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Identification and Mapping of QTL for Stripe Rust Resistance in the Chinese Wheat Cultivar Shumai126.

Yufan Wang, Yanling Hu, Fangyi Gong, Yarong Jin, Yingjie Xia, Yu He, Yun Jiang, Qiang Zhou, Jingshu He, Lihua Feng, Guo-Yue Chen, You-Liang Zheng, Dengcai Liu, Lin Huang, Bihua Wu,

Stripe rust, caused by Puccinia striiformis f. sp. tritici, is a damaging disease of wheat globally, and breeding resistant cultivars is the best control strategy. The Chinese winter wheat cultivar Shumai126 (SM126) exhibited strong resistance to P. striiformis f. sp. tritici in the field for more than ten years. The ... Read more >>

Plant Dis (Plant disease)
[2021, :]

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Boosting the Energy Density of Li||CFx Primary Batteries Using a 1,3-Dimethyl-2-imidazolidinone-Based Electrolyte.

Ang Fu, Yukang Xiao, Junhua Jian, Lin Huang, Chao Tang, Xunxin Chen, Yue Zou, Jiuzhou Wang, Yong Yang, Jianming Zheng,

Elevating the discharge voltage plateau is regarded as the most effective strategy to improve the energy density of Li||CF<i><sub>x</sub></i> batteries in consideration of the finite capacity of CF<i><sub>x</sub></i> (<i>x</i> ∼ 1) cathodes. Here, an electrolyte, with LiBF<sub>4</sub> in 1,3-dimethyl-2-imidazolidinone (DMI)/1,2-dimethoxyethane (DME), is developed for the first time to substantially promote ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, :]

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Orthogonal interlayer coupling in an all-antiferromagnetic junction

Yongjian Zhou, Liyang Liao, Tingwen Guo, Hua Bai, Mingkun Zhao, Cai-Hua Wan, Lin Huang, Lei Han, Ruyi Chen, Zhiyuan Zhou, Xiufeng Han, Feng Pan, Cheng Song,

The interlayer coupling of two ferromagnetic layers results in found of giant magnetoresistance, which forms the foundation of spintronics and accelerates the development of information technology. Compared with ferromagnets, antiferromagnets (AFMs) possess huge potential in ultrafast and high-density data processing and information storage because of their terahertz spin dynamics and ... Read more >>

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Rosmarinic acid inhibits proliferation and migration, promotes apoptosis and enhances cisplatin sensitivity of melanoma cells through inhibiting ADAM17/EGFR/AKT/GSK3β axis.

Lin Huang, Jiangyan Chen, Jin Quan, Debing Xiang,

Rosmarinic acid (RA), a naturally occurring polyphenolic compound, exerts multiple biological properties including anti-cancer. The metalloprotease, a disintegrin and metalloproteinase 17 (ADAM17), can activate ligands of the epidermal growth factor receptor (EGFR) and contribute to tumor progression. We aimed to investigate whether RA could exhibit anti-cancer effects in melanoma cells ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3065-3076]

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Population differentiation and epidemic tracking of Bursaphelenchus xylophilus in China based on chromosome-level assembly and whole genome sequencing data.

Xiaolei Ding, Yunfei Guo, Jianren Ye, Xiaoqin Wu, Sixi Lin, Fengmao Chen, Lihua Zhu, Lin Huang, Xiaofeng Song, Yi Zhang, Ling Dai, Xiaotong Xi, Jinsi Huang, Kai Wang, Ben Fan, De-Wei Li,

<h4>Background</h4>Bursaphelenchus xylophilus, the pinewood nematode, kills millions of pine trees worldwide every year, and causes enormous economic and ecological losses. Despite extensive research on population variation, there is little understanding of the population-wide variation spectrum in China.<h4>Results</h4>We sequenced an inbred B. xylophilus strain using Pacbio+Illumina+Bionano+Hi-C and generated a chromosome-level assembly ... Read more >>

Pest Manag Sci (Pest management science)
[2021, :]

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Terpolymerization of Ethylene and Two Different Methoxyaryl-Substituted Propylenes by Scandium Catalyst Makes Tough and Fast Self-Healing Elastomers.

Yang Yang, Haobing Wang, Lin Huang, Masayoshi Nishiura, Yuji Higaki, Zhaomin Hou,

The terpolymerization of a non-polar olefin (such as ethylene) and two different polar functional olefins in a controlled fashion is of great interest and importance but has hardly been explored to date. We report for the first time the terpolymerization of ethylene (E) and two different methoxyaryl-substituted propylenes (A<sup>R1</sup> P=hexylanisyl ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2021, 60(50):26192-26198]

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Docosahexaenoic acid reduces hypoglycemia-induced neuronal necroptosis via the peroxisome proliferator-activated receptor γ/nuclear factor-κB pathway.

Lin Huang, Yue Zhou, Zhi-Xian Gou, Feng Zhang, Li-Qun Lu,

DHA has been shown to be neuroprotective and important to neurogenesis, but its role in HG-induced brain injury and the underlying mechanisms remain unknown. To elucidate the therapeutic effect of DHA, we established a mouse model with insulin-induced hypoglycemic brain injury and an in vitro model of HT-22 cells using ... Read more >>

Brain Res (Brain research)
[2022, 1774:147708]

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First assessment of thermoacoustic tomography for in vivo detection of rheumatoid arthritis in the finger joints detection of rheumatoid arthritis in the finger joints.

Zihui Chi, Lin Huang, Dan Wu, Xiaojun Long, Xueliang Xu, Huabei Jiang,

<h4>Background</h4>The diagnosis of rheumatoid arthritis (RA) is complicated because of the complexity of symptoms and joint structures. Current clinical imaging techniques for the diagnosis of RA have strengths and weaknesses. Emerging imaging techniques need to be developed for the diagnosis or auxiliary diagnosis of RA.<h4>Purpose</h4>This study aimed to demonstrate the potential ... Read more >>

Med Phys (Medical physics)
[2021, :]

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TbMYC4A Is a Candidate Gene Controlling the Blue Aleurone Trait in a Wheat-Triticum boeoticum Substitution Line.

Xin Liu, Minghu Zhang, Xiaomei Jiang, Hui Li, Zhenjiao Jia, Ming Hao, Bo Jiang, Lin Huang, Shunzong Ning, Zhongwei Yuan, Xuejiao Chen, Xue Chen, Dengcai Liu, Baolong Liu, Lianquan Zhang,

<i>Triticum boeoticum</i> Boiss (A<sup>b</sup>A<sup>b</sup>, 2n = 2x = 14) is one of the sources of the blue grain trait controlled by <i>blue aleurone layer 2</i> (<i>Ba2</i>). However, the underlying genes have not been cloned. In this study, a transcriptomic comparison between a blue-grained wheat-<i>T. boeoticum</i> substitution line and its wheat ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2021, 12:762265]

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Diaporthe sapindicola sp. nov. Causes Leaf Spots of Sapindus mukorossi in China.

Yuan-Zhi Si, De-Wei Li, Jing Zhong, Lin Huang, Li-Hua Zhu,

<i>Sapindus mukorossi</i> Gaertn. (Sapindaceae), soapberry is an important biodiesel tree in southern China. In recent years, leaf spot disease on soapberry has been observed frequently in soapberry germplasm repository, Jianning County, Sanming City, Fujian Province, China. The symptoms initially appeared as irregular small yellow spots, and the center of the ... Read more >>

Plant Dis (Plant disease)
[2021, :]

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Therapeutic Drug Monitoring and Pharmacogenetic Testing in Northern China.

Chunyan Zhang, Jing Lei, Yi Liu, Yu Wang, Lin Huang, Yufei Feng,

<b>Background:</b> Therapeutic drug monitoring (TDM) and pharmacogenetic (PGx) testing are widely used as approaches to improve individualized (personalized) pharmacotherapy. Little is known about TDM and PGx testing services in China. This study is aimed to describe the TDM and PGx testing services in northern China, and to lay the foundation ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:754380]

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Electrochemical Oxo-Fluorosulfonylation of Alkynes under Air: Facile Access to β-Keto Sulfonyl Fluorides.

Dengfeng Chen, Xingliang Nie, Qingyuan Feng, Yingyin Zhang, Yiheng Wang, Qiuyue Wang, Lin Huang, Shenlin Huang, Saihu Liao,

Radical fluorosulfonylation is emerging as an appealing approach for the synthesis of sulfonyl fluorides, which have widespread applications in many fields, in particular in the context of chemical biology and drug development. Here, we report the first investigation of FSO<sub>2</sub> radical generation under electrochemical conditions, and the establishment of a ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2021, :]

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Intelligent Pore Switch of Hollow Mesoporous Organosilica Nanoparticles for High Contrast Magnetic Resonance Imaging and Tumor-Specific Chemotherapy.

Lin Huang, Jie Feng, Wenpei Fan, Wei Tang, Xiaoxiang Rong, Wangjun Liao, Zhenni Wei, Yikai Xu, Aiguo Wu, Xiaoyuan Chen, Zheyu Shen,

Hollow mesoporous organosilica nanoparticles (HMONs) are widely considered as a promising drug nanocarrier, but the loaded drugs can easily leak from HMONs, resulting in the considerably decreased drug loading capacity and increased biosafety risk. This study reports the smart use of core/shell Fe<sub>3</sub>O<sub>4</sub>/Gd<sub>2</sub>O<sub>3</sub> (FG) hybrid nanoparticles as a gatekeeper to ... Read more >>

Nano Lett (Nano letters)
[2021, 21(22):9551-9559]

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Treatment Effects of Integrated TCM and Western Medicine Treatment Scheme on COVID-19: A Single-armed Clinical Trial

Jianfeng Bao, Zhijun Xie, Shourong Liu, Lin Huang, Jing Sun, Yujun Tang, Haiping Chen, Jianjiang Qi, Jianchun Guo, Liangbin Miao, Zhaoyi Li, Hui Yang, Yi Zhang, Zhiyu Li, Yuan Xu, Shengyou Lin, Yunhao Xun, Li Zhang, Jie Bao, Zhaobin Cai, Jinsong Huang, Chengping Wen,

<h4>Backgroud</h4> : The outbreak of COVID-19 has brought unprecedented perils to human health and raised public health concerns in more than two hundred countries. Safe and effective treatment scheme is needed urgently. <h4>Objective</h4> : To evaluate the effects of integrated TCM and western medicine treatment scheme on COVID-19. <h4>Methods</h4> : ... Read more >>

(Clinical Complementary Medicine and Pharmacology)
[2021, :]

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The Value of Clock Drawing Process Assessment in Screening for Mild Cognitive Impairment and Alzheimer's Dementia.

Yanlu Huang, Feng-Feng Pan, Lin Huang, Qihao Guo,

Many clock drawing test (CDT) scoring systems focus on drawing results and lack drawing process assessments. This study created a CDT scoring procedure with drawing process assessment and explored its diagnostic value in screening for mild cognitive impairment (MCI) and early Alzheimer's disease (AD) from normal control (NC). We used ... Read more >>

Assessment (Assessment)
[2021, :10731911211053851]

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Protein Phosphatase CgPpz1 Regulates Potassium Uptake, Stress Responses and Plant Infection in Colletotrichum gloeosporioides.

Yun-Zhao Zhang, Bing Li, Yu-Ting Pan, Yu-Lan Fang, De-Wei Li, Lin Huang,

Protein phosphatases (PPs) play important roles in the regulation of various cellular processes in eukaryotes. The ascomycete Colletotrichum gloeosporioides is a causal agent of anthracnose disease on some important crops and trees. In this study, CgPPZ1, a protein phosphate gene and a homolog of yeast PPZ1, was identified in C. ... Read more >>

Phytopathology (Phytopathology)
[2021, :]

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Successful implantation of leadless pacemaker in a patient with giant right atrium and tricuspid valve stenosis.

Qinmei Xiong, Jinzhu Hu, Qiongqiong Zhou, Lin Huang, Jianhua Yu, Juxiang Li, Qi Chen, Kui Hong,

With the steadily increasing amount of leadless pacemaker implantations performed worldwide, it has called attention to the delivery difficulty in patients with severe large right heart. Nevertheless, limited studies have reported leadless pacemaker implantation in patients with tricuspid stenosis. Here, we report the successful implantation of leadless pacemaker in a ... Read more >>

Ann Noninvasive Electrocardiol (Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc)
[2021, :e12905]

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Determinizing the contributions of human activities and climate change on greening in the Beijing-Tianjin-Hebei Region, China.

Wei Cao, Dan Wu, Lin Huang, Mei Pan, Taoli Huhe,

China accounts for 25% of the global greening. There are temporal and spatial differences of China's greening and intrinsic driving forces. Thus, it is crucial to determinize the contributions of human activities and climate change on greening at region scale. The Beijing-Tianjin-Hebei Region (BTHR) is one of the most active ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):21201]

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Plasmonic tweezers for optical manipulation and biomedical applications.

Hongtao Tan, Huiqian Hu, Lin Huang, Kun Qian,

Plasmonic tweezers are an emerging research topic because of their breakthrough in the conventional diffraction limit and precise manipulation at the nanoscale. Notably, their compatibility with analytical techniques (e.g. fluorescence, surface-enhanced Raman scattering (SERS), and laser desorption/ionization mass spectrometry (LDI MS)) opens up opportunities in optical manipulation and biomedical applications. ... Read more >>

Analyst (The Analyst)
[2020, 145(17):5699-5712]

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Positron Emission Computed Tomography Imaging of Synaptic Vesicle Glycoprotein 2A in Alzheimer's Disease.

Yanyan Kong, Shibo Zhang, Lin Huang, Chencheng Zhang, Fang Xie, Zhengwei Zhang, Qi Huang, Donglang Jiang, Junpeng Li, Weiyan Zhou, Tao Hua, Bomin Sun, Jiao Wang, Yihui Guan,

Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-dependent dementia. There is currently no effective treatment for AD, which may be attributed in part to lack of a clear underlying mechanism. Early diagnosis of AD is of great significance to control the development of the disease. Synaptic ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2021, 13:731114]

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A high-flux, self-cleaning solar water evaporation system

Chenyang Dang, Meihua Chen, Lin Huang, Mingming Chu, Yiming Li, Lujia Liu, Xue Cao,

Solar interfacial evaporation is a promising technology to produce clean water from seawater or polluted water. However, the evaporation rate upon existing photothermal materials is normally limited to 2 kg m-2 h-1 or below, which is hard to fulfil the daily water demand of a family, let alone enormous water ... Read more >>

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Characterization and fine mapping of a lesion mimic mutant (Lm5) with enhanced stripe rust and powdery mildew resistance in bread wheat (Triticum aestivum L.).

Cong Li, Hang Liu, Jian Wang, Qi Pan, Yue Wang, Kunyan Wu, Peiying Jia, Yang Mu, Huaping Tang, Qiang Xu, Qiantao Jiang, Yaxi Liu, Pengfei Qi, Xiaojun Zhang, Lin Huang, Guoyue Chen, Jirui Wang, Yuming Wei, Youliang Zheng, Lulu Gou, Qifu Yao, Xiujin Lan, Jian Ma,

<h4>Key message</h4>A novel light intensity-dependent lesion mimic mutant with enhanced disease resistance was physiologically, biochemically, and genetically characterized, and the causative gene was fine mapped to a 1.28 Mbp interval containing 17 high-confidence genes. Lesion mimic mutants are ideal for studying disease resistance and programmed cell death photosynthesis in plants ... Read more >>

Theor Appl Genet (TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik)
[2021, :]

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Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice.

Lin Huang, Lijuan Zhu, Zhaoping Ou, Chaoyang Ma, Li Kong, You Huang, Yazhi Chen, Haoqiang Zhao, Lixin Wen, Jing Wu, Zhihang Yuan, Jine Yi,

Betulinic acid (BA) is a pentacyclic triterpenoid compound with potential antioxidant and anti-inflammatory effects. In this study, T-2 toxin was injected intraperitoneally in mice to establish kidney damage model and to evaluate the protective effects of BA and further reveal the molecular mechanism. BA pretreatment inhibited the T-2 toxin-stimulated increase ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2021, 101(Pt B):108210]

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AutoCNV: a semiautomatic CNV interpretation system based on the 2019 ACMG/ClinGen Technical Standards for CNVs.

Chunna Fan, Zhonghua Wang, Yan Sun, Jun Sun, Xi Liu, Licheng Kang, Yingshuo Xu, Manqiu Yang, Wentao Dai, Lijie Song, Xiaoming Wei, Jiale Xiang, Hui Huang, Meizhen Zhou, Fanwei Zeng, Lin Huang, Zhengfeng Xu, Zhiyu Peng,

<h4>Background</h4>The American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen) presented technical standards for interpretation and reporting of constitutional copy-number variants in 2019 (the standards). Although ClinGen developed a web-based CNV classification calculator based on scoring metrics, it can only track and tally points that ... Read more >>

BMC Genomics (BMC genomics)
[2021, 22(1):721]

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Impact of Different Type and Frequency of Social Participation on Depressive Symptoms Among Older Chinese Adults: Is There a Gender Difference?

Shujuan Xiao, Huang Lin, Chongbang Zhao, Xiao Zheng, Lei Shi, Jiachi Zhang, Benli Xue, Jinghui Chang, Jiangyun Chen, Chichen Zhang,

<b>Objectives:</b> Social participation may prevent depressive symptoms in older adults. But research to date ignores gender differences in the associations between social participation and depressive symptoms. The purpose of this study was to determine the effect of different type and frequency of social participation on depressive symptoms, as well as ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2021, 12:758105]

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