Full Text Journal Articles by
Author Lieven Annemans

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TRUST4RD: tool for reducing uncertainties in the evidence generation for specialised treatments for rare diseases.

Lieven Annemans, Amr Makady,

BACKGROUND:Many treatments developed for rare diseases will have an Orphan Medicinal Product (OMP) designation, indicating that they are likely to deliver benefit in an area of high unmet need. Their approval may be based on a small or uncontrolled trial, as randomised controlled trials (RCTs) of sufficient size are often ... Read more >>

Orphanet J Rare Dis (Orphanet Journal of Rare Diseases)
[2020, 15(1):127]

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Do custom 3D-printed revision acetabular implants provide enough value to justify the additional costs? The health-economic comparison of a new porous 3D-printed hip implant for revision arthroplasty of Paprosky type 3B acetabular defects and its closest alternative.

Philip Tack, Jan Victor, Paul Gemmel, Lieven Annemans,

PURPOSE:Total hip arthroplasty (THA) is a common operation for patients suffering from hip arthrosis. It has been proven effective in improving quality of life while being cost-effective. Meanwhile, the number of revision hip arthroplasty is growing and those may require bone reconstruction and are potential indications for 3D custom implants. ... Read more >>

Orthop Traumatol Surg Res (Orthopaedics & traumatology, surgery & research : OTSR)
[2020, :]

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Creating the BELgian COngenital heart disease database combining administrative and clinical data (BELCODAC): Rationale, design and methodology.

Fouke Ombelet, Eva Goossens, Ruben Willems, Lieven Annemans, Werner Budts, Julie De Backer, Katya De Groote, Stéphane Moniotte, Liesbet Van Bulck, Ariane Marelli, Philip Moons, ,

BACKGROUND:Congenital heart disease (CHD) entails a broad spectrum of malformations with various degrees of severity and prognosis. Consequently, new and specific healthcare needs are emerging, requiring responsive healthcare provision. Research on this matter is predominantly performed on population-based databases, to inform clinicians, researchers and policy-makers on health outcomes and economic ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2020, :]

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Feel4Diabetes healthy diet score: development and evaluation of clinical validity.

Eeva Virtanen, Jemina Kivelä, Katja Wikström, Christina-Paulina Lambrinou, Pilar De Miguel-Etayo, Nele Huys, Katalin Vraukó-Tóth, Luis A Moreno, Natalya Usheva, Nevena Chakarova, Sándorné A Rado, Violeta Iotova, Konstantinos Makrilakis, Greet Cardon, Stavros Liatis, Yannis Manios, Jaana Lindström, ,

BACKGROUND:The aim of this paper is to present the development of the Feel4Diabetes Healthy Diet Score and to evaluate its clinical validity. METHODS:Study population consisted of 3268 adults (63% women) from high diabetes risk families living in 6 European countries. Participants filled in questionnaires at baseline and after 1 year, reflecting ... Read more >>

BMC Endocr Disord (BMC endocrine disorders)
[2020, 20(Suppl 2):46]

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Effective strategies for childhood obesity prevention via school based, family involved interventions: a critical review for the development of the Feel4Diabetes-study school based component.

Christina-Paulina Lambrinou, Odysseas Androutsos, Eva Karaglani, Greet Cardon, Nele Huys, Katja Wikström, Jemina Kivelä, Winne Ko, Ernest Karuranga, Kaloyan Tsochev, Violeta Iotova, Roumyana Dimova, Pilar De Miguel-Etayo, Esther M González-Gil, Hajnalka Tamás, Zoltán Jancsó, Stavros Liatis, Konstantinos Makrilakis, Yannis Manios, ,

BACKGROUND:Although there are many interventions targeting childhood obesity prevention, only few have demonstrated positive results. The current review aimed to gather and evaluate available school-based intervention studies with family involvement targeting dietary, physical activity and sedentary behaviors among primary schoolchildren and their families, in order to identify the most effective ... Read more >>

BMC Endocr Disord (BMC endocrine disorders)
[2020, 20(Suppl 2):52]

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Cost-Effectiveness of Alirocumab in Patients With Acute Coronary Syndromes: The ODYSSEY OUTCOMES Trial.

Deepak L Bhatt, Andrew H Briggs, Shelby D Reed, Lieven Annemans, Michael Szarek, Vera A Bittner, Rafael Diaz, Shaun G Goodman, Robert A Harrington, Keiko Higuchi, Florence Joulain, J Wouter Jukema, Qian H Li, Kenneth W Mahaffey, Robert J Sanchez, Matthew T Roe, Renato D Lopes, Harvey D White, Andreas M Zeiher, Gregory G Schwartz, Ph Gabriel Steg, ,

BACKGROUND:Cholesterol reduction with proprotein convertase subtilisin-kexin type 9 inhibitors reduces ischemic events; however, the cost-effectiveness in statin-treated patients with recent acute coronary syndrome remains uncertain. OBJECTIVES:This study sought to determine whether further cholesterol reduction with alirocumab would be cost-effective in patients with a recent acute coronary syndrome on optimal statin ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2020, 75(18):2297-2308]

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Healthcare resource utilization in patients on lipid-lowering therapies outside Western Europe and North America: findings of the cross-sectional observational International ChoLesterol management Practice Study (ICLPS).

Lieven Annemans, Joseph Azuri, Khalid Al-Rasadi, Ibrahim Al-Zakwani, Veronique Daclin, Florence Mercier, Nicolas Danchin,

BACKGROUND:Few recent large-scale studies have examined healthcare consumption associated with dyslipidemia in countries outside Western Europe and North America. METHODS:This analysis, from a cross-sectional observational study conducted in 18 countries in Eastern Europe, Asia, Africa, the Middle East and Latin America, evaluated avoidable healthcare consumption (defined as ≥1 hospitalization for ... Read more >>

Lipids Health Dis (Lipids in health and disease)
[2020, 19(1):64]

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Methodology of the health economic evaluation of the Feel4Diabetes-study.

Ruben Willems, Lore Pil, Christina-Paulina Lambrinou, Jemina Kivelä, Katja Wikström, Esther M Gonzalez-Gil, Pilar De Miguel-Etayo, Anna Nánási, Csilla Semánová, Vicky Van Stappen, Greet Cardon, Kaloyan Tsochev, Violeta Iotova, Nevena Chakarova, Konstantinos Makrilakis, George Dafoulas, Patrick Timpel, Peter Schwarz, Yannis Manios, Lieven Annemans, ,

BACKGROUND:The clinical and economic burden of type 2 diabetes mellitus on society is rising. Effective and efficient preventive measures may stop the increasing prevalence, given that type 2 diabetes mellitus is mainly a lifestyle-driven disease. The Feel4Diabetes-study aimed to tackle unhealthy lifestyle (unhealthy diet, lack of physical activity, sedentary behaviour, ... Read more >>

BMC Endocr Disord (BMC endocrine disorders)
[2020, 20(Suppl 1):14]

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Intra- and inter- observer reliability of anthropometric measurements and blood pressure in primary schoolchildren and adults: the Feel4Diabetes-study.

Odysseas Androutsos, Costas Anastasiou, Christina-Paulina Lambrinou, Christina Mavrogianni, Greet Cardon, Vicky Van Stappen, Jemina Kivelä, Katja Wikström, Luis A Moreno, Violeta Iotova, Kaloyan Tsochev, Nevena Chakarova, Tímea Ungvári, Zoltán Jancso, Konstantinos Makrilakis, Yannis Manios, ,

BACKGROUND:Feel4Diabetes was a large-scale, multicenter lifestyle intervention aiming to prevent type 2 diabetes among families from vulnerable population groups in six European countries (Belgium, Bulgaria, Finland, Greece, Hungary and Spain). The current study aimed to describe the process that was followed to harmonize and standardize the measurement of anthropometric (weight, ... Read more >>

BMC Endocr Disord (BMC endocrine disorders)
[2020, 20(Suppl 1):27]

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Sociodemographic and lifestyle-related risk factors for identifying vulnerable groups for type 2 diabetes: a narrative review with emphasis on data from Europe.

Ioannis Kyrou, Constantine Tsigos, Christina Mavrogianni, Greet Cardon, Vicky Van Stappen, Julie Latomme, Jemina Kivelä, Katja Wikström, Kaloyan Tsochev, Anna Nanasi, Csilla Semanova, Rocío Mateo-Gallego, Itziar Lamiquiz-Moneo, George Dafoulas, Patrick Timpel, Peter E H Schwarz, Violeta Iotova, Tsvetalina Tankova, Konstantinos Makrilakis, Yannis Manios, ,

BACKGROUND:Type 2 diabetes mellitus (T2DM) comprises the vast majority of all diabetes cases in adults, with alarmingly increasing prevalence over the past few decades worldwide. A particularly heavy healthcare burden of diabetes is noted in Europe, where 8.8% of the population aged 20-79 years is estimated to have diabetes according to ... Read more >>

BMC Endocr Disord (BMC endocrine disorders)
[2020, 20(Suppl 1):134]

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Two-stage, school and community-based population screening successfully identifies individuals and families at high-risk for type 2 diabetes: the Feel4Diabetes-study.

Yannis Manios, Christina Mavrogianni, Christina-Paulina Lambrinou, Greet Cardon, Jaana Lindström, Violeta Iotova, Tsvetalina Tankova, Fernando Civeira, Jemina Kivelä, Zoltán Jancsó, Samyah Shadid, Kaloyan Tsochev, Rocío Mateo-Gallego, Sándorné Radó, George Dafoulas, Konstantinos Makrilakis, Odysseas Androutsos, ,

BACKGROUND:The implementation of population screening and early prevention strategies targeting individuals at high-risk for type 2 diabetes (T2D) seems to be a public health priority. The current work aimed to describe the screening procedure applied in the Feel4Diabetes-study and examine its effectiveness in identifying individuals and families at high risk, ... Read more >>

BMC Endocr Disord (BMC endocrine disorders)
[2020, 20(Suppl 1):12]

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Universal Mental Health Interventions for Children and Adolescents: A Systematic Review of Health Economic Evaluations.

Masja Schmidt, Amber Werbrouck, Nick Verhaeghe, Koen Putman, Steven Simoens, Lieven Annemans,

BACKGROUND:Effective mental health interventions may reduce the impact that mental health problems have on young people's well-being. Nevertheless, little is known about the cost effectiveness of such interventions for children and adolescents. OBJECTIVES:The objectives of this systematic review were to summarize and assess recent health economic evaluations of universal mental ... Read more >>

Appl Health Econ Health Policy (Applied health economics and health policy)
[2020, 18(2):155-175]

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Development and reliability of questionnaires for the assessment of diet and physical activity behaviors in a multi-country sample in Europe the Feel4Diabetes Study.

Costas A Anastasiou, Evaggelia Fappa, Konstantina Zachari, Christina Mavrogianni, Vicky Van Stappen, Jemina Kivelä, Eeva Virtanen, Esther M González-Gil, Paloma Flores-Barrantes, Anna Nánási, Csilla Semánová, Roumyana Dimova, Natalya Usheva, Violeta Iotova, Greet Cardon, Yannis Manios, Konstantinos Makrilakis, ,

BACKGROUND:Assessment of diet and physical activity and their determinants still remains a demanding task, especially when the objective is to evaluate the efficacy of lifestyle interventions. In the context of the Feel4Diabetes study (a European community based intervention study in families with school aged children and at high risk of ... Read more >>

BMC Endocr Disord (BMC endocrine disorders)
[2020, 20(Suppl 1):135]

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Obtaining evidence base for the development of Feel4Diabetes intervention to prevent type 2 diabetes - a narrative literature review.

Jemina Kivelä, Katja Wikström, Eeva Virtanen, Michael Georgoulis, Greet Cardon, Fernando Civeira, Violeta Iotova, Ernest Karuranga, Winne Ko, Stavros Liatis, Konstantinos Makrilakis, Yannis Manios, Rocío Mateo-Gallego, Anna Nanasi, Imre Rurik, Tsvetalina Tankova, Kaloyan Tsochev, Vicky Van Stappen, Jaana Lindström, ,

BACKGROUND:Feel4Diabetes was a school and community based intervention aiming to promote healthy lifestyle and tackle obesity for the prevention of type 2 diabetes among families in 6 European countries. We conducted this literature review in order to guide the development of evidence-based implementation of the Feel4Diabetes intervention. We focused on ... Read more >>

BMC Endocr Disord (BMC endocrine disorders)
[2020, 20(Suppl 1):140]

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The Use of Computer Simulation Modeling to Estimate Complications in Patients with Type 2 Diabetes Mellitus: Comparative Validation of the Cornerstone Diabetes Simulation Model.

Zhuo T Su, Jose Bartelt-Hofer, Stephen Brown, Elisheva Lew, Luc Sauriol, Lieven Annemans, Daniel T Grima,

OBJECTIVE:The objective of this study was to assess the validity of the Cornerstone Diabetes Simulation (CDS), a Microsoft Excel®-based patient-level simulation for type 2 diabetes mellitus based on risk equations from the revised United Kingdom Prospective Diabetes Study Outcomes Model (UKPDS-OM2, also known as UKPDS 82). METHODS:Three levels of validation were conducted. ... Read more >>

Pharmacoecon Open (PharmacoEconomics - open)
[2020, 4(1):37-44]

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Belgian multicentre study on lumbar spine imaging: Radiation dose and cost analysis; Evaluation of compliance with recommendations for efficient use of medical imaging.

Bieke De Roo, Pieter Hoste, Nele Stichelbaut, Lieven Annemans, Klaus Bacher, Koenraad Verstraete,

PURPOSE:To assess compliance of lumbar spine imaging referrals with national imaging recommendations and to evaluate the impact of inappropriate imaging on the collective radiation dose and health insurance costs. METHOD:In 2011 and 2015, 633 lumbar spine imaging referrals were evaluated across 9 Belgian hospitals. For each patient, a new clinical ... Read more >>

Eur J Radiol (European journal of radiology)
[2020, 125:108864]

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Appropriateness of End-of-Life Care in People Dying With Dementia: Applying Quality Indicators on Linked Administrative Databases.

Robrecht De Schreye, Tinne Smets, Luc Deliens, Lieven Annemans, Birgit Gielen, Joachim Cohen,

OBJECTIVES:Dementia is a progressive incurable life-limiting illness. Previous research suggests end-of-life care for people with dementia should have a symptomatic focus with an effort to avoid burdensome interventions that would not improve quality of life. This study aims to assess the appropriateness of end-of-life care in people who died with ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2020, :]

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Cost-effectiveness of an in-home respite care program to support informal caregivers of persons with dementia: A model-based analysis.

Sophie Vandepitte, Koen Putman, Nele Van Den Noortgate, Nick Verhaeghe, Lieven Annemans,

OBJECTIVES:To evaluate cost-effectiveness of an in-home respite care program in addition to standard community-based dementia care to support informal caregivers of persons with dementia compared with standard community-based dementia care. METHODS:An age-dependent decision-analytic Markov model was applied from a third-party payer and a societal perspective projecting results of a quasi-experimental ... Read more >>

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[2020, 35(6):601-609]

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A Trial-Based Cost-Utility Analysis of Metastasis-Directed Therapy for Oligorecurrent Prostate Cancer.

Elise De Bleser, Ruben Willems, Karel Decaestecker, Lieven Annemans, Aurélie De Bruycker, Valérie Fonteyne, Nicolaas Lumen, Filip Ameye, Ignace Billiet, Steven Joniau, Gert De Meerleer, Piet Ost, Renée Bultijnck,

The optimal management of patients with oligorecurrent prostate cancer (PCa) is unknown. There is growing interest in metastasis-directed therapy (MDT) for this population. The objective was to assess cost-utility from a Belgian healthcare payer's perspective of MDT and delayed androgen deprivation therapy (ADT) in comparison with surveillance and delayed ADT, ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(1):]

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Long-Term Outcome of Acute Coronary Syndromes in Patients on Chronic Oral Anticoagulants: Data from the EPICOR Study.

Janina Stepinska, Izabela Wojtkowska, Lieven Annemans, Nicolas Danchin, Stuart J Pocock, Frans Van de Werf, Jesús Medina, Hector Bueno,

OBJECTIVE:To analyze characteristics, management and outcomes of patients with acute coronary syndromes (ACS) receiving chronic oral anticoagulant (OAC) therapy enrolled in the EPICOR (long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients) prospective, international, observational study of antithrombotic management patterns in ACS survivors (NCT01171404). METHODS:This post-hoc analysis evaluated ... Read more >>

Curr Vasc Pharmacol (Current vascular pharmacology)
[2020, 18(1):92-99]

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Do physical activity and screen time mediate the association between European fathers' and their children's weight status? Cross-sectional data from the Feel4Diabetes-study.

Julie Latomme, Nele Huys, Greet Cardon, Philip J Morgan, Mina Lateva, Nevena Chakarova, Jemina Kivelä, Jaana Lindström, Odysseas Androutsos, Esther M González-Gil, Pilar De Miguel-Etayo, Anna Nánási, László R Kolozsvári, Yannis Manios, Marieke De Craemer, ,

BACKGROUND:Most research on parenting and childhood obesity and obesity-related behaviours has focused on mothers while fathers have been underrepresented. Yet, recent literature has suggested that fathers uniquely influence their children's lifestyle behaviours, and hence could also affect their weight status, but this has not yet been scientifically proven. Therefore, the ... Read more >>

Int J Behav Nutr Phys Act (The international journal of behavioral nutrition and physical activity)
[2019, 16(1):100]

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Cost-utility analysis of lifestyle interventions to prevent type 2 diabetes in women with prior gestational diabetes.

Amber Werbrouck, Masja Schmidt, Koen Putman, Lieven Annemans, Katrien Benhalima, Steven Simoens, Nick Verhaeghe,

BACKGROUND:To compare estimated costs and health outcomes of lifestyle interventions for the prevention of type 2 diabetes mellitus in women who had gestational diabetes. METHODS:An age-specific Markov model was applied comparing costs and quality-adjusted life years (QALYs) of three alternatives: 'doing nothing'; an annual reminder system (ARS) with an awareness ... Read more >>

Eur J Public Health (European journal of public health)
[2020, 30(3):473-478]

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Opinions of general and adult congenital heart disease cardiologists on care for adults with congenital heart disease in Belgium: a qualitative study.

Ruben Willems, Michèle de Hosson, Julie De Backer, Lieven Annemans,

BACKGROUND:The growing adult congenital heart disease (CHD) population requires efficient healthcare organisation. It has been suggested that clinically appropriate care be provided for individual patients on the least complex level possible, in order to alleviate saturation of special care programmes. METHODS:Semi-structured interviews with 10 general and 10 adult CHD cardiologists ... Read more >>

Cardiol Young (Cardiology in the young)
[2019, 29(11):1368-1374]

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Correction: Osteopathic care for spinal complaints: A systematic literature review.

Nick Verhaeghe, Janne Schepers, Patrick van Dun, Lieven Annemans,

[This corrects the article DOI: 10.1371/journal.pone.0206284.]. ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221140]

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A proposal for value informed, affordable ("via") prices for innovative medicines.

Lieven Annemans,

J Med Econ (Journal of medical economics)
[2019, 22(11):1235-1239]

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