Full Text Journal Articles by
Author Lin Li

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MnO2 nanosheets anchored with polypyrrole nanoparticles as a multifunctional platform for combined photothermal/photodynamic therapy of tumors.

Bei Li, Xiaodong Wang, Shasha Hong, Qi Wang, Lin Li, Omer Eltayeb, Chuan Dong, Shaomin Shuang,

Herein, [email protected]<sub>2</sub> nanocomposites were first harvested by anchoring MnO<sub>2</sub> nanosheets on polypyrrole (PPy) nanoparticles via an in situ redox reaction, then polyethylene glycol (PEG) modifier and methylene blue (MB) photosensitizer were linked through electrostatic interactions to obtain [email protected]<sub>2</sub>-PEG-MB nanoarchitectures. PPy nanoparticles ensure photothermal therapy (PTT) ability and MnO<sub>2</sub> nanosheets ameliorate ... Read more >>

Food Funct (Food & function)
[2021, 12(14):6334-6347]

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Co-delivery of proteins and small molecule drugs for mitochondria-targeted combination therapy.

Si Si Liew, Jia Zhou, Lin Li, Shao Q Yao,

Herein, we report the first use of gluthathione (GSH)-responsive nanogel-based carriers for mitochondria-targeted delivery of functional proteins and antibodies. We further demonstrated the successful co-encapsulation of a protein and small molecule (RNase A/Doxorubicin) in dual-cargo nanocapsules for mitochondria-targeted combination therapy. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(26):3215-3218]

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A spiropyran functionalized fluorescent probe for mitochondria targeting and imaging of endogenous hydrogen sulfide in living cells.

Qiaoling Liu, Ying Zhao, Yan Zhang, Kaixin Xie, Ruirong Liu, Borong Ren, Yanmei Yan, Lin Li,

A turn-on spiropyran functionalized fluorescein derivative (FMC) is developed for targeting HS- in mitochondria. FMC exhibits very weak fluorescence at 525 nm under the excitation of 470 nm in aqueous solution due to its colorless spiropyran form; upon addition of HS-, a strong fluorescence enhancement by 6.4-fold is observed with ... Read more >>

Analyst (The Analyst)
[2021, 145(24):8016-8021]

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Hg2+ detection, pH sensing and cell imaging based on bright blue-fluorescent N-doped carbon dots.

Dan Chang, Lin Li, Lihong Shi, Yongxing Yang,

A multifunctional sensing platform based on bright blue-fluorescent nitrogen-doped carbon dots (N-CDs) has been ingeniously designed for the sensitive determination of Hg2+ and pH. The N-CDs were facilely fabricated via a one-step hydrothermal treatment of citric acid and folic acid with admirable merits including exceptional stability, low toxicity and distinguished ... Read more >>

Analyst (The Analyst)
[2021, 145(24):8030-8037]

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A new ferroptosis-related gene model for prognostic prediction of papillary thyroid carcinoma.

Xiaoyu Qian, Jian Tang, Lin Li, Ziqiang Chen, Liang Chen, Yongquan Chu,

Papillary thyroid carcinoma (PTC) is a highly heterogeneous malignancy with diverse prognoses. Ferroptosis is a new type of cell death dependent on iron. Nevertheless, the predictive ability of ferroptosis-related genes for PTC is unclear. Based on the mRNA expression information from The Cancer Genome Atlas, we compared tumor and normal ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2341-2351]

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Association between atherosclerotic cardiovascular diseases risk and renal outcome in patients with type 2 diabetes mellitus.

Honghong Ren, Lijun Zhao, Yutong Zou, Yiting Wang, Junlin Zhang, Yucheng Wu, Rui Zhang, Tingli Wang, Jiali Wang, Yitao Zhu, Ruikun Guo, Huan Xu, Lin Li, Mark E Cooper, Fang Liu,

<h4>Aims</h4>Chronic kidney disease (CKD) and diabetes mellitus increase atherosclerotic cardiovascular diseases (ASCVD) risk. However, the association between renal outcome of diabetic kidney disease (DKD) and ASCVD risk is unclear.<h4>Methods</h4>This retrospective study enrolled 218 type 2 diabetic patients with biopsy-proven DKD, and without known cardiovascular diseases. Baseline characteristics were obtained and ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):477-487]

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Sestrin2 in hypoxia and hypoxia-related diseases.

Xiaojing Che, Jiagui Chai, Yan Fang, Xifeng Zhang, Anju Zu, Lin Li, Shibo Sun, Weimin Yang,

<b>Objectives:</b> Sestrin2 is a stress-inducible protein and play an important role in adapting stress states of cells. This article reviewed the role of Sestrin2 in hypoxia and hypoxia-related diseases to provide new perspectives for future research and new therapeutic targets for hypoxia-related diseases.<b>Methods:</b> A review was conducted through an electronic ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):111-116]

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Binaphthyl-based chiral ligands: design, synthesis and evaluation of their performance in enantioselective addition of diethylzinc to aromatic aldehydes.

Chao Yao, Piao Wu, Yue Huang, Yaoqi Chen, Lin Li, Yue-Ming Li,

The design strategy and the performance of binaphthyl-based chiral ligands were evaluated with computation and enantioselective addition of diethylzinc to aromatic aldehydes. Under optimized conditions, enantioselective addition of diethylzinc to aromatic aldehydes provided the desired optically active secondary alcohols in high isolated yields (up to 91%) and excellent enantiomeric excesses ... Read more >>

Org Biomol Chem (Organic & biomolecular chemistry)
[2020, 18(47):9712-9725]

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Application of Carbon Nanoparticle Tracers in the Lateral Neck Lymph Nodes of CN1bx Patients with Papillary Thyroid Carcinoma.

XiaoYu Qian, Jian Tang, Yongquan Chu, Liang Chen, Ziqiang Chen, Lin Li,

This study aimed to investigate the applicability of carbon nanoparticle tracers in the lateral neck lymph nodes of CN1bx patients with papillary thyroid carcinoma surgery. 73 patients with papillary thyroid carcinoma at our hospital between January 2019 to December 2019 were suspected metastasis in the lateral neck lymph node before ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(11):5408-5413]

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Modification of an ultrathin C60 interlayer on the electronic structure and molecular packing of C8-BTBT on HOPG.

Yuan Zhao, Xiaoliang Liu, Lin Li, Shitan Wang, Youzhen Li, Haipeng Xie, Dongmei Niu, Han Huang, Yongli Gao,

X-ray photoelectron spectroscopy (XPS), ultraviolet photoelectron spectroscopy (UPS), atomic force microscopy (AFM) and X-ray diffraction (XRD) were applied to investigate the electronic structure and molecular packing of C8-BTBT on HOPG with an ultrathin C<sub>60</sub> interlayer. It was found that C8-BTBT displays a Vollmer-Weber (V-W) growth mode on HOPG, with an ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2020, 22(43):25264-25271]

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Advanced non-noble materials in bifunctional catalysts for ORR and OER toward aqueous metal-air batteries.

Yun-Long Zhang, Kokswee Goh, Lei Zhao, Xu-Lei Sui, Xiao-Fei Gong, Jia-Jun Cai, Qing-Yan Zhou, Hong-Da Zhang, Lin Li, Fan-Rong Kong, Da-Ming Gu, Zhen-Bo Wang,

The catalyst in the oxygen electrode is the core component of the aqueous metal-air battery, which plays a vital role in the determination of the open circuit potential, energy density, and cycle life of the battery. For rechargeable aqueous metal-air batteries, the catalyst should have both good oxygen reduction reaction ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(42):21534-21559]

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Bioapplications of small molecule Aza-BODIPY: from rational structural design to in vivo investigations.

Zhenxiong Shi, Xu Han, Wenbo Hu, Hua Bai, Bo Peng, Lei Ji, Quli Fan, Lin Li, Wei Huang,

Boron-dipyrromethene (BODIPY) belongs to a family of organoboron compounds, commercialized as fluorescent dyes by Invitrogen™. As BODIPY derivatives, Aza-boron-dipyrromethene (Aza-BODIPY) dyes display superior spectral performances, such as red-shifted spectra and high molar extinction coefficients, and are considered to be extremely attractive organic materials for various bioapplications. Therefore, scientists from different ... Read more >>

Chem Soc Rev (Chemical Society reviews)
[2020, 49(21):7533-7567]

Cited: 6 times

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Evaluation and application of an efficient plant DNA extraction protocol for laboratory and field testing.

Qi Wang, Xiaoxia Shen, Tian Qiu, Wei Wu, Lin Li, Zhi'an Wang, Huixia Shou,

Nucleic acids in plant tissue lysates can be captured quickly by a cellulose filter paper and prepared for amplification after a quick purification. In this study, a published filter paper strip method was modified by sticking the filter paper on a polyvinyl chloride resin (PVC) sheet. This modified method is ... Read more >>

J Zhejiang Univ Sci B (Journal of Zhejiang University. Science. B)
[2021, 22(2):99-111]

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Effects of ionic strength and (−)-epigallocatechin gallate on physicochemical characteristics of soybean 11S and 7S proteins

Yaxuan Yang, Qiming Wang, Yuwan Tang, Lin Lei, Jichun Zhao, Yuhao Zhang, Lin Li, Qiang Wang, Jian Ming,

Polyphenols can interact with proteins to improve their physicochemical and functional properties. This study was aimed to determine the interactions of EGCG with 11S and 7S at different NaCl concentrations. Results of turbidity indicated that the binding affinity of EGCG with 11S and 7S were strongest at 0.3 M NaCl concentration. ... Read more >>

(Food hydrocolloids.)
[2021, 119:Not Available]

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Physical Stability, Rheology, Thermal Conductivity and Optical and Corrosion Properties of a Graphene Quantum Dot Fluid.

Zhongzhu Qiu, Lin Li, Qunzhi Zhu, Ruitang Guo, Yuan Yao, Congcong Wu, Shengnan Li, Peng Li,

Because of their unique and tunable photoluminescence properties, exceptional physicochemical properties, high photostability, biocompatibility and small size, Graphene quantum dots (GQDs) have received a lot of attention. However, insufficient investigations have been carried out on GQD fluids. In this paper, the properties of a prepared GQD fluid are studied experimentally, ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(10):5312-5318]

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Protein post-translational modifications after spinal cord injury.

Shuang Zhu, Bing-Sheng Yang, Si-Jing Li, Ge Tong, Jian-Ye Tan, Guo-Feng Wu, Lin Li, Guo-Li Chen, Qian Chen, Li-Jun Lin,

Deficits in intrinsic neuronal capacities in the spinal cord, a lack of growth support, and suppression of axonal outgrowth by inhibitory molecules mean that spinal cord injury almost always has devastating consequences. As such, one of the primary targets for the treatment of spinal cord injury is to develop strategies ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(10):1935-1943]

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Intracellular delivery of therapeutic proteins through N-terminal site-specific modification.

Si Si Liew, Chengwu Zhang, Jie Zhang, Hongyan Sun, Lin Li, Shao Q Yao,

A versatile strategy for the intracellular delivery of functional proteins/antibodies was developed using N-terminal site-specific modification. Adopting orthogonal dual-labeling strategies, a cell-permeable RNase A prodrug was designed complementing N-terminal site-specific modification with lysine labeling. Upon successful cytosolic uptake, the prodrug showed reactive oxygen species (ROS)-dependent targeted cancer therapy. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(77):11473-11476]

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Mitochondria-targeted polydopamine nanoprobes for visualizing endogenous sulfur dioxide derivatives in a rat epilepsy model.

Qiaoqiao Ci, Xiaofei Qin, Jinhua Liu, Rui Wang, Zheng Li, Wenjing Qin, Kah-Leong Lim, Cheng-Wu Zhang, Lin Li,

Epilepsy is the fourth most common neurological disorder, and aberrantly elevated sulfur dioxide derivatives (SO<sub>3</sub><sup>2-</sup>/HSO<sub>3</sub><sup>-</sup>) are thought to underlie the hippocampal neuronal apoptosis in epilepsy. We have designed and synthesized a mitochondria-targeted polydopamine nanoprobe for visualizing endogenous SO<sub>3</sub><sup>2-</sup>/HSO<sub>3</sub><sup>-</sup> by the nucleophilic addition reaction. The nanoprobe was used for imaging SO<sub>2</sub> ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(79):11823-11826]

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Competitive adsorption and dilatational rheology of pork myofibrillar and sarcoplasmic proteins at the O/W emulsion interface

Li Lin, Youling L Xiong,

The competitive adsorption behavior of pork sarcoplasmic (SP) and myofibrillar (MP) proteins, alone or mixed (ratios 6:4, 5:5 and 4:6, w/w) in 0.6 M NaCl, at the oil-water interface was investigated. SP adsorbed more rapidly than MP at the oil surface establishing a ~10 mN/m dynamic interfacial pressure (π). However, the dilatational ... Read more >>

(Food hydrocolloids.)
[2021, 118:Not Available]

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Molecular cloning and characterization of FADD from the grass carp (Ctenopharyngodon idellus) in response to bacterial infection

Zhijie Lu, Meizhen Tang, Yanan Li, Fei Shi, Fanbin Zhan, Menglan Zhang, Lijuan Zhao, Jun Li, Li Lin, Zhendong Qin,

Fas-associated protein with Death Domain (FADD) is closely associated with cell death and plays a key role in hematopoiesis, cell cycle regulation, embryogenesis, and particularly, innate immune signaling. However, the mechanisms underlying the apoptotic and immune responses against bacterial infection associated with FADD in teleost fish have yet to be ... Read more >>

Aquaculture (Aquaculture (Amsterdam, Netherlands))
[2021, 542:Not Available]

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Retrograde nerve growth factor signaling abnormalities and the pathogenesis of familial dysautonomia.

Soumitra Ghosh, Lin Li, Warren G Tourtellotte,

Neural Regen Res (Neural regeneration research)
[2021, 16(9):1795-1796]

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A mitochondrion-targeting Mn(ii)-terpyridine complex for two-photon photodynamic therapy.

Xinda Yang, Duoteng Zhang, Jie Li, Wenhui Ji, Naidi Yang, Shunxin Gu, Qiong Wu, Qin Jiang, Pengfei Shi, Lin Li,

We developed a mitochondrion-targeting Mn<sup>II</sup>-terpyridine complex (MTP) for two-photon photodynamic therapy. MTP was subjected to two-photon excitation in the NIR region to generate <sup>1</sup>O<sub>2</sub> and hence produce a PDT effect. This use of MTP overcame the drawbacks of traditional PDT agents. The Mn<sup>II</sup> center of MTP apparently catalyzed the H<sub>2</sub>O<sub>2</sub>-mediated ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(63):9032-9035]

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Fe3+ detection, bioimaging, and patterning based on bright blue-fluorescent N-doped carbon dots.

Lin Li, Lihong Shi, Jing Jia, Dan Chang, Chuan Dong, Shaomin Shuang,

Bright blue fluorescent N-doped carbon dots (N-CDs) with satisfactory yield (54%) were successfully fabricated by one-step hydrothermal treatment of astragalus. The obtained N-CDs possessed superior stability, solubility and high resistance to photo bleaching, and can be used as label-free nanosensors for the determination of Fe<sup>3+</sup>. The quantitative analysis of Fe<sup>3+</sup> ... Read more >>

Analyst (The Analyst)
[2020, 145(16):5450-5457]

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Typical hydrodynamic models for aquaculture nets: A comparative study under pure current conditions

Hui Cheng, Lin Li, Karl Gunnar Aarsæther, Muk Chen Ong,

The net is regarded as the most critical component in marine aquaculture facilities as it is the only barrier which protects the environment from fish escapes. Accurate predictions of the net cage deformation and drag force on the nets are needed, both for ensuring fish welfare and for dimensioning of ... Read more >>

(Aquacultural engineering.)
[2021, 90:Not Available]

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Neuronal activity-induced SUMOylation of Akt1 by PIAS3 is required for long-term potentiation of synaptic transmission.

Li Meng, Cai-Ping Du, Chun-Yuan Lu, Kun Zhang, Lin Li, Jing-Zhi Yan, Xiao-Yu Hou,

Neuronal activity regulates spatial distribution of the SUMOylation system in cytosolic and dendritic sites, which has been implicated in learning, memory, and underlying synaptic structural and functional remodeling in the hippocampus. However, the functional target proteins for activated small ubiquitin-like modifiers (SUMOs) and downstream molecular consequences behind long-term potentiation (LTP) ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(8):e21769]

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