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Author Liangjie Xu

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Maternal pre-pregnancy body mass index, gestational weight gain trajectory, and risk of adverse perinatal outcomes.

Haibo Li, Chong Miao, Liangjie Xu, Haiyan Gao, Meng Bai, Wenjuan Liu, Wei Li, Zhengqin Wu, Yibing Zhu,

<h4>Objective</h4>To evaluate the relationships of pre-pregnancy BMI and gestational weight gain (GWG) trajectory with adverse perinatal outcomes (APOs).<h4>Methods</h4>A retrospective cohort study was conducted in China, and 12,855 women who had a singleton birth were included. The WHO classification categorized pre-pregnancy BMI, and five GWG trajectories were identified using the latent ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

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Impaired Autophagy Induced by oxLDL/β2GPI/anti-β2GPI Complex through PI3K/AKT/mTOR and eNOS Signaling Pathways Contributes to Endothelial Cell Dysfunction.

Guiting Zhang, Chao He, Qianqian Wu, Guoying Xu, Ming Kuang, Ting Wang, Liangjie Xu, Hong Zhou, Wei Yuan,

Endothelial cell dysfunction plays a fundamental role in the pathogenesis of atherosclerosis (AS), and endothelial autophagy has protective effects on the development of AS. Our previous study had shown that oxidized low-density lipoprotein/<i>β</i>2-glycoprotein I/anti-<i>β</i>2-glycoprotein I antibody (oxLDL/<i>β</i>2GPI/anti-<i>β</i>2GPI) complex could promote the expressions of inflammatory cytokines and enhance the adhesion of ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2021, 2021:6662225]

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Contributions of Costimulatory Molecule CD137 in Endothelial Cells.

Wei Yuan, Chong Xu, Bo Li, Hao Xia, Yingjie Pan, Wei Zhong, Liangjie Xu, Rui Chen, Bin Wang,

CD137 (4-1BB, tumor necrosis factor receptor superfamily 9) is a surface glycoprotein of the tumor necrosis factor receptor family that can be induced on a variety of immunocytes and nonimmune cells, including endothelial cells and smooth muscle cells. The importance of CD137 in immune response has been well recognized; however, ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, 10(11):e020721]

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T helper 17 cell responses induce cardiac hypertrophy and remodeling in essential hypertension.

Liangjie Xu, Guanghua Chen, Yi Liang, Cuicui Zhou, Fen Zhang, Tingpan Fan, Xinxin Chen, Hong Zhou, Wei Yuan,

<h4>Introduction</h4>An increasing body of evidence has shown that type 17 helper T (TH17) cell responses play an important role in the progression of cardiac remodeling stimulated by long‑term pressure overload.<h4>Objectives</h4>We aimed to investigate the relationship between TH17 responses and cardiac remodeling, and the prognostic value of TH17 responses in hypertensive ... Read more >>

Pol Arch Intern Med (Polish archives of internal medicine)
[2021, 131(3):257-265]

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OxLDL/β2GPI/anti‑β2GPI Ab complex induces inflammatory activation via the TLR4/NF‑κB pathway in HUVECs.

Guiting Zhang, Qianqian Cai, Hong Zhou, Chao He, Yudan Chen, Peng Zhang, Ting Wang, Liangjie Xu, Jinchuan Yan,

Patients with antiphospholipid syndrome have been identified to have higher incidence rates of atherosclerosis (AS) due to the elevated levels of anti‑β2‑glycoprotein I (β2GPI) antibody (Ab). Our previous studies revealed that the anti‑β2GPI Ab formed a stable oxidized low‑density lipoprotein (oxLDL)/β2GPI/anti‑β2GPI Ab complex, which accelerated AS development by promoting the accumulation of lipids ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2021, 23(2):]

Cited: 2 times

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Echocardiographic evaluation of left ventricular end diastolic pressure in patients with diastolic heart failure: A comparative study with real-time catheterization.

Fen Zhang, Yi Liang, Xinxin Chen, Liangjie Xu, Cuicui Zhou, Tingpan Fan, Jinchaun Yan,

To evaluate the left ventricular end diastolic pressure (LVEDP) in patients with diastolic heart failure by echocardiography and explore the clinical value of echocardiography.From July 2017 to January 2018, 120 patients were prospectively selected from the affiliated hospital of Jiangsu university diagnosed as diastolic heart failure (York Heart Association class ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(49):e22683]

Cited: 1 time

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Serial assessment of focal myocardial function after percutaneous coronary intervention for ST-elevation myocardial infarction: Value of layer-specific speckle tracking echocardiography.

Jing Ping Sun, Yi Liang, Fen Zhang, Xinxin Chen, Wei Yuan, Liangjie Xu, Robert C Bahler, Jinchuan Yan,

<h4>Background</h4>Ischemia-reperfusion injury (IRI) frequently follows successful PCI for STEMI and is recognized by multiple modalities. Multilayer speckle tracking echocardiography (STE) has the potential of detecting myocardial dysfunction in different myocardial layers. Our objective was to describe the changes in layer-specific myocardial function over the 24 hours after successful PCI for ST-elevation ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2020, 37(9):1413-1421]

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CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF-κB Pathway.

Tianxin Geng, Yang Yan, Yue Zhang, Liangjie Xu, Guangyao Zang, Jin Chuan Yan,

<h4>Background</h4>Endothelial dysfunction and apoptosis resulting from oxidative stress can lead to the development of atherosclerosis. Our group has previously showed that CD137 signaling contributes to the progression of atherosclerosis and the vulnerability of plaques. The aim of this study is to investigate the effects of CD137 signaling in atherosclerosis on ... Read more >>

Mediators Inflamm (Mediators of inflammation)
[2020, 2020:4321912]

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Assessment of Left Ventricular Systolic Function After Revascularization in Patients with ST Segment Elevation Myocardial Infarction by Stratified Strain Technique

Yi Liang, Xinxin Chen, Liangjie Xu, Cuicui Zhou, Tingpan Fan, Wei Yuan, fen zhang,

<h4>Objective: </h4> Stratified strain was used to evaluate the local stratified strain and the overall longitudinal strain of the left ventricle of the affected myocardium after revascularization in patients with ST-segment elevation myocardial infarction (STEMI). <h4>Methods: </h4>: 120 patients diagnosed as STEMI in the Affiliated Hospital of Jiangsu University from ... Read more >>

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Use of Inflammatory Biomarkers and Real-Time Cardiac Catheterisation to Evaluate the Left Ventricular Diastolic Function in Patients With Diastolic Heart Failure.

Liangjie Xu, Jinchuan Yan, Fen Zhang, Cuicui Zhou, Tingpan Fan, Xinxin Chen, Xinggang Cui, Hong Zhou, Yi Liang,

<h4>Background</h4>Interleukin (IL)-17 and its related cytokines have been shown to be involved in myocardial fibrosis and irreversible ventricular remodelling, which have predictive values in the development of left ventricular diastolic dysfunction (LVDD). This study aimed to assess the correlation between IL-17 and LVDD, and investigate the prognostic value of IL-17 ... Read more >>

Heart Lung Circ (Heart, lung & circulation)
[2021, 30(3):396-403]

Cited: 2 times

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Echocardiographic assessment of simultaneously measured left ventricular filling pressures in patients with normal left ventricular ejection fraction.

Jing Ping Sun, Yi Liang, Fen Zhang, Xinxin Chen, Wei Yuan, Liangjie Xu, Robert C Bahler, Jinchuan Yan,

<h4>Background</h4>Assessment of left ventricular (LV) diastolic function is part of routine echocardiographic examinations. Accuracy of the 2016 ASE/EACVI algorithm to detect LV diastolic dysfunction in patients with a normal LV ejection fraction (LVEF) has been examined but simultaneous measurements of LV pressures and echocardiographic parameters of diastolic function are sparse.<h4>Methods</h4>The ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2020, 37(9):1382-1391]

Cited: 0 times

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CD137 signaling induces macrophage M2 polarization in atherosclerosis through STAT6/PPARδ pathway.

Tianxin Geng, Yang Yan, Liangjie Xu, Mengfei Cao, Yu Xu, Jun Pu, Jin Chuan Yan,

CD137 signaling plays an important role in the formation and development of atherosclerotic plaques. The purpose of the present study was to investigate the effects of CD137 signaling on macrophage polarization during atherosclerosis and to explore the underlying mechanisms. The effect of CD137 signaling on macrophage phenotype in atherosclerotic plaques ... Read more >>

Cell Signal (Cellular signalling)
[2020, 72:109628]

Cited: 2 times

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Exosome derived from CD137-modified endothelial cells regulates the Th17 responses in atherosclerosis.

Liangjie Xu, Tianxin Geng, Guangyao Zang, Li Bo, Yi Liang, Hong Zhou, Jinchuan Yan,

The role of exosomes derived from endothelial cells (ECs) in the progression of atherosclerosis (AS) and inflammation remains largely unexplored. We aimed to investigate whether exosome derived from CD137-modified ECs (CD137-Exo) played a major role in AS and to elucidate the potential mechanism underlying the inflammatory effect. Exosomes derived from ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2020, 24(8):4659-4667]

Cited: 3 times

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Interleukin-17A contributes to atrial fibrillation recurrence and left atrial reservoir function after catheter ablation.

Liangjie Xu, Ning Wang, Yi Liang, Hong Zhou, Jinchuan Yan,

Pol Arch Intern Med (Polish archives of internal medicine)
[2019, 129(6):432-435]

Cited: 2 times

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Quantitative evaluation of myocardial layer-specific strain using two-dimensional speckle tracking echocardiography among young adults with essential hypertension in China.

Liangjie Xu, Ning Wang, Xinxin Chen, Yi Liang, Hong Zhou, Jinchuan Yan,

The myocardial wall of the left ventricle is a complex, multilayered structure, which is altered in young adults with hypertension. The aim of this study was to define the characteristics of longitudinal and circumferential strain in young adults with hypertension.Two-dimensional speckle tracking echocardiography was used to analyze longitudinal and circumferential ... Read more >>

Medicine (Baltimore) (Medicine)
[2018, 97(39):e12448]

Cited: 2 times

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The role of nuclear factor of activated T cells in pulmonary arterial hypertension.

Rui Chen, Jinchuan Yan, Peijing Liu, Zhongqun Wang, Cuiping Wang, Wei Zhong, Liangjie Xu,

Nuclear factor of activated T cells (NFAT) was first identified as a transcription factor about 3 decades ago and was not well studied until the development of immunosuppressant. Numerous studies confirm that calcineurin/NFAT signaling is very important in the development of vasculature and cardiovascular system during embryogenesis and is involved ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2017, 16(6):508-514]

Cited: 5 times

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Ghrelin attenuates vascular calcification in diabetic patients with amputation.

Suining Xu, Fei Ye, Lihua Li, Jinchuan Yan, Zhengyang Bao, Zhen Sun, Liangjie Xu, Jie Zhu, Zhongqun Wang,

Vascular calcification is established to be a critical factor in diabetes mellitus, which causes cardiovascular and amputation complication of diabetic patients. OPG/RANKL/RANK axis serves as a regulatory role in vascular calcification. Ghrelin, an endogenous ligand of growth hormone secretagogue receptor (GHSR), has been reported to exhibit potent cardiovascular protective effects. ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2017, 91:1053-1064]

Cited: 5 times

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[Impact of new regional cooperative rescue model on first medical contact to balloon time and outcome in patients with ST-segment elevation myocardial infarction].

Yi Liang, Liangjie Xu, Jinchuan Yan, Peijing Liu, Wei Yuan, Xiaojie Chen, Zhongqun Wang,

<h4>Objective</h4>To evaluate the effect of new regional cooperative rescue model on the first medical contact-to-balloon time and outcome in patients with ST-elevation myocardial infarction.<h4>Method</h4>Patients with acute myocardial infraction (AMI) and onset time within 24 hours transferred from other hospitals to our clinic and underwent emergent percutaneous coronary intervention (PCI) between ... Read more >>

Zhonghua Xin Xue Guan Bing Za Zhi (Zhonghua xin xue guan bing za zhi)
[2014, 42(8):646-649]

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OX40-OX40L interaction promotes proliferation and activation of lymphocytes via NFATc1 in ApoE-deficient mice.

Jinchuan Yan, Hongling Su, Liangjie Xu, Cuiping Wang,

<h4>Background</h4>Our previous studies have shown that OX40-OX40L interaction regulates the expression of nuclear factor of activated T cells c1(NFATc1) in ApoE(-/-) mice during atherogenesis. The aim of this study was to investigate whether OX40-OX40L interaction promotes Th cell activation via NFATc1 in ApoE(-/-) mice.<h4>Methods and results</h4>The lymphocytes isolated from spleen ... Read more >>

PLoS One (PloS one)
[2013, 8(4):e60854]

Cited: 10 times

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Regression of atherosclerosis plaques in apolipoprotein E-/- mice after lentivirus-mediated RNA interference of CD40.

Biao Wang, Hui Qian, Haibing Yang, Liangjie Xu, Wenrong Xu, Jinchuan Yan,

<h4>Background</h4>A role of CD40 (cluster of differentiation 40) is suggested in development of atherosclerosis plaques, especially in advanced plaques. However, the role of lentiviruses carrying small interfering RNA (siRNA) of CD40 in progression and destabilization of advanced atherosclerotic plaques remains unknown. The aim of this study was to determine whether ... Read more >>

Int J Cardiol (International journal of cardiology)
[2013, 163(1):34-39]

Cited: 14 times

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Enhanced levels of soluble and membrane-bound CD137 levels in patients with acute coronary syndromes.

Liu Dongming, Lu Zuxun, Xu Liangjie, Wang Biao, Yang Ping,

<h4>Background</h4>Increasing evidence shows that costimulatory molecules of the tumor necrosis factor superfamily such as CD40/CD40 ligand and OX40/OX40 ligand have been implicated in atherosclerosis. We investigated whether the expression levels of the tumor necrosis factor superfamily members CD137 in serum and membrane-bound were related to acute coronary syndromes (ACS).<h4>Methods</h4>Thirty normal ... Read more >>

Clin Chim Acta (Clinica chimica acta; international journal of clinical chemistry)
[2010, 411(5-6):406-410]

Cited: 18 times

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