Full Text Journal Articles by
Author Lihua Wang

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Curcumin micelles suppress gastric tumor cell growth by upregulating ROS generation, disrupting redox equilibrium and affecting mitochondrial bioenergetics.

Xiaokun Lin, Lihua Wang, Liqian Zhao, Zheng Zhu, TongZuan Chen, Shinuo Chen, Yecheng Tao, Tianni Zeng, Yaoyao Zhong, Hanxiao Sun, Zhixiang Wang, Weisheng Zheng, Yuhao Zhang, Wencan Wu, Kaihui Nan, Tongke Chen,

Gastric cancer is the fourth most common cancer and the second most frequent cause of cancer death worldwide. Chemotherapy is an important treatment. However, traditional chemotherapy drugs have low bioavailability and targeting ability. Therefore, we developed curcumin-encapsulated micelles for the treatment of gastric cancer and investigated their antitumor efficacy and ... Read more >>

Food Funct (Food & function)
[2020, 11(5):4146-4159]

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RDM1 plays an oncogenic role in human ovarian carcinoma cells.

Lu Tong, Wenjiao Cao, Jun Sheng, Enhao Zhu, Ying Yu, Tianying Zhong, Yajun Chen, Lihua Wang,

Ovarian cancer is one of the deadliest gynecological cancer, with a low overall 5-year survival rate. RDM1, RAD52 motif-containing protein 1, is sensitive to cisplatin, a common chemotherapy drug and it has an important role inDNA damage repair pathway. Until now, the effect of RDM1 in ovarian cancer is undiscovered. ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):885-892]

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A curcumin derivative, WZ35, suppresses hepatocellular cancer cell growth via downregulating YAP-mediated autophagy.

Lihua Wang, Zheng Zhu, Lei Han, Liqian Zhao, Jialei Weng, Hongbao Yang, Shijia Wu, Kaiyuan Chen, Liang Wu, Tongke Chen,

Hepatocellular carcinoma (HCC) is a common cancer type throughout the world. Due to the high occurrence rate and mortality, liver cancer is one of the leading causes of cancer associated death. With the development of monoclonal antibodies and immunotherapy, the mortality of HCC cancer patients has reduced. However, the recurrence ... Read more >>

Food Funct (Food & function)
[2019, 10(6):3748-3757]

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Hsa-circ-0001860 promotes Smad7 to enhance MPA resistance in endometrial cancer via miR-520h

Shuang Yuan, Panchan Zheng, Judan Zeng, Xiao Sun, Lihua Wang,

Abstract Background Medroxyprogesterone acetate (MPA) is one of the most commonly prescribed progestin for the treatment of endometrial cancer (EC). Despite initial benefits, many patients ultimately develop progesterone resistance. Circular RNA (circRNA) is a kind of noncoding RNA, contributing greatly to the development of human tumor. However, the role of ... Read more >>

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Room-temperature superplasticity in Au nanowires and their atomistic mechanisms.

Pan Liu, Lihua Wang, Yonghai Yue, Shuangxi Song, Xiaodong Wang, Kolan Madhav Reddy, Xiaozhou Liao, Ze Zhang, Mingwei Chen, Xiaodong Han,

We report experimental observation of room-temperature superplasticity and the distinct nanosize effect on the deformation mechanisms of Au nanowires. The Au nanowires were subjected to in situ tensile straining in a transmission electron microscope by using a home-made strain actuator, and a super large plastic strain with ∼150% uniform elongation ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(18):8727-8735]

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Interobserver variability in target volume delineation in definitive radiotherapy for thoracic esophageal cancer: A multi-center study from China

Xiao Chang, Wei Deng, Xin Wang, Zongmei Zhou, Jun Yang, Wenling Guo, Miaoling Liu, Xiaolu Qi, Ling Li, Kaixian Zhang, Min Zhang, Yonggang Shi, Ke Liu, Yidian Zhao, Huitao Wang, Zhilong Yu, Jihong Zhang, Lihua Wang, Xueying Qiao, Chun Han, Shuchai Zhu, Ruohui Zhang, Junqiang Chen, Cairong Hu, Fuquan Zhang, Xiaorong Hou, Qingsong Pang, Wencheng Zhang, Gaofeng Li, Hailei Lin, Xinchen Sun, Xiaoling Ge, Caihong Li, Hong Ge, Dingjie Li, Yadi Wang, Na Lu, Xianshu Gao, Shangbin Qin, Yuan Tian, Zefen Xiao,

Abstract Purpose: To investigate the interobserver variability (IOV) in target volume delineation of definitive radiotherapy for thoracic esophageal cancer (TEC) among cancer centers in China, and ultimately improve contouring consistency as much as possible to lay the foundation for multi-center prospective studies. Methods: Sixteen cancer centers throughout China participated in ... Read more >>

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White-coat hypertension and incident end-stage renal disease in patients with non-dialysis chronic kidney disease: results from the C-STRIDE Study.

Qin Wang, Yu Wang, Jinwei Wang, Luxia Zhang, Ming-Hui Zhao, ,

BACKGROUND:Controversy remains whether white coat hypertension (WCH) is associated with renal prognosis in patients with chronic kidney disease (CKD). METHODS:In the present multicenter, prospective study, we analyzed data of participants with CKD stage 1-4 from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE). WCH was defined according to two ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):238]

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Encapsulation and release of living tumor cells using hydrogels with the hybridization chain reaction.

Dekai Ye, Min Li, Tingting Zhai, Ping Song, Lu Song, Hua Wang, Xiuhai Mao, Fei Wang, Xueli Zhang, Zhilei Ge, Jiye Shi, Lihua Wang, Chunhai Fan, Qian Li, Xiaolei Zuo,

Circulating tumor cells (CTCs) enable noninvasive liquid biopsy and identification of cancer. Various approaches exist for the capture and release of CTCs, including microfluidic methods and those involving magnetic beads or nanostructured solid interfaces. However, the concomitant cell damage and fragmentation that often occur during capture make it difficult to ... Read more >>

Nat Protoc (Nature protocols)
[2020, 15(7):2163-2185]

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Facile large-area uniform photolithography of membrane diffractive lens based on vacuum assisted self contact method.

Guohan Gao, Lihua Wang, Heng Shi, Dun Liu, Bin Fan, Chunlin Guan,

Optical polyimide (PI) membrane is a promising substrate material for diffractive lens applied in future large-aperture space based imaging system because of its light weight, environmental adaptability and deployable feature. In this letter, we put forward a facile large-area uniform photolithography technique using vacuum assisted self contact method to fabricate ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9005]

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Unraveling Cell-Type-Specific Targeted Delivery of Membrane-Camouflaged Nanoparticles with Plasmonic Imaging.

Xiaodong Xie, Xingjie Hu, Qian Li, Min Yin, Haiyun Song, Jun Hu, Lihua Wang, Chunhai Fan, Nan Chen,

Cell-membrane-camouflaged nanoparticles (CMC-NPs) have been increasingly exploited to develop various therapeutic tools due to their high biocompatibility and cell-type-specific tumor-targeting properties. However, the molecular mechanism of CMC-NPs for homotypic targeting remains elusive. Here, we develop a plasmonic imaging method by coating gold nanoparticles (AuNPs) with cancer cell membranes and perform ... Read more >>

Nano Lett. (Nano letters)
[2020, :]

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Short-Term Systolic Blood Pressure Variability and Kidney Disease Progression in Patients With Chronic Kidney Disease: Results From C-STRIDE.

Qin Wang, Yu Wang, Jinwei Wang, Luxia Zhang, Ming-Hui Zhao, ,

Background It is unclear whether short-term blood pressure variability is associated with renal outcomes in patients with chronic kidney disease. Methods and Results This study analyzed data from participants in the C-STRIDE (Chinese Cohort Study of Chronic Kidney Disease) who had chronic kidney disease stages 1 to 4. Short-term blood ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(12):e015359]

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Overexpression of ASPH protein predicts poor outcomes in retroperitoneal liposarcoma patients

Mengmeng Xiao, Xiaobing Chen, Yuqing Cui, Lihua Wang, Xiaosong Rao, Xuesong Chen, Chenghua Luo,

Abstract Introduction: No druggable targets and prognostic factors are currently available for retroperitoneal liposarcoma (RPLS) due to very limited understanding of its molecular mechanisms and pathogenesis. This study aims to decipher expression profiling and prognostic value of aspartate-β-hydroxylase (ASPH), an activator of Notch signaling pathway, in RPLS. Methods: Totally 138 ... Read more >>

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Characteristics of Circular RNA Expression in Ishikawa Human Endometrial Carcinoma Cells with Progesterone Treatment

Lihua Wang, Panchan Zheng, Wenjiao Cao, Xiao Sun, Wuyuan Gao, Yudong Wang,

Abstract Background Progestins are commonly used as the conservative endocrine treatment of young early endometrial cancer (EC) patients. Circular RNAs (circRNAs) are new group players in multiple cellular functions. This study aims to identify the differentially expressed circular RNAs (DE-circRNAs) in endometrial cancer (EC) cells upon the progesterone treatment, ... Read more >>

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Programming Biomimetically Confined Aptamers with DNA Frameworks.

Xiuhai Mao, Mengmeng Liu, Lei Yan, Mengying Deng, Fan Li, Min Li, Fei Wang, Jiang Li, Lihua Wang, Yang Tian, Chunhai Fan, Xiaolei Zuo,

Active sites of proteins are generally encapsulated within three-dimensional peptide scaffolds that provide the molecular-scale confinement microenvironment. Nevertheless, the ability to tune thermodynamic stability in biomimetic molecular confinement relies on the macromolecular crowding effect of lack of stoichiometry and reconfigurability. Here, we report a framework nucleic acid (FNA)-based strategy to ... Read more >>

ACS Nano (ACS nano)
[2020, :]

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Pretreatment serum neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios: Two tumor-related systemic inflammatory markers in patients with thymic epithelial tumors.

Lihua Wang, Maomei Ruan, Hui Yan, Bei Lei, Xiaoyan Sun, Cheng Chang, Liu Liu, Wenhui Xie,

OBJECTIVES:To understand underlying changes in pretreatment serum inflammatory markers associated with thymic epithelial tumors (TETs) development. METHODS:A retrospective analysis of 113 TETs patients who underwent 18-fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography combined computed tomography (PET/CT) one to two weeks before tumor resection or biopsy was performed. Pretreatment serum neutrophil, monocyte, ... Read more >>

Cytokine (Cytokine)
[2020, 133:155149]

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The Effects of Different Concentrate-to-Forage Ratio Diets on Rumen Bacterial Microbiota and the Structures of Holstein Cows During the Feeding Cycle.

Lijun Wang, Yang Li, Yonggen Zhang, Lihua Wang,

The objectives of this study were to investigate the ruminal bacterial changes during the feeding cycle. Six ruminally cannulated Holstein cows were used in this experiment. The high-forage (HF) and high-concentrate (HC) diets contained 70% and 30% dietary forage, respectively. Dairy cows were fed their respective diets for at least ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2020, 10(6):]

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AMPH1 functions as a tumour suppressor in ovarian cancer via the inactivation of PI3K/AKT pathway.

Yajun Chen, Wenjiao Cao, Lihua Wang, Tianying Zhong,

AMPH1, an abundant protein in nerve terminals, plays a critical role in the recruitment of dynamin to sites of clathrin-mediated endocytosis. Recently, it is reported to be involved in breast cancer and lung cancer. However, the impact of AMPH1 on ovarian cancer is unclear. In this study, we used gain-of-function ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2020, :]

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Ribophorin II is upregulated in myelodysplastic syndromes and prevents apoptosis and cell cycle progression.

Jinhai Ren, Ying Wang, Lihua Wang, Xiaoling Guo, Xiaonan Guo,

IMPACT STATEMENT:This study explored the role of ribophorin II (RPN2) in myelodysplastic syndromes (MDSs) cell proliferation and growth and revealed that RPN2 knockdown suppressed OCI-AML3 cell growth and proliferation and triggered cell cycle arrest and elicited apoptosis in OCI-AML3 cells. In addition, it shed light on the etiology of RPN2's ... Read more >>

Exp. Biol. Med. (Maywood) (Experimental biology and medicine (Maywood, N.J.))
[2020, :1535370220927996]

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A practical method of using the anatomical space of the vesicouterine ligament for laparoscopic radical hysterectomy: a retrospective cohort study.

Jing Wang, Lulu Sun, Ting Ni, Yong Huang, Lihua Wang, Jiangjing Yuan, Qiong Fan, Yuhong Li, Yudong Wang,

OBJECTIVE:To investigate the practicality of a new method using anatomical spaces for performing standard laparoscopic radical hysterectomy (LRH) without ureteral injury in patients with cervical cancer. METHODS:Clinicopathological characteristics and perioperative complications were retrospectively analysed in 440 patients with stages IB1 to IIB cervical cancer. The patients were assigned to two ... Read more >>

J. Int. Med. Res. (The Journal of International Medical Research)
[2020, 48(6):300060520926857]

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Genome survey of Zanthoxylum bungeanum and development of genomic-SSR markers in congeneric species.

Jingmiao Li, Siqiao Li, Lijuan Kong, Lihua Wang, Anzhi Wei, Yulin Liu,

Zanthoxylum bungeanum, a spice and medicinal plant, is cultivated in many parts of China and some countries in Southeast Asia; however, data on its genome are lacking. In the present study, we performed a whole-genome survey and developed novel genomic-SSR markers of Z. bungeanum. Clean data (∼197.16 Gb) were obtained ... Read more >>

Biosci. Rep. (Bioscience reports)
[2020, 40(6):]

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Programming Switchable Transcription of Topologically Constrained DNA.

Kai Jiao, Bing Zhu, Linjie Guo, Haibin Zhou, Fei Wang, Xueli Zhang, Jiye Shi, Qian Li, Lihua Wang, Jiang Li, Chunhai Fan,

Genomic DNA is compacted via chromatin condensation in mammalian cells, and transcription of such topologically constrained DNA to messenger RNA is under strict spatiotemporal regulation. Nevertheless, control of DNA topology has been poorly explored in in vitro transcription and gene transfection. Here we report the construction of topologically ordered (TO-) ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2020, 142(24):10739-10746]

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Translocation of tetrahedral DNA nanostructures through a solid-state nanopore.

Xinjia Zhao, Ruiping Ma, Ying Hu, Xiaoyu Chen, Ruifen Dou, Ke Liu, Chengjun Cui, Huajie Liu, Qian Li, Dun Pan, Xinyan Shan, Lihua Wang, Chunhai Fan, Xinghua Lu,

Tetrahedral DNA nanostructures (TDNs) are programmable DNA nanostructures that have great potential in bio-sensing, cell imaging and therapeutic applications. In this study, we investigate the translocation behavior of individual TDNs through solid-state nanopores. Pronounced translocation signals for TDNs are observed that are sensitive to the size of the nanostructures. TDNs ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(13):6263-6269]

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DNA Nanoribbon-Templated Self-Assembly of Ultrasmall Fluorescent Copper Nanoclusters with Enhanced Luminescence.

Xiangyuan Ouyang, Meifang Wang, Linjie Guo, Chengjun Cui, Ting Liu, Yongan Ren, Yan Zhao, Zhilei Ge, Xiniu Guo, Gang Xie, Jiang Li, Chunhai Fan, Lihua Wang,

Fluorescent copper nanoclusters (CuNCs) have been widely used in chemical sensors, biological imaging, and light-emitting devices. However, individual fluorescent CuNCs have limitations in their capabilities arising from poor photostability and weak emission intensities. As one kind of aggregation-induced emission luminogen (AIEgen), the formation of aggregates with high compactness and good ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2020, 59(29):11836-11844]

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The role of mitochondrial dynamics in human cancers.

Yawen Ma, Lihua Wang, Renbing Jia,

Mitochondria are crucial cellular organelles. Under extracellular stimulations, mitochondria undergo constant fusion and fission dynamics to meet different cellular demands. Mitochondrial dynamics is regulated by specialized proteins and lipids. Dysregulated mitochondrial dynamics has been linked to the initiation and progression of diverse human cancers, affecting aspects such as cancer metastasis, ... Read more >>

Am J Cancer Res (American journal of cancer research)
[2020, 10(5):1278-1293]

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Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.

Lisa de Las Fuentes, Yun Ju Sung, Raymond Noordam, Thomas Winkler, Mary F Feitosa, Karen Schwander, Amy R Bentley, Michael R Brown, Xiuqing Guo, Alisa Manning, Daniel I Chasman, Hugues Aschard, Traci M Bartz, Lawrence F Bielak, Archie Campbell, Ching-Yu Cheng, Rajkumar Dorajoo, Fernando P Hartwig, A R V R Horimoto, Changwei Li, Ruifang Li-Gao, Yongmei Liu, Jonathan Marten, Solomon K Musani, Ioanna Ntalla, Tuomo Rankinen, Melissa Richard, Xueling Sim, Albert V Smith, Salman M Tajuddin, Bamidele O Tayo, Dina Vojinovic, Helen R Warren, Deng Xuan, Maris Alver, Mathilde Boissel, Jin-Fang Chai, Xu Chen, Kaare Christensen, Jasmin Divers, Evangelos Evangelou, Chuan Gao, Giorgia Girotto, Sarah E Harris, Meian He, Fang-Chi Hsu, Brigitte Kühnel, Federica Laguzzi, Xiaoyin Li, Leo-Pekka Lyytikäinen, Ilja M Nolte, Alaitz Poveda, Rainer Rauramaa, Muhammad Riaz, Rico Rueedi, Xiao-Ou Shu, Harold Snieder, Tamar Sofer, Fumihiko Takeuchi, Niek Verweij, Erin B Ware, Stefan Weiss, Lisa R Yanek, Najaf Amin, Dan E Arking, Donna K Arnett, Sven Bergmann, Eric Boerwinkle, Jennifer A Brody, Ulrich Broeckel, Marco Brumat, Gregory Burke, Claudia P Cabrera, Mickaël Canouil, Miao Li Chee, Yii-Der Ida Chen, Massimiliano Cocca, John Connell, H Janaka de Silva, Paul S de Vries, Gudny Eiriksdottir, Jessica D Faul, Virginia Fisher, Terrence Forrester, Ervin F Fox, Yechiel Friedlander, He Gao, Bruna Gigante, Franco Giulianini, Chi Charles Gu, Dongfeng Gu, Tamara B Harris, Jiang He, Sami Heikkinen, Chew-Kiat Heng, Steven Hunt, M Arfan Ikram, Marguerite R Irvin, Mika Kähönen, Maryam Kavousi, Chiea Chuen Khor, Tuomas O Kilpeläinen, Woon-Puay Koh, Pirjo Komulainen, Aldi T Kraja, J E Krieger, Carl D Langefeld, Yize Li, Jingjing Liang, David C M Liewald, Ching-Ti Liu, Jianjun Liu, Kurt K Lohman, Reedik Mägi, Colin A McKenzie, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Lili Milani, Dennis O Mook-Kanamori, Mike A Nalls, Christopher P Nelson, Jill M Norris, Jeff O'Connell, Adesola Ogunniyi, Sandosh Padmanabhan, Nicholette D Palmer, Nancy L Pedersen, Thomas Perls, Annette Peters, Astrid Petersmann, Patricia A Peyser, Ozren Polasek, David J Porteous, Leslie J Raffel, Treva K Rice, Jerome I Rotter, Igor Rudan, Oscar-Leonel Rueda-Ochoa, Charumathi Sabanayagam, Babatunde L Salako, Pamela J Schreiner, James M Shikany, Stephen S Sidney, Mario Sims, Colleen M Sitlani, Jennifer A Smith, John M Starr, Konstantin Strauch, Morris A Swertz, Alexander Teumer, Yih Chung Tham, André G Uitterlinden, Dhananjay Vaidya, M Yldau van der Ende, Melanie Waldenberger, Lihua Wang, Ya-Xing Wang, Wen-Bin Wei, David R Weir, Wanqing Wen, Jie Yao, Bing Yu, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Alan B Zonderman, Diane M Becker, Donald W Bowden, Ian J Deary, Marcus Dörr, Tõnu Esko, Barry I Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Jost Bruno Jonas, Candace M Kammerer, Norihiro Kato, Timo A Lakka, Karin Leander, Terho Lehtimäki, , Patrik K E Magnusson, Pedro Marques-Vidal, Brenda W J H Penninx, Nilesh J Samani, Pim van der Harst, Lynne E Wagenknecht, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Claude Bouchard, Richard S Cooper, Adolfo Correa, Michele K Evans, Vilmundur Gudnason, Caroline Hayward, Bernardo L Horta, Tanika N Kelly, Stephen B Kritchevsky, Daniel Levy, Walter R Palmas, A C Pereira, Michael M Province, Bruce M Psaty, Paul M Ridker, Charles N Rotimi, E Shyong Tai, Rob M van Dam, Cornelia M van Duijn, Tien Yin Wong, Kenneth Rice, W James Gauderman, Alanna C Morrison, Kari E North, Sharon L R Kardia, Mark J Caulfield, Paul Elliott, Patricia B Munroe, Paul W Franks, Dabeeru C Rao, Myriam Fornage,

Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, "Some College" (yes/no) and "Graduated College" (yes/no). Interactions ... Read more >>

Mol. Psychiatry (Molecular psychiatry)
[2020, :]

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