Full Text Journal Articles by
Author Libo Xu

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The effects of different parity and delivery mode on wheezing disorders in the children-a retrospective cohort study in Fujian, China.

Haiyan Gao, Chong Miao, Haibo Li, Meng Bai, Huijie Zhang, Zhengqin Wu, Wei Li, Wenjuan Liu, Libo Xu, Guanghua Liu, Yibing Zhu,

<h4>Background</h4>The relationship between childbirth delivery methods and the risk of wheezing in children remains controversial. Few studies have explored it under different maternal conditions.<h4>Objective</h4>To explore the influence of childbirth delivery method on the onset of wheezing in children of different parity.<h4>Methods</h4>A total of 21716 patients were included in this retrospective ... Read more >>

J Asthma (The Journal of asthma : official journal of the Association for the Care of Asthma)
[2021, :1-8]

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[Retracted] Oncolytic adenovirus‑mediated mda‑7/IL‑24 expression suppresses osteosarcoma growth and enhances sensitivity to doxorubicin.

Zongming Liu, Libo Xu, Hongping Yuan, Yang Zhang, Xiaona Zhang, Dongxu Zhao,

Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blot assay data shown in Figs. 1B, 5A, 6A and C were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2021, 24(6):]

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RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction.

Mengxin Li, Xuyang Chen, Xuanzhong Wang, Xiaodong Wei, Ding Wang, Xiaorui Liu, Libo Xu, Wuren Batu, Yang Li, Baofeng Guo, Ling Zhang,

The resistance to cisplatin (DDP) and dose-related toxicity are the two important obstacles in the chemotherapy of prostate cancer (PCa) patients. The present study demonstrated that cotreatment of DDP and RSL3, a type of small molecular compound which can inactivate glutathione peroxidase 4 (GPX4) and induce ferroptosis, synergistically inhibited the ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 192:114741]

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Risk factors associated with wheezing in severe pediatric community-acquired pneumonia: a retrospective study.

Lumin Chen, Chong Miao, Yanling Chen, Xian Han, Ziying Lin, Hong Ye, Chengyi Wang, Huijie Zhang, Jingjing Li, Xi Liu, Libo Xu, Guanghua Liu,

<h4>Background</h4>Wheezing is a common clinical manifestation in children with pneumonia. However, the risk factors associated with the development of wheezing pneumonia and its clinical features are not fully characterized, especially in children with severe pneumonia.<h4>Methods</h4>We retrospectively recruited 1434 pediatric patients diagnosed with severe pneumonia between April 2012 and September 2019 ... Read more >>

Minerva Pediatr (Minerva pediatrica)
[2021, :]

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Two-Step Calibration Method for Inverse Finite Element with Small Sample Features.

Libo Xu, Feifei Zhao, Jingli Du, Hong Bao,

When the inverse finite element method (inverse FEM) is used to reconstruct the deformation field of a multi-element structure with strain measurements, strain measurement errors can lower the reconstruction accuracy of the deformation field. Furthermore, the calibration ability of a self-structuring fuzzy network (SSFN) is weak when few strain samples ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2020, 20(16):]

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Corrigendum to "RGFP966, a histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7" [Biochem. Pharmacol. 180 (2020) 114118].

Hang Liang, Qian Wang, Ding Wang, Hongwu Zheng, Dhan V Kalvakolanu, Hua Lu, Naiyan Wen, Xuyang Chen, Libo Xu, Jiaxin Ren, Baofeng Guo, Ling Zhang,

Biochem Pharmacol (Biochemical pharmacology)
[2020, 182:114223]

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RGFP966, a histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7.

Hang Liang, Qian Wang, Ding Wang, Hongwu Zheng, Dhan V Kalvakolanu, Hua Lu, Naiyan Wen, Xuyang Chen, Libo Xu, Jiaxin Ren, Baofeng Guo, Ling Zhang,

Glioma stem cells (GSC) play a major role in drug resistance and tumor recurrence. Using a genetic screen with a set of shRNAs that can target chromatin regulators in a GSC model, we have HDAC3 as a major negative regulator of GSC differentiation. Inhibition of HDAC3 using a pharmacological inhibitor ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2020, 180:114118]

Cited: 1 time

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Use of complete blood count for predicting preterm birth in asymptomatic pregnant women: A propensity score-matched analysis.

Mei Ma, Mei Zhu, Bimin Zhuo, Li Li, Honglei Chen, Libo Xu, Zhihui Wu, Feng Cheng, Liangpu Xu, Jianying Yan,

<h4>Background</h4>Accurate prediction of preterm birth (PTB) is still difficult, mostly because of the multifactorial etiology of PTB. Previous studies have been mostly focused on the prediction of PTB in symptomatic women or those presenting with threatened preterm labor. We aimed to study whether complete blood count (CBC) parameters at 20-30 weeks ... Read more >>

J Clin Lab Anal (Journal of clinical laboratory analysis)
[2020, 34(8):e23313]

Cited: 2 times

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SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.

Qian Wang, Shengnan Jia, Yan Jiao, Libo Xu, Ding Wang, Xuyang Chen, Xindan Hu, Hang Liang, Naiyan Wen, Shengnan Zhang, Baofeng Guo, Ling Zhang,

Colorectal cancer is one of the most common cancers worldwide with a high incidence rate. Therefore, the molecular basis of colorectal tumorigenesis and evolution must be clarified. Structure-specific recognition protein 1 (SSRP1) is involved in transcriptional regulation, DNA damage repair, and cell cycle regulation and has been confirmed to be ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2019, 16(12):1573-1582]

Cited: 1 time

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Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.

Naiyan Wen, Baofeng Guo, Hongwu Zheng, Libo Xu, Hang Liang, Qian Wang, Ding Wang, Xuyang Chen, Shengnan Zhang, Yang Li, Ling Zhang,

Bromodomain and extraterminal domain proteins, especially bromodomain‑containing protein 4 (Brd4), have recently emerged as therapeutic targets for several cancers, although the role and mechanism of Brd4 in glioblastoma multiforme (GBM) are unclear. In this study, we aimed to explore the underlying mechanisms of the anti‑tumor effects of Brd4 and the ... Read more >>

Int J Oncol (International journal of oncology)
[2019, 55(4):879-895]

Cited: 19 times

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Efficacy and Safety of Immunotherapy and Standard of Care in High-Grade Gliomas: A Systematic Review and Meta-analysis

Shengnan Zhang, Libo Xu, Guanyu Chen, Jiangmin Liu, Qian Wang, Xindan Hu, Naiyan Wen, Xiaomin Liu, Xinyu Peng, Lei Fan, Baofeng Guo, Ling Zhang,

BACKGROUND: Immunotherapy combined with standard of care (SOC) is often used for high-grade glioma (HGG). There are few comparisons of immunotherapy with SOC treatment or without SOC treatment (IMT) versus SOC. It is important to understand what interventions exist and their relative effectivenesses. METHODS: The Cochrane Library, Embase, Medline, and ... Read more >>

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ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization.

Fei Li, Zhong Deng, Ling Zhang, Caizhi Wu, Ying Jin, Inah Hwang, Olga Vladimirova, Libo Xu, Lynnie Yang, Bin Lu, Javaraju Dheekollu, Jian-Yi Li, Hua Feng, Jian Hu, Christopher R Vakoc, Haoqiang Ying, Jihye Paik, Paul M Lieberman, Hongwu Zheng,

Loss of the histone H3.3-specific chaperone component ATRX or its partner DAXX frequently occurs in human cancers that employ alternative lengthening of telomeres (ALT) for chromosomal end protection, yet the underlying mechanism remains unclear. Here, we report that ATRX/DAXX does not serve as an immediate repressive switch for ALT. Instead, ... Read more >>

EMBO J (The EMBO journal)
[2019, 38(19):e96659]

Cited: 12 times

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Synergistic Suppression of Melanoma Growth by a Combination of Natural dsRNA and Panaxadiolsaponins.

Yanying Zhao, Haipeng Liu, Libo Xu, Baofeng Guo, Dhananjaya V Kalvakolanu, Xichun Liu, Jiadi Hu, Duoduo Zhang, Yuanjie Sun, Ling Zhang, Deqi Xu, Xuejian Zhao,

Melanoma is one of the most lethal skin malignancies in the world. Interferons (IFNs) have been also demonstrated in response to tumor cell and IFNs such as IFN-α have been used for melanoma treatment. The long chain double-stranded RNA (dsRNA) (from a variety of nonviral sources) is a potent activator ... Read more >>

J Interferon Cytokine Res (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research)
[2018, 38(9):378-387]

Cited: 0 times

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Development of CDV-specific monoclonal antibodies for differentiation of variable epitopes of nucleocapsid protein.

Zhenwei Bi, Yongshan Wang, Qunxing Pan, Xingxia Xia, Libo Xu,

The highly contagious canine distemper viruses (CDVs) are still a major threat to a wide range of natural susceptible hosts. The nucleocapsid (N) protein plays various roles in the virus-induced immune response. But precise mapping of epitopes and antigenic variations in N protein of CDV are still scant. In this ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2017, 211:84-91]

Cited: 1 time

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Inhibition of prostate cancer RM1 cell growth in vitro by hydroxyapatite nanoparticle‑delivered short hairpin RNAs against Stat3.

Zuowen Liang, Hongliang Wang, Baofeng Guo, Fubiao Li, Jinsha Liu, Zhewen Liu, Libo Xu, Wenjing Yun, Xuejian Zhao, Ling Zhang,

The present study investigated the effect of signal transducer and activator of transcription 3 (Stat3) interference on RM1 prostate cancer cell viability in vitro, using plasmid‑based Stat3 specific short hairpin RNA (sh‑Stat3) delivered by hydroxyapatite nanoparticles (HAP). HAP carrying sh‑Stat3 plasmids were transfected into tumor cells. MTT assays were used to ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2017, 16(1):459-465]

Cited: 1 time

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Comparison of clinical and survival characteristics between prostate cancer patients of PSA-based screening and clinical diagnosis in China.

Libo Xu, Jinguo Wang, Baofeng Guo, Haixia Zhang, Kaichen Wang, Ding Wang, Chang Dai, Ling Zhang, Xuejian Zhao,

Prostate-specific antigen (PSA)-based mass screening remains the most controversial topic in prostate cancer. PSA-based mass screening has not been widely used in China yet. The aim of our study was to evaluate the effect of the PSA-based screening in China. The cohort consisted of 1,012 prostate cancer patients. Data were ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(1):428-441]

Cited: 3 times

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Thiazomycin, nocathiacin and analogs show strong activity against clinical strains of drug-resistant Mycobacterium tuberculosis.

Sheo B Singh, Libo Xu, Peter T Meinke, Natalia Kurepina, Barry N Kreiswirth, David B Olsen, Katherine Young,

Thiazolyl peptides are a class of natural products with potent Gram-positive antibacterial activities. Lack of aqueous solubility precluded this class of compounds from advancing to clinical evaluations. Nocathiacins and thiazomycins are sub-classes of thiazolyl peptides that are endowed with structural features amenable for chemical modifications. Semi-synthetic modifications of nocathiacin led ... Read more >>

J Antibiot (Tokyo) (The Journal of antibiotics)
[2017, 70(5):671-674]

Cited: 0 times

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Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.

Jiayi Xu, Songnian Lin, Robert W Myers, Maria E Trujillo, Michele J Pachanski, Sunita Malkani, Hsuan-Shen Chen, Zhesheng Chen, Brian Campbell, George J Eiermann, Nadine Elowe, Brian T Farrer, Wen Feng, Qinghong Fu, Roman Kats-Kagan, Michael Kavana, Daniel R McMasters, Kaushik Mitra, Xinchun Tong, Libo Xu, Fengqi Zhang, Rui Zhang, George H Addona, Joel P Berger, Bei Zhang, Emma R Parmee,

Systemically acting glucokinase activators (GKA) have been demonstrated in clinical trials to effectively lower blood glucose in patients with type II diabetes. However, mechanism-based hypoglycemia is a major adverse effect that limits the therapeutic potential of these agents. We hypothesized that the predominant mechanism leading to hypoglycemia is GKA-induced excessive ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2017, 27(9):2063-2068]

Cited: 3 times

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Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.

Jiayi Xu, Songnian Lin, Robert W Myers, George Addona, Joel P Berger, Brian Campbell, Hsuan-Shen Chen, Zhesheng Chen, George J Eiermann, Nadine H Elowe, Brian T Farrer, Wen Feng, Qinghong Fu, Roman Kats-Kagan, Michael Kavana, Sunita Malkani, Daniel R McMasters, Kaushik Mitra, Michele J Pachanski, Xinchun Tong, Maria E Trujillo, Libo Xu, Bei Zhang, Fengqi Zhang, Rui Zhang, Emma R Parmee,

Glucokinase (GK, hexokinase IV) is a unique hexokinase that plays a central role in mammalian glucose homeostasis. Glucose phosphorylation by GK in the pancreatic β-cell is the rate-limiting step that controls glucose-stimulated insulin secretion. Similarly, GK-mediated glucose phosphorylation in hepatocytes plays a major role in increasing hepatic glucose uptake and ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2017, 27(9):2069-2073]

Cited: 2 times

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miR-96 promotes the growth of prostate carcinoma cells by suppressing MTSS1.

Libo Xu, Jiateng Zhong, Baofeng Guo, Qi Zhu, Hang Liang, Naiyan Wen, Wenjing Yun, Ling Zhang,

Prostate carcinoma (PC) is one of the most common cancers for males. However, the molecular mechanisms of PC progression are still to be uncovered. MicroRNA (miRNA) has been shown to be associated with the initiation and progression of prostate cancer. Among the identified tumor-promoting miRNAs, miR-96 has been well established ... Read more >>

Tumour Biol (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine)
[2016, 37(9):12023-12032]

Cited: 15 times

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A framework for mining actionable navigation patterns from in-store RFID datasets via indoor mapping.

Bin Shen, Qiuhua Zheng, Xingsen Li, Libo Xu,

With the quick development of RFID technology and the decreasing prices of RFID devices, RFID is becoming widely used in various intelligent services. Especially in the retail application domain, RFID is increasingly adopted to capture the shopping tracks and behavior of in-store customers. To further enhance the potential of this ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2015, 15(3):5344-5375]

Cited: 4 times

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Plasmid-Based Stat3 siRNA Delivered by Functional Graphene Oxide Suppresses Mouse Malignant Melanoma Cell Growth.

Di Yin, Yang Li, Baofeng Guo, Zhewen Liu, Yang Xu, Xiaoqin Wang, Yanwei Du, Libo Xu, Yan Meng, Xuejian Zhao, Ling Zhang,

RNA interference (RNAi) has been used for cancer gene therapy in recent years. However, the application of RNAi is hindered in the absence of safe and efficient gene delivery. In this article, a novel vehicle of graphene oxide functionalized with polyethylenimine and polyethylene glycol (GO-PEI-PEG) was successfully synthetized and then ... Read more >>

Oncol Res (Oncology research)
[2016, 23(5):229-236]

Cited: 5 times

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Oncolytic adenovirus‑mediated mda‑7/IL‑24 expression suppresses osteosarcoma growth and enhances sensitivity to doxorubicin.

Zongming Liu, Libo Xu, Hongping Yuan, Yang Zhang, Xiaona Zhang, Dongxu Zhao,

Osteosarcoma (OS) is a malignant disease with a high mortality rate and poor response to current chemotherapy. Melanoma differentiation associated gene‑7 (Mda7)/interleukin (IL)‑24 has been demonstrated to suppress the growth of OS. However, the expression level of Mda7/IL‑24 mediated by the current adenoviral vector is limited for effective clinical treatment ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2015, 12(4):6358-6364]

Cited: 8 times

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Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial.

Yong Huo, Jianping Li, Xianhui Qin, Yining Huang, Xiaobin Wang, Rebecca F Gottesman, Genfu Tang, Binyan Wang, Dafang Chen, Mingli He, Jia Fu, Yefeng Cai, Xiuli Shi, Yan Zhang, Yimin Cui, Ningling Sun, Xiaoying Li, Xiaoshu Cheng, Jian'an Wang, Xinchun Yang, Tianlun Yang, Chuanshi Xiao, Gang Zhao, Qiang Dong, Dingliang Zhu, Xian Wang, Junbo Ge, Lianyou Zhao, Dayi Hu, Lisheng Liu, Fan Fan Hou, ,

<h4>Importance</h4>Uncertainty remains about the efficacy of folic acid therapy for the primary prevention of stroke because of limited and inconsistent data.<h4>Objective</h4>To test the primary hypothesis that therapy with enalapril and folic acid is more effective in reducing first stroke than enalapril alone among Chinese adults with hypertension.<h4>Design, setting, and participants</h4>The ... Read more >>

JAMA (JAMA)
[2015, 313(13):1325-1335]

Cited: 242 times

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Synthesis and antibacterial activity of novel water-soluble nocathiacin analogs.

Libo Xu, Amy K Farthing, James F Dropinski, Peter T Meinke, Christine McCallum, Emily Hickey, Kun Liu,

Semi-synthetic water-soluble analogs were synthesized from nocathiacin I through the formation of a versatile intermediate nocathiacin amine 5, and subsequent transformation via reductive amination, acylation or urea formation. Several of the novel analogs displayed much improved aqueous solubility over 1, while retained antibacterial activity. Compound 15 and 16 from the ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2013, 23(1):366-369]

Cited: 9 times

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