Full Text Journal Articles by
Author Lina Tao

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Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation.

Yueming Zhang, Jian Chang, Huan Gao, Xiaoyu Qu, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song,

<h4>Context</h4>Severe nephrotoxicity greatly limits the clinical use of the common effective chemotherapeutic agent cyclophosphamide (CYP). Huaiqihuang (HQH) is a Chinese herbal complex with various pharmacological activities, widely used for treating kidney disease.<h4>Objective</h4>This study estimates the protective effect of HQH against CYP-induced nephrotoxicity in rats.<h4>Materials and methods</h4>Four groups of 10 Sprague-Dawley ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1425-1431]

Cited: 0 times

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Polypharmacy and potentially inappropriate medications among elderly patients in the geriatric department at a single-center in China: A retrospective cross-sectional study.

Lina Tao, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Yueming Zhang, Yanqing Song,

<h4>Abstract</h4>The aging of the population has become a worldwide concern, especially in China. Polypharmacy and potentially inappropriate medications (PIMs) are prominent issues in elderly patients. Therefore, the aim of this study was to investigate the prevalence of polypharmacy and PIMs in older inpatients and further to explore the factors associated ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(42):e27494]

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Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.

Jinghui Zhai, Huan Gao, Shuo Wang, Sixi Zhang, Xiaoyu Qu, Yueming Zhang, Lina Tao, Jingmeng Sun, Yanqing Song, Li Fu,

The NOD-like receptor family pyrin domain-containing (NLRP3) inflammasomes is centrally implicated in cisplatin (CP)-induced kidney injury. Autophagy is critical for inhibiting production of NLRP3 protein that effectively reduces the inflammatory response. Ginsenoside Rg3 (SY), an active component extracted from ginseng, is reported to protect against CP-induced nephrotoxicity. However, the mechanisms ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2021, 35(11):e22896]

Cited: 1 time

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Broad neutralization of CSFV with novel monoclonal antibodies in vivo.

Huiling Xu, Guangwei Han, Ying Lu, Zehui Liu, Lina Tao, Fang He,

Classical swine fever is a highly contagious disease in China. Although vaccination against Classical swine fever virus (CSFV) has been widely carried out in China, CSFV cases still emerge in an endless stream. Therefore, it is necessary to take new antiviral measures to eliminate CSFV. Glycoprotein E2 of CSFV is ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, 173:513-523]

Cited: 1 time

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Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study.

Yanqing Song, Tingting Hu, Huan Gao, Jinghui Zhai, Jiawei Gong, Yueming Zhang, Lina Tao, Jingmeng Sun, Zhiyuan Li, Xiaoyu Qu,

Cisplatin (CDDP)-induced acute kidney injury (AKI) limits the therapeutic use of CDDP, which urgently needs to be addressed. Our previous study demonstrated that astragaloside IV (AS IV), an active compound of the traditional Chinese herb Astragalus membranaceus, alleviated CDDP-induced AKI. To explore the mechanism, we performed a metabolomics study to ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 183:114299]

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Octenyl succinic anhydride modification of bovine bone and fish skin gelatins and their application for fish oil-loaded emulsions

Ting Zhang, Mengzhen Ding, Lina Tao, Lijie Liu, Ningping Tao, Xichang Wang, Jian Zhong,

Molecular modification of emulsifiers has attracted many attentions in the field of emulsions. In this work, an octenyl succinic anhydride (OSA) modification method is developed to modify bovine bone gelatins and fish skin gelatins, and then the effect of OSA modification on the gelatins and their application for fish oil-loaded ... Read more >>

(Food hydrocolloids.)
[2020, 108:Not Available]

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Astragaloside IV enhances cisplatin chemosensitivity in hepatocellular carcinoma by suppressing MRP2.

Xiaoyu Qu, Huan Gao, Jinghui Zhai, Jingmeng Sun, Lina Tao, Yueming Zhang, Yanqing Song, Tingting Hu,

Decreased chemosensitivity among tumor cells is often an obstacle in cisplatin (Cis) chemotherapy. Overexpression of multidrug resistance-associated protein 2 (MRP2) is a key mechanism underlying decreased Cis chemosensitivity and resistance. Astragaloside IV (AS IV) is an important component derived from the well-known traditional Chinese herb Astragalus membranaceus. The aim of ... Read more >>

Eur J Pharm Sci (European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences)
[2020, 148:105325]

Cited: 3 times

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Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway.

Yueming Zhang, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song, Jie Zhang,

Severe hepatotoxicity greatly limits the clinical application of the first-line anti-tuberculosis drug isoniazid(INH). Quercetin(Que) has multiple pharmacological properties, and is regarded as a potential protective agent against a variety of organ injuries. However, the exact effect of quercetin on INH-induced hepatotoxicity and the underlying mechanisms are not yet completely understood. ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2020, 85:106634]

Cited: 3 times

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Effect of extraction methods on the structural characteristics, functional properties, and emulsion stabilization ability of Tilapia skin gelatins.

Ting Zhang, Rui Sun, Mengzhen Ding, Lina Tao, Lijie Liu, Ningping Tao, Xichang Wang, Jian Zhong,

The application of fish gelatins in emulsions has attracted much attention and their stabilization mechanisms remain unclear. This work explores the effect of extraction methods on the structural characteristics, functional properties, and emulsion application of Tilapia skin gelatins. The creaming stability of Tilapia skin gelatin-stabilized emulsions are dependent on gelatin ... Read more >>

Food Chem (Food chemistry)
[2020, 328:127114]

Cited: 2 times

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Omeprazole attenuates cisplatin-induced kidney injury through suppression of the TLR4/NF-κB/NLRP3 signaling pathway.

Huan Gao, Xiangfeng Wang, Xiaoyu Qu, Jinghui Zhai, Lina Tao, Yueming Zhang, Yanqing Song, Wenrui Zhang,

Renal toxicity is the primary factor that limits clinical use of cisplatin (CP). A previous study showed that omeprazole (OME) protected against CP-induced toxicity in human renal tubular HK-2 cells and rat kidneys. However, the protective mechanisms of OME have not been characterized. We evaluated the ability of OME to ... Read more >>

Toxicology (Toxicology)
[2020, 440:152487]

Cited: 2 times

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Identification of key metabolites during cisplatin-induced acute kidney injury using an HPLC-TOF/MS-based non-targeted urine and kidney metabolomics approach in rats.

Xiaoyu Qu, Huan Gao, Jingmeng Sun, Lina Tao, Yueming Zhang, Jinghui Zhai, Yanqing Song, Tingting Hu, Zhiyuan Li,

Kidney injury is a major adverse effect of cisplatin use. Metabolomics has been used to characterize physiological or pathological conditions through identification of metabolites and characterization of the metabolic pathway. Metabolomics profiling could allow for identification of nephrotoxic mechanisms of cisplatin and identification of biomarkers of cisplatin-induced injury. In this ... Read more >>

Toxicology (Toxicology)
[2020, 431:152366]

Cited: 3 times

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Calycosin ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1-NOD-like receptor protein 3 pathway.

Jinghui Zhai, Lina Tao, Sixi Zhang, Huan Gao, Yueming Zhang, Jingmeng Sun, Yanqing Song, Xiaoyu Qu,

The limitation of doxorubicin (DOX), which is widely used for the treatment of solid tumors and hematologic malignancies, is a vital problem in clinical application. The most serious of limit factors is cardiotoxicity. Calycosin (CA), an isoflavonoid that is the major active component in Radix astragali, has been reported in ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, 34(3):649-659]

Cited: 10 times

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Allogenic chondrocyte/osteoblast-loaded β-tricalcium phosphate bioceramic scaffolds for articular cartilage defect treatment.

Shuai Wu, Zhiguo Kai, Dong Wang, Lina Tao, Peng Zhang, Dawei Wang, Dongxing Liu, Shui Sun, Jian Zhong,

The medical community has expressed significant interest in the treatment of cartilage defect. Successful repair of articular cartilage defects remains a challenge in clinics. Due to the huge advantages of 3D micro/nanomaterials, 3D artificial micro/nano scaffolds have been widely developed and explored in the tissue repair of articular joints. In ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2019, 47(1):1570-1576]

Cited: 3 times

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Quercetin protected against isoniazide-induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway.

Yueming Zhang, Wenrui Zhang, Lina Tao, Jinghui Zhai, Huan Gao, Yanqing Song, Xiaoyu Qu,

Isoniazid (INH) is one of the most commonly used antituberculosis drugs, but its clinical applications have been limited by severe hepatic toxicity. Quercetin (Que), a natural flavonoid, has been proved to have many medicinal properties. This study aimed to clarify the possible protective effects of Que against INH-induced hepatotoxicity using ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2019, 33(9):e22369]

Cited: 3 times

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Dioscorea bulbifera L. delays the excretion of doxorubicin and aggravates doxorubicin-induced cardiotoxicity and nephrotoxicity by inhibiting the expression of P-glycoprotein in mice liver and kidney.

Xiaoyu Qu, Jinghui Zhai, Tingting Hu, Huan Gao, Lina Tao, Yueming Zhang, Yanqing Song, Sixi Zhang,

We aimed to investigate the drug-drug interaction (DDI) between doxorubicin (DOX) and <i>Dioscorea bulbifera L.</i> (DB) solution in mice, and to explore the effect of P-glycoprotein (P-gp) on this type of DDI. The toxicity of DOX in the liver, kidneys, and heart was assessed with alanine aminotransferase (ALT), aspartate aminotransferase ... Read more >>

Xenobiotica (Xenobiotica; the fate of foreign compounds in biological systems)
[2019, 49(9):1116-1125]

Cited: 1 time

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Salvianolic Acid B Attenuates Apoptosis of HUVEC Cells Treated with High Glucose or High Fat via Sirt1 Activation.

Jinghui Zhai, Lina Tao, Yueming Zhang, Huan Gao, Xiaoyu Qu, Yanqing Song, Sixi Zhang,

High glucose and high fat are important inducements for the development and progression of diabetic cardiopathy. Salvianolic acid B (SAB), which is the most abundant and bioactive compound in Danshen, attenuates oxidative stress-related disorders, such as cardiovascular diseases, cerebral ischemia, and diabetes. However, the effect of SAB on diabetic cardiopathy ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2019, 2019:9846325]

Cited: 4 times

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Prophylactic Therapy of Silymarin (Milk Thistle) on Antituberculosis Drug-Induced Liver Injury: A Meta-Analysis of Randomized Controlled Trials.

Lina Tao, Xiaoyu Qu, Yue Zhang, Yanqing Song, Si-Xi Zhang,

<h4>Background</h4>Prophylactic therapy with silymarin to prevent the development of antituberculosis drug-induced liver injury (anti-TB DILI) has been under debate. We aimed to evaluate the effect of silymarin in the prevention of anti-TB DILI.<h4>Methods</h4>We searched MEDLINE, PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) up to 30th November 2018. ... Read more >>

Can J Gastroenterol Hepatol (Canadian journal of gastroenterology & hepatology)
[2019, 2019:3192351]

Cited: 3 times

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Astragaloside IV protects against cisplatin-induced liver and kidney injury via autophagy-mediated inhibition of NLRP3 in rats.

Xiaoyu Qu, Huan Gao, Lina Tao, Yueming Zhang, Jinghui Zhai, Jingmeng Sun, Yanqing Song, Sixi Zhang,

The aim of this study was to explore the role of the NOD-like receptor family, pyrin domain containing (NLRP3) inflammasome and autophagy in Astragaloside IV (AS IV)-mediated protection against cisplatin-induced liver and kidney injury in rats. Rats were intraperitoneally administered cisplatin at a dose of 15 mg/kg and orally administered ... Read more >>

J Toxicol Sci (The Journal of toxicological sciences)
[2019, 44(3):167-175]

Cited: 9 times

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Omeprazole protects against cisplatin-induced nephrotoxicity by alleviating oxidative stress, inflammation, and transporter-mediated cisplatin accumulation in rats and HK-2 cells.

Huan Gao, Sixi Zhang, Tingting Hu, Xiaoyu Qu, Jinghui Zhai, Yueming Zhang, Lina Tao, Jianyuan Yin, Yanqing Song,

The present study assessed the therapeutic potential of omeprazole (OME), the most commonly prescribed proton pump inhibitor (PPI) used to treat gastroesophageal hyperacidity, against cisplatin (CP)-induced toxicity in human renal tubular HK-2 cells and rat kidneys. Herein, we observed that exposure of HK-2 cells to OME reversed the injury caused by CP, ... Read more >>

Chem Biol Interact (Chemico-biological interactions)
[2019, 297:130-140]

Cited: 3 times

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Salvianolic acid inhibits the effects of high glucose on vascular endothelial dysfunction by modulating the Sirt1-eNOS pathway.

Jinghui Zhai, Xiaoyu Qu, Yueming Zhang, Huan Gao, Lina Tao, Yanqing Song, Sixi Zhang,

Salvianolic acid (SA) is known for improving blood circulation, scavenging hydroxyl radicals, and preventing platelet aggregation. The research explored whether SA can protect against cardiovascular disease induced by high glucose conditions. Our results indicate that SA significantly increases cells viability and nitric oxide levels while decreasing reactive oxygen species generation. ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2019, 33(2):e22245]

Cited: 1 time

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Autophagy inhibition-enhanced assembly of the NLRP3 inflammasome is associated with cisplatin-induced acute injury to the liver and kidneys in rats.

Xiaoyu Qu, Huan Gao, Lina Tao, Yueming Zhang, Jinghui Zhai, Yanqing Song, Sixi Zhang,

The nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome has a key role in the inflammatory response. We found that cisplatin (7.5, 15 mg/kg, IV) could induce acute injury to the liver and kidneys of rats. Western blot and immunohistochemical analyses showed that expression of NLRP3, caspase-1 and ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2018, :e22208]

Cited: 5 times

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Quantitative determination of mogroside V in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.

Huiyu Yan, Lina Tao, Xiaoyu Qu, Liting Zhou, Sixi Zhang,

Mogroside V is the most abundant (approximately 0.50%) cucurbitane-type triterpene glycoside in Siraitia grosvenorii and exhibits significant antitussive, expectorant, anti-carcinogenic, and anti-inflammatory effects. A sensitive, robust and selective liquid chromatography tandem with mass spectrometry (LC-MS/MS) was developed and validated for the determination and pharmacokinetic investigation of mogroside V in rat ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(3):867-873]

Cited: 0 times

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Dysregulation of BSEP and MRP2 May Play an Important Role in Isoniazid-Induced Liver Injury via the SIRT1/FXR Pathway in Rats and HepG2 Cells.

Xiaoyu Qu, Yueming Zhang, Sixi Zhang, Jinghui Zhai, Huan Gao, Lina Tao, Yanqing Song,

To explore the role of the abnormal expression of the bile salt export pump (BSEP) and multidrug resistance protein 2 (MRP2) in isoniazid (INH)-induced liver injury, we assessed the liver injury induced by INH in rats and HepG2 cells in vitro. The regulatory pathways via Sirtuin 1 (SIRT1) and farnesoid ... Read more >>

Biol Pharm Bull (Biological & pharmaceutical bulletin)
[2018, 41(8):1211-1218]

Cited: 4 times

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A meta-analysis of apremilast on psoriatic arthritis long-term assessment of clinical efficacy (PALACE).

Xiaoyu Qu, Sixi Zhang, Lina Tao, Yanqing Song,

The aim of this article was to assess the efficacy and safety of apremilast in treatment of psoriatic arthritis (PsA) with meta-analysis method. We included four randomized clinical trials identified from MEDLINE, EMBASE, Cochrane Library, "ISRCTN Register" and "ClinicalTrials.gov" which compared apremilast with placebo. The meta-analysis was performed by the ... Read more >>

Expert Rev Clin Pharmacol (Expert review of clinical pharmacology)
[2016, 9(6):799-805]

Cited: 3 times

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A local reaction at or near injection site: case definition and guidelines for collection, analysis, and presentation of immunization safety data.

Jane Gidudu, Katrin S Kohl, Scott Halperin, Sandra Jo Hammer, Paul T Heath, Renald Hennig, Bernard Hoet, Edward Rothstein, Anne Schuind, Frederick Varricchio, Wikke Walop, ,

The need for developing a case definition and guidelines for a local reaction at or near the injection site, methods for the development of the case definition and guidelines as an adverse event following immunization as well as the rationale for selected decisions about the case definition for a local ... Read more >>

Vaccine (Vaccine)
[2008, 26(52):6800-6813]

Cited: 20 times

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