Full Text Journal Articles by
Author Linda C Hsieh Wilson

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Sulfated glycans engage the Ang-Tie pathway to regulate vascular development.

Matthew E Griffin, Alexander W Sorum, Gregory M Miller, William A Goddard, Linda C Hsieh-Wilson,

The angiopoietin (Ang)-Tie pathway is essential for the proper maturation and remodeling of the vasculature. Despite its importance in disease, the mechanisms that control signal transduction through this pathway are poorly understood. Here, we demonstrate that heparan sulfate glycosaminoglycans (HS GAGs) regulate Ang-Tie signaling through direct interactions with both Ang ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

Cited: 0 times

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Photoaffinity Probes for the Identification of Sequence-Specific Glycosaminoglycan-Binding Proteins.

Amélie M Joffrin, Linda C Hsieh-Wilson,

Glycosaminoglycan (GAG)-protein interactions mediate critical physiological and pathological processes, such as neuronal plasticity, development, and viral invasion. However, mapping GAG-protein interaction networks is challenging as these interactions often require specific GAG sulfation patterns and involve transmembrane receptors or extracellular matrix-associated proteins. Here, we report the first GAG polysaccharide-based photoaffinity probes ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2020, 142(32):13672-13676]

Cited: 0 times

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Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly.

Nitin J Pawar, Lei Wang, Takuya Higo, Chandrabali Bhattacharya, Pavan K Kancharla, Fuming Zhang, Kedar Baryal, Chang-Xin Huo, Jian Liu, Robert J Linhardt, Xuefei Huang, Linda C Hsieh-Wilson,

The complex sulfation motifs of heparan sulfate glycosaminoglycans (HS GAGs) play critical roles in many important biological processes. However, an understanding of their specific functions has been hampered by an inability to synthesize large numbers of diverse, yet defined, HS structures. Herein, we describe a new approach to access the ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2019, 58(51):18577-18583]

Cited: 0 times

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O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis.

Xuexia Li, Qiang Zhu, Xiaoliu Shi, Yaxian Cheng, Xueliu Li, Huan Xu, Xiaotao Duan, Linda C Hsieh-Wilson, Jennifer Chu, Jerry Pelletier, Maowei Ni, Zhiguo Zheng, Sihui Li, Wen Yi,

Protein synthesis is essential for cell growth, proliferation, and survival. Protein synthesis is a tightly regulated process that involves multiple mechanisms. Deregulation of protein synthesis is considered as a key factor in the development and progression of a number of diseases, such as cancer. Here we show that the dynamic ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2019, 116(16):7857-7866]

Cited: 1 time

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Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15.

Liang-Chih Liu, Yuan-Liang Wang, Pei-Le Lin, Xiang Zhang, Wei-Chung Cheng, Shu-Hsuan Liu, Chih-Jung Chen, Yu Hung, Chia-Ing Jan, Ling-Chu Chang, Xiaoyang Qi, Linda C Hsieh-Wilson, Shao-Chun Wang,

The long noncoding RNA HOTAIR plays significant roles in promoting cancer metastasis. However, how it conveys an invasive advantage in cancer cells is not clear. Here we identify the chondroitin sulfotransferase CHST15 (GalNAc4S-6ST) as a novel HOX transcript antisense intergenic RNA (HOTAIR) target gene using RNA profiling and show that ... Read more >>

Int J Cancer (International journal of cancer)
[2019, 145(9):2478-2487]

Cited: 9 times

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An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation.

Jingchao Li, Zhonghua Li, Xiaotao Duan, Ke Qin, Liuyi Dang, Shisheng Sun, Li Cai, Linda C Hsieh-Wilson, Liming Wu, Wen Yi,

O-linked N-acetylglucosamine ( O-GlcNAc) is a ubiquitous post-translational modification of proteins and is essential for cell function. Quantifying the dynamics of O-GlcNAcylation in a proteome-wide level is critical for uncovering cellular mechanisms and functional roles of O-GlcNAcylation in cells. Here, we develop an isotope-coded photocleavable probe for profiling protein O-GlcNAcylation ... Read more >>

ACS Chem. Biol. (ACS chemical biology)
[2019, 14(1):4-10]

Cited: 1 time

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A Molecular Window into the Brain: Special Issue on Molecules and the Brain.

Linda C Hsieh-Wilson,

Biochemistry (Biochemistry)
[2018, 57(27):3989-3990]

Cited: 0 times

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Optimization of Chemoenzymatic Mass Tagging by Strain-Promoted Cycloaddition (SPAAC) for the Determination of O-GlcNAc Stoichiometry by Western Blotting.

Narek Darabedian, John W Thompson, Kelly N Chuh, Linda C Hsieh-Wilson, Matthew R Pratt,

The dynamic modification of intracellular proteins by O-linked β -N-acetylglucosamine (O-GlcNAcylation) plays critical roles in many cellular processes. Although various methods have been developed for O-GlcNAc detection, there are few techniques for monitoring glycosylation stoichiometry and state (i.e., mono-, di-, etc., O-GlcNAcylated). Measuring the levels of O-GlcNAcylation on a given ... Read more >>

Biochemistry (Biochemistry)
[2018, 57(40):5769-5774]

Cited: 2 times

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Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).

Jennifer N Rauch, John J Chen, Alexander W Sorum, Gregory M Miller, Tal Sharf, Stephanie K See, Linda C Hsieh-Wilson, Martin Kampmann, Kenneth S Kosik,

The misfolding and accumulation of tau protein into intracellular aggregates known as neurofibrillary tangles is a pathological hallmark of neurodegenerative diseases such as Alzheimer's disease. However, while tau propagation is a known marker for disease progression, exactly how tau propagates from one cell to another and what mechanisms govern this ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):6382]

Cited: 25 times

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Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates.

Barbara E Stopschinski, Brandon B Holmes, Gregory M Miller, Victor A Manon, Jaime Vaquer-Alicea, William L Prueitt, Linda C Hsieh-Wilson, Marc I Diamond,

Transcellular propagation of protein aggregate "seeds" has been proposed to mediate the progression of neurodegenerative diseases in tauopathies and α-synucleinopathies. We previously reported that tau and α-synuclein aggregates bind heparan sulfate proteoglycans (HSPGs) on the cell surface, promoting cellular uptake and intracellular seeding. However, the specificity and binding mode of ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2018, 293(27):10826-10840]

Cited: 21 times

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Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation.

Sheldon T Cheung, Michelle S Miller, Reynand Pacoma, Jason Roland, Jian Liu, Andrew M Schumacher, Linda C Hsieh-Wilson,

Glycosaminoglycans (GAGs) play critical roles in diverse processes ranging from viral infection to neuroregeneration. Their regiospecific sulfation patterns, which are generated by sulfotransferases, are key structural determinants that underlie their biological activity. Small-molecule modulators of these sulfotransferases could serve as powerful tools for understanding the physiological functions of GAGs, as ... Read more >>

ACS Chem Biol (ACS chemical biology)
[2017, 12(12):3126-3133]

Cited: 4 times

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Predicting glycosaminoglycan surface protein interactions and implications for studying axonal growth.

Adam R Griffith, Claude J Rogers, Gregory M Miller, Ravinder Abrol, Linda C Hsieh-Wilson, William A Goddard,

Cell-surface carbohydrates play important roles in numerous biological processes through their interactions with various protein-binding partners. These interactions are made possible by the vast structural diversity of carbohydrates and the diverse array of carbohydrate presentations on the cell surface. Among the most complex and important carbohydrates are glycosaminoglycans (GAGs), which ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2017, 114(52):13697-13702]

Cited: 4 times

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Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration.

Andrew C Wang, Elizabeth H Jensen, Jessica E Rexach, Harry V Vinters, Linda C Hsieh-Wilson,

O-GlcNAc glycosylation (or O-GlcNAcylation) is a dynamic, inducible posttranslational modification found on proteins associated with neurodegenerative diseases such as α-synuclein, amyloid precursor protein, and tau. Deletion of the O-GlcNAc transferase (ogt) gene responsible for the modification causes early postnatal lethality in mice, complicating efforts to study O-GlcNAcylation in mature neurons ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2016, 113(52):15120-15125]

Cited: 38 times

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Glycan Engineering for Cell and Developmental Biology.

Matthew E Griffin, Linda C Hsieh-Wilson,

Cell-surface glycans are a diverse class of macromolecules that participate in many key biological processes, including cell-cell communication, development, and disease progression. Thus, the ability to modulate the structures of glycans on cell surfaces provides a powerful means not only to understand fundamental processes but also to direct activity and ... Read more >>

Cell Chem Biol (Cell chemical biology)
[2016, 23(1):108-121]

Cited: 16 times

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Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans.

Gregory M Miller, Linda C Hsieh-Wilson,

Chondroitin sulfate proteoglycans (CSPGs) play important roles in the developing and mature nervous system, where they guide axons, maintain stable connections, restrict synaptic plasticity, and prevent axon regeneration following CNS injury. The chondroitin sulfate glycosaminoglycan (CS GAG) chains that decorate CSPGs are essential for their functions. Through these sugar chains, ... Read more >>

Exp Neurol (Experimental neurology)
[2015, 274(Pt B):115-125]

Cited: 19 times

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Long-lived engineering of glycans to direct stem cell fate.

Abigail Pulsipher, Matthew E Griffin, Shannon E Stone, Linda C Hsieh-Wilson,

Glycans mediate many critical, long-term biological processes, such as stem cell differentiation. However, few methods are available for the sustained remodeling of cells with specific glycan structures. A new strategy that enables the long-lived presentation of defined glycosaminoglycans on cell surfaces using HaloTag proteins (HTPs) as anchors is reported. By ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2015, 54(5):1466-1470]

Cited: 9 times

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Photoactivatable glycopolymers for the proteome-wide identification of fucose-α(1-2)-galactose binding proteins.

Arif Wibowo, Eric C Peters, Linda C Hsieh-Wilson,

Although fucose-α(1-2)-galactose (Fucα(1-2)Gal)-containing glycans have been implicated in cognitive processes such as learning and memory, their precise molecular mechanisms are poorly understood. Here we employed the use of multivalent glycopolymers to enable the first proteome-wide identification of weak affinity, low abundance Fucα(1-2)Gal glycan-binding proteins (GBPs). Biotin-terminated glycopolymers containing photoactivatable cross-linking ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2014, 136(27):9528-9531]

Cited: 7 times

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Synthetic probes of glycosaminoglycan function.

Matthew E Griffin, Linda C Hsieh-Wilson,

Glycosaminoglycans (GAGs) participate in many critical biological processes by modulating the activities of a wide range of proteins, including growth factors, chemokines, and viral receptors. Recent studies using synthetic oligosaccharides and glycomimetic polymers have established the importance of specific structural determinants in controlling GAG function. These findings illustrate the power ... Read more >>

Curr Opin Chem Biol (Current opinion in chemical biology)
[2013, 17(6):1014-1022]

Cited: 7 times

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Directing neuronal signaling through cell-surface glycan engineering.

Abigail Pulsipher, Matthew E Griffin, Shannon E Stone, Joshua M Brown, Linda C Hsieh-Wilson,

The ability to tailor plasma membranes with specific glycans may enable the control of signaling events that are critical for proper development and function. We report a method to modify cell surfaces with specific sulfated chondroitin sulfate (CS) glycosaminoglycans using chemically modified liposomes. Neurons engineered to display CS-E-enriched polysaccharides exhibited ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2014, 136(19):6794-6797]

Cited: 27 times

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Tunable heparan sulfate mimetics for modulating chemokine activity.

Gloria J Sheng, Young In Oh, Shuh-Kuen Chang, Linda C Hsieh-Wilson,

Heparan sulfate (HS) glycosaminoglycans participate in critical biological processes by modulating the activity of a diverse set of protein binding partners. Such proteins include all known members of the chemokine superfamily, which are thought to guide the migration of immune cells through their interactions with HS. Here, we describe an ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2013, 135(30):10898-10901]

Cited: 38 times

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Chemistry. Improving biologic drugs via total chemical synthesis.

Linda C Hsieh-Wilson, Matthew E Griffin,

Science (Science (New York, N.Y.))
[2013, 342(6164):1332-1333]

Cited: 3 times

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Tailored glycopolymers as anticoagulant heparin mimetics.

Young In Oh, Gloria J Sheng, Shuh-Kuen Chang, Linda C Hsieh-Wilson,

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2013, 52(45):11796-11799]

Cited: 20 times

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Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodent brains.

Gunnar Dick, Chin Lik Tan, Joao Nuno Alves, Erich M E Ehlert, Gregory M Miller, Linda C Hsieh-Wilson, Kazuyuki Sugahara, Arie Oosterhof, Toin H van Kuppevelt, Joost Verhaagen, James W Fawcett, Jessica C F Kwok,

Chondroitin sulfate (CS) and the CS-rich extracellular matrix structures called perineuronal nets (PNNs) restrict plasticity and regeneration in the CNS. Plasticity is enhanced by chondroitinase ABC treatment that removes CS from its core protein in the chondroitin sulfate proteoglycans or by preventing the formation of PNNs, suggesting that chondroitin sulfate ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2013, 288(38):27384-27395]

Cited: 43 times

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Visualization of O-GlcNAc glycosylation stoichiometry and dynamics using resolvable poly(ethylene glycol) mass tags.

Peter M Clark, Jessica E Rexach, Linda C Hsieh-Wilson,

O-linked N-acetylglucosamine (O-GlcNAc) glycosylation is a dynamic protein posttranslational modification with roles in processes such as transcription, cell cycle regulation, and metabolism. Detailed mechanistic studies of O-GlcNAc have been hindered by a lack of methods for measuring O-GlcNAc stoichiometries and the interplay of glycosylation with other posttranslational modifications. We recently ... Read more >>

Curr Protoc Chem Biol (Current protocols in chemical biology)
[2013, 5(4):281-302]

Cited: 5 times

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A sulfated carbohydrate epitope inhibits axon regeneration after injury.

Joshua M Brown, Jiang Xia, BinQuan Zhuang, Kin-Sang Cho, Claude J Rogers, Cristal I Gama, Manish Rawat, Sarah E Tully, Noriko Uetani, Daniel E Mason, Michel L Tremblay, Eric C Peters, Osami Habuchi, Dong F Chen, Linda C Hsieh-Wilson,

Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons in the central nervous system (CNS), but the structural diversity of their polysaccharides has hampered efforts to dissect the structure-activity relationships underlying their physiological activity. By taking advantage of our ability to chemically synthesize specific oligosaccharides, we demonstrate that ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2012, 109(13):4768-4773]

Cited: 60 times

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