Full Text Journal Articles by
Author Liana G Apostolova

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New insights into atypical Alzheimer's disease in the era of biomarkers.

Jonathan Graff-Radford, Keir X X Yong, Liana G Apostolova, Femke H Bouwman, Maria Carrillo, Bradford C Dickerson, Gil D Rabinovici, Jonathan M Schott, David T Jones, Melissa E Murray,

Most patients with Alzheimer's disease present with amnestic problems; however, a substantial proportion, over-represented in young-onset cases, have atypical phenotypes including predominant visual, language, executive, behavioural, or motor dysfunction. In the past, these individuals often received a late diagnosis; however, availability of CSF and PET biomarkers of Alzheimer's disease pathologies ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):222-234]

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Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis.

Brian W Kunkle, Michael Schmidt, Hans-Ulrich Klein, Adam C Naj, Kara L Hamilton-Nelson, Eric B Larson, Denis A Evans, Phil L De Jager, Paul K Crane, Joe D Buxbaum, Nilufer Ertekin-Taner, Lisa L Barnes, M Daniele Fallin, Jennifer J Manly, Rodney C P Go, Thomas O Obisesan, M Ilyas Kamboh, David A Bennett, Kathleen S Hall, Alison M Goate, Tatiana M Foroud, Eden R Martin, Li-Sao Wang, Goldie S Byrd, Lindsay A Farrer, Jonathan L Haines, Gerard D Schellenberg, Richard Mayeux, Margaret A Pericak-Vance, Christiane Reitz, , Neill R Graff-Radford, Izri Martinez, Temitope Ayodele, Mark W Logue, Laura B Cantwell, Melissa Jean-Francois, Amanda B Kuzma, L D Adams, Jeffery M Vance, Michael L Cuccaro, Jaeyoon Chung, Jesse Mez, Kathryn L Lunetta, Gyungah R Jun, Oscar L Lopez, Hugh C Hendrie, Eric M Reiman, Neil W Kowall, James B Leverenz, Scott A Small, Allan I Levey, Todd E Golde, Andrew J Saykin, Takiyah D Starks, Marilyn S Albert, Bradley T Hyman, Ronald C Petersen, Mary Sano, Thomas Wisniewski, Robert Vassar, Jeffrey A Kaye, Victor W Henderson, Charles DeCarli, Frank M LaFerla, James B Brewer, Bruce L Miller, Russell H Swerdlow, Linda J Van Eldik, Henry L Paulson, John Q Trojanowski, Helena C Chui, Roger N Rosenberg, Suzanne Craft, Thomas J Grabowski, Sanjay Asthana, John C Morris, Stephen M Strittmatter, Walter A Kukull,

<h4>Importance</h4>Compared with non-Hispanic White individuals, African American individuals from the same community are approximately twice as likely to develop Alzheimer disease. Despite this disparity, the largest Alzheimer disease genome-wide association studies to date have been conducted in non-Hispanic White individuals. In the largest association analyses of Alzheimer disease in African ... Read more >>

JAMA Neurol (JAMA neurology)
[2021, 78(1):102-113]

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Tau-related white-matter alterations along spatially selective pathways.

Qiuting Wen, Shannon L Risacher, Linhui Xie, Junjie Li, Jaroslaw Harezlak, Martin R Farlow, Frederick W Unverzagt, Sujuan Gao, Liana G Apostolova, Andrew J Saykin, Yu-Chien Wu,

Progressive accumulation of tau neurofibrillary tangles in the brain is a defining pathologic feature of Alzheimer's disease (AD). Tau pathology exhibits a predictable spatiotemporal spreading pattern, but the underlying mechanisms of this spread are poorly understood. Although AD is conventionally considered a disease of the gray matter, it is also ... Read more >>

Neuroimage (NeuroImage)
[2021, 226:117560]

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Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology.

Kwangsik Nho, Kelly Nudelman, Mariet Allen, Angela Hodges, Sungeun Kim, Shannon L Risacher, Liana G Apostolova, Kuang Lin, Katie Lunnon, Xue Wang, Jeremy D Burgess, Nilüfer Ertekin-Taner, Ronald C Petersen, Lisu Wang, Zhenhao Qi, Aiqing He, Isaac Neuhaus, Vishal Patel, Tatiana Foroud, Kelley M Faber, Simon Lovestone, Andrew Simmons, Michael W Weiner, Andrew J Saykin, ,

<h4>Introduction</h4>Abnormal gene expression patterns may contribute to the onset and progression of late-onset Alzheimer's disease (LOAD).<h4>Methods</h4>We performed transcriptome-wide meta-analysis (N = 1440) of blood-based microarray gene expression profiles as well as neuroimaging and cerebrospinal fluid (CSF) endophenotype analysis.<h4>Results</h4>We identified and replicated five genes (CREB5, CD46, TMBIM6, IRAK3, and RPAIN) as ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2020, 16(9):1213-1223]

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Neurodegenerative changes in early- and late-onset cognitive impairment with and without brain amyloidosis.

Eddie C Stage, Diana Svaldi, Meredith Phillips, Victor Hugo Canela, Tugce Duran, Naira Goukasian, Shannon L Risacher, Andrew J Saykin, Liana G Apostolova, ,

<h4>Background</h4>A substantial number of patients clinically diagnosed with Alzheimer's disease do not harbor amyloid pathology. We analyzed the presence and extent of tau deposition and neurodegeneration in amyloid-positive (AD) and amyloid-negative (nonAD) ADNI subjects while also taking into account age of onset (< or > 65 years) as we expected that the emerging ... Read more >>

Alzheimers Res Ther (Alzheimer's research & therapy)
[2020, 12(1):93]

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Testing influences of APOE and BDNF genes and heart failure on cognitive function.

Miyeon Jung, Liana G Apostolova, Sujuan Gao, Heather N Burney, Dongbing Lai, Tatiana Foroud, Andrew J Saykin, Susan J Pressler,

<h4>Background</h4>Apolipoprotein E (APOE) ε2, ε4 and brain-derived neurotrophic factor (BDNF) Val66Met alleles have been associated with cognition. Associations of these alleles with cognition in heart failure (HF) and influences of HF across the cognitive spectrum (i.e., cognitively normal to Alzheimer's dementia [AD]) remain unexplored.<h4>Objectives</h4>To investigate influences of APOE ε2, ε4, ... Read more >>

Heart Lung (Heart & lung : the journal of critical care)
[2021, 50(1):51-58]

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Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease.

Aparna Vasanthakumar, Justin W Davis, Kenneth Idler, Jeffrey F Waring, Elizabeth Asque, Bridget Riley-Gillis, Shaun Grosskurth, Gyan Srivastava, Sungeun Kim, Kwangsik Nho, Kelly N H Nudelman, Kelley Faber, Yu Sun, Tatiana M Foroud, Karol Estrada, Liana G Apostolova, Qingqin S Li, Andrew J Saykin, ,

<h4>Background</h4>Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease impacting an estimated 44 million adults worldwide. The causal pathology of AD (accumulation of amyloid-beta and tau), precedes hallmark symptoms of dementia by more than a decade, necessitating development of early diagnostic markers of disease onset, particularly for new drugs that ... Read more >>

Clin Epigenetics (Clinical epigenetics)
[2020, 12(1):84]

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Visual contrast sensitivity is associated with the presence of cerebral amyloid and tau deposition.

Shannon L Risacher, Darrell WuDunn, Eileen F Tallman, John D West, Sujuan Gao, Martin R Farlow, Jared R Brosch, Liana G Apostolova, Andrew J Saykin,

Visual deficits are common in neurodegenerative diseases including Alzheimer's disease. We sought to determine the association between visual contrast sensitivity and neuroimaging measures of Alzheimer's disease-related pathophysiology, including cerebral amyloid and tau deposition and neurodegeneration. A total of 74 participants (7 Alzheimer's disease, 16 mild cognitive impairment, 20 subjective cognitive ... Read more >>

Brain Commun (Brain communications)
[2020, 2(1):fcaa019]

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Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.

Eric M Reiman, Joseph F Arboleda-Velasquez, Yakeel T Quiroz, Matthew J Huentelman, Thomas G Beach, Richard J Caselli, Yinghua Chen, Yi Su, Amanda J Myers, John Hardy, Jean Paul Vonsattel, Steven G Younkin, David A Bennett, Philip L De Jager, Eric B Larson, Paul K Crane, C Dirk Keene, M Ilyas Kamboh, Julia K Kofler, Linda Duque, John R Gilbert, Harry E Gwirtsman, Joseph D Buxbaum, Dennis W Dickson, Matthew P Frosch, Bernardino F Ghetti, Kathryn L Lunetta, Li-San Wang, Bradley T Hyman, Walter A Kukull, Tatiana Foroud, Jonathan L Haines, Richard P Mayeux, Margaret A Pericak-Vance, Julie A Schneider, John Q Trojanowski, Lindsay A Farrer, Gerard D Schellenberg, Gary W Beecham, Thomas J Montine, Gyungah R Jun, ,

Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer's dementia, while the APOE2 allele is associated with a lower risk of Alzheimer's dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk. We generated Alzheimer's dementia odds ratios ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):667]

Cited: 17 times

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Association of Hypercholesterolemia with Alzheimer's Disease Pathology and Cerebral Amyloid Angiopathy.

Chenjia Xu, Liana G Apostolova, Adrian L Oblak, Sujuan Gao,

<h4>Background</h4>Animal studies have shown that diet-induced hypercholesterolemia (HC) increases amyloid-β (Aβ) accumulation and accelerates Alzheimer's disease (AD) pathology. However, the association of HC with AD in human studies has not been consistently established.<h4>Objective</h4>We aimed to investigate the relationship between HC and risk of AD neuropathology in a large national sample ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2020, 73(4):1305-1311]

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Novel Markers of Angiogenesis in the Setting of Cognitive Impairment and Dementia.

Christopher M Callahan, Liana G Apostolova, Sujuan Gao, Shannon L Risacher, Jamie Case, Andrew J Saykin, Kathleen A Lane, Cecily G Swinford, Mervin C Yoder,

<h4>Background</h4>Aberrant angiogenesis may play a role in the development of Alzheimer's disease and related dementia.<h4>Objective</h4>To explore the relationship between angiogenesis activity and evidence of neurodegeneration among older adults.<h4>Methods</h4>Cross-sectional study of 49 older adults clinically characterized as cognitively normal, mild cognitive impairment, or early Alzheimer's disease. In addition to neuroimaging, we ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2020, 75(3):959-969]

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Association of brain amyloidosis with the incidence and frequency of neuropsychiatric symptoms in ADNI: a multisite observational cohort study.

Naira Goukasian, Kristy S Hwang, Tamineh Romero, Jonathan Grotts, Triet M Do, Jenna R Groh, Daniel R Bateman, Liana G Apostolova,

<h4>Objective</h4>To investigate the relationship between amyloid burden and frequency of existing and incidence of new neuropsychiatric symptoms (NPS) in elderly with and without cognitive decline.<h4>Methods</h4>275 cognitively normal controls (NC), 100 subjective memory complaint (SMC), 559 mild cognitive impairment (MCI) and 143 Alzheimer's disease dementia subjects from the Alzheimer's Disease Neuroimaging ... Read more >>

BMJ Open (BMJ open)
[2019, 9(12):e031947]

Cited: 2 times

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Blood-based biomarkers for Alzheimer's disease and related dementias: Keys to success and things to consider.

Henrik Zetterberg, Liana G Apostolova, Peter J Snyder,

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2019, 11:784-786]

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Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group.

Tianye Jia, Congying Chu, Yun Liu, Jenny van Dongen, Evangelos Papastergios, Nicola J Armstrong, Mark E Bastin, Tania Carrillo-Roa, Anouk den Braber, Mathew Harris, Rick Jansen, Jingyu Liu, Michelle Luciano, Anil P S Ori, Roberto Roiz Santiañez, Barbara Ruggeri, Daniil Sarkisyan, Jean Shin, Kim Sungeun, Diana Tordesillas Gutiérrez, Dennis Van't Ent, David Ames, Eric Artiges, Georgy Bakalkin, Tobias Banaschewski, Arun L W Bokde, Henry Brodaty, Uli Bromberg, Rachel Brouwer, Christian Büchel, Erin Burke Quinlan, Wiepke Cahn, Greig I de Zubicaray, Stefan Ehrlich, Tomas J Ekström, Herta Flor, Juliane H Fröhner, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Jacqueline Hoare, Bernd Ittermann, Neda Jahanshad, Jiyang Jiang, John B Kwok, Nicholas G Martin, Jean-Luc Martinot, Karen A Mather, Katie L McMahon, Allan F McRae, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Philipp G Sämann, Peter R Schofield, Michael N Smolka, Dan J Stein, Lachlan T Strike, Jalmar Teeuw, Anbupalam Thalamuthu, Julian Trollor, Henrik Walter, Joanna M Wardlaw, Wei Wen, Robert Whelan, Liana G Apostolova, Elisabeth B Binder, Dorret I Boomsma, Vince Calhoun, Benedicto Crespo-Facorro, Ian J Deary, Hilleke Hulshoff Pol, Roel A Ophoff, Zdenka Pausova, Perminder S Sachdev, Andrew Saykin, Margaret J Wright, Paul M Thompson, Gunter Schumann, Sylvane Desrivières,

DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2019, :]

Cited: 6 times

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White matter alterations in early-stage Alzheimer's disease: A tract-specific study.

Qiuting Wen, Sourajit M Mustafi, Junjie Li, Shannon L Risacher, Eileen Tallman, Steven A Brown, John D West, Jaroslaw Harezlak, Martin R Farlow, Frederick W Unverzagt, Sujuan Gao, Liana G Apostolova, Andrew J Saykin, Yu-Chien Wu,

<h4>Introduction</h4>Diffusion magnetic resonance imaging may allow for microscopic characterization of white matter degeneration in early stages of Alzheimer's disease.<h4>Methods</h4>Multishell Diffusion magnetic resonance imaging data were acquired from 100 participants (40 cognitively normal, 38 with subjective cognitive decline, and 22 with mild cognitive impairment [MCI]). White matter microscopic degeneration in 27 ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2019, 11:576-587]

Cited: 5 times

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Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Brian W Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C Bis, Vincent Damotte, Adam C Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alexandre Amlie-Wolf, Céline Bellenguez, Aura Frizatti, Vincent Chouraki, Eden R Martin, Kristel Sleegers, Nandini Badarinarayan, Johanna Jakobsdottir, Kara L Hamilton-Nelson, Sonia Moreno-Grau, Robert Olaso, Rachel Raybould, Yuning Chen, Amanda B Kuzma, Mikko Hiltunen, Taniesha Morgan, Shahzad Ahmad, Badri N Vardarajan, Jacques Epelbaum, Per Hoffmann, Merce Boada, Gary W Beecham, Jean-Guillaume Garnier, Denise Harold, Annette L Fitzpatrick, Otto Valladares, Marie-Laure Moutet, Amy Gerrish, Albert V Smith, Liming Qu, Delphine Bacq, Nicola Denning, Xueqiu Jian, Yi Zhao, Maria Del Zompo, Nick C Fox, Seung-Hoan Choi, Ignacio Mateo, Joseph T Hughes, Hieab H Adams, John Malamon, Florentino Sanchez-Garcia, Yogen Patel, Jennifer A Brody, Beth A Dombroski, Maria Candida Deniz Naranjo, Makrina Daniilidou, Gudny Eiriksdottir, Shubhabrata Mukherjee, David Wallon, James Uphill, Thor Aspelund, Laura B Cantwell, Fabienne Garzia, Daniela Galimberti, Edith Hofer, Mariusz Butkiewicz, Bertrand Fin, Elio Scarpini, Chloe Sarnowski, Will S Bush, Stéphane Meslage, Johannes Kornhuber, Charles C White, Yuenjoo Song, Robert C Barber, Sebastiaan Engelborghs, Sabrina Sordon, Dina Voijnovic, Perrie M Adams, Rik Vandenberghe, Manuel Mayhaus, L Adrienne Cupples, Marilyn S Albert, Peter P De Deyn, Wei Gu, Jayanadra J Himali, Duane Beekly, Alessio Squassina, Annette M Hartmann, Adelina Orellana, Deborah Blacker, Eloy Rodriguez-Rodriguez, Simon Lovestone, Melissa E Garcia, Rachelle S Doody, Carmen Munoz-Fernadez, Rebecca Sussams, Honghuang Lin, Thomas J Fairchild, Yolanda A Benito, Clive Holmes, Hata Karamujić-Čomić, Matthew P Frosch, Hakan Thonberg, Wolfgang Maier, Gennady Roshchupkin, Bernardino Ghetti, Vilmantas Giedraitis, Amit Kawalia, Shuo Li, Ryan M Huebinger, Lena Kilander, Susanne Moebus, Isabel Hernández, M Ilyas Kamboh, RoseMarie Brundin, James Turton, Qiong Yang, Mindy J Katz, Letizia Concari, Jenny Lord, Alexa S Beiser, C Dirk Keene, Seppo Helisalmi, Iwona Kloszewska, Walter A Kukull, Anne Maria Koivisto, Aoibhinn Lynch, Lluís Tarraga, Eric B Larson, Annakaisa Haapasalo, Brian Lawlor, Thomas H Mosley, Richard B Lipton, Vincenzo Solfrizzi, Michael Gill, W T Longstreth, Thomas J Montine, Vincenza Frisardi, Monica Diez-Fairen, Fernando Rivadeneira, Ronald C Petersen, Vincent Deramecourt, Ignacio Alvarez, Francesca Salani, Antonio Ciaramella, Eric Boerwinkle, Eric M Reiman, Nathalie Fievet, Jerome I Rotter, Joan S Reisch, Olivier Hanon, Chiara Cupidi, A G Andre Uitterlinden, Donald R Royall, Carole Dufouil, Raffaele Giovanni Maletta, Itziar de Rojas, Mary Sano, Alexis Brice, Roberta Cecchetti, Peter St George-Hyslop, Karen Ritchie, Magda Tsolaki, Debby W Tsuang, Bruno Dubois, David Craig, Chuang-Kuo Wu, Hilkka Soininen, Despoina Avramidou, Roger L Albin, Laura Fratiglioni, Antonia Germanou, Liana G Apostolova, Lina Keller, Maria Koutroumani, Steven E Arnold, Francesco Panza, Olymbia Gkatzima, Sanjay Asthana, Didier Hannequin, Patrice Whitehead, Craig S Atwood, Paolo Caffarra, Harald Hampel, Inés Quintela, Ángel Carracedo, Lars Lannfelt, David C Rubinsztein, Lisa L Barnes, Florence Pasquier, Lutz Frölich, Sandra Barral, Bernadette McGuinness, Thomas G Beach, Janet A Johnston, James T Becker, Peter Passmore, Eileen H Bigio, Jonathan M Schott, Thomas D Bird, Jason D Warren, Bradley F Boeve, Michelle K Lupton, James D Bowen, Petra Proitsi, Adam Boxer, John F Powell, James R Burke, John S K Kauwe, Jeffrey M Burns, Michelangelo Mancuso, Joseph D Buxbaum, Ubaldo Bonuccelli, Nigel J Cairns, Andrew McQuillin, Chuanhai Cao, Gill Livingston, Chris S Carlson, Nicholas J Bass, Cynthia M Carlsson, John Hardy, Regina M Carney, Jose Bras, Minerva M Carrasquillo, Rita Guerreiro, Mariet Allen, Helena C Chui, Elizabeth Fisher, Carlo Masullo, Elizabeth A Crocco, Charles DeCarli, Gina Bisceglio, Malcolm Dick, Li Ma, Ranjan Duara, Neill R Graff-Radford, Denis A Evans, Angela Hodges, Kelley M Faber, Martin Scherer, Kenneth B Fallon, Matthias Riemenschneider, David W Fardo, Reinhard Heun, Martin R Farlow, Heike Kölsch, Steven Ferris, Markus Leber, Tatiana M Foroud, Isabella Heuser, Douglas R Galasko, Ina Giegling, Marla Gearing, Michael Hüll, Daniel H Geschwind, John R Gilbert, John Morris, Robert C Green, Kevin Mayo, John H Growdon, Thomas Feulner, Ronald L Hamilton, Lindy E Harrell, Dmitriy Drichel, Lawrence S Honig, Thomas D Cushion, Matthew J Huentelman, Paul Hollingworth, Christine M Hulette, Bradley T Hyman, Rachel Marshall, Gail P Jarvik, Alun Meggy, Erin Abner, Georgina E Menzies, Lee-Way Jin, Ganna Leonenko, Luis M Real, Gyungah R Jun, Clinton T Baldwin, Detelina Grozeva, Anna Karydas, Giancarlo Russo, Jeffrey A Kaye, Ronald Kim, Frank Jessen, Neil W Kowall, Bruno Vellas, Joel H Kramer, Emma Vardy, Frank M LaFerla, Karl-Heinz Jöckel, James J Lah, Martin Dichgans, James B Leverenz, David Mann, Allan I Levey, Stuart Pickering-Brown, Andrew P Lieberman, Norman Klopp, Kathryn L Lunetta, H-Erich Wichmann, Constantine G Lyketsos, Kevin Morgan, Daniel C Marson, Kristelle Brown, Frank Martiniuk, Christopher Medway, Deborah C Mash, Markus M Nöthen, Eliezer Masliah, Nigel M Hooper, Wayne C McCormick, Antonio Daniele, Susan M McCurry, Anthony Bayer, Andrew N McDavid, John Gallacher, Ann C McKee, Hendrik van den Bussche, Marsel Mesulam, Carol Brayne, Bruce L Miller, Steffi Riedel-Heller, Carol A Miller, Joshua W Miller, Ammar Al-Chalabi, John C Morris, Christopher E Shaw, Amanda J Myers, Jens Wiltfang, Sid O'Bryant, John M Olichney, Victoria Alvarez, Joseph E Parisi, Andrew B Singleton, Henry L Paulson, John Collinge, William R Perry, Simon Mead, Elaine Peskind, David H Cribbs, Martin Rossor, Aimee Pierce, Natalie S Ryan, Wayne W Poon, Benedetta Nacmias, Huntington Potter, Sandro Sorbi, Joseph F Quinn, Eleonora Sacchinelli, Ashok Raj, Gianfranco Spalletta, Murray Raskind, Carlo Caltagirone, Paola Bossù, Maria Donata Orfei, Barry Reisberg, Robert Clarke, Christiane Reitz, A David Smith, John M Ringman, Donald Warden, Erik D Roberson, Gordon Wilcock, Ekaterina Rogaeva, Amalia Cecilia Bruni, Howard J Rosen, Maura Gallo, Roger N Rosenberg, Yoav Ben-Shlomo, Mark A Sager, Patrizia Mecocci, Andrew J Saykin, Pau Pastor, Michael L Cuccaro, Jeffery M Vance, Julie A Schneider, Lori S Schneider, Susan Slifer, William W Seeley, Amanda G Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Russell H Swerdlow, Mitchell Tang, Rudolph E Tanzi, John Q Trojanowski, Juan C Troncoso, Vivianna M Van Deerlin, Linda J Van Eldik, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Kirk C Wilhelmsen, Jennifer Williamson, Thomas S Wingo, Randall L Woltjer, Clinton B Wright, Chang-En Yu, Lei Yu, Yasaman Saba, , , , , Alberto Pilotto, Maria J Bullido, Oliver Peters, Paul K Crane, David Bennett, Paola Bosco, Eliecer Coto, Virginia Boccardi, Phil L De Jager, Alberto Lleo, Nick Warner, Oscar L Lopez, Martin Ingelsson, Panagiotis Deloukas, Carlos Cruchaga, Caroline Graff, Rhian Gwilliam, Myriam Fornage, Alison M Goate, Pascual Sanchez-Juan, Patrick G Kehoe, Najaf Amin, Nilifur Ertekin-Taner, Claudine Berr, Stéphanie Debette, Seth Love, Lenore J Launer, Steven G Younkin, Jean-Francois Dartigues, Chris Corcoran, M Arfan Ikram, Dennis W Dickson, Gael Nicolas, Dominique Campion, JoAnn Tschanz, Helena Schmidt, Hakon Hakonarson, Jordi Clarimon, Ron Munger, Reinhold Schmidt, Lindsay A Farrer, Christine Van Broeckhoven, Michael C O'Donovan, Anita L DeStefano, Lesley Jones, Jonathan L Haines, Jean-Francois Deleuze, Michael J Owen, Vilmundur Gudnason, Richard Mayeux, Valentina Escott-Price, Bruce M Psaty, Alfredo Ramirez, Li-San Wang, Agustin Ruiz, Cornelia M van Duijn, Peter A Holmans, Sudha Seshadri, Julie Williams, Phillippe Amouyel, Gerard D Schellenberg, Jean-Charles Lambert, Margaret A Pericak-Vance,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Genet (Nature genetics)
[2019, 51(9):1423-1424]

Cited: 5 times

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Plasma amyloid beta levels are associated with cerebral amyloid and tau deposition.

Shannon L Risacher, Noelia Fandos, Judith Romero, Ian Sherriff, Pedro Pesini, Andrew J Saykin, Liana G Apostolova,

<h4>Introduction</h4>We investigated the relationship of plasma amyloid beta (Aβ) with cerebral deposition of Aβ and tau on positron emission tomography (PET).<h4>Methods</h4>Forty-four participants (18 cognitively normal older adults [CN], 10 mild cognitive impairment, 16 Alzheimer's disease [AD]) underwent amyloid PET and a blood draw. Free and total plasma Aβ40 and Aβ42 ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2019, 11:510-519]

Cited: 5 times

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Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment.

Naira Goukasian, Shai Porat, Anna Blanken, David Avila, Dimitar Zlatev, Sona Hurtz, Kristy S Hwang, Jonathan Pierce, Shantanu H Joshi, Ellen Woo, Liana G Apostolova,

We analyzed structural magnetic resonance imaging data from 58 cognitively normal and 101 mild cognitive impairment subjects. We used a general linear regression model to study the association between cognitive performance with hippocampal atrophy and ventricular enlargement using the radial distance method. Bilateral hippocampal atrophy was associated with baseline and ... Read more >>

Dement Geriatr Cogn Dis Extra (Dementia and geriatric cognitive disorders extra)
[2019, 9(2):281-293]

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The Functional Ability of MCI and Alzheimer's Patients Predicts Caregiver Burden.

Jose Lara-Ruiz, Kaitlyn Kauzor, Marina Nakhala, Dayana Banuelos, Ellen Woo, Liana G Apostolova, Jill Razani,

Sixty patients and their caregivers participated in this study. Patients completed activities of daily living tasks and several neuropsychological tests assessing memory, abstract reasoning, and language. Caregivers completed self-report measures assessing caregiver burden and psychological distress. Results revealed that the mAD caregivers endorsed greater physical burden and feelings of missing ... Read more >>

GeroPsych (Bern) (GeroPsych)
[2019, 32(1):31-39]

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Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Ganesh Chauhan, Hieab H H Adams, Claudia L Satizabal, Joshua C Bis, Alexander Teumer, Muralidharan Sargurupremraj, Edith Hofer, Stella Trompet, Saima Hilal, Albert Vernon Smith, Xueqiu Jian, Rainer Malik, Matthew Traylor, Sara L Pulit, Philippe Amouyel, Bernard Mazoyer, Yi-Cheng Zhu, Sara Kaffashian, Sabrina Schilling, Gary W Beecham, Thomas J Montine, Gerard D Schellenberg, Olafur Kjartansson, Vilmundur Guðnason, David S Knopman, Michael E Griswold, B Gwen Windham, Rebecca F Gottesman, Thomas H Mosley, Reinhold Schmidt, Yasaman Saba, Helena Schmidt, Fumihiko Takeuchi, Shuhei Yamaguchi, Toru Nabika, Norihiro Kato, Kumar B Rajan, Neelum T Aggarwal, Philip L De Jager, Denis A Evans, Bruce M Psaty, Jerome I Rotter, Kenneth Rice, Oscar L Lopez, Jiemin Liao, Christopher Chen, Ching-Yu Cheng, Tien Y Wong, Mohammad K Ikram, Sven J van der Lee, Najaf Amin, Vincent Chouraki, Anita L DeStefano, Hugo J Aparicio, Jose R Romero, Pauline Maillard, Charles DeCarli, Joanna M Wardlaw, Maria Del C Valdés Hernández, Michelle Luciano, David Liewald, Ian J Deary, John M Starr, Mark E Bastin, Susana Muñoz Maniega, P Eline Slagboom, Marian Beekman, Joris Deelen, Hae-Won Uh, Robin Lemmens, Henry Brodaty, Margaret J Wright, David Ames, Giorgio B Boncoraglio, Jemma C Hopewell, Ashley H Beecham, Susan H Blanton, Clinton B Wright, Ralph L Sacco, Wei Wen, Anbupalam Thalamuthu, Nicola J Armstrong, Elizabeth Chong, Peter R Schofield, John B Kwok, Jeroen van der Grond, David J Stott, Ian Ford, J Wouter Jukema, Meike W Vernooij, Albert Hofman, André G Uitterlinden, Aad van der Lugt, Katharina Wittfeld, Hans J Grabe, Norbert Hosten, Bettina von Sarnowski, Uwe Völker, Christopher Levi, Jordi Jimenez-Conde, Pankaj Sharma, Cathie L M Sudlow, Jonathan Rosand, Daniel Woo, John W Cole, James F Meschia, Agnieszka Slowik, Vincent Thijs, Arne Lindgren, Olle Melander, Raji P Grewal, Tatjana Rundek, Kathy Rexrode, Peter M Rothwell, Donna K Arnett, Christina Jern, Julie A Johnson, Oscar R Benavente, Sylvia Wasssertheil-Smoller, Jin-Moo Lee, Quenna Wong, Braxton D Mitchell, Stephen S Rich, Patrick F McArdle, Mirjam I Geerlings, Yolanda van der Graaf, Paul I W de Bakker, Folkert W Asselbergs, Velandai Srikanth, Russell Thomson, Rebekah McWhirter, Chris Moran, Michele Callisaya, Thanh Phan, Loes C A Rutten-Jacobs, Steve Bevan, Christophe Tzourio, Karen A Mather, Perminder S Sachdev, Cornelia M van Duijn, Bradford B Worrall, Martin Dichgans, Steven J Kittner, Hugh S Markus, Mohammad A Ikram, Myriam Fornage, Lenore J Launer, Sudha Seshadri, W T Longstreth, Stéphanie Debette, ,

<h4>Objective</h4>To explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts.<h4>Methods</h4>We performed meta-analyses of genome-wide association studies (GWAS) and examined associations of vascular risk factors and their genetic risk scores (GRS) with MRI-defined BI and a subset of BI, namely, small subcortical BI (SSBI), in ... Read more >>

Neurology (Neurology)
[2019, :]

Cited: 2 times

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Resting state network modularity along the prodromal late onset Alzheimer's disease continuum.

Joey A Contreras, Andrea Avena-Koenigsberger, Shannon L Risacher, John D West, Eileen Tallman, Brenna C McDonald, Martin R Farlow, Liana G Apostolova, Joaquín Goñi, Mario Dzemidzic, Yu-Chien Wu, Daniel Kessler, Lucas Jeub, Santo Fortunato, Andrew J Saykin, Olaf Sporns,

Alzheimer's disease is considered a disconnection syndrome, motivating the use of brain network measures to detect changes in whole-brain resting state functional connectivity (FC). We investigated changes in FC within and among resting state networks (RSN) across four different stages in the Alzheimer's disease continuum. FC changes were examined in ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2019, 22:101687]

Cited: 5 times

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Neurodegenerative Patterns of Cognitive Clusters of Early-Onset Alzheimer's Disease Subjects: Evidence for Disease Heterogeneity.

Meredith L Phillips, Eddie C Stage, Kathleen A Lane, Sujuan Gao, Shannon L Risacher, Naira Goukasian, Andrew J Saykin, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova, ,

<h4>Background/aims</h4>Alzheimer's disease (AD) with onset before 65 (early-onset AD [EOAD]) occurs in approximately 6% of cases and can affect nonmemory domains. Here, we analyze patterns of impairment in amnestic EOAD individuals using data-driven statistical analyses.<h4>Methods</h4>Cognitive data of 146 EOAD subjects were Z-normalized to 395 cognitively normal (CN) individuals. Domain-averaged Z-scores ... Read more >>

Dement Geriatr Cogn Disord (Dementia and geriatric cognitive disorders)
[2019, 48(3-4):131-142]

Cited: 0 times

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Volumetric comparison of hippocampal subfields extracted from 4-minute accelerated vs. 8-minute high-resolution T2-weighted 3T MRI scans.

Shan Cong, Shannon L Risacher, John D West, Yu-Chien Wu, Liana G Apostolova, Eileen Tallman, Maher Rizkalla, Paul Salama, Andrew J Saykin, Li Shen,

The hippocampus has been widely studied using neuroimaging, as it plays an important role in memory and learning. However, hippocampal subfield information is difficult to capture by standard magnetic resonance imaging (MRI) techniques. To facilitate morphometric study of hippocampal subfields, ADNI introduced a high resolution (0.4 mm in plane) T2-weighted turbo ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2018, 12(6):1583-1595]

Cited: 1 time

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Detection of tau in Gerstmann-Sträussler-Scheinker disease (PRNP F198S) by [18F]Flortaucipir PET.

Shannon L Risacher, Martin R Farlow, Daniel R Bateman, Francine Epperson, Eileen F Tallman, Rose Richardson, Jill R Murrell, Frederick W Unverzagt, Liana G Apostolova, Jose M Bonnin, Bernardino Ghetti, Andrew J Saykin,

This study aimed to determine the pattern of [<sup>18</sup>F]flortaucipir uptake in individuals affected by Gerstmann-Sträussler-Scheinker disease (GSS) associated with the PRNP F198S mutation. The aims were to: 1) determine the pattern of [<sup>18</sup>F]flortaucipir uptake in two GSS patients; 2) compare tau distribution by [<sup>18</sup>F]flortaucipir PET imaging among three groups: two GSS ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2018, 6(1):114]

Cited: 1 time

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Automated and manual hippocampal segmentation techniques: Comparison of results, reproducibility and clinical applicability.

Sona Hurtz, Nicole Chow, Amity E Watson, Johanne H Somme, Naira Goukasian, Kristy S Hwang, John Morra, David Elashoff, Sujuan Gao, Ronald C Petersen, Paul S Aisen, Paul M Thompson, Liana G Apostolova,

<h4>Background</h4>Imaging techniques used to measure hippocampal atrophy are key to understanding the clinical progression of Alzheimer's disease (AD). Various semi-automated hippocampal segmentation techniques are available and require human expert input to learn how to accurately segment new data. Our goal was to compare 1) the performance of our automated hippocampal ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2019, 21:101574]

Cited: 1 time

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