Full Text Journal Articles by
Author Lin Li

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A spiropyran functionalized fluorescent probe for mitochondria targeting and imaging of endogenous hydrogen sulfide in living cells.

Qiaoling Liu, Ying Zhao, Yan Zhang, Kaixin Xie, Ruirong Liu, Borong Ren, Yanmei Yan, Lin Li,

A turn-on spiropyran functionalized fluorescein derivative (FMC) is developed for targeting HS- in mitochondria. FMC exhibits very weak fluorescence at 525 nm under the excitation of 470 nm in aqueous solution due to its colorless spiropyran form; upon addition of HS-, a strong fluorescence enhancement by 6.4-fold is observed with ... Read more >>

Analyst (The Analyst)
[2021, 145(24):8016-8021]

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Hg2+ detection, pH sensing and cell imaging based on bright blue-fluorescent N-doped carbon dots.

Dan Chang, Lin Li, Lihong Shi, Yongxing Yang,

A multifunctional sensing platform based on bright blue-fluorescent nitrogen-doped carbon dots (N-CDs) has been ingeniously designed for the sensitive determination of Hg2+ and pH. The N-CDs were facilely fabricated via a one-step hydrothermal treatment of citric acid and folic acid with admirable merits including exceptional stability, low toxicity and distinguished ... Read more >>

Analyst (The Analyst)
[2021, 145(24):8030-8037]

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Binaphthyl-based chiral ligands: design, synthesis and evaluation of their performance in enantioselective addition of diethylzinc to aromatic aldehydes.

Chao Yao, Piao Wu, Yue Huang, Yaoqi Chen, Lin Li, Yue-Ming Li,

The design strategy and the performance of binaphthyl-based chiral ligands were evaluated with computation and enantioselective addition of diethylzinc to aromatic aldehydes. Under optimized conditions, enantioselective addition of diethylzinc to aromatic aldehydes provided the desired optically active secondary alcohols in high isolated yields (up to 91%) and excellent enantiomeric excesses ... Read more >>

Org Biomol Chem (Organic & biomolecular chemistry)
[2020, 18(47):9712-9725]

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Modification of an ultrathin C60 interlayer on the electronic structure and molecular packing of C8-BTBT on HOPG.

Yuan Zhao, Xiaoliang Liu, Lin Li, Shitan Wang, Youzhen Li, Haipeng Xie, Dongmei Niu, Han Huang, Yongli Gao,

X-ray photoelectron spectroscopy (XPS), ultraviolet photoelectron spectroscopy (UPS), atomic force microscopy (AFM) and X-ray diffraction (XRD) were applied to investigate the electronic structure and molecular packing of C8-BTBT on HOPG with an ultrathin C<sub>60</sub> interlayer. It was found that C8-BTBT displays a Vollmer-Weber (V-W) growth mode on HOPG, with an ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2020, 22(43):25264-25271]

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Advanced non-noble materials in bifunctional catalysts for ORR and OER toward aqueous metal-air batteries.

Yun-Long Zhang, Kokswee Goh, Lei Zhao, Xu-Lei Sui, Xiao-Fei Gong, Jia-Jun Cai, Qing-Yan Zhou, Hong-Da Zhang, Lin Li, Fan-Rong Kong, Da-Ming Gu, Zhen-Bo Wang,

The catalyst in the oxygen electrode is the core component of the aqueous metal-air battery, which plays a vital role in the determination of the open circuit potential, energy density, and cycle life of the battery. For rechargeable aqueous metal-air batteries, the catalyst should have both good oxygen reduction reaction ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(42):21534-21559]

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Bioapplications of small molecule Aza-BODIPY: from rational structural design to in vivo investigations.

Zhenxiong Shi, Xu Han, Wenbo Hu, Hua Bai, Bo Peng, Lei Ji, Quli Fan, Lin Li, Wei Huang,

Boron-dipyrromethene (BODIPY) belongs to a family of organoboron compounds, commercialized as fluorescent dyes by Invitrogen™. As BODIPY derivatives, Aza-boron-dipyrromethene (Aza-BODIPY) dyes display superior spectral performances, such as red-shifted spectra and high molar extinction coefficients, and are considered to be extremely attractive organic materials for various bioapplications. Therefore, scientists from different ... Read more >>

Chem Soc Rev (Chemical Society reviews)
[2020, 49(21):7533-7567]

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Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist DA-CH5 is superior to exendin-4 in protecting neurons in the 6-hydroxydopamine rat Parkinson model.

Ling-Yu Zhang, Qian-Qian Jin, Christian Hölscher, Lin Li,

Patients with Parkinson's disease (PD) have impaired insulin signaling in the brain. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), can re-sensitize insulin signaling. In a recent phase II clinical trial, the first GLP-1 mimic, exendin-4, has shown reliable curative effect in patients with PD. DA-CH5 is ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(8):1660-1670]

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Mitochondria-targeted polydopamine nanoprobes for visualizing endogenous sulfur dioxide derivatives in a rat epilepsy model.

Qiaoqiao Ci, Xiaofei Qin, Jinhua Liu, Rui Wang, Zheng Li, Wenjing Qin, Kah-Leong Lim, Cheng-Wu Zhang, Lin Li,

Epilepsy is the fourth most common neurological disorder, and aberrantly elevated sulfur dioxide derivatives (SO<sub>3</sub><sup>2-</sup>/HSO<sub>3</sub><sup>-</sup>) are thought to underlie the hippocampal neuronal apoptosis in epilepsy. We have designed and synthesized a mitochondria-targeted polydopamine nanoprobe for visualizing endogenous SO<sub>3</sub><sup>2-</sup>/HSO<sub>3</sub><sup>-</sup> by the nucleophilic addition reaction. The nanoprobe was used for imaging SO<sub>2</sub> ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(79):11823-11826]

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Intracellular delivery of therapeutic proteins through N-terminal site-specific modification.

Si Si Liew, Chengwu Zhang, Jie Zhang, Hongyan Sun, Lin Li, Shao Q Yao,

A versatile strategy for the intracellular delivery of functional proteins/antibodies was developed using N-terminal site-specific modification. Adopting orthogonal dual-labeling strategies, a cell-permeable RNase A prodrug was designed complementing N-terminal site-specific modification with lysine labeling. Upon successful cytosolic uptake, the prodrug showed reactive oxygen species (ROS)-dependent targeted cancer therapy. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(77):11473-11476]

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A mitochondrion-targeting Mn(ii)-terpyridine complex for two-photon photodynamic therapy.

Xinda Yang, Duoteng Zhang, Jie Li, Wenhui Ji, Naidi Yang, Shunxin Gu, Qiong Wu, Qin Jiang, Pengfei Shi, Lin Li,

We developed a mitochondrion-targeting Mn<sup>II</sup>-terpyridine complex (MTP) for two-photon photodynamic therapy. MTP was subjected to two-photon excitation in the NIR region to generate <sup>1</sup>O<sub>2</sub> and hence produce a PDT effect. This use of MTP overcame the drawbacks of traditional PDT agents. The Mn<sup>II</sup> center of MTP apparently catalyzed the H<sub>2</sub>O<sub>2</sub>-mediated ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(63):9032-9035]

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Fe3+ detection, bioimaging, and patterning based on bright blue-fluorescent N-doped carbon dots.

Lin Li, Lihong Shi, Jing Jia, Dan Chang, Chuan Dong, Shaomin Shuang,

Bright blue fluorescent N-doped carbon dots (N-CDs) with satisfactory yield (54%) were successfully fabricated by one-step hydrothermal treatment of astragalus. The obtained N-CDs possessed superior stability, solubility and high resistance to photo bleaching, and can be used as label-free nanosensors for the determination of Fe<sup>3+</sup>. The quantitative analysis of Fe<sup>3+</sup> ... Read more >>

Analyst (The Analyst)
[2020, 145(16):5450-5457]

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Synthetic method, growth mechanism and electrochemical properties of PbSnS2 nanosheets for supercapacitors.

Yuhan Zeng, Hehe Huang, Shenhu Huang, Tongtong Jiang, Zekai Fang, Lin Li, Yuming Dai,

Facile hydrothermally synthesized PbSnS2 nanosheets with various morphologies were developed to obtain high performance electrode materials for supercapacitors. A precipitation-dissolution mechanism was proposed to demonstrate the growth process of PbSnS2. The as-prepared nanosheets exhibited superior capacitance (678.8 F g-1 at 50 mV s-1) and a long cycle life (95.5% capacitance ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(37):5062-5065]

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Association of dietary patterns with the newly diagnosed diabetes mellitus and central obesity: a community based cross-sectional study.

Xueyao Yin, Yixin Chen, Weina Lu, Ting Jin, Lin Li,

<h4>Aim</h4>The purpose of this study was to investigate the association of dietary patterns with the risk of insulin resistance (IR), diabetes mellitus (DM), and central obesity in China.<h4>Methods</h4>We performed a cross-sectional study on 1432 participants, aged 40-65 years in Hangzhou, Zhejiang province, China. Dietary intake was assessed using a semi-quantitative ... Read more >>

Nutr Diabetes (Nutrition & diabetes)
[2020, 10(1):16]

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Performance assessment of different machine learning approaches in predicting diabetic ketoacidosis in adults with type 1 diabetes using electronic health records data.

Lin Li, Chuang-Chung Lee, Fang Liz Zhou, Cliona Molony, Zoran Doder, Evgeny Zalmover, Kristen Sharma, Juhaeri Juhaeri, Chuntao Wu,

<h4>Purpose</h4>To assess the performance of different machine learning (ML) approaches in identifying risk factors for diabetic ketoacidosis (DKA) and predicting DKA.<h4>Methods</h4>This study applied flexible ML (XGBoost, distributed random forest [DRF] and feedforward network) and conventional ML approaches (logistic regression and least absolute shrinkage and selection operator [LASSO]) to 3,400 DKA ... Read more >>

Pharmacoepidemiol Drug Saf (Pharmacoepidemiology and drug safety)
[2021, :]

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What makes you continuously use chatbot services? Evidence from chinese online travel agencies

Lin Li, Kyung Young Lee, Emmanuel Emokpae, Sung-Byung Yang,

Thanks to artificial intelligence, chatbots have been applied to many consumer-facing applications, especially to online travel agencies (OTAs). This study aims to identify five quality dimensions of chatbot services and investigate their effect on user confirmation, which in turn leads to use continuance. In addition, the moderating role of technology ... Read more >>

(Electronic Markets)
[2021, :1-25]

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An Analytical Model for Estimating the Bending Curvatures of Metal Sheets in Laser Peen Forming.

Yunxia Ye, Zeng Nie, Xu Huang, Xudong Ren, Lin Li,

Laser peen forming (LPF) is suitable for shaping sheet metals without the requirement for die/mold and without causing high temperatures. An analytical model for estimating the bending curvatures of LPF is convenient and necessary for better understanding of the physical processes involved. In this paper, we describe a new analytical ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2021, 14(2):]

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Palladium Catalyzed Cascade Azidation / Carbonylation of Aryl Halides with Sodium Azide for the Synthesis of Amides.

Zhuang Qi, Shan-Shan Li, Lin Li, Qi Qin, Li-Miao Yang, Ying-Kang Liang, Yun Kang, Xiang-Zhi Zhang, Ai-Jun Ma, Jin-Bao Peng,

Amide synthesis is one of the most important transformations in organic chemistry due to their ubiquitous presence in our daily life. In this communication, a palladium catalyzed cascade azidation / carbonylation of aryl halides for the synthesis of amides was developed. Both iodo- and bromobenzene derivatives were transformed to the ... Read more >>

Chem Asian J (Chemistry, an Asian journal)
[2021, :]

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A transparent paper-based platform for multiplexed bioassays by wavelength-dependent absorbance/transmittance.

Lijun Zong, Yufeng Han, Lei Gao, Chao Du, Xiaopan Zhang, Lin Li, Xiao Huang, Jinhua Liu, Hai-Dong Yu, Wei Huang,

This communication describes the rational design of a transparent paper-based chemosensing platform for multi-target detection by wavelength-dependent absorbance/transmittance. The platform was successfully applied in the examination of bovine serum albumin (BSA) and cholesterol in serum with a low detection limit of 0.1 μM and 0.1 mM, respectively. With low cost ... Read more >>

Analyst (The Analyst)
[2019, 144(24):7157-7161]

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Internal standard fluorogenic probe based on vibration-induced emission for visualizing PTP1B in living cells.

Qiuyu Gong, Wenjing Qin, Peng Xiao, Xiang Wu, Lin Li, Gaobin Zhang, Renshuai Zhang, Jinpeng Sun, Shao Q Yao, Wei Huang,

Herein, as a proof of concept, we developed the first enzymatic VIE fluorogenic probe for protein tyrosine phosphatase 1B (PTP1B). The detection and imaging of PTP1B using VIE in living cells were both realized. Particularly importantly, the designed probe herein provides a guideline and platform for the development of new ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2019, 56(1):58-61]

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Multiple modes of action of myricetin in influenza A virus infection.

Huiting Sang, Yingna Huang, Yuanxin Tian, Miaomiao Liu, Liurong Chen, Lin Li, Shuwen Liu, Jie Yang,

Influenza A virus remains a major threat to public health worldwide after its first pandemic. Scientists keep searching novel anti-influenza drugs, of which natural products present to be an important source. Myricetin, a natural flavonol compound, which exists in many edible plants, which has a wide range of biological activities, ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, :]

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Nuclear factor Y participates in alcoholic liver disease by activating SREBP1 expression in mice.

Yanjie Zhang, Yajun Sun, Yange Zhang, Qin Miao, Qi Wang, Bin Yang, Yanzhong Li, Lin Li, Ruiling Zhang,

Chronic and excessive alcohol consumption leads to alcoholic liver disease (ALD). However, the molecular mechanisms in the regulation of ALD have not been fully deciphered. Liver lipid accumulation is an important research direction in ALD. In this study, the physiological role of nuclear factor Y (NF-Y) in ALD and the ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 541:90-94]

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MicroRNA-374b inhibits breast cancer progression through regulating CCND1 and TGFA genes.

Yan Liu, Ai Zhang, Ping-Ping Bao, Li Lin, Yina Wang, Haijian Wu, Xiao-Ou Shu, Aiguo Liu, Qiuyin Cai,

Emerging evidence indicates that microRNAs (miRNAs) play a critical role in breast cancer development. We recently reported that a higher expression of miR-374b in tumor tissues was associated with a better disease-free survival of triple-negative breast cancer (TNBC). However, the functional significance and molecular mechanisms underlying the role of miR-374b ... Read more >>

Carcinogenesis (Carcinogenesis)
[2021, :]

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Pre-stimulus alpha activities predict the confidence in subjective judgment by modulating post-stimulus theta oscillation

Haoyue Qian, Yang Lu, Zhiyuan Liu, Xue Weng, Xiuyan Guo, Lin Li, Li Zheng, Min Xu, Xiaohan Cai, Weiwei Men, Jiahong Gao, Xiangping Gao,

Even when making arbitrary decisions, people tend to feel varying levels of confidence, which is associated with the pre-stimulus neural oscillation of the brain. We investigated varying confidence in a pure subjective judgment task, and how this confidence was predicted by pre-stimulus alpha oscillations. Participants made pure subjective judgments where ... Read more >>

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Low- and high-dose radioiodine ablation for low-/intermediate-risk differentiated thyroid cancer in China: A large randomized clinical trial.

Ping Dong, Li Wang, Yuan Qu, Rui Huang, Lin Li,

<h4>Background</h4>To determine whether 1.1 GBq radioiodine therapy is as effective as 3.7 GBq for ablation in Chinese patients with differentiated thyroid cancer (DTC).<h4>Methods</h4>In this single-center randomized study, we compared the successful radioiodine ablation rates of 1.1 GBq and 3.7 GBq for patients with DTC.<h4>Results</h4>At 6-8 months after radioiodine ablation, there were ... Read more >>

Head Neck (Head & neck)
[2021, :]

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Habit Formation in Wearable Activity Tracker Use Among Older Adults: Qualitative Study.

Wei Peng, Lin Li, Anastasia Kononova, Shelia Cotten, Kendra Kamp, Marie Bowen,

<h4>Background</h4>Wearable activity trackers are popular devices used to motivate behavior change. Wearable activity trackers are especially beneficial for encouraging light physical activity such as walking, which is an ideal behavior for older adults or individuals who cannot be physically active at moderate and vigorous levels. A common problem is that ... Read more >>

JMIR Mhealth Uhealth (JMIR mHealth and uHealth)
[2021, 9(1):e22488]

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