Full Text Journal Articles by
Author Lincoln D Nadauld

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Discovery of TITIN Gene Truncating Variant Mutations and 5-Year Outcomes in Patients With Nonischemic Dilated Cardiomyopathy.

Jeffrey L Anderson, G Bryce Christensen, Helaman Escobar, Benjamin D Horne, Stacey Knight, Victoria Jacobs, Kia Afshar, Virginia B Hebl, Joseph B Muhlestein, Kirk U Knowlton, John F Carlquist, Lincoln D Nadauld,

Genetic factors play an important role in nonischemic dilated cardiomyopathy (NIDC). However, prime opportunities remain for genetic discovery and prognostic understanding. TITIN gene truncating variant mutations (TTNtv) are of interest because of their frequent appearance in NIDC series. We sought to discover known and novel TTNtv mutations in a NIDC ... Read more >>

Am J Cardiol (The American journal of cardiology)
[2020, :]

Cited: 0 times

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An elevated neutrophil-to-lymphocyte ratio associates with weight loss and cachexia in cancer.

Tyler Barker, Gail Fulde, Bryce Moulton, Lincoln D Nadauld, Terence Rhodes,

Systemic inflammation is present during and serves as a diagnostic tool for cancer-associated cachexia and is detrimental to serum 25-hydroxyvitamin D (25(OH)D) concentrations in non-cancer conditions. The neutrophil-to-lymphocyte ratio (NLR) is a desirable measure of systemic inflammation because it is easily calculated from a routine complete blood cell count with ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):7535]

Cited: 0 times

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Therapeutic Monitoring of Circulating DNA Mutations in Metastatic Cancer with Personalized Digital PCR.

Christina M Wood-Bouwens, Derrick Haslem, Bryce Moulton, Alison F Almeda, Hojoon Lee, Gregory M Heestand, Lincoln D Nadauld, Hanlee P Ji,

As a high-performance solution for longitudinal monitoring of patients being treated for metastatic cancer, a single-color digital PCR (dPCR) assay that detects and quantifies specific cancer mutations present in circulating tumor DNA (ctDNA) was developed. This customizable assay has a high sensitivity of detection. One can detect a mutation allelic ... Read more >>

J Mol Diagn (The Journal of molecular diagnostics : JMD)
[2020, 22(2):247-261]

Cited: 1 time

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Whole genome analysis identifies the association of TP53 genomic deletions with lower survival in Stage III colorectal cancer.

Li C Xia, Paul Van Hummelen, Matthew Kubit, HoJoon Lee, John M Bell, Susan M Grimes, Christina Wood-Bouwens, Stephanie U Greer, Tyler Barker, Derrick S Haslem, James M Ford, Gail Fulde, Hanlee P Ji, Lincoln D Nadauld,

DNA copy number aberrations (CNA) are frequently observed in colorectal cancers (CRC). There is an urgent need for CNA-based biomarkers in clinics,. n For Stage III CRC, if combined with imaging or pathologic evidence, these markers promise more precise care. We conducted this Stage III specific biomarker discovery with a cohort of ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5009]

Cited: 0 times

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Implementing Precision Medicine in Community-Based Oncology Programs: Three Models.

Laura A Levit, Edward S Kim, Barbara L McAneny, Lincoln D Nadauld, Kathryn Levit, Caroline Schenkel, Richard L Schilsky,

The use of precision medicine and the number of genomic-based treatments and immunotherapies is increasing. Nevertheless, oncology providers face challenges to implementing precision medicine, including in community practices, where most patients receive treatment. On January 31, 2018, ASCO hosted Precision Medicine: Expanding Opportunities, the inaugural event in ASCO's new State ... Read more >>

J Oncol Pract (Journal of oncology practice)
[2019, 15(6):325-329]

Cited: 3 times

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Organoid Modeling of the Tumor Immune Microenvironment.

James T Neal, Xingnan Li, Junjie Zhu, Valeria Giangarra, Caitlin L Grzeskowiak, Jihang Ju, Iris H Liu, Shin-Heng Chiou, Ameen A Salahudeen, Amber R Smith, Brian C Deutsch, Lillian Liao, Allison J Zemek, Fan Zhao, Kasper Karlsson, Liora M Schultz, Thomas J Metzner, Lincoln D Nadauld, Yuen-Yi Tseng, Sahar Alkhairy, Coyin Oh, Paula Keskula, Daniel Mendoza-Villanueva, Francisco M De La Vega, Pamela L Kunz, Joseph C Liao, John T Leppert, John B Sunwoo, Chiara Sabatti, Jesse S Boehm, William C Hahn, Grace X Y Zheng, Mark M Davis, Calvin J Kuo,

In vitro cancer cultures, including three-dimensional organoids, typically contain exclusively neoplastic epithelium but require artificial reconstitution to recapitulate the tumor microenvironment (TME). The co-culture of primary tumor epithelia with endogenous, syngeneic tumor-infiltrating lymphocytes (TILs) as a cohesive unit has been particularly elusive. Here, an air-liquid interface (ALI) method propagated patient-derived organoids ... Read more >>

Cell (Cell)
[2018, 175(7):1972-1988.e16]

Cited: 56 times

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Strategies For Clinical Implementation: Precision Oncology At Three Distinct Institutions.

Lincoln D Nadauld, James M Ford, Daryl Pritchard, Thomas Brown,

Despite rapid advances in molecular diagnostics and targeted therapeutics, the adoption of precision medicine into clinical oncology workflows has been slow. Questions about clinical utility, inconsistent reimbursement for molecular diagnostics, and limited access to targeted therapies are some of the major hurdles that have hampered clinical adoption. Despite these challenges, ... Read more >>

Health Aff (Millwood) (Health affairs (Project Hope))
[2018, 37(5):751-756]

Cited: 4 times

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Precision oncology in advanced cancer patients improves overall survival with lower weekly healthcare costs.

Derrick S Haslem, Ingo Chakravarty, Gail Fulde, Heather Gilbert, Brian P Tudor, Karen Lin, James M Ford, Lincoln D Nadauld,

The impact of precision oncology on guiding treatment decisions of late-stage cancer patients was previously studied in a retrospective analysis. However, the overall survival and costs were not previously evaluated. We report the overall survival and healthcare costs associated with precision oncology in these patients with advanced cancer. Building on ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(15):12316-12322]

Cited: 3 times

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Precision Oncology Strategy in Trastuzumab-Resistant Human Epidermal Growth Factor Receptor 2-Positive Colon Cancer: Case Report of Durable Response to Ado-Trastuzumab Emtansine.

Derrick S Haslem, Hanlee P Ji, James M Ford, Lincoln D Nadauld,

(JCO precision oncology)
[2017, 1:]

Cited: 0 times

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A Retrospective Analysis of Precision Medicine Outcomes in Patients With Advanced Cancer Reveals Improved Progression-Free Survival Without Increased Health Care Costs.

Derrick S Haslem, S Burke Van Norman, Gail Fulde, Andrew J Knighton, Tom Belnap, Allison M Butler, Sharanya Rhagunath, David Newman, Heather Gilbert, Brian P Tudor, Karen Lin, Gary R Stone, David L Loughmiller, Pravin J Mishra, Rajendu Srivastava, James M Ford, Lincoln D Nadauld,

PURPOSE:The advent of genomic diagnostic technologies such as next-generation sequencing has recently enabled the use of genomic information to guide targeted treatment in patients with cancer, an approach known as precision medicine. However, clinical outcomes, including survival and the cost of health care associated with precision cancer medicine, have been ... Read more >>

J Oncol Pract (Journal of oncology practice)
[2017, 13(2):e108-e119]

Cited: 21 times

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Molecular profiling of gastric cancer: toward personalized cancer medicine.

Lincoln D Nadauld, James M Ford,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2013, 31(7):838-839]

Cited: 22 times

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Pyoderma gangrenosum with the use of sunitinib.

Lincoln D Nadauld, Martin B Miller, Sandy Srinivas,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2011, 29(10):e266-7]

Cited: 9 times

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Family history as a positive prognostic factor in gastric cancer.

Lincoln D Nadauld, James M Ford,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2012, 30(7):683-684]

Cited: 2 times

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DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC.

Kunal Rai, Sharmistha Sarkar, Talmage J Broadbent, Matthew Voas, Kenneth F Grossmann, Lincoln D Nadauld, Somaye Dehghanizadeh, Fanuel T Hagos, Yumei Li, Rachel K Toth, Stephanie Chidester, Timothy M Bahr, W Evan Johnson, Brad Sklow, Randall Burt, Bradley R Cairns, David A Jones,

Although genome-wide hypomethylation is a hallmark of many cancers, roles for active DNA demethylation during tumorigenesis are unknown. Here, loss of the APC tumor suppressor gene causes upregulation of a DNA demethylase system and the concomitant hypomethylation of key intestinal cell fating genes. Notably, this hypomethylation maintained zebrafish intestinal cells ... Read more >>

Cell (Cell)
[2010, 142(6):930-942]

Cited: 49 times

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Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases.

Lincoln D Nadauld, Reid Phelps, Brent C Moore, Annie Eisinger, Imelda T Sandoval, Stephanie Chidester, Peter W Peterson, Elizabeth J Manos, Bradford Sklow, Randall W Burt, David A Jones,

Mutations in the human adenomatous polyposis coli (APC) gene are thought to initiate colorectal tumorigenesis. The tumor suppressor function of APC is attributed primarily to its ability to regulate the WNT pathway by targeting the destruction of beta-catenin. We report here a novel role for APC in regulating degradation of ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2006, 281(49):37828-37835]

Cited: 31 times

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The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid.

Annie L Eisinger, Lincoln D Nadauld, Dawne N Shelton, Peter W Peterson, Reid A Phelps, Stephanie Chidester, Diana M Stafforini, Stephen M Prescott, David A Jones,

Mutations in the adenomatous polyposis coli (APC) gene result in uncontrolled proliferation of intestinal epithelial cells and are associated with the earliest stages of colorectal carcinogenesis. Cyclooxygenase-2 (COX-2) is elevated in human colorectal cancers and plays an important role in colorectal tumorigenesis; however, the mechanisms by which APC mutations result ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2006, 281(29):20474-20482]

Cited: 31 times

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Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli.

Annie L Eisinger, Lincoln D Nadauld, Dawne N Shelton, Stephen M Prescott, Diana M Stafforini, David A Jones,

Mutations in adenomatous polyposis coli (APC) underlie the earliest stages of colorectal carcinogenesis. Consequences of APC mutation include stabilization of beta-catenin, dysregulation of cyclooxygenase-2 (COX-2) expression, and loss of retinoic acid production, events with poorly defined interactions. Here we showed that treatment of zebrafish expressing a truncated form of Apc ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2007, 282(40):29394-29400]

Cited: 14 times

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Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development.

Kunal Rai, Lincoln D Nadauld, Stephanie Chidester, Elizabeth J Manos, Smitha R James, Adam R Karpf, Bradley R Cairns, David A Jones,

DNA methylation and histone methylation are two key epigenetic modifications that help govern heterochromatin dynamics. The roles for these chromatin-modifying activities in directing tissue-specific development remain largely unknown. To address this issue, we examined the roles of DNA methyltransferase 1 (Dnmt1) and the H3K9 histone methyltransferase Suv39h1 in zebra fish ... Read more >>

Mol. Cell. Biol. (Molecular and cellular biology)
[2006, 26(19):7077-7085]

Cited: 89 times

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Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development.

Lincoln D Nadauld, Stephanie Chidester, Dawne N Shelton, Kunal Rai, Talmage Broadbent, Imelda T Sandoval, Peter W Peterson, Elizabeth J Manos, Chris M Ireland, H Joseph Yost, David A Jones,

Congenital hypertrophy/hyperplasia of the retinal pigmented epithelium is an ocular lesion found in patients harboring mutations in the adenomatous polyposis coli (APC) tumor suppressor gene. We report that Apc-deficient zebrafish display developmental abnormalities of both the lens and retina. Injection of dominant-negative Lef reduced Wnt signaling in the lens but ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2006, 103(36):13409-13414]

Cited: 25 times

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The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli.

Lincoln D Nadauld, Dawne N Shelton, Stephanie Chidester, H Joseph Yost, David A Jones,

Retinoic acid (RA) is a potent signaling molecule that plays important roles in multiple and diverse developmental processes. The contribution of retinoic acid to promoting the development and differentiation of the vertebrate intestine and the factors that regulate RA production in the gut remain poorly defined. Herein, we report that ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2005, 280(34):30490-30495]

Cited: 23 times

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Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation.

Lincoln D Nadauld, Imelda T Sandoval, Stephanie Chidester, H Joseph Yost, David A Jones,

Mutations in the APC (adenomatous polyposis coli) tumor suppressor gene cause uncontrolled proliferation and impaired differentiation of intestinal epithelial cells. Recent studies indicate that human colon adenomas and carcinomas lack retinol dehydrogenases (RDHs) and that APC regulates the expression of human RDHL. These data suggest a model wherein APC controls ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2004, 279(49):51581-51589]

Cited: 38 times

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