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Author Liam Gaziano

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Risk of stroke in relation to degree of asymptomatic carotid stenosis: a population-based cohort study, systematic review, and meta-analysis.

Dominic P J Howard, Liam Gaziano, Peter M Rothwell, ,

<h4>Background</h4>There is uncertainty around which patients with asymptomatic carotid stenosis should be offered surgical intervention. Although stroke rates were unrelated to the degree of stenosis in the medical-treatment-only groups in previous randomised trials, this could simply reflect recruitment bias and there has been no systematic analysis of a stenosis-risk association ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):193-202]

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Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Liam Gaziano, Claudia Giambartolomei, Alexandre Pereira, Anna Gaulton, Daniel Posner, Sonja Swanson, Yuk-Lam Ho, Sudha Iyengar, Nicole Kosik, Marijana Vujkovic, David Gagnon, Patrícia Bento, Pedro Beltrao, Inigo Barrio-Hernandez, Lars Rönnblom, Niklas Hagberg, Christian Lundtoft, Claudia Langenberg, Maik Pietzner, Dennis Valentine, Elias Allara, Praveen Surendran, Stephen Burgess, Jing Hua Zhao, James Peters, Bram Prins, John Danesh, Poornima Devineni, Yunling Shi, Kristine Lynch, Scott DuVall, Helene Garcon, Lauren Thomann, Jin Zhou, Bryan Gorman, Jennifer Huffman, Christopher O’Donnell, Philip Tsao, Jean Beckham, Saiju Pyarajan, Sumitra Muralidhar, Grant Huang, Rachel Ramoni, Adriana Hung, Kyong-Mi Chang, Yan Sun, Jacob Joseph, Andrew Leach, Todd Edwards, Kelly Cho, Michael Gaziano, Adam Butterworth, Juan Casas,

Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted Mendelian randomization (MR) analyses, deriving genetic instruments based on transcriptomic and proteomic data for 1,263 actionable proteins that are targeted by approved drugs or in ... Read more >>

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