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RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection.

Shuang Lu, Ni Zhu, Weiwei Guo, Xin Wang, Kaiji Li, Jie Yan, Cuiping Jiang, Shiyu Han, Hanmin Xiang, Xiaohan Wu, Yuanyuan Liu, Hairong Xiong, Liangjun Chen, Zuojiong Gong, Fan Luo, Wei Hou,

Hantaan virus (HTNV), a Hantavirus serotype that is prevalent in Asia, causes hemorrhagic fever with renal syndrome (HFRS) with high mortality in human race. However, the pathogenesis of HTNV infection remains elusive. Circular RNAs (circRNAs), a new type of non-coding RNAs, play a crucial role in various pathogenic processes. Nevertheless, ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2020, 10:97]

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The presence of SARS-CoV-2 RNA in the feces of COVID-19 patients.

Yifei Chen, Liangjun Chen, Qiaoling Deng, Guqin Zhang, Kaisong Wu, Lan Ni, Yibin Yang, Bing Liu, Wei Wang, Chaojie Wei, Jiong Yang, Guangming Ye, Zhenshun Cheng,

In December 2019, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan, China, and has spread globally. However, the transmission route of SARS-CoV-2 has not been fully understood. In this study, we aimed to investigate SARS-CoV-2 shedding in the excreta of COVID-19 patients. Electronical ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, 92(7):833-840]

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m6A-dependent up-regulation of DRG1 by METTL3 and ELAVL1 promotes growth, migration, and colony formation in osteosarcoma.

Zhian Ling, Liangjun Chen, Jinmin Zhao,

Osteosarcoma (OS) is a malignant tumor commonly observed in children and adolescents. Developmentally regulated GTP-binding protein (DRG) 1 plays an important role in embryonic development; aberrantly expressed DRG1 has been associated with pathological processes in cancer. The present study aimed to explore the role of DRG1 in OS and the ... Read more >>

Biosci. Rep. (Bioscience reports)
[2020, 40(4):]

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Environmental contamination of the SARS-CoV-2 in healthcare premises: An urgent call for protection for healthcare workers

Guangming Ye, Hualiang Lin, Liangjun Chen, Shichan Wang, Zhikun Zeng, Wei Wang, Shiyu Zhang, Terri Rebmann, Yirong Li, Zhenyu Pan, Zhonghua Yang, Ying Wang, Fubing Wang, Zhengmin Qian, Xinghuan Wang,

Importance A large number of healthcare workers (HCWs) were infected by SARS-CoV-2 during the ongoing outbreak of COVID-19 in Wuhan, China. Hospitals are significant epicenters for the human-to-human transmission of the SARS-CoV-2 for HCWs, patients, and visitors. No data has been reported on the details of hospital environmental contamination status ... Read more >>

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Can routine laboratory tests discriminate 2019 novel coronavirus infected pneumonia from other community-acquired pneumonia?

Yunbao Pan, Guangming Ye, Xiantao Zeng, Guohong Liu, Xiaojiao Zeng, Xianghu Jiang, Jin Zhao, Liangjun Chen, Shuang Guo, Qiaoling Deng, Xiaoyue Hong, Ying Yang, Yirong Li, Xinghuan Wang,

Background. The clinical presentation of 2019 Novel Coronavirus (2019-nCov) infected pneumonia (NCIP) resembles that of other etiologies of community-acquired pneumonia (CAP). We aimed to identify clinical laboratory features to distinguish NCIP from CAP. Methods. We compared the ability of the hematological and biochemical features of 84 patients with NCIP at ... Read more >>

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Restoration of leukomonocyte counts is associated with viral clearance in COVID-19 hospitalized patients

Xiaoping Chen, Jiaxin Ling, Pingzheng Mo, Yongxi Zhang, Qunqun Jiang, Zhiyong Ma, Qian Cao, Wenjia Hu, Shi Zou, Liangjun Chen, Lei Yao, Mingqi Luo, Tielong Chen, Liping Deng, Ke Liang, Shihui Song, Rongrong Yang, Ruiying Zheng, Shicheng Gao, Xien Gui, Hengning Ke, Wei Hou, Åke Lundkvist, Yong Xiong,

Background: Viral clearance is one important indicator for the recovery of SARS-CoV-2 infected patients. Suboptimal T and B cell responses can delay viral clearance in MERS and SARS patients. The role of leukomonocytes in viral clearance of COVID-19 patients is not yet well defined.Methods: From January 26 to February 28, ... Read more >>

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Re: Profile of specific antibodies to SARS-CoV-2: The first report.

Zhikun Zeng, Liangjun Chen, Yunbao Pan, Qiaoling Deng, Guangming Ye, Yirong Li, Xinghuan Wang,

J. Infect. (The Journal of infection)
[2020, 81(1):e80-e81]

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RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak.

Liangjun Chen, Weiyong Liu, Qi Zhang, Ke Xu, Guangming Ye, Weichen Wu, Ziyong Sun, Fang Liu, Kailang Wu, Bo Zhong, Yi Mei, Wenxia Zhang, Yu Chen, Yirong Li, Mang Shi, Ke Lan, Yingle Liu,

From December 2019, an outbreak of unusual pneumonia was reported in Wuhan with many cases linked to Huanan Seafood Market that sells seafood as well as live exotic animals. We investigated two patients who developed acute respiratory syndromes after independent contact history with this market. The two patients shared common ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):313-319]

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Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation.

Guangming Ye, Zhenyu Pan, Yunbao Pan, Qiaoling Deng, Liangjun Chen, Jin Li, Yirong Li, Xinghuan Wang,

OBJECTIVES:Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. However, limited data was available for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reactivation. This study aimed to evaluate the clinical characteristics of the SARS-CoV-2 reactivation. METHODS:Clinical records, ... Read more >>

J. Infect. (The Journal of infection)
[2020, 80(5):e14-e17]

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Can routine laboratory tests discriminate SARS-CoV-2-infected pneumonia from other causes of community-acquired pneumonia?

Yunbao Pan, Guangming Ye, Xiantao Zeng, Guohong Liu, Xiaojiao Zeng, Xianghu Jiang, Jin Zhao, Liangjun Chen, Shuang Guo, Qiaoling Deng, Xiaoyue Hong, Ying Yang, Yirong Li, Xinghuan Wang,

BACKGROUND:The clinical presentation of SARS-CoV-2-infected pneumonia (COVID-19) resembles that of other etiologies of community-acquired pneumonia (CAP). We aimed to identify clinical laboratory features to distinguish COVID-19 from CAP. METHODS:We compared the hematological and biochemical features of 84 patients with COVID-19 at hospital admission and 221 patients with CAP. Parameters independently ... Read more >>

Clin Transl Med (Clinical and translational medicine)
[2020, 10(1):161-168]

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Assessment of a new arbidol derivative against herpes simplex virus II in human cervical epithelial cells and in BALB/c mice.

Nian Ma, Mengxin Shen, Tian Chen, Yuanyuan Liu, Yidong Mao, Liangjun Chen, Hairong Xiong, Wei Hou, Dongying Liu, Zhanqiu Yang,

As one of the highly contagious forms, herpes simplex virus type 2 (HSV-2) commonly caused severe genital diseases and closely referred to the HIV infection. The lack of effective vaccines and drug-resistance proclaimed the preoccupation for alternative antiviral agents against HSV-2. Molecules bearing indole nucleus presented diverse biological properties involving ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2019, 118:109359]

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Water-Based Purification of Ultrathin Silver Nanowires toward Transparent Conductive Films with a Transmittance Higher than 99.

Guinan Chen, Lili Bi, Zhonglin Yang, Liangjun Chen, Guixin Wang, Changhui Ye,

Ultrathin silver nanowires (UTAgNWs) are indispensable to achieve transparent conductive films (TCFs) with overall optoelectronic performance exceeding that of the state-of-the-art indium tin oxide films. Impurities in raw UTAgNW products severely impair the optical properties of TCFs. Unfortunately, highly effective and environment-friendly approaches for purification of UTAgNWs are still lacking. ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2019, 11(25):22648-22654]

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