Full Text Journal Articles by
Author Lin Zhu

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Glycyrrhizic acid promotes neural repair by directly driving functional remyelination.

Jing Tian, Xing Li, Li Zhao, Peixin Shen, Zhezhi Wang, Lin Zhu, Cuiqin Li, Chun Su, Yuan Zhang,

Natural compounds are a rich source of effective candidate drugs for the treatment of neurological disorders. Glycyrrhizic acid (GA), the major water-soluble ingredient isolated from Glycyrrhiza glabra, is reported to show anti-inflammatory and immunomodulatory activities. However, its effect on CNS demyelinating disease is unclear. In this study, we showed that ... Read more >>

Food Funct (Food & function)
[2020, 11(1):992-1005]

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A dual-zwitterion functionalized ultra-hydrophilic metal-organic framework with ingenious synergy for enhanced enrichment of glycopeptides.

Dapeng Li, Jinghui Zhang, Guangshan Xie, Fenfen Ji, Xiaojian Shao, Lin Zhu, Zongwei Cai,

A rational strategy was introduced for the synthesis of a novel dual functionalized metal-organic framework nanocomposite (AuGC/ZIF-8) with ultra-hydrophilicity to enhance glycopeptide enrichment. The advantages of ingenious synergy, low-cost, facile and large-scale synthesis, and excellent enrichment performance will enable it to have a bright future in nanomaterial synthesis, glycoproteomics analysis, ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(93):13967-13970]

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A case report of Noonan syndrome-like disorder with loose anagen hair 2 treated with recombinant human growth hormone.

Ping Zhou, Lin Zhu, Qiongli Fan, Yongfang Liu, Tianxiu Zhang, Ting Yang, Jie Chen, Qian Cheng, Tingyu Li, Li Chen,

Protein phosphatase 1 catalytic subunit beta (PPP1CB) is a disease-causing gene of Noonan-like syndrome, which acts via the RAS/MAPK pathway. To date, only 17 patients diagnosed with PPP1CB-related Noonan-like syndrome have been reported around the world, with few reports in Asia. Twelve reported patients are of short stature and only ... Read more >>

Am. J. Med. Genet. A (American journal of medical genetics. Part A)
[2020, :]

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The protective role of Neuregulin1-ErbB4 signaling in a chronic social defeat stress model.

Wenjuan Wang, Yong Qiao, Huiying Qu, Lin Zhu, Linlin Mu, Chunyue Li, Jie Fang, Hong Lian,

Major depressive disorder (MDD) is a highly prevalent debilitating psychiatric disease and a serious public health problem worldwide. Brain structural MRI and postmortem studies on patients with depression have revealed changes in the anatomy and functionality in various brain regions, including the amygdala, thalamus, hippocampus, and prefrontal cortex (PFC). The ... Read more >>

Neuroreport (Neuroreport)
[2020, 31(9):678-685]

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Amifostine-loaded armored dissolving microneedles for long-term prevention of ionizing radiation-induced injury.

Xiang Yu, Minshu Li, Lin Zhu, Jingfei Li, Guoli Zhang, Rongzhen Fang, Zhihong Wu, Yiguang Jin,

Amifostine is a cytoprotective agent against the hematopoietic damage induced by ionizing radiation, although the intravenous injection of amifostine is a unique administration method with strict dosing time limitation. Hence, the fields of application of amifostine are greatly limited. Here, we have developed an amifostine-loaded armored microneedle (AAMN) with long-term ... Read more >>

Acta Biomater (Acta biomaterialia)
[2020, :]

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Development and evaluation of reverse transcription-insulated isothermal PCR assay to detect duck hepatitis A virus type A in liver samples using the POCKITTM system.

Yupeng Ren, Hua Yue, Lin Zhu, Cheng Tang, Bin Zhang,

Duck hepatitis A virus (DHAV) infection is characterized by severe hepatitis. In recent years, DHAV-A has become widespread in Asia and has led to economic losses. Conventional methods of DHAV-A detection must often be performed in the laboratory with inconvenience equipment. We have developed a rapid reverse transcription insulated isothermal ... Read more >>

J. Vet. Med. Sci. (The Journal of veterinary medical science)
[2019, 81(10):1533-1539]

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Identification of lysine acetylation sites on MERS-CoV replicase pp1ab.

Lin Zhu, Sin-Yee Fung, Guangshan Xie, Lok-Yin Roy Wong, Dong Yan Jin, Zongwei Cai,

MERS is a life-threatening disease and MERS-CoV has the potential to cause the next pandemic. Protein acetylation is known to play a crucial role in host response to viral infection. Acetylation of viral proteins encoded by other RNA viruses have been reported to affect viral replication. It is therefore of ... Read more >>

Mol. Cell Proteomics (Molecular & cellular proteomics : MCP)
[2020, :]

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Folate-targeted pH-sensitive bortezomib conjugates for cancer treatment.

Yin Liu, Zhi Dai, Jiao Wang, Ying Tu, Lin Zhu,

In this study, a folate-targeted pH-sensitive bortezomib conjugate was developed for cancer-specific drug delivery and therapy. The conjugate showed improved cellular uptake, penetration, and anticancer activity compared to free bortezomib, a bortezomib-mannitol derivative, and a PEGylated bortezomib conjugate in folate receptor overexpressing cancer cells and their 3D spheroids. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(29):4254-4257]

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Agronomic and environmental benefits of nutrient expert on maize and rice in Northeast China.

Yin Wang, Chunlin Li, Yuxi Li, Lin Zhu, Shuoran Liu, Li Yan, Guozhong Feng, Qiang Gao,

Agricultural production in China is facing great challenges to ensure food security and cleaner environment; further improvements are therefore required in crop nutrient management to increase grain yield and nutrient use efficiency while synchronously reducing environmental pollution. In this study, a total of 87 site-years of on-farm experiments were conducted ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, :]

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A novel electron transfer flavoprotein dehydrogenase (ETFDH) gene mutation identified in a newborn with glutaric acidemia type II: a case report of a Chinese family.

Mingcai Ou, Lin Zhu, Yong Zhang, Yaguo Zhang, Jingyao Zhou, Yu Zhang, Xuelian Chen, Lijuan Yang, Ting Li, Xingyue Su, Qi Hu, Wenjun Wang,

BACKGROUND:Glutaric acidemia type II (GA II) or multiple acyl-CoA dehydrogenase deficiency (MADD, OMIM 231680) is an inherited autosomal recessive disease affecting fatty acid, amino acid and choline metabolism, due to mutations in one of three genes namely, electron transfer flavoprotein alpha-subunit, ETFA, electron transfer flavoprotein β-subunit, ETFB and electron transfer ... Read more >>

BMC Med. Genet. (BMC medical genetics)
[2020, 21(1):98]

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Clinical and genetic analysis of five Chinese patients with urea cycle disorders.

Zhenzhu Zheng, Yiming Lin, Weihua Lin, Lin Zhu, Mengyi Jiang, Wenjun Wang, Qingliu Fu,

BACKGROUND:The urea cycle plays a key role in preventing the accumulation of toxic nitrogenous waste products, including two essential enzymes: ornithine transcarbamylase (OTC) and argininosuccinate lyase (ASL). Ornithine transcarbamylase deficiency (OTCD) results from mutations in the OTC. Meanwhile, argininosuccinate lyase deficiency (ASLD) is caused by mutations in the ASL. METHODS:Blood ... Read more >>

Mol Genet Genomic Med (Molecular genetics & genomic medicine)
[2020, :e1301]

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Intranasal tetrandrine temperature-sensitive in situ hydrogels for the treatment of microwave-induced brain injury.

Lihua Zhang, Lulu Pang, Siqing Zhu, Jinqiu Ma, Ruiteng Li, Yijing Liu, Lin Zhu, Xiaomei Zhuang, Weijia Zhi, Xiang Yu, Lina Du, Hongyan Zuo, Yiguang Jin,

The brain is the most sensitive organ to microwave radiation. However, few effective drugs are available for the treatment of microwave-induced brain injury due to the poor drug permeation into the brain. Here, intranasal tetrandrine (TET) temperature-sensitive in situ hydrogels (ISGs) were prepared with poloxamers 407 and 188. Its characteristics ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2020, 583:119384]

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Serum metabolomic profiles reveal the impact of BuZangTongLuo formula on metabolic pathways in diabetic mice with hindlimb ischemia.

Junping Zheng, Yanlei Guo, Baifei Hu, Lin Zhu, Yong Yang, Shengrong Li, Na Li, Hongtao Liu,

ETHNOPHARMACOLOGICAL RELEVANCE:BuZangTongLuo Formula (BZTLF) was the decoction of eight traditional Chinese medicines including Astragalus membranaceus, Dioscorea opposita, Salvia miltiorrhiza, Scrophularia ningpoensis, Ophiopogon japonicus, Panax ginseng, Fritillariae cirrhosae and Whitmania pigra. This formula has been used as an effective remedy for treatment of diabetic ischemia clinically. AIM OF THE STUDY:In previous ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2020, 258:112928]

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A Clinical Study on Hyperbaric Oxygen Therapy to Treat Severe Traumatic Brain Injury Traumatic Brain Injury

lin zhu, Wen Shi Guo, Juan Lu,

Abstract This clinical research initiates to study the early hyperbaric oxygen therapy applied in Severe Traumatic Brain Injury based on lots of clinical treatment practice for the Severe Craniocerebral Injury patients, whose survival and rehabilitation has drawn great attention among neurosurgeon experts. Background : 1. To investigate the clinical effect ... Read more >>

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Effect of Chitosan oligosaccharides on ischemic symptom and gut microbiota disbalance in mice with hindlimb ischemia.

Lin Zhu, Baifei Hu, Yanlei Guo, Huabing Yang, Junping Zheng, Xiaowei Yao, Haiming Hu, Hongtao Liu,

This study was designed to explore the effect of Chitosan oligosaccharides (COS) on mouse hindlimb ischemia by femoral artery ligation. Here, we demonstrated that COS treatment statistically promoted the blood perfusion and neovascularization in ischemic hindlimb of mice, accompanied by the suppression of inflammation and oxidative stress. By 16S rDNA ... Read more >>

Carbohydr Polym (Carbohydrate polymers)
[2020, 240:116271]

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Screening 3.4 million newborns for primary carnitine deficiency in Zhejiang Province, China.

Yiming Lin, Hao Xu, Duo Zhou, Zhenzhen Hu, Chao Zhang, Lingwei Hu, Yu Zhang, Lin Zhu, Bin Lu, Ting Zhang, Xinwen Huang,

Testing for primary carnitine deficiency (PCD) has been implemented in many newborn screening (NBS) programs, but few large-scale studies on NBS for PCD have been reported in China. This study aimed to assess the incidence and biochemical, clinical, and genetic characteristics of PCD discovered by NBS. Dried blood spots from ... Read more >>

Clin. Chim. Acta (Clinica Chimica Acta; International Journal of Clinical Chemistry)
[2020, 507:199-204]

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Effects of Hypoxia and Radiation-Induced Exosomes on Migration of Lung Cancer Cells and Angiogenesis of Umbilical Vein Endothelial Cells.

Fang Mo, Yanwu Xu, Junling Zhang, Lin Zhu, Chen Wang, Xiaofei Chu, Yan Pan, Yang Bai, Chunlin Shao, Jianghong Zhang,

Numerous studies have shown that exosomes play important roles in tumor biology development. However, the function of exosomal protein in cancer progression under different oxygen condition after irradiation is poorly understood. In this study, non-small cell lung cancer (NSCLC) A549 cells were γ-ray irradiated under normoxic or hypoxic conditions, then ... Read more >>

Radiat. Res. (Radiation research)
[2020, :]

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Land subsidence and its relation with groundwater aquifers in Beijing Plain of China.

Beibei Chen, Huili Gong, Yun Chen, Xiaojuan Li, Chaofan Zhou, Kunchao Lei, Lin Zhu, Li Duan, Xiaoxiao Zhao,

Beijing is a major metropolis with significant land subsidence because of long-term overexploitation of groundwater. While the South-to-North Water Diversion Project (SWDP) has provided new water sources Beijing; it has changed the pattern of land subsidence evolution in Beijing since 2015. Here we address how land subsidence evolution before and ... Read more >>

Sci. Total Environ. (The Science of the Total Environment)
[2020, 735:139111]

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Multi-Level Representation Learning for Chinese Medical Entity Recognition: Model Development and Validation.

Zhichang Zhang, Lin Zhu, Peilin Yu,

BACKGROUND:Medical entity recognition is a key technology that supports the development of smart medicine. Existing methods on English medical entity recognition have undergone great development, but their progress in the Chinese language has been slow. Because of limitations due to the complexity of the Chinese language and annotated corpora, these ... Read more >>

JMIR Med Inform (JMIR medical informatics)
[2020, 8(5):e17637]

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Older age is a risk factor associated with poor prognosis of patients with squamous cell carcinoma of the oral cavity.

Shuwei Chen, Zhu Lin, Jingtao Chen, Ankui Yang, Quan Zhang, Chuanbo Xie, Xing Zhang, Zhongyuan Yang, Wenkuan Chen, Ming Song,

PURPOSE:Whether or not young patients with squamous cell carcinoma of oral cavity (OC-SCC) have a difference in prognosis remains a controversy. This study aimed to analyze the clinical characteristics and difference of survival rates between adult patients less than 40 years of age and those 40 years of age and older. METHODS:A ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2020, :]

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Population-Level Benefits of Extragenital Gonorrhea Screening among Men Who Have Sex with Men: An Exploratory Modeling Analysis.

Rebecca Earnest, Minttu M Rönn, Meghan Bellerose, Thomas L Gift, Andrés A Berruti, Katherine K Hsu, Christian Testa, Lin Zhu, Yelena Malyuta, Nicolas A Menzies, Joshua A Salomon,

BACKGROUND:Men who have sex with men (MSM) are disproportionately burdened by gonorrhea and face high rates of extragenital (rectal and pharyngeal) infection, which is mostly asymptomatic and often missed by urogenital-only screening. Extragenital screening likely remains below CDC-recommended levels. Since increasing screening coverage is often resource-intensive, we assessed whether improved ... Read more >>

Sex Transm Dis (Sexually transmitted diseases)
[2020, :]

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Expander implantation for correction of high-riding nipple with enlarged nipple-areola complex using revision mastopexy: A case report.

Feng Qin, Nan-Ze Yu, Elan Yang, Ang Zeng, Yan Hao, Lin Zhu, Xiao-Jun Wang,

BACKGROUND:High-riding nipple is one of the common complications after mastopexty and breast reconstruction. However, to date, a limited number of techniques have concentrated on how to lower the high-riding nipple with enlarged areola. CASE SUMMARY:This is a case report describing a combination of surgical techniques to decrease high-riding nipple. A ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2020, 8(9):1674-1678]

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DNA enzyme mediated ratiometric fluorescence assay for Pb(II) ion using magnetic nanosphere-loaded gold nanoparticles and CdSe/ZnS quantum dots.

Long Wu, Lin Zhu, Jing Ma, Jinjie Li, Jiawei Liu, Yiping Chen,

Based on the inner filter effect mechanism of quantum dots, a ratiometric fluorescence nanoprobe was constructed for the determination of Pb(II) ion. Green emitting quantum dots conjugated with DNA substrate (DNA2) acted as donors providing green fluorescence, while gold nanoparticles coupled with DNA enzyme (DNA1) as acceptors quench the green fluorescence. ... Read more >>

Mikrochim Acta (Mikrochimica acta)
[2020, 187(5):273]

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Associations between serum carotenoid levels and the risk of non-Hodgkin lymphoma: a case-control study.

Shan Li, Xianglu Zhu, Lin Zhu, Xin Hu, Shujuan Wen,

Limited studies have investigated the effects of serum carotenoids on the risk of non-Hodgkin lymphoma (NHL) and the findings have been inconclusive. This study aims to assess the association between serum total or specific carotenoid levels and NHL risk. This 1:1 matched, hospital-based case-control study enrolled 512 newly diagnosed (within ... Read more >>

Br. J. Nutr. (The British journal of nutrition)
[2020, :1-31]

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Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease.

Lin Zhu, Zan Wang, Zhanhong Du, Xinyang Qi, Hao Shu, Duan Liu, Fan Su, Qing Ye, Xuemei Liu, Zheng Zhou, Yongqiang Tang, Ru Song, Xiaobin Wang, Li Lin, Shijiang Li, Ying Han, Liping Wang, Zhijun Zhang,

The parahippocampal gyrus-orbitofrontal cortex (PHG-OFC) circuit in humans is homologous to the postrhinal cortex (POR)-ventral lateral orbitofrontal cortex (vlOFC) circuit in rodents. Both are associated with visuospatial malfunctions in Alzheimer's disease (AD). However, the underlying mechanisms remain to be elucidated. In this study, we explored the relationship between an impaired ... Read more >>

Neurosci Bull (Neuroscience bulletin)
[2020, :]

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