Full Text Journal Articles by
Author Liesbeth Aerts

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Dementia and COVID-19: a health and research funding crisis.

Liesbeth Aerts, Elsa Lauwers, Bart De Strooper,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(2):90]

Cited: 0 times

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Prolonged use of antipsychotic medications in long-term aged care in Australia: a snapshot from the HALT project.

Fleur Harrison, Monica Cations, Tiffany Jessop, Liesbeth Aerts, Lynn Chenoweth, Allan Shell, Perminder Sachdev, Sarah Hilmer, Brian Draper, Henry Brodaty,

OBJECTIVES:Use of antipsychotic drugs in long-term aged care (LTC) is prevalent and commonly exceeds the recommended duration, but contributors to this problem are not well understood. The objective of this study is to provide a snapshot of the features of and contributors to prolonged use of antipsychotic medications (>12 weeks) ... Read more >>

Int Psychogeriatr (International psychogeriatrics)
[2020, 32(3):335-345]

Cited: 1 time

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Why deprescribing antipsychotics in older people with dementia in long-term care is not always successful: Insights from the HALT study.

Liesbeth Aerts, Monica Cations, Fleur Harrison, Tiffany Jessop, Allan Shell, Lynn Chenoweth, Henry Brodaty,

<h4>Introduction</h4>Antipsychotic medications are commonly used to manage behavioural and psychological symptoms of dementia despite their side effects and harms. While the Halting Antipsychotic Use in Long-Term care (HALT) deprescribing trial was successful at reducing antipsychotic use, 19% of participants had their antipsychotics represcribed or never reached a dose of zero. ... Read more >>

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[2019, 34(11):1572-1581]

Cited: 3 times

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Antipsychotic Deprescription for Older Adults in Long-term Care: The HALT Study.

Henry Brodaty, Liesbeth Aerts, Fleur Harrison, Tiffany Jessop, Monica Cations, Lynn Chenoweth, Allan Shell, Gordana C Popovic, Megan Heffernan, Sarah Hilmer, Perminder S Sachdev, Brian Draper,

OBJECTIVES:Despite limited efficacy and significant safety concerns, antipsychotic medications are frequently used to treat behavioral and psychological symptoms of dementia (BPSD) in long-term residential care. This study evaluates the sustained reduction of antipsychotic use for BPSD through a deprescribing intervention and education of health care professionals. DESIGN:Repeated-measures, longitudinal, single-arm study. ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2018, 19(7):592-600.e7]

Cited: 10 times

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Response to: English Language Proficiency, Hearing Impairment, and Functional Change in Mild Cognitive Impairment.

Liesbeth Aerts, Nicole A Kochan, Simone Reppermund, Perminder S Sachdev, Henry Brodaty,

Am J Geriatr Psychiatry (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry)
[2017, 25(11):1293-1294]

Cited: 0 times

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Effects of MCI subtype and reversion on progression to dementia in a community sample.

Liesbeth Aerts, Megan Heffernan, Nicole A Kochan, John D Crawford, Brian Draper, Julian N Trollor, Perminder S Sachdev, Henry Brodaty,

<h4>Objective</h4>We sought to understand the trajectory of mild cognitive impairment (MCI) better by examining longitudinally different MCI subtypes and progression to dementia and reversion to normal cognition in a community sample.<h4>Methods</h4>We evaluated the stability of MCI subtypes and risk of dementia over 4 biennial assessments as part of an ongoing ... Read more >>

Neurology (Neurology)
[2017, 88(23):2225-2232]

Cited: 20 times

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Operationalizing the Diagnostic Criteria for Mild Cognitive Impairment: The Salience of Objective Measures in Predicting Incident Dementia.

Henry Brodaty, Liesbeth Aerts, John D Crawford, Megan Heffernan, Nicole A Kochan, Simone Reppermund, Kristan Kang, Kate Maston, Brian Draper, Julian N Trollor, Perminder S Sachdev,

<h4>Objective</h4>Mild cognitive impairment (MCI) is considered an intermediate stage between normal aging and dementia. It is diagnosed in the presence of subjective cognitive decline and objective cognitive impairment without significant functional impairment, although there are no standard operationalizations for each of these criteria. The objective of this study is to ... Read more >>

Am J Geriatr Psychiatry (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry)
[2017, 25(5):485-497]

Cited: 5 times

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Apathy in Dementia: Systematic Review of Recent Evidence on Pharmacological Treatments.

Fleur Harrison, Liesbeth Aerts, Henry Brodaty,

Increasing recognition that apathy is one of the most prevalent behavioral and psychological symptoms of dementia and causes substantial caregiver distress has led to trials evaluating psychosocial and pharmacological treatments of apathy in dementia. We evaluated evidence of the efficacy of pharmacotherapies for apathy in dementia from studies since 2013. ... Read more >>

Curr Psychiatry Rep (Current psychiatry reports)
[2016, 18(11):103]

Cited: 14 times

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A Comprehensive Review of the Quality and Feasibility of Dementia Assessment Measures: The Dementia Outcomes Measurement Suite.

Adam Bentvelzen, Liesbeth Aerts, Katrin Seeher, Jacqueline Wesson, Henry Brodaty,

The diagnosis of dementia and the management of its associated symptoms are aided by high-quality assessment tools. However, there is disagreement on the optimal tools among abundant alternatives and lack of consistent quality standards across the different domains of dementia-related change (ie, cognition, severity, function, behavioral and psychological symptoms, delirium, ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2017, 18(10):826-837]

Cited: 7 times

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In Vitro Comparison of the Activity Requirements and Substrate Specificity of Human and Triboleum castaneum PINK1 Orthologues.

Liesbeth Aerts, Katleen Craessaerts, Bart De Strooper, Vanessa A Morais,

Mutations in the gene encoding the mitochondrial kinase PINK1 cause early-onset familial Parkinson's disease. To understand the biological function of PINK1 and its role in the pathogenesis of Parkinson's disease, it is useful to study its kinase activity towards substrates both in vivo and in vitro. For in vitro kinase ... Read more >>

PLoS One (PloS one)
[2016, 11(1):e0146083]

Cited: 0 times

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PINK1 activation-turning on a promiscuous kinase.

Liesbeth Aerts, Bart De Strooper, Vanessa A Morais,

PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1] is a serine/threonine kinase targeted to mitochondria and implicated in early-onset recessive Parkinson's disease (PD). Through the phosphorylation of its downstream targets, PINK1 regulates multiple mitochondrial processes, including ATP production, stress-response and mitochondrial dynamics and quality control. The orchestration of such ... Read more >>

Biochem Soc Trans (Biochemical Society transactions)
[2015, 43(2):280-286]

Cited: 8 times

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PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402.

Liesbeth Aerts, Katleen Craessaerts, Bart De Strooper, Vanessa A Morais,

Mutations in the PINK1 gene cause early-onset recessive Parkinson disease. PINK1 is a mitochondrially targeted kinase that regulates multiple aspects of mitochondrial biology, from oxidative phosphorylation to mitochondrial clearance. PINK1 itself is also phosphorylated, and this might be linked to the regulation of its multiple activities. Here we systematically analyze ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2015, 290(5):2798-2811]

Cited: 38 times

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From challenges to perspectives: Reflections of young scientists on the current state of academic research.

Kevin Titeca, Liesbeth Aerts, Michiel Krols, Lana Vandersarren, Ozden Akay, Sule Yılmaz, Nevena Hristozova, Michal Janiak,

EMBO Rep (EMBO reports)
[2014, 15(10):1010-1014]

Cited: 0 times

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PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Vanessa A Morais, Dominik Haddad, Katleen Craessaerts, Pieter-Jan De Bock, Jef Swerts, Sven Vilain, Liesbeth Aerts, Lut Overbergh, Anne Grünewald, Philip Seibler, Christine Klein, Kris Gevaert, Patrik Verstreken, Bart De Strooper,

Under resting conditions, Pink1 knockout cells and cells derived from patients with PINK1 mutations display a loss of mitochondrial complex I reductive activity, causing a decrease in the mitochondrial membrane potential. Analyzing the phosphoproteome of complex I in liver and brain from Pink1(-/-) mice, we found specific loss of phosphorylation ... Read more >>

Science (Science (New York, N.Y.))
[2014, 344(6180):203-207]

Cited: 132 times

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VEGF mediates commissural axon chemoattraction through its receptor Flk1.

Carmen Ruiz de Almodovar, Pierre J Fabre, Ellen Knevels, Cathy Coulon, Inmaculada Segura, Patrick C G Haddick, Liesbeth Aerts, Nicolas Delattin, Geraldine Strasser, Won-Jong Oh, Christian Lange, Stefan Vinckier, Jody Haigh, Coralie Fouquet, Chengua Gu, Kari Alitalo, Valerie Castellani, Marc Tessier-Lavigne, Alain Chedotal, Frederic Charron, Peter Carmeliet,

Growing axons are guided to their targets by attractive and repulsive cues. In the developing spinal cord, Netrin-1 and Shh guide commissural axons toward the midline. However, the combined inhibition of their activity in commissural axon turning assays does not completely abrogate turning toward floor plate tissue, suggesting that additional ... Read more >>

Neuron (Neuron)
[2011, 70(5):966-978]

Cited: 74 times

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