annually. In an ovine model of acute lung injury, γ-tocopherol had a beneficial effect when nebulized into the airway. We hypothesize that γ-tocopherol scavenges reactive oxygen species (ROS) and reactive nitrogen species resulting from burn ... Read more >>

Shock (Shock (Augusta, Ga.))
[2012, 38(6):671-676]

Cited: 12 times

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Nebulization with γ-tocopherol ameliorates acute lung injury after burn and smoke inhalation in the ovine model.

Yusuke Yamamoto, Perenlei Enkhbaatar, Linda E Sousse, Hiroyuki Sakurai, Sebastian W Rehberg, Sven Asmussen, Edward R Kraft, Charlotte L Wright, Eva Bartha, Robert A Cox, Hal K Hawkins, Lillian D Traber, Maret G Traber, Csaba Szabo, David N Herndon, Daniel L Traber,

We hypothesize that the nebulization of γ-tocopherol (g-T) in the airway of our ovine model of acute respiratory distress syndrome will effectively improve pulmonary function following burn and smoke inhalation after 96 h. Adult ewes (n = 14) were subjected to 40% total body surface area burn and were insufflated ... Read more >>

Shock (Shock (Augusta, Ga.))
[2012, 37(4):408-414]

Cited: 9 times

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Development of a long-term ovine model of cutaneous burn and smoke inhalation injury and the effects of early excision and skin autografting.

Yusuke Yamamoto, Perenlei Enkhbaatar, Hiroyuki Sakurai, Sebastian Rehberg, Sven Asmussen, Hiroshi Ito, Linda E Sousse, Robert A Cox, Donald J Deyo, Lillian D Traber, Maret G Traber, David N Herndon, Daniel L Traber,

<h4>Unlabelled</h4>Smoke inhalation injury frequently increases the risk of pneumonia and mortality in burn patients. The pathophysiology of acute lung injury secondary to burn and smoke inhalation is well studied, but long-term pulmonary function, especially the process of lung tissue healing following burn and smoke inhalation, has not been fully investigated. ... Read more >>

Burns (Burns : journal of the International Society for Burn Injuries)
[2012, 38(6):908-916]

Cited: 5 times

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Pseudomonas aeruginosa is associated with increased lung cytokines and asymmetric dimethylarginine compared with methicillin-resistant Staphylococcus aureus.

Linda E Sousse, Collette C Jonkam, Daniel L Traber, Hal K Hawkins, Sebastian W Rehberg, Lillian D Traber, David N Herndon, Perenlei Enkhbaatar,

The objective of the study was to investigate pulmonary responses to Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) using ovine and mice models of sepsis with emphasis on lung cytokine expression, asymmetric dimethylarginine (ADMA) concentration, and the arginase pathway. Sheep were instilled with either MRSA, P. aeruginosa, or saline under ... Read more >>

Shock (Shock (Augusta, Ga.))
[2011, 36(5):466-470]

Cited: 9 times

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Acute lung injury-induced collagen deposition is associated with elevated asymmetric dimethylarginine and arginase activity.

Linda E Sousse, Yusuke Yamamoto, Perenlei Enkhbaatar, Sebastian W Rehberg, Sandra M Wells, Scott Leonard, Maret G Traber, Yong-Ming Yu, Robert A Cox, Hal K Hawkins, Lillian D Traber, David N Herndon, Daniel L Traber,

Evidence suggests that lung structure and function are partly maintained by a balance between the competing arginine-metabolizing enzymes arginase and nitric oxide (NO) synthase. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NO synthase. It is metabolized by dimethylarginine dimethylaminohydrolase 2 (DDAH-2), which is oxidant-sensitive. The mechanism that induces excess ... Read more >>

Shock (Shock (Augusta, Ga.))
[2011, 35(3):282-288]

Cited: 12 times

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