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Author Lihua Zheng

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A CEP Peptide Receptor-like Kinase Regulates Auxin Biosynthesis and Ethylene Signaling to Coordinate Root Growth and Symbiotic Nodulation in Medicago truncatula.

Fugui Zhu, Jie Deng, Hong Chen, Peng Liu, Lihua Zheng, Qinyi Ye, Rui Li, Mathias Brault, Jiangqi Wen, Florian Frugier, Jiangli Dong, Tao Wang,

Because of the high energy consumed during symbiotic nitrogen fixation, legumes must balance growth and symbiotic nodulation. Both lateral roots and nodules form on the root system and the developmental coordination of these organs according to reduced nitrogen (N) availability remains elusive. We show that the Compact Root Architecture 2 ... Read more >>

Plant Cell (The Plant cell)
[2020, :]

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OASTL-A1 functions as a cytosolic cysteine synthase and affects arsenic tolerance in rice.

Chengcheng Wang, Lihua Zheng, Zhong Tang, Shengkai Sun, Jian Feng Ma, Xin-Yuan Huang, Fang-Jie Zhao,

Arsenic (As) contamination in paddy soil can cause phytotoxicity and elevated As accumulation in rice grains. Arsenic detoxification is closely linked to sulfur assimilation, but the genes involved have not been described in rice. In this study, we characterize the function of OASTL-A1, an O-acetylserine(thiol) lyase, in cysteine biosynthesis and ... Read more >>

J. Exp. Bot. (Journal of experimental botany)
[2020, 71(12):3678-3689]

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Ethyl-p-methoxycinnamate enhances oct4 expression and reinforces pluripotency through the NF-κB signaling pathway.

Huihan Ai, Hongshuang Qin, Jiawei Li, Chunxue Niu, Zhenbo Song, Yongli Bao, Luguo Sun, Lihua Zheng, Yuxin Li,

Pluripotent stem cells are have therapeutic applications in regenerative medicine and drug discovery. However, the differentiation of stem cells in vitro hinders their large-scale production and clinical applications. The maintenance of cell pluripotency relies on a complex network of transcription factors; of these, octamer-binding transcription factor-4 (Oct4) plays a key ... Read more >>

Biochem. Pharmacol. (Biochemical pharmacology)
[2020, 177:113984]

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Res-WGAN: Image Classification for Plant Small-scale Datasets

Mi Jiaqi, Hao xia, Yang Si, Yang Xiande, Gao Wanlin, Li Minzan, Zheng Lihua, Minjuan Wang,

Abstract Background: Artificial identification of rare plants is an important yet challenging problem in plant taxonomy. Although deep learning-based method can accurately predict rare plant category from training samples, accuracy requirements of only few experts are satisfied due to the small sample size. Thus, effective data augmentation is vital to ... Read more >>

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Prognostic significance of preoperative albumin to fibrinogen ratio associated nomograms in patients with breast invasive ductal carcinoma.

Lihua Zheng, Yaheng Zhao, Feng Liu, Peng Liu, Wei Li, Yan Yang, Hongsong Zhang, Yunjiang Liu,

Plasma albumin to fibrinogen ratio is involved in human cancer, but its prognostic significance in breast cancer is controversy. In the context of breast invasive ductal carcinoma, this research aims to retrospectively evaluate by preoperative plasma albumin to fibrinogen ratio (AFR) and forecast oncological outcome and recurrence.This retrospective study comprised ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(26):e20681]

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Tanshinone I regulates autophagic signaling via the activation of AMP-activated protein kinase in cancer cells.

Lihua Zheng, Ying Zhang, Guijian Liu, Shi Cheng, Ge Zhang, Cheng An, Shipeng Sun, Jian Wang, Bo Pang, Shanhu Li,

Tanshinone I, one of the components of Salvia miltiorrhiza Bunge, exhibits anti-tumor ability and induces autophagy. But the mechanisms are not fully understood. This study aims to investigate whether AMP-activated protein kinase dependent pathway is involved in the autophagic signaling regulation and its relationship with tumor suppression. Breast cancer cells ... Read more >>

Anticancer Drugs (Anti-cancer drugs)
[2020, 31(6):601-608]

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Res-WGAN: Image Classification for Plant Small-scale Datasets

Mi Jiaqi, Hao Xia, Yang Si, Gao Wanlin, Li Minzan, Minjuan Wang, Zheng Lihua,

Abstract Background: The artificial identification of rare plants is always a challenging problem in plant taxonomy. Although the convolutional neural network (CNN) in the deep learning method can better realize the automatic classification of plant samples through training, the model accuracy is difficult to reach the human eye discrimination due ... Read more >>

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Nomograms for predicting the likelihood of non-sentinel lymph node metastases in breast cancer patients with a positive sentinel node biopsy.

Lihua Zheng, Feng Liu, Shuo Zhang, Yaheng Zhao, Yunjiang Liu,

BACKGROUND:Breast cancer patients with sentinel lymph node (SLN) metastases may have a low risk of non-SLN metastases. Accurate estimates of the likelihood of additional disease in the non-SLN metastases can avoid many complications mentioned the axillary lymph node dissection (ALND). This study aims to develop a new model based on ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(52):e18522]

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Prognostic Significance of plasma albumin to fibrinogen ratio Associated Nomograms in Patients with breast invasive ductal carcinoma

Lihua Zheng, Feng Liu, Yaheng Zhao, Wei Li, Yan Yang, Hongsong Zhang, Yunjiang Liu,

Abstract Background : In the context of breast invasive ductal carcinoma, this research aims to retrospectively evaluate by preoperative plasma albumin to fibrinogen ratio (AFR) and forecast oncological outcome and recurrence. Methods : This reflective study included 230 patients who had surgical procedures at the Fourth Hospital of Hebei Medical ... Read more >>

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An Improved Protocol for the Virtual Screening Discovery of Novel Histone Deacetylase Inhibitors.

Qiuhang Song, Tingting Liu, Yucui Liu, Shuyue Wang, Cong Fan, Lihua Zheng, Yongli Bao, Luguo Sun, Chunlei Yu, Ying Sun, Zhenbo Song, Guannan Wang, Yanxin Huang, Yuxin Li,

Histone deacetylases (HDACs) are enzymes that play a key role in structural modification and gene expression. The overexpression of HDAC is associated with cancer, and thus inhibiting the enzyme could be an efficient cancer therapy. To discover new HDAC inhibitors (HDACis), we proposed an improved protocol combining a hierarchical pharmacophore ... Read more >>

Chem. Pharm. Bull. (Chemical & pharmaceutical bulletin)
[2019, 67(10):1076-1081]

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Micro-RNA-27a/b negatively regulates hepatic gluconeogenesis by targeting FOXO1.

Shuyue Wang, Huihan Ai, Lei Liu, Xiaojun Zhang, Feng Gao, Lihua Zheng, Jingwen Yi, Luguo Sun, Chunlei Yu, Huiying Zhao, Yuxin Li,

In the context of hepatic insulin resistance, hepatic gluconeogenesis is abnormally increased, which results in increased hepatic glucose production and hyperglycemia, but the underlying mechanisms remain to be fully elucidated. Micro-RNAs (miRNAs) have been identified as critical regulators of diabetes and other metabolic disorders. In this study, we found that ... Read more >>

Am. J. Physiol. Endocrinol. Metab. (American journal of physiology. Endocrinology and metabolism)
[2019, 317(5):E911-E924]

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Dracorhodin perchlorate protects pancreatic β-cells against glucotoxicity- or lipotoxicity-induced dysfunction and apoptosis in vitro and in vivo.

Lei Liu, Chen Liang, Pucheng Mei, Hong Zhu, Meiling Hou, Chunlei Yu, Zhenbo Song, Yongli Bao, Yanxin Huang, Jingwen Yi, Shuyue Wang, Yin Wu, Lihua Zheng, Ying Sun, Guannan Wang, Mingxin Huo, Shaonian Yang, Luguo Sun, Yuxin Li,

Glucotoxicity or lipotoxicity leads to hyperglycemia and insulin secretion deficiency, which are important causes for the onset of type 2 diabetes mellitus (T2DM). Thus, the restoration of β-cell function is a long-sought goal in diabetes research. Previous studies have implicated pancreatic and duodenal homeobox 1 gene (Pdx1) in β-cell function and ... Read more >>

FEBS J. (The FEBS journal)
[2019, 286(18):3718-3736]

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Characterization and antioxidant activities of polysaccharides from Passiflora edulis Sims peel under different degradation methods

Feng Xiong, Xia Li, Lihua Zheng, Nan Hu, Mengjia Cui, Haiyun Li,

Water extracted polysaccharide from P. edulis peel (WPEP) was degraded using hydrochloric acid, ultrasonic-assisted hydrochloric acid, and α-amylase to obtained A-WPEP (acid hydrolysis WPEP), U-WPEP (ultrasonic-assisted acid hydrolysis WPEP), and M-WPEP (Enzymatic hydrolysis WPEP), respectively, and its relationship between structure and antioxidant activities was studied. Results showed that the solubility, ... Read more >>

(Carbohydrate Polymers)
[2019, 218:46-52]

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Characterization and antioxidant activities of polysaccharides from Passiflora edulis Sims peel under different degradation methods.

Feng Xiong, Xia Li, Lihua Zheng, Nan Hu, Mengjia Cui, Haiyun Li,

Water extracted polysaccharide from P. edulis peel (WPEP) was degraded using hydrochloric acid, ultrasonic-assisted hydrochloric acid, and α-amylase to obtained A-WPEP (acid hydrolysis WPEP), U-WPEP (ultrasonic-assisted acid hydrolysis WPEP), and M-WPEP (Enzymatic hydrolysis WPEP), respectively, and its relationship between structure and antioxidant activities was studied. Results showed that the solubility, ... Read more >>

Carbohydr Polym (Carbohydrate polymers)
[2019, 218:46-52]

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Antioxidant constituents of chrysanthemum 'jinsidaju' cultivated in Kaifeng.

Fenqin Zhao, Qianqian Zhang, Yan Yan, Haiyan Jia, Xinran Zhao, Xiying Li, Lihua Zheng, Guang Han,

Dendranthema morifolium cv. 'jinsidaju', cultivated only in Kaifeng, has been eaten for more than 1000 years. During the antioxidant-activity-guided studies on its chemistry and health care function, two new bisabolane-type sesquiterpenes, (6R,7R)-7-hydroxybisabol-2,9E,11-triene-4-one (jinsidajuol A, 1) and (6R,7R)-7-hydroxy-11-methoxybisabol-2,9E-diene-4-one (jinsidajuol B, 2), and thirteen known compounds (3-15) were isolated from the flowers. Their ... Read more >>

Fitoterapia (Fitoterapia)
[2019, 134:39-43]

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Dynamic Protein S-Acylation in Plants.

Lihua Zheng, Peng Liu, Qianwen Liu, Tao Wang, Jiangli Dong,

Lipid modification is an important post-translational modification. S-acylation is unique among lipid modifications, as it is reversible and has thus attracted much attention. We summarize some proteins that have been shown experimentally to be S-acylated in plants. Two of these S-acylated proteins have been matched to the S-acyl transferase. More ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(3):]

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A novel benzamine lead compound of histone deacetylase inhibitor ZINC24469384 can suppresses HepG2 cells proliferation by upregulating NR1H4.

Qiuhang Song, Mingyue Li, Cong Fan, Yucui Liu, Lihua Zheng, Yongli Bao, Luguo Sun, Chunlei Yu, Zhenbo Song, Ying Sun, Guannan Wang, Yanxin Huang, Yuxin Li,

Histone deacetylases (HDACs) can enzymatically transferred acetyl functional group from protein or lysine residues of histone, so they can regulate the expression of lots of genes. Now HDACs are used as drug targets and many HDAC inhibitors (HDACis) were approved for cancer therapy or in clinical trials. However, the physiological ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):2350]

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Propofol partially attenuates complete freund's adjuvant-induced neuroinflammation through inhibition of the ERK1/2/NF-κB pathway.

Lijian Cheng, Zhenhong Chen, Lihua Wang, Yunping Lan, Lihua Zheng, Fangpu Wu,

Peripheral inflammation in male C57BL/6 mice was induced by intraplantar injection of 20 μL complete freund's adjuvant (CFA) in the left hind paw. Mice were randomly divided into three groups: Sham, CFA, and propofol+CFA. Mechanical allodynia was assessed by von Frey analysis, and heat hyperalgesia was detected by exposure of the ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2019, 120(6):9400-9408]

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Synthesis and structure anti-inflammatory activity relationships studies of andrographolide derivatives.

Ling Liu, Yan Yan, Lihua Zheng, Haiyan Jia, Guang Han,

Andrographolide is a main bioactive diterpene lactone in A. paniculata with anti-inflammatory activity. In this study, a series of andrographolide derivatives were synthesized and evaluated for their structure-anti-inflammatory activity relationships in vivo. Among all compounds, isoandrographolide and 14-deoxyandrographolide showed stronger anti-inflammatory activity than andrographolide. The results indicated that the introduction ... Read more >>

Nat. Prod. Res. (Natural product research)
[2020, 34(6):782-789]

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Enhanced visible light photoreduction of aqueous Cr(VI) by Ag/Bi4O7/g-C3N4 nanosheets ternary metal/non-metal Z-scheme heterojunction.

Mao Ye, Wei Wei, Lihua Zheng, Yuze Liu, Dewei Wu, Xiangyu Gu, Ang Wei,

In this paper, we successfully constructed a ternary metal/non-metal nanomaterial which can synergize Z-scheme heterojunction and plasmonic metal/semiconductor for enhancing visible light photoreduction of aqueous Cr(VI). The as-formed ternary metal/non-metal nanomaterial was composed of g-C3N4 nanosheets mutual modified by Ag nanoparticles and Bi4O7. In the ternary nanomaterial, g-C3N4 nanosheets and ... Read more >>

J. Hazard. Mater. (Journal of hazardous materials)
[2019, 365:674-683]

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20(S)-25-methoxyl-dammarane-3β,12β,20-triol attenuates endoplasmic reticulum stress via ERK/MAPK signaling pathway.

Hongshuang Qin, Wei Li, Ying Sun, Yongli Bao, Luguo Sun, Zhenbo Song, Lihua Zheng, Yuqing Zhao, Yuxin Li,

Endoplasmic reticulum (ER) stress, together with unfolded protein response (UPR), can remove unfolded proteins and promote survival. However, severe and prolonged ER stress leads to cell death, tissue injury, and many serious diseases. Therefore, it is essential to identify drugs that can attenuate ER stress for ER-related disease treatment. A ... Read more >>

Eur. J. Pharmacol. (European journal of pharmacology)
[2018, 836:75-82]

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Application of computed tomography venography in the diagnosis and severity assessment of iliac vein compression syndrome: A retrospective study.

Peng Liu, Junlu Peng, Lihua Zheng, Haili Lu, Weifang Yu, Xia Jiang, Lei Zhang, Haixia Song, Zengren Zhao,

The objectives are to evaluate the application of computed tomography venography (CTV) in the diagnosis of iliac vein compression syndrome (IVCS), and to assess the factors related to the incidence and development of IVCS and the recurrence of varicose veins.Imaging data of 120 patients with chronic venous disease (CVD) of ... Read more >>

Medicine (Baltimore) (Medicine)
[2018, 97(34):e12002]

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Prohibitin 2 localizes in nucleolus to regulate ribosomal RNA transcription and facilitate cell proliferation in RD cells.

Zilong Zhou, Huihan Ai, Kun Li, Xinlei Yao, Wenbin Zhu, Lei Liu, Chunlei Yu, Zhenbo Song, Yongli Bao, Yanxin Huang, Yin Wu, Lihua Zheng, Ying Sun, Guannan Wang, Kewei Ma, Luguo Sun, Yuxin Li,

Prohibitin 2 (PHB2), as a conserved multifunctional protein, is traditionally localized in the mitochondrial inner membrane and essential for maintenance of mitochondrial function. Here, we investigated the role of PHB2 in human rhabdomyosarcoma (RMS) RD cells and found substantial localization of PHB2 in the nucleolus. We demonstrated that PHB2 knockdown ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):1479]

Cited: 3 times

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Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo.

Yan Li, Yannan Wu, Xinlei Yao, Fang Hao, Chunlei Yu, Yongli Bao, Yin Wu, Zhenbo Song, Ying Sun, Lihua Zheng, Guannan Wang, Yanxin Huang, Luguo Sun, Yuxin Li,

Ginkgolide A (GA) is a natural compound isolated from Ginkgo biloba and has been used to treat cardiovascular diseases and diabetic vascular complications. However, only a few studies have been conducted on the anti-inflammatory effects of GA. In particular, no related reports have been published in a common inflammation model ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2017, 18(4):]

Cited: 6 times

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Structure, cytotoxic activity and mechanism of protoilludane sesquiterpene aryl esters from the mycelium of Armillaria mellea.

Zhijin Li, Yunchao Wang, Bin Jiang, Wenliang Li, Lihua Zheng, Xiaoguang Yang, Yongli Bao, Luguo Sun, Yanxin Huang, Yuxin Li,

Armillaria mellea (Vahl. ex. Fr.) Karst is an important traditional Chinese medicine used in dispelling wind and removing obstruction in the meridians, and strengthening tendons and bones. Armillaria mellea has been recorded in the book Caobenshiyi which was written by ancestor for the function of suppressing hyderactive liver for calming ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2016, 184:119-127]

Cited: 1 time

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